I. - Basic information

I.1 - Surname

Nosek

I.2 - Name

Jozef

I.3 - Degrees

Prof., RNDr., DrSc.

I.4 - Year of birth

1967

I.5 - Name of the workplace

Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava

I.6 - Address of the workplace

Ilkovičova 6, 842 15 Bratislava 4, Slovakia

I.7 - Position

Professor

I.8 - E-mail address

jozef.nosek@uniba.sk

I.9 - Hyperlink to the entry of a person in the Register of university staff

https://www.portalvs.sk/regzam/detail/4385

I.10 - Name of the study field in which a person works at the university

Chemistry

I.11 - ORCID iD

https://orcid.org/0000-0002-1020-5451

II. - Higher education and further qualification growth

II.1 - First degree of higher education

II.2 - Second degree of higher education

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Natural Sciences

II.b - Year

1990

II.c - Study field and programme

Molecular Biology and Genetics

II.3 - Third degree of higher education

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Natural Sciences

II.b - Year

1994

II.c - Study field and programme

Genetics

II.4 - Associate professor

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Natural Sciences

II.b - Year

2000

II.c - Study field and programme

Biochemistry

II.5 - Professor

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Natural Sciences

II.b - Year

2008

II.c - Study field and programme

Biochemistry

II.6 - Doctor of Science (DrSc.)

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Natural Sciences

II.b - Year

2006

II.c - Study field and programme

Molecular Biology

III. - Current and previous employment

III.a - Occupation-position	III.b - Institution	III.c - Duration
PhD student	Comenius University in Bratislava, Faculty of Natural Sciences	1990-1992
Research fellow	Comenius University in Bratislava, Faculty of Natural Sciences	1992-1995
Assistant Professor	Comenius University in Bratislava, Faculty of Natural Sciences	1995-2003
Associate Professor	Comenius University in Bratislava, Faculty of Natural Sciences	2003-2010
Professor	Comenius University in Bratislava, Faculty of Natural Sciences	since 2010

IV. - Development of pedagogical, professional, language, digital and other skills

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes

V.1.a - Name of the profile course	V.1.b - Study programme	V.1.c - Degree	V.1.d - Field of study
Essential Cell Biology	Biochemistry, Biochemistry (conversion programme)	I.	Chemistry
Methods in Molecular and Cell Biology	Biochemistry, Biochemistry (conversion programme)	I.	Chemistry
Bachelor Thesis in Biochemistry (1)	Biochemistry	I.	Chemistry
Genomics	Biochemistry	II.	Chemistry
Molecular Biology of the Cell (1)	Biochemistry	II.	Chemistry
Molecular and Cell Biology	Biochemistry	III.	Chemistry
Doctoral Seminar in Biochemistry (2)	Biochemistry	III.	Chemistry

V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year

V.2.a - Name of the study programme	V.2.b - Degree	V.2.c - Field of study
Biochemistry	I.	Chemistry
Biochemistry (conversion programme)	I.	Chemistry
Biochemistry	II.	Chemistry
Biochemistry	III.	Chemistry

V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year

V.3.a - Name of the field of habilitation procedure and inaugural procedure	V.3.b - Study field to which it is assigned
Biochemistry	Chemistry

V.4 - Overview of supervised final theses

V.4.1 - Number of currently supervised theses

V.4.a - Bachelor's (first degree)

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.4.2 - Number of defended theses

V.4.a - Bachelor's (first degree)

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.5 - Overview of other courses taught in the current academic year according to study programmes

V.5.a - Name of the course	V.5.b - Study programme	V.5.c - Degree	V.5.d - Field of study
Bachelor Thesis in Biochemistry (2)	Biochemistry, Biochemistry (conversion programme)	I.	Chemistry

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations

VI.1.1 - Number of the research/artistic/other outputs

VI.1.a - Overall

112

VI.1.b - Over the last six years

VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases

VI.1.a - Overall

112

VI.1.b - Over the last six years

VI.1.3 - Number of citations corresponding to the research/artistic/other outputs

VI.1.a - Overall

1741

VI.1.b - Over the last six years

821

VI.1.4 - Number of citations registered in the Web of Science or Scopus databases

VI.1.a - Overall

1741

VI.1.b - Over the last six years

821

VI.1.5 - Number of invited lectures at the international, national level

VI.1.a - Overall

VI.1.b - Over the last six years

VI.2 - The most significant research/artistic/other outputs

Lang, B.F., Jakúbková, M., Hegedűsová, E., Daoud, R., Forget, L., Brejová, B., Vinař, T., Kosa, P., Fričová, D., Neboháčová, M., Griač, P., Tomáška, Ľ., Burger, G., Nosek, J. (2014) Massive programmed translational jumping in mitochondria. Proceedings of the National Academy of Sciences of the United States of America111(16): 5926-5931.

