I. - Basic information

I.1 - Surname

Pecháňová

I.2 - Name

Oľga

I.3 - Degrees

doc., RNDr., DrSc.

I.4 - Year of birth

1962

I.5 - Name of the workplace

Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences

I.6 - Address of the workplace

Dúbravská cesta 9, 841 04 Bratislava

I.7 - Position

Director

I.8 - E-mail address

olga.pechanova@savba.sk

I.9 - Hyperlink to the entry of a person in the Register of university staff

https://www.portalvs.sk/regzam/detail/19100

I.10 - Name of the study field in which a person works at the university

Biology

I.11 - ORCID iD

https://orcid.org/0000-0001-5476-2949

II. - Higher education and further qualification growth

II.1 - First degree of higher education

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Natural Sciences

II.b - Year

1984

II.c - Study field and programme

Biochemistry

II.2 - Second degree of higher education

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Natural Sciences

II.b - Year

1986

II.c - Study field and programme

Biochemistry

II.3 - Third degree of higher education

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Medicine

II.b - Year

1995

II.c - Study field and programme

General Biology

II.4 - Associate professor

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Medicine

II.b - Year

2015

II.c - Study field and programme

Normal and pathological physiology

II.5 - Professor

II.6 - Doctor of Science (DrSc.)

II.a - Name of the university or institution

Institute of Normal and Pathological Physiology, Slovak Academy of Sciences

II.b - Year

2006

II.c - Study field and programme

Animal Physiology

III. - Current and previous employment

III.a - Occupation-position	III.b - Institution	III.c - Duration
esearcher, director	Institute of Normal and Pathological Physiology, Slovak Academy of Sciences	1986-2018
director	Centre of Experimental Medicine, Institute of Normal and Pathological Physiology, Slovak Academy of Sciences	since 2018

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other	IV.b - Name of the institution	IV.c - Year
	about 200 international and national congresses and conferences with about 60 invited lectures

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes

V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year

V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year

V.4 - Overview of supervised final theses

V.4.1 - Number of currently supervised theses

V.4.c - Dissertation (third degree)

V.4.2 - Number of defended theses

V.4.a - Bachelor's (first degree)

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.5 - Overview of other courses taught in the current academic year according to study programmes

V.5.a - Name of the course	V.5.b - Study programme	V.5.c - Degree	V.5.d - Field of study
Physiological Biochemistry	Biology, Medical Biology	I.	Biology

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations

VI.1.1 - Number of the research/artistic/other outputs

VI.1.a - Overall

165

VI.1.b - Over the last six years

VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases

VI.1.a - Overall

165

VI.1.b - Over the last six years

VI.1.3 - Number of citations corresponding to the research/artistic/other outputs

VI.1.a - Overall

2914

VI.1.b - Over the last six years

923

VI.1.4 - Number of citations registered in the Web of Science or Scopus databases

VI.1.a - Overall

2914

VI.1.b - Over the last six years

923

VI.1.5 - Number of invited lectures at the international, national level

VI.1.a - Overall

VI.1.b - Over the last six years

VI.2 - The most significant research/artistic/other outputs

Pechánová O, Varga ZV, Cebová M, Giricz Z, Pacher P, Ferdinandy P. Cardiac NO signalling in the metabolic syndrome. Br J Pharmacol. 2015 Mar;172(6):1415-33. doi: 10.1111/bph.12960. (40 citations)

Pechanova O, Paulis L, Simko F. Peripheral and central effects of melatonin on blood pressure regulation. Int J Mol Sci. 2014 Oct 8;15(10):17920-37. doi: 10.3390/ijms151017920. (80 citations)

Pechánová O, Bernátová I, Babál P, Martínez MC, Kyselá S, Stvrtina S, Andriantsitohaina R. Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension. J Hypertens. 2004 Aug;22(8):1551-9. doi: 10.1097/01.hjh.0000133734.32125.c7. (101 citations)

Bernátová I, Pechánová O, Babál P, Kyselá S, Stvrtina S, Andriantsitohaina R. Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension. Am J Physiol Heart Circ Physiol. 2002, Mar;282(3):H942-8. doi: 10.1152/ajpheart.00724.2001. (110 citations)

Pechánová O, Bernátová I, Pelouch V, Simko F. Protein remodelling of the heart in NO-deficient hypertension: the effect of captopril. J Mol Cell Cardiol. 1997 Dec;29(12):3365-74. doi: 10.1006/jmcc.1997.0566. (112 citations)

VI.3 - The most significant research/artistic/other outputs over the last six years

Pechanova O, Dayar E, Cebova M. Therapeutic Potential of Polyphenols-LoadedbPolymeric Nanoparticles in Cardiovascular System. Molecules. 2020 Jul

22;25(15):3322. doi: 10.3390/molecules25153322.

Pechanova O, Barta A, Koneracka M, Zavisova V, Kubovcikova M, Klimentova J, Tӧrӧk J, Zemancikova A, Cebova M. Protective Effects of Nanoparticle-Loaded Aliskiren on Cardiovascular System in Spontaneously Hypertensive Rats. Molecules. 2019 Jul 25;24(15):2710. doi: 10.3390/molecules24152710.

Vrankova S, Zemancikova A, Torok J, Pechanova O. Effect of low dose L-NAME pretreatment on nitric oxide/reactive oxygen species balance and vasoactivity in L-NAME/salt-induced hypertensive rats. J Physiol Pharmacol. 2019 Aug;70(4). doi: 10.26402/jpp.2019.4.05.

