Research/art/teacher profile of a person
Name and surname:
Mgr. Lucia Kováčiková, PhD.
Document type:
Research/art/teacher profile of a person
The name of the university:
Comenius University Bratislava
The seat of the university:
Šafárikovo námestie 6, 818 06 Bratislava

I. - Basic information

I.1 - Surname
Kováčiková
I.2 - Name
Lucia
I.3 - Degrees
Mgr., PhD.
I.4 - Year of birth
1983
I.5 - Name of the workplace
Institution of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, SAS
I.6 - Address of the workplace
Dúbravská cesta 9, 84104 Bratislava
I.7 - Position
senior researcher
I.8 - E-mail address
lucia.kovacikova@savba.sk, lucia.kovacikova@uniba.sk, kovacik.lucia@gmail.com
I.9 - Hyperlink to the entry of a person in the Register of university staff
https://www.portalvs.sk/regzam/detail/34239
I.10 - Name of the study field in which a person works at the university
chemistry, organic chemistry, bioorganic chemistry, medicinal chemistry
I.11 - ORCID iD
https://orcid.org/0000-0001-8075-6307

II. - Higher education and further qualification growth

II.1 - First degree of higher education
II.2 - Second degree of higher education
II.a - Name of the university or institution
Comenius University in Bratislava, Facuty of Natural Sciences
II.b - Year
2006
II.c - Study field and programme
Teaching of General Education Subjects, Specialization: Biology - Chemistry
II.3 - Third degree of higher education
II.a - Name of the university or institution
Comenius University in Bratislava, Facuty of Natural Sciences
II.b - Year
2010
II.c - Study field and programme
chemistry, organic chemistry
II.4 - Associate professor
II.5 - Professor
II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position III.b - Institution III.c - Duration
senior researcher Institution of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, SAS 2021 - present
Assistent professor Comenius University in Bratislava, Facuty of Natural Sciences 2021 - present
researcher Institution of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, SAS 2011 - 2021
Teamleader Institution of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine, SAS 2025 - present

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other IV.b - Name of the institution IV.c - Year
Protection of animals used for scientific or educational purposes Institute of Veterinary Education Doctors 2019
Promoting the quality of social dialogue: English language - Advanced Implementation Agency of the Ministry of Labour and Social Affairs SR 2020-2022

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes
V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year
V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year
V.4 - Overview of supervised final theses
V.4.1 - Number of currently supervised theses
V.4.a - Bachelor's (first degree)
0
V.4.b - Diploma (second degree)
0
V.4.c - Dissertation (third degree)
1
V.4.2 - Number of defended theses
V.4.a - Bachelor's (first degree)
3
V.4.b - Diploma (second degree)
1
V.5 - Overview of other courses taught in the current academic year according to study programmes
V.5.a - Name of the course V.5.b - Study programme V.5.c - Degree V.5.d - Field of study
Testovanie bioaktívnych zlúčenín Organická a bioorganická chémia II. chémia
Cvičenia z organickej chémie pre biológov biológia / medicínska biológia I. biológia
Seminár z organickej chémie biológia / medicínska biológia I. biológia
Výberové cvičenia zo syntézy a identifikácie organických zlúčenín pre biológov biológia / medicínska biológia I. biológia
Seminár a cvičenie diplomantov organická a bioorganická chémia II. chémia

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations
VI.1.1 - Number of the research/artistic/other outputs
VI.1.a - Overall
93
VI.1.b - Over the last six years
59
VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases
VI.1.a - Overall
28
VI.1.b - Over the last six years
18
VI.1.3 - Number of citations corresponding to the research/artistic/other outputs
VI.1.a - Overall
472
VI.1.b - Over the last six years
340
VI.1.4 - Number of citations registered in the Web of Science or Scopus databases
VI.1.a - Overall
378
VI.1.b - Over the last six years
217
VI.1.5 - Number of invited lectures at the international, national level
VI.1.a - Overall
1
VI.1.b - Over the last six years
1
VI.2 - The most significant research/artistic/other outputs
1

L. Kovacikova, M. Soltesova-Prnova, M. Majekova, A. Bohac, C. Karasu, M. Stefek (2021). Development of Novel Indole-Based Bifunctional Aldose Reductase Inhibitors/Antioxidants as Promising Drugs for the Treatment of Diabetic Complications. Molecules, 26, 2867. (22 citations)