Valach, M., Farkas, Z., Fričová, D., Kováč, J., Brejová, B., Vinař, T., Pfeiffer, I., Kucsera, J., Tomáška, Ľ., Lang, B.F., Nosek, J. (2011) Evolution of linear chromosomes and multipartite genomes in yeast mitochondria. Nucleic Acids Research 39(10): 4202-4219.

Tomáška, Ľ., Nosek, J., Kramara, J., Griffith, J.D. (2009) Telomeric circles: universal players in telomere maintenance? Nature Structural & Molecular Biology 16(10): 1010-1015.

Kosa, P., Valach, M., Tomáška, Ľ., Wolfe, K.H, Nosek, J. (2006) Complete DNA sequences of the mitochondrial genomes of the pathogenic yeasts Candida orthopsilosis and Candida metapsilosis: Insight into the evolution of linear DNA genomes from mitochondrial telomere mutants. Nucleic Acids Research34(8): 2472-2481.

Nosek, J., Ryčovská, A., Makhov, A.M., Griffith, J.D., Tomáška, Ľ. (2005) Amplification of telomeric arrays via rolling-circle mechanism. Journal of Biological Chemistry 280: 10840-10845.

VI.3 - The most significant research/artistic/other outputs over the last six years

Tóth, R., Nosek, J., Mora-Montes, H.M., Gabaldón, T., Bliss, J.M., Nosanchuk, J.D., Turner, S.A., Butler, G., Vágvölgyi, C., Gácser, A. (2019) Candida parapsilosis: from genes to the bedside. Clinical Microbiology Reviews 32(2): e00111-18.

Brejová, B., Lichancová, H., Brázdovič, F., Hegedűsová, E., Forgáčová Jakúbková, M., Hodorová, V., Džugasová, V., Baláž, A., Zeiselová, L., Cillingová, A., Neboháčová, M., Raclavský, V., Tomáška, Ľ., Lang, B.F., Vinař, T., Nosek, J. (2019) Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus. Current Genetics 65(2): 539-560.

Brejová, B., Hodorová, V., Mutalová, S., Cillingová, A., Tomáška, Ľ, Vinař, T., Nosek, J. (2024) Chromosome-level genome assembly of the yeast Lodderomyces beijingensis reveals the genetic nature of metabolic adaptations and identifies subtelomeres as hotspots for amplification of mating type loci. DNA Research 31(3): dsae014.

Mixão, V., del Olmo, V., Hegedűsová, E., Saus, E., Pryszcz, L.P., Cillingová, A., Nosek, J., and Gabaldón, T. (2022) Genome analysis of five recently described species of the CUG-Ser clade uncovers Candida theae as a new hybrid lineage with pathogenic potential in the Candida parapsilosis species complex. DNA Research 29(2): dsac010.

Cillingová, A., Tóth, R., Mojáková, A., Zeman, I., Vrzoňová, R., Siváková, B., Baráth, P., Neboháčová, M., Klepcová, Z., Brázdovič, F., Lichancová, H., Hodorová, V., Brejová, B., Vinař, T., Mutalová, S., Vozáriková, V., Mutti, G., Tomáška, Ľ., Gácser, A., Gabaldón, T., Nosek, J. (2022) Transcriptome and proteome profiling reveals complex adaptations of Candida parapsilosis cells assimilating hydroxyaromatic carbon sources. PLoS Genetics 18(3): e1009815.

VI.4 - The most significant citations corresponding to the research/artistic/other outputs

Lang, B.F., Jakúbková, M., Hegedűsová, E., Daoud, R., Forget, L., Brejová, B., Vinař, T., Kosa, P., Fričová, D., Neboháčová, M., Griač, P., Tomáška, Ľ., Burger, G., Nosek, J. (2014) Massive programmed translational jumping in mitochondria. Proceedings of the National Academy of Sciences of the United States of America 111(16): 5926-5931.

Cited in: Baranov, P.V., Atkins, J.F., Yordanova, M.M. (2015) Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning. Nature Reviews Genetics 16: 517-529.

Nosek, J., Tomáška, Ľ., Burger, G., Lang, B.F. (2015) Programmed translational bypassing elements in mitochondria: structure, mobility and evolutionary origin. Trends in Genetics 31(4): 187-194.

Cited in: Chen, J., Coakley, A., O’Connor, M., Petrov, A., O’Leary, S.E., Atkins, J.F., and Puglisi, J.D. (2015) Coupling of mRNA Structure Rearrangement to Ribosome Movement during Bypassing of Non-coding Regions. Cell 163: 1267-1280.

Tomáška, Ľ., Nosek, J., Kramara, J., Griffith, J.D. (2009) Telomeric circles: universal players in telomere maintenance? Nature Structural & Molecular Biology 16(10): 1010-1015.

Cited in: Mazzucco, G., Huda, A., Galli, M., Piccini, D., Giannattasio, M., Pessina, F., Doksani, Y. (2020) Telomere damage induces internal loops that generate telomeric circles. Nature Communications 11: 5297.

