Research/art/teacher profile of a person
Name and surname:
prof. RNDr. Katarína Mikušová, DrSc.
Document type:
Research/art/teacher profile of a person
The name of the university:
Comenius University Bratislava
The seat of the university:
Šafárikovo námestie 6, 818 06 Bratislava

I. - Basic information

I.1 - Surname
Mikušová
I.2 - Name
Katarína
I.3 - Degrees
Prof., RNDr., DrSc.
I.4 - Year of birth
1965
I.5 - Name of the workplace
Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava
I.6 - Address of the workplace
Mlynská dolina, Ilkovičova 6, 84215 Bratislava
I.7 - Position
head of the department
I.8 - E-mail address
katarina.mikusova@uniba.sk
I.9 - Hyperlink to the entry of a person in the Register of university staff
https://www.portalvs.sk/regzam/detail/4363
I.10 - Name of the study field in which a person works at the university
biochemistry
I.11 - ORCID iD
https://orcid.org/0000-0002-0100-4877

II. - Higher education and further qualification growth

II.1 - First degree of higher education
II.a - Name of the university or institution
n/a
II.2 - Second degree of higher education
II.a - Name of the university or institution
Comenius University in Bratislava, Faculty of Natural Sciences
II.b - Year
1988
II.c - Study field and programme
chemistry, biochemistry
II.3 - Third degree of higher education
II.a - Name of the university or institution
Comenius University in Bratislava, Faculty of Natural Sciences
II.b - Year
1998
II.c - Study field and programme
biochemistry
II.4 - Associate professor
II.a - Name of the university or institution
Comenius University in Bratislava, Faculty of Natural Sciences
II.b - Year
2005
II.c - Study field and programme
biochemistry
II.5 - Professor
II.a - Name of the university or institution
Comenius University in Bratislava, Faculty of Natural Sciences
II.b - Year
2022
II.c - Study field and programme
biochemistry
II.6 - Doctor of Science (DrSc.)
II.a - Name of the university or institution
Comenius University in Bratislava, Faculty of Natural Sciences
II.b - Year
2016
II.c - Study field and programme
biochemistry

III. - Current and previous employment

III.a - Occupation-position III.b - Institution III.c - Duration
head of the department of biochemistry Comenius University in Bratislava, Faculty of Natural Sciences 2012 - present
associate professor Comenius University in Bratislava, Faculty of Natural Sciences 2005 - 2022
assistent professor Comenius University in Bratislava, Faculty of Natural Sciences 1995-2005
research assistant Colorado State University, Fort Collins, USA 1992-1995
university teacher - assistant Comenius University in Bratislava, Faculty of Natural Sciences 1988-1989
professor Comenius University in Bratislava, Faculty of Natural Sciences 2022 - present

IV. - Development of pedagogical, professional, language, digital and other skills

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes
V.1.a - Name of the profile course V.1.b - Study programme V.1.c - Degree V.1.d - Field of study
Biochemistry (2) biochemistry 1. chemistry
Biochemistry - Bachelor's thesis (2) biochemistry 1 chemistry
Biochemistry - Master's thesis (1) biochemistry 2 chemistry
Laboratory practice biochemistry 2 chemistry
Biochemistry and molecular biology - selected chapters biochemistry 2 chemistry
Biochemistry - Master's thesis (1) biochemistry 2 chemistry
Advanced biochemistry biochemistry 3 chemistry
Biochemistry (1) biochemistry 1. chemistry
V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year
V.2.a - Name of the study programme V.2.b - Degree V.2.c - Field of study
Biochemistry 1 Chemistry
Biochemistry (convers.) 1 Chemistry
Biochemistry 2 Chemistry
Biochemistry 3 Chemistry
V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year
V.3.a - Name of the field of habilitation procedure and inaugural procedure V.3.b - Study field to which it is assigned
Organic Chemistry Chemistry
V.4 - Overview of supervised final theses
V.4.1 - Number of currently supervised theses
V.4.a - Bachelor's (first degree)
1
V.4.b - Diploma (second degree)
2
V.4.c - Dissertation (third degree)
1
V.4.2 - Number of defended theses
V.4.a - Bachelor's (first degree)
26
V.4.b - Diploma (second degree)
23
V.4.c - Dissertation (third degree)
7
V.5 - Overview of other courses taught in the current academic year according to study programmes
V.5.a - Name of the course V.5.b - Study programme V.5.c - Degree V.5.d - Field of study
Perspectives of biochemistry biochemistry 1 chemistry
Elective laboratory practice in biochemistry 1 biochemistry 2 chemistry
Antibiotics biochemistry 2 chemistry
Elective laboratory practice in biochemistry 2 biochemistry 2 chemistry
Doctoral seminar 1 biochemistry 3 chemistry
Doctoral seminar 3 biochemistry 3 chemistry
Biochemistry Biological Chemistry 1 chemistry
Structure and function of biomolecules Biological Chemistry 1 Chemistry