2

M. Hlavac, L. Kovacikova, M. Soltesova Prnova, P. Sramel, G. Addova, M. Majekova, G. Hanquet, A. Bohac, M. Stefek (2020). Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity. J Med Chem, 63, 369-381. (24 citations)

3

Kovacikova, L.; Majekova, M.; Stefek, M. (2015).Substituted Pyridoindoles as Biological Antioxidants: Drug Design, Chemical Synthesis, and Biological Activity. Advanced Protocols in Oxidative Stress III. Book Series: Methods in Molecular Biology. (6 citations)

4

MILÁČKOVÁ, Ivana - ŠOLTÉSOVÁ PRNOVÁ, Marta - MÁJEKOVÁ, Magdaléna - SOTNÍKOVÁ, Ružena - STAŠKO, Michal - KOVÁČIKOVÁ, Lucia - BANERJEE, Sreeparna - VEVERKA, Miroslav - ŠTEFEK, Milan. 2-Chloro-1,4-naphthoquinone derivative of quercetin as an inhibitor of aldose reductase and anti-inflammatory agent. In Journal of Enzyme Inhibition and Medicinal Chemistry, 2015, vol. 30, no. 1, p. 107-113. (35 citations)

5

Remko, M.; Bohac, A.; Kovacikova, L. (2011). Molecular structure, pKa, lipophilicity, solubility, absorption, polar surface area, and blood brain barrier penetration of some antiangiogenic agents. Str. Chem. (56 citations)

VI.3 - The most significant research/artistic/other outputs over the last six years
1

KOUSAXIDIS, Antonios - PAOLI, Paolo - KOVÁČIKOVÁ, Lucia - GENOVESE, Massimo - SANTI, Alice - ŠTEFEK, Milan - PETROU, Anthi - NICOLAOU, Ioannis. Rational design and synthesis of novel N-benzylindole-based epalrestat analogs as selective aldose reductase inhibitors: An unexpected discovery of a new glucose-lowering agent (AK-4) acting as a mitochondrial uncoupler. In European Journal of Medicinal Chemistry, 2025, vol. 281, art.no. 117035. (2024: 5.9 - IF, Q1 - JCR, 1.142 - SJR, Q1 - SJR). ISSN 0223-5234. Dostupné na: https://doi.org/10.1016/j.ejmech.2024.117035

2

KOVÁČIKOVÁ, Lucia - GAIKWAD, Sunil - ALMÁŠIOVÁ, Kristína - ALMÁSSY, Ambroz - ADDOVÁ, Gabriela - MÁJEKOVÁ, Magdaléna - HANQUET, Gilles - DOBRIČIĆ, Vladimir - BOHÁČ, Andrej - ŠTEFEK, Milan. Selectivity of N(2)-substituted oxotriazinoindole aldose reductase inhibitors is determined by the interaction pattern with Pro301-Arg312 loop of aldehyde reductase. Medicinal Chemistry Research, 2024, 33, 492-503. https://doi.org/10.1007/s00044-024-03194-3

3

KOVÁČIKOVÁ, Lucia - ŠOLTÉSOVÁ PRNOVÁ, Marta - BOĎO, Pavol - ŠTEFEK, Milan. Cemtirestat dimerization in liposomes and erythrocytes exposed to peroxyl radicals was reverted by thiol-disulfide exchange with GSH. In Free Radical Research : official journal of the Society for Free Radical Research -European Region, 2024, vol. 58, no. 1, p.1-10. (2023: 3.6 - IF, Q2 - JCR, 0.778 - SJR, Q2 - SJR). ISSN 1071-5762. Dostupné na: https://doi.org/10.1080/10715762.2023.2298852

4

M. Hlaváč, L. Kováčiková, M. Šoltésová Prnová, G. Addová, G. Hanquet, M. Štefek, A. Boháč (2021) Novel substituted N-benzyl(oxotriazinoindole) inhibitors of aldose reductase exploiting ALR2 unoccupied interactive pocket. Bioorganic & Medicinal Chemistry, 29 115885. (2 citations)

5

M. Hlavac, L. Kovacikova, M. Soltesova Prnova, P. Sramel, G. Addova, M. Majekova, G. Hanquet, A. Bohac, M. Stefek (2020). Development of Novel Oxotriazinoindole Inhibitors of Aldose Reductase: Isosteric Sulfur/Oxygen Replacement in the Thioxotriazinoindole Cemtirestat Markedly Improved Inhibition Selectivity. J Med Chem, 63, 369-381. (12 citations)

VI.4 - The most significant citations corresponding to the research/artistic/other outputs
1

J Med Chem, 2020, 63, 369-381: HAN, Z.F. - QI, G. - ZHU, J.K. - ZHANG, Y.D. - XU, Y. - YAN, K. - ZHU, C.J. - HAO, X. Novel 3,4-dihydroquinolin-2(1 H )-one derivatives as dual inhibitor targeting AKR1B1/ROS for treatment of diabetic complications: Design, synthesis and biological evaluation. In BIOORGANIC CHEMISTRY. ISSN 0045-2068, 2020, vol. 105, art. no. 104428.