Nosek, J., Ryčovská, A., Makhov, A.M., Griffith, J.D., Tomáška, Ľ. (2005) Amplification of telomeric arrays via rolling-circle mechanism. Journal of Biological Chemistry 280: 10840-10845.

Cited in: McEachern, M.J., Haber, J.E. (2006) Break-induced replication and recombinational telomere elongation in yeast. Annual Reviews of Biochemistry 75: 111–135.

Nosek, J., Tomáška, Ľ., Fukuhara, H., Suyama, Y., Kováč, L. (1998) Linear mitochondrial genomes: 30 years down the line. Trends in Genetics 14: 184-188.

Cited in: Williamson, D. (2002) The curious history of yeast mitochondrial DNA. Nature Reviews in Genetics 3: 1-7.

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

APVV-22-0144 (2023-2027) Comparative transcriptomics as a window into the world of fundamental biological processes (Principal Investigator). The project is focused on the comparative transcriptome analysis of non-conventional yeasts.

APVV 20-0166 (2021-2025) Nonconventional yeasts as producers of high value-added lipids (Research Collaborator). The project is focused on the exploration of different yeast species as lipid producers.

APVV-19-0068 (2020-2024) Exploring yeast biodiversity for uncovering novel mechanisms of telomere maintenance of eukaryotic chromosomes (Research Collaborator). The project is focused on the telomeres of non-conventional yeasts and the molecular mechanisms of their replication.

APVV-18-0239 [2019-2023] Non-conventional applications of emerging sequencing technologies in comparative and functional genomics (Principal Investigator). The project was focused on new experimental and bioinformatics methods that in combination with the third-generation sequencing technologies allow determination of highly-contiguous sequences of non-conventional yeast species.

VEGA 1/0031/24 (2024-2028) Mitochondria as signal centers of the eukaryotic cell (Deputy of Principal Investigator). The project is focused on researching mitochondrial functions and their role in intracellular communication.

VEGA 1/0234/23 (2023-2026) Alternative telomere maintenance mechanisms in cells of non-conventional yeast species (Principal Investigator). The project is focused on the analysis of molecular mechanisms of telomere maintenance in yeasts and their mutants lacking functional telomerase.

VEGA 1/0061/20 (2020-2023) Post-translational and epigenetic modifications and their significance for the regulation of mitochondrial functions (Deputy of Principal Investigator). The project was focused on the analysis of post-translational modifications of mitochondrial proteins.

VEGA 1/0027/19 (2019-2022) Functional analysis of metabolic gene clusters coding for the enzymes of catabolic degradation of hydroxyaromatic compounds (Principal Investigator). The project was focused on the analysis of biochemical pathways involved in the degradation of hydroxyaromatic compounds and their integration with the central metabolism of eukaryotic cells.

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VII.a - Activity, position	VII.b - Name of the institution, board	VII.c - Duration
Chair of the Committee for PhD Programme in Biochemistry	Comenius University in Bratislava, Faculty of Natural Sciences	since 2012
Guarantor of the Programme in Biochemistry (I, II, III degree).	Comenius University in Bratislava, Faculty of Natural Sciences	since 2012
Chair of the Committee for Biochemistry	Slovak Commission for Scientific Degrees	2012-2021
Member of the Scientific Board	Comenius University in Bratislava, Faculty of Natural Sciences	since 2007
Member of the Committee for the Study Programmes of the Chemistry Section	Comenius University in Bratislava, Faculty of Natural Sciences	since 2022

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution	VIII.b - Address of the institution	VIII.c - Duration (indicate the duration of stay)	VIII.d - Mobility scheme, employment contract, other (describe)
Institut Curie, Section de Biologie	Orsay, France	09/1992 - 03/1994	A fellowship of the University of Paris XI and a fellowship of the Commission of the European Communities (Community’s Action for Cooperation in Science and Technology with Central and Eastern European Countries)
Institut Curie, Section de Biologie	Orsay, France	08/1995 - 09/1995	Collaboration on a research project
Institut Curie, Section de Biologie	Orsay, France	09/1996 - 03/1997	A fellowship (Ministére de l’Education Nationale, de l’Enseignement Supérieur, de la Recherche et de l’Insertion Professionelle de la Republique Française)
Institut de Génétique et Microbiologie, Université de Paris XI	Orsay, France	10/2002 - 01/2003	A fellowship of the European Molecular Biology Organization (EMBO)
Institut de Génétique et Microbiologie, Université de Paris XI	Orsay, France	10/2003-10/2003	Collaboration on a research project

IX. - Other relevant facts

Date of last update

2025-01-27

Name and surname:	prof. RNDr. Jozef Nosek, DrSc.
Document type:	Research/art/teacher profile of a person
The name of the university:	Comenius University Bratislava
The seat of the university:	Šafárikovo námestie 6, 818 06 Bratislava