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations
VI.1.1 - Number of the research/artistic/other outputs
VI.1.a - Overall
143
VI.1.b - Over the last six years
26
VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases
VI.1.a - Overall
68
VI.1.b - Over the last six years
19
VI.1.3 - Number of citations corresponding to the research/artistic/other outputs
VI.1.a - Overall
2803
VI.1.b - Over the last six years
1253
VI.1.4 - Number of citations registered in the Web of Science or Scopus databases
VI.1.a - Overall
3968
VI.1.b - Over the last six years
1627
VI.1.5 - Number of invited lectures at the international, national level
VI.1.a - Overall
9
VI.1.b - Over the last six years
1
VI.2 - The most significant research/artistic/other outputs
1

ADC Mikušová, Katarína - Huang, Hairong - Yagi, Tetsuya - Holsters, Marcelle - Vereecke, Danny - D´Haeze, Wim - Scherman, Michael S. - Brennan, Patrick J. - McNeil, Michael R. - Crick, Dean C. : Decaprenylphosphoryl arabinofuranose, the donorof the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose. In: Journal of Bacteriology. - Vol. 187, No. 23 (2005), s. 8020-8025, IF (JCR) 2005=4,167, Citations (109)

2

ADC Beláňová, Martina - Dianišková, Petronela - Brennan, Patrick J. - Completo, Gladys C. - Rose, Natisha L. - Lowary, Todd L. - Mikušová, Katarína: Galactosyl transferases in mycobacterial cell wall synthesis. In: Journal of Bacteriology. - Vol. 190, No. 3 (2008), p. 1141-1145. - IF (JCR) 2008=3,636 Citations (49)

3

ADC Makarov, Vadim - Manina, Giulia - Mikušová, Katarína - Moellmann, Ute - Ryabova, Olga - Saint-Joanis, Brigitte - Dhar, Neeraj - Pasca, Maria Rosalia - Buroni, Silvia - Lucarelli, Anna Paola - Milano, Anna - De Rossi, Edda - Beláňová,Martina - Bobovska, Adela - Dianišková, Petronela - Korduláková, Jana - Sala, Claudia - Fullam, Elizabeth - Schneider, Patricia - McKinney, John D. - Brodin, Priscille - Christophe, Thierry - Waddell, Simon - Butcher, Philip - Albrethsen, Jakob - Rosenkrands, Ida - Brosch, Roland - Nandi, Vrinda - Bharath, Sowmya - Gaonkar, Sheshagiri - Shandil, Radha K. - Balasubramanian, Venkataraman - Balganesh, Tanjore - Tyagi, Sandeep - Grosset, Jacques - Riccardi, Giovanna - Cole, Stewart T. : Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis. In: Science. - Vol. 324, No. 5928 (2009), s. 801-804, IF (JCR) 2009=29,747, Citations (387)