Simko F, Pechanova O, Repova K, Aziriova S, Krajcirovicova K, Celec P, Tothova L, Vrankova S, Balazova L, Zorad S, Adamcova M. Lactacystin-Induced

Model of Hypertension in Rats: Effects of Melatonin and Captopril. Int J Mol Sci. 2017 Jul 25;18(8):1612. doi: 10.3390/ijms18081612.

Cebova M, Klimentova J, Janega P, Pechanova O. Effect of Bioactive Compound of <i>Aronia melanocarpa</i> on Cardiovascular System in Experimental

Hypertension. Oxid Med Cell Longev. 2017;2017:8156594. doi: 10.1155/2017/8156594.

VI.4 - The most significant citations corresponding to the research/artistic/other outputs

LEIKERT, J.F. - RATHEL, T.R. - WOHLFART, P. - CHEYNIER, V. - VOLLMAR, A.M. - DIRSCH, V.M. Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from

endothelial cells. In CIRCULATION. ISSN 0009-7322, SEP 24 2002, vol. 106, no. 13, p. 1614-1617.

LOPEZ-SEPULVEDA, R. - JIMENEZ, R. - ROMERO, M. - ZARZUELO, M.J. - SANCHEZ, M. - GOMEZ-GUZMAN, M. - VARGAS, F. - O'VALLE, F. - ZARZUELO, A. - PEREZ-VIZCAINO, F. - DUARTE, J. Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats. In HYPERTENSION. ISSN 0194-911X, APR 2008, vol. 51, no. 4, p. 1088-1095.

LI, H. - CAI, J. - CHEN, R. - ZHAO, Z. - YING, Z. - WANG, L. - CHEN, J. - HAO, K. - KINNEY, P.L. - CHEN, H. - KAN, H. Particulate matter exposure and stress hormone levels: A randomized, double-blind, crossover trial of air purification. In CIRCULATION, 2017, vol. 136, no. 7, pp. 618-627., Registrované v: WOS

Activation of endothelial nitric oxide synthase by dietary isoflavones: Role of NO in Nrf2-mediated antioxidant gene expression. In CARDIOVASCULAR RESEARCH. ISSN 0008-6363, JUL 15 2007, vol. 75, no. 2, p. 261-274

LEHTIMA¨KI, T. - HARTIALA, J.J. - VIIKARI, J. - KOSKENVUO, J.W. A moderate dose of red wine, but not dealcoholized red wine increases coronary flow reserve. In ATHEROSCLEROSIS. ISSN 0021-9150, 2007, vol. 195, no. 2, pp. e176-e181

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

Effects of nanoencapsulated simvastatin on cardiovascular system in experimental metabolic syndrome/(Účinky nanoenkapsulovaného simvastatínu na kardiovaskulárny system pri experimentálnom mentabolickom syndróme. APVV : Years of realization: 2015-2019; Project number: APVV-14-0932

Magnesium Nanocomposites for Biodegradable Medical Implants/Horčíkové nanokompozity pre biodegradovateľné medicínske implantáty, Grant scheme: MVTS, SAS -TÜBITAK; Years of realization: 2014 –2017; Project number: JRP 2014/5Project

EU-ROS: The European Network on Oxidative Stress and Redox Biology Research/(EU-ROS: Európska sieť pre výskum oxidačného stresu redoxnú biológiu.

Grant scheme: COST; Years of realization: 2013-2016; Project number: BM1203

Gasotransmitters: from basic science to therapeutic applications, Grant scheme: COST, Years of realization: 2011 – 2015, Project number: COST BM1005

Experimental myocardial infarction: Contribution of hypertension and obesity, effects of toll-like receptor inhibitor, Grant scheme: VEGA, Years of realization: 2019 - 2022, Project number: 2/0112/19

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VII.a - Activity, position	VII.b - Name of the institution, board	VII.c - Duration
Členka	Vedecká rada LFUK	2010-2015
Členka	Vedecká rada LFUK	od 2015
Členka	Vedecká rada LFUK	od 2021

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution	VIII.b - Address of the institution	VIII.c - Duration (indicate the duration of stay)	VIII.d - Mobility scheme, employment contract, other (describe)
"Osaka City University, Japan "	Abeno-Ku: Osaka 545, Japan	2007	hosťujúci profesor
University in Kragujevac	Svetozara Markovića 69, Kragujevac 34000, Serbia	from 2013	hosťujúci profesor
Viktor Babes University in Timisoara	Piața Eftimie Murgu 2, Timișoara 300041	from 2019	hosťujúci profesor
University of Helsinky	Haartmaninkatu 8, 00014 Helsinki, Finland	2000	hosťujúci profesor

IX. - Other relevant facts

IX.a - If relevant, other activities related to higher education or research/artistic/other activities are mentioned

GUEST EDITION: Physiological Research 2006, 2016, Journal of Hypertension 2009, 2010, Oxidative Medicine and Cellular Longevity 2018, 2021 Molecules 2020, Pathophysiology 2020

SCIENTIFIC SOCIETIES: President of the International Society for Pathophysiology, member of the Executive Committee of European Council of Cardiovascular Research, European Academy of Science and Art, Slovak Physiological Society, C.I.A.N.S., member of the International Society for Heart Research, International Society for Hypertension, Spanish Society for Hypertension, Federation of European Physiological Societies, International Union of the Physiological Societies

Name and surname:	doc. RNDr. Oľga Pecháňová, DrSc.
Document type:	Research/art/teacher profile of a person
The name of the university:	Comenius University Bratislava
The seat of the university:	Šafárikovo námestie 6, 818 06 Bratislava