2

STRUCTURAL CHEMISTRY 2011, 22,635-648: Fuchs, K ; Duran, R ; Denys, A ; Bize, PE ; Borchard, G ; Jordan, O: Drug-eluting embolic microspheres for local drug delivery. JOURNAL OF CONTROLLED RELEASE 262, 127-138. DOI10.1016/j.jconrel.2017.07.016

3

Molecules 2021, 26, 2867: Kumari, P; Kohal, R ; Bhavana (Bhavana); Gupta, GD; Verma, SK: Selectivity challenges for aldose reductase inhibitors: A review on comparative SAR and interaction studies. JOURNAL OF MOLECULAR STRUCTURE 2024, 1318, 139207. DOI10.1016/j.molstruc.2024.139207

4

European Journal of Medicinal Chemistry, 2021, vol. 223, art. no. 113630. Bernardoni, BL; D'Agostino, I; Scianò, F; La Motta, C: The challenging inhibition of Aldose Reductase for the treatment of diabetic complications: a 2019-2023 update of the patent literature. EXPERT OPINION ON THERAPEUTIC PATENTS 2024, 34, 1085-1104. DOI10.1080/13543776.2024.2412573.

5

European Journal of Medicinal Chemistry, 2025, vol. 281, art.no. 117035. ZOGNJANI, Blinera - NIXHA, Arleta Rifati - DURAN, Hatice Esra - ARSLAN, Mustafa - YILDIZTEKIN, Gizem - ECE, Abdulilah - TURKES, Cueneyt. N-substituted phthalimide-carboxylic acid hybrids as dual-targeted aldose reductase inhibitors: Synthesis, mechanistic insights, and cancer-relevant profiling. In BIOORGANIC CHEMISTRY. , vol. 163, art. no. 108788. Dostupné na: https://doi.org/10.1016/j.bioorg.2025.108788

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

IX. - Other relevant facts

IX.a - If relevant, other activities related to higher education or research/artistic/other activities are mentioned

2024 Cena Slovenskej akadémie vied za výsledky vedeckovýskumnej práce

2023 ocenená práca Bc.študentky na ŠVK Cenou dekana za chémiu

2009 ocenenie Pfizer Research Award

Spoluriešiteľ 2 patentov:

ŠTEFEK, Milan - KOVÁČIKOVÁ, Lucia - ŠOLTÉSOVÁ PRNOVÁ, Marta - ADDOVÁ, Gabriela - BOHÁČ, A. Zlúčenina cemtirestat disulfid, prekurzor inhibítora aldoketoreduktáz, spôsob jeho prípravy, farmaceutický prostriedok s jeho obsahom a jeho použitie : patentová prihláška PP 50074-2020, dátum podania prihlášky: 14.12.2020. Banská Bystrica : Úrad priemyselného vlastníctva Slovenskej republiky, 2020. 25 s. (SK patent, EU patent, CN patent, IN patentová prihláška)

ŠTEFEK, Milan - KOVÁČIKOVÁ, Lucia - MILÁČKOVÁ, Ivana - VEVERKA, Miroslav - ŠVAJDLENKA, Emil - VEVERKOVÁ, Eva. Deriváty kvercetínu, farmaceutická kompozícia s ich obsahom a ich použitie : patentová prihláška PP 5006-2012, dátum podania prihlášky: 29.02.2012, medzinárodné patentové triedenie: CO7D311/30 verzia MPT: 16, CO7D407/12, A61K31/35, A61P3/10, A61P9/10, A61P11/06, A61P13/12, A61P25/00, A61P27/02, A61P27/00, A61P35/00, A61P39/06. Prihlasovateľ: Ústav experimentálnej farmakológie a toxikológie SAV, Dúbravská cesta 9, 841 04 Bratislava, SK. Banská Bystrica : Úrad priemyselného vlastníctva Slovenskej republiky, 2012

Date of last update
2026-04-13