4

ADC Trefzer, Claudia - Škovierová, Henrieta - Buroni, Silvia - Bobovská, Adela - Nenci, Simone - Molteni, Elisabetta - Pojer, Florence - Pasca, Maria R. - Makarov, Vadim - Cole, Stewart T. - Riccardi, Giovanna - Mikušová, Katarína - Johnsson, Kai: Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-beta-D-ribofuranose 2 '-Oxidase DprE1. In: Journal of the American Chemical Society. - Vol. 134, No. 2 (2012), s. 912-915, IF (JCR) 2012=10,677 Citations (the 110)

5

ADC Brecik, Miroslav - Centárová, Ivana - Mukherjee, Raju - Kolly, Gaelle S. - Huszár, Stanislav - Bobovská, Adela - Kilacsková, Emöke - Mokošová, Veronika - Svetlíková, Zuzana - Šarkan, Michal - Neres, Joao - Korduláková, Jana - Cole, Stewart T. - Mikušová, Katarína: DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization. In: ACS Chemical Biology. - Vol. 10, No. 7 (2015), p. 1631-1636. IF (JCR) 2015=5,090 [2014-5,331] Citations (84)

VI.3 - The most significant research/artistic/other outputs over the last six years
1

V3 Fan, Dongguang - Wang, Bin - Stelitano, Giovanni - Savková, Karin - Shi, Rui - Huszár, Stanislav - Han, Quanquan - Mikušová, Katarína - Chiarelli, Laurent Roberto - Lu, Yu - Qiao, Chunhua: Structural and Activity Relationships of 6-Sulfonyl-8-Nitrobenzothiazinones as Antitubercular Agents. In: Journal of Medicinal Chemistry. - Vol. 64, No. 19 (2021), pp. 14526-14539. - IF (JCR) 2021=8.039 Citations (6)

2

Savkova, K., M. Danchenko, V. Fabianova, J. Bellova, M. Bencurova, S. Huszar, J. Kordulakova, B. Sivakova, P. Barath and K. Mikusova (2024). "Compartmentalization of galactan biosynthesis in mycobacteria." J Biol Chem 300(3): 105768.

3

ADC Makarov, Vadim - Mikušová, Katarína : Development of Macozinone for TB treatment: An Update. 

In: Applied sciences. - Vol. 10, No 7 (2020), s. [1-11], art. no. 2269 [online]. IF (JCR) 2019=2,474 Citations (21)

4

ADC Liu, Lingfeng - Kong, Chengcheng - Fumagalli, Marco - Savková, Karin - Xu, Yiwen - Huszár, Stanislav - Sammartino, José Camilla - Fan, Dongguang - Chiarelli, Laurent R. - Mikušová,Katarína - Sun, Zhaogang - Qiao, Chunhua: Design, synthesis and evaluation of covalent inhibitors of DprE1 as antitubercular agents. In: European Journal of Medicinal Chemistry. - Vol. 208 (2020), p. [1-11], Art. No. 112773. IF (JCR) 2019=5.573 Citations (9)

5

ADC Savkova, Karin - Huszar, Stanislav - Barath, Peter - Pakanova, Zuzana - Kozmon, Stanislav - Vancova, Marie - Tesarova, Martina - Blasko, Jaroslav - Kalinak, Michal - Singh, Vinayak - Kordulakova, Jana - Mikusova, Katarina: An ABC transporter Wzm-Wzt catalyzes translocation of lipid-linked galactan across the plasma membrane in mycobacteria. In: Proc Natl Acad Sci U S A Vol. 118 No. 17, e2023663118 (2021) IF (JCR) 2019=9,412 Citations (2)

VI.4 - The most significant citations corresponding to the research/artistic/other outputs
1

ADC Beláňová, Martina - Dianišková, Petronela - Brennan, Patrick J. - Completo, Gladys C. - Rose, Natisha L. - Lowary, Todd L. - Mikušová, Katarína: Galactosyl transferases in mycobacterial cell wall synthesis. In: Journal of Bacteriology. - Vol. 190, No. 3 (2008), p. 1141-1145.


[o1] Cuthbertson, L.; Kos, V.; Whitfield, C., ABC transporters involved in export of cell surface glycoconjugates. Microbiology and Molecular Biology Reviews 2010, 74, 341-62.

2

ADC Mikušová, Katarína - Huang, Hairong - Yagi, Tetsuya - Holsters, Marcelle - Vereecke, Danny - D´Haeze, Wim - Scherman, Michael S. - Brennan, Patrick J. - McNeil, Michael R. - Crick, Dean C. : Decaprenylphosphoryl arabinofuranose, the donorof the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose. In: Journal of Bacteriology. - Vol. 187, No. 23 (2005), s. 8020-8025


[o1] Neres, J.; Pojer, F.; Molteni, E.; Chiarelli, L. R.; Dhar, N.; Boy-Rottger, S.; Buroni, S.; Fullam, E.; Degiacomi, G.; Lucarelli, A. P.; Read, R. J.; Zanoni, G.; Edmondson, D. E.; De Rossi, E.; Pasca, M. R.; McKinney, J. D.; Dyson, P. J.; Riccardi, G.; Mattevi, A.; Cole, S. T.; Binda, C., Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis. Science Translational Medicine 2012, 4, 150ra121.

3

ADC Makarov, Vadim - Manina, Giulia - Mikušová, Katarína - Moellmann, Ute - Ryabova, Olga - Saint-Joanis, Brigitte - Dhar, Neeraj - Pasca, Maria Rosalia - Buroni, Silvia - Lucarelli, Anna Paola - Milano, Anna - De Rossi, Edda - Beláňová,Martina - Bobovska, Adela - Dianišková, Petronela - Korduláková, Jana - Sala, Claudia - Fullam, Elizabeth - Schneider, Patricia - McKinney, John D. - Brodin, Priscille - Christophe, Thierry - Waddell, Simon - Butcher, Philip - Albrethsen, Jakob - Rosenkrands, Ida - Brosch, Roland - Nandi, Vrinda - Bharath, Sowmya - Gaonkar, Sheshagiri - Shandil, Radha K. - Balasubramanian, Venkataraman - Balganesh, Tanjore - Tyagi, Sandeep - Grosset, Jacques - Riccardi, Giovanna - Cole, Stewart T. : Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis. In: Science. - Vol. 324, No. 5928 (2009), s. 801-804,


[o1] Cheng, Y.; Xie, J.; Lee, K. H.; Gaur, R. L.; Song, A.; Dai, T.; Ren, H.; Wu, J.; Sun, Z.; Banaei, N.; Akin, D.; Rao, J., Rapid and specific labeling of single live Mycobacterium tuberculosis with a dual-targeting fluorogenic probe. Science Translational Medicine 2018, 10 (454).

4

ADC Trefzer, Claudia - Škovierová, Henrieta - Buroni, Silvia - Bobovská, Adela - Nenci, Simone - Molteni, Elisabetta - Pojer, Florence - Pasca, Maria R. - Makarov, Vadim - Cole, Stewart T. - Riccardi, Giovanna - Mikušová, Katarína - Johnsson, Kai: Benzothiazinones Are Suicide Inhibitors of Mycobacterial Decaprenylphosphoryl-beta-D-ribofuranose 2 '-Oxidase DprE1. In: Journal of the American Chemical Society. - Vol. 134, No. 2 (2012), s. 912-915


[o1] Liu, R.; Lyu, X.; Batt, S. M.; Hsu, M. H.; Harbut, M. B.; Vilcheze, C.; Cheng, B.; Ajayi, K.; Yang, B.; Yang, Y.; Guo, H.; Lin, C.; Gan, F.; Wang, C.; Franzblau, S. G.; Jacobs, W. R., Jr.; Besra, G. S.; Johnson, E. F.; Petrassi, M.; Chatterjee, A. K.; Futterer, K.; Wang, F., Determinants of the inhibition of DprE1 and CYP2C9 by antitubercular thiophenes. Angewandte Chemie 2017, 56, 13011-13015.

5

ADC Brecik, Miroslav - Centárová, Ivana - Mukherjee, Raju - Kolly, Gaelle S. - Huszár, Stanislav - Bobovská, Adela - Kilacsková, Emöke - Mokošová, Veronika - Svetlíková, Zuzana - Šarkan, Michal - Neres, Joao - Korduláková, Jana - Cole, Stewart T. - Mikušová, Katarína: DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization. In: ACS Chemical Biology. - Vol. 10, No. 7 (2015), p. 1631-1636.


[o1] Bahuguna, A. and D. S. Rawat, An overview of new antitubercular drugs, drug candidates, and their targets. Medicinal Research Reviews 2020, 40, 263-292.

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years
1

Computer-aided design of novel antituberculosis compounds and their experimental evaluation 

APVV 20-0230 (2021-2025)

Investigator (Principal Investigator for the partner institution)

2

Design, Synthesis and Mode of Action Study of New Original Heterocyclic Compounds with Activity on Latent Tuberculosis Infection; 

Ministry of Education, School, Science, Research and Sport of the Slovak Republic, scientific and technical services within the Slovak-Russian cooperation, contract number 0395/2016 (2016 - 2018)

Principal Investigator

3

Topological aspects of mycobacterial arabinogalactan biosynthesis - functional characterization of selected mycobacterial ABC transporters.

APVV-15-0515 (2016-2020) 

Principal Investigator

4

Investigation of the mechanism of action of antimycobacterial inhibitors - development of a new methodology for the investigation of mechanisms of action of new antimycobacterial compounds;

VEGA 1/0301/18 (2018 – 2021) 

Deputy of the principal investigator

5

Deciphering the final stages of mycobacterial cell wall core biosythesis

Recovery and resilience facility

Project number: 09I01-03-V03-00001 (September 2023 - June 2026

Acronym: MyTB-Core

Principal investigator

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VII.a - Activity, position VII.b - Name of the institution, board VII.c - Duration
Co-guarantee of the Board for the Doctoral Study Program "Biochemistry" Comenius University in Bratislava, Faculty of Natural Sciences 2009 - present
Alternating chairman (previously member) of the state exam committee for Biochemistry master's degree Comenius University in Bratislava, Faculty of Natural Sciences 2005 - present
Member of the state exam committee for Biochemistry bachelor's degree Comenius University in Bratislava, Faculty of Natural Science 2005 - present
Member of the VEGA Evaluation Committee for Chemical Sciences Ministry of Education, School, Science, Research and Sport of the Slovak Republic since 2021
Chair of the "ad hoc" committee for the defense of doctoral theses in the field of Biochemistry Ministry of Education, School, Science, Research and Sport of the Slovak Republic since 2021

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution VIII.b - Address of the institution VIII.c - Duration (indicate the duration of stay) VIII.d - Mobility scheme, employment contract, other (describe)
Department of Microbiology, Immunology, and Pathology, Colorado State University Fort Collins, USA 06/1992-07/1995 research assistant (work contract)
Department of Microbiology, Immunology, and Pathology, Colorado State University Fort Collins, USA 10 short term stays (1-2 months) between 1996-2008 visiting scientist - invitation by prof. P.J. Brennan to perform investigation of metabolic pathways of mycobacterial cell wall synthesis
AstraZeneca Bangalore, India 25/09/2006-06/10/2006 visiting scientist - invitation by Dr. T. Balganesh to perform optimization of high throughput screening of mannosyltransferase PimA

IX. - Other relevant facts

IX.a - If relevant, other activities related to higher education or research/artistic/other activities are mentioned

Member of the Learned Society of Slovakia since 2021

Date of last update
2025-02-20