Research/art/teacher profile of a person
Name and surname:
doc. RNDr. Jana Korduláková, PhD.
Document type:
Research/art/teacher profile of a person
The name of the university:
Comenius University Bratislava
The seat of the university:
Šafárikovo námestie 6, 818 06 Bratislava

I. - Basic information

I.1 - Surname
Korduláková
I.2 - Name
Jana
I.3 - Degrees
doc., RNDr., PhD.
I.4 - Year of birth
1977
I.5 - Name of the workplace
Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava
I.6 - Address of the workplace
Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia
I.7 - Position
Associate Professor
I.8 - E-mail address
jana.kordulakova@uniba.sk
I.9 - Hyperlink to the entry of a person in the Register of university staff
https://www.portalvs.sk/regzam/detail/4299
I.10 - Name of the study field in which a person works at the university
chemistry, biology, teaching chemistry
I.11 - ORCID iD
0000-0003-2834-0165

II. - Higher education and further qualification growth

II.1 - First degree of higher education
II.2 - Second degree of higher education
II.a - Name of the university or institution
Faculty of Natural Sciences, Comenius University in Bratislava
II.b - Year
2000
II.c - Study field and programme
Chemistry, Biochemistry
II.3 - Third degree of higher education
II.a - Name of the university or institution
Faculty of Natural Sciences, Comenius University in Bratislava
II.b - Year
2004
II.c - Study field and programme
Biochemistry
II.4 - Associate professor
II.a - Name of the university or institution
Faculty of Natural Sciences, Comenius University in Bratislava
II.b - Year
2012
II.c - Study field and programme
Biochemistry
II.5 - Professor
II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position III.b - Institution III.c - Duration
Assistant Professor Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava 2003 - 2012
Associate Professor Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava 2012 - till now

IV. - Development of pedagogical, professional, language, digital and other skills

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes
V.1.a - Name of the profile course V.1.b - Study programme V.1.c - Degree V.1.d - Field of study
Biochemistry (2) Biochemistry I. Chemistry
Biochemistry Biology, Medicinal Biology I. Biology
Bachelor Work in Biochemistry (2) Biochemistry I. Chemistry
Selected Chapters from Biochemistry Teaching Chemistry II. Teaching and Pedagogical Sciences
Diploma Work in Biochemistry (3) Biochemistry II. Chemistry
Advanced Biochemistry Biochemistry III. Chemistry
V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year
V.2.a - Name of the study programme V.2.b - Degree V.2.c - Field of study
Biochemistry I. Chemistry
Biochemistry (conversion programme) I. Chemistry
Biochemistry II. Chemistry
Biochemistry III. Chemistry
V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year
V.3.a - Name of the field of habilitation procedure and inaugural procedure V.3.b - Study field to which it is assigned
Biochemistry (Habilitation procedure) Chemistry
V.4 - Overview of supervised final theses
V.4.1 - Number of currently supervised theses
V.4.a - Bachelor's (first degree)
1
V.4.b - Diploma (second degree)
2
V.4.c - Dissertation (third degree)
1
V.4.2 - Number of defended theses
V.4.a - Bachelor's (first degree)
17
V.4.b - Diploma (second degree)
14
V.4.c - Dissertation (third degree)
4
V.5 - Overview of other courses taught in the current academic year according to study programmes
V.5.a - Name of the course V.5.b - Study programme V.5.c - Degree V.5.d - Field of study
Structure and Function of Biomolecules Biological chemistry II. Chemistry
Perspectives of Chemistry Chemistry, Biochemistry I. Chemistry
Antibiotics Biochemistry II. Chemistry
Perspectives of Chemistry Biochemistry, Biology, Medicinal Biology I. chemistry

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations
VI.1.1 - Number of the research/artistic/other outputs
VI.1.a - Overall
97
VI.1.b - Over the last six years
28
VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases
VI.1.a - Overall
58
VI.1.b - Over the last six years
24
VI.1.3 - Number of citations corresponding to the research/artistic/other outputs
VI.1.a - Overall
2439
VI.1.b - Over the last six years
1417
VI.1.4 - Number of citations registered in the Web of Science or Scopus databases
VI.1.a - Overall
2439
VI.1.b - Over the last six years
1417
VI.1.5 - Number of invited lectures at the international, national level
VI.1.a - Overall
1
VI.1.b - Over the last six years
0
VI.2 - The most significant research/artistic/other outputs
1

ADC - Kordulakova, J., Gilleron, M., Mikusova, K., Puzo, G., Brennan, P. J., Gicquel, B., and Jackson, M. (2002) Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria. J Biol Chem 277, 31335-31344, IF (JCR) 2002=6.696


Citations (79)

2

ADC - Kordulakova, J., Gilleron, M., Puzo, G., Brennan, P. J., Gicquel, B., Mikusova, K., and Jackson, M. (2003) Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species. J Biol Chem 278, 36285-36295, IF (JCR) 2003=6.482


Citations (50)

3

ADC - Kordulakova, J., Janin, Y. L., Liav, A., Barilone, N., Dos Vultos, T., Rauzier, J., Brennan, P. J., Gicquel, B., and Jackson, M. (2007) Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis. Antimicrob Agents Chemother 51, 3824-3829, IF (JCR) 2007=4.989


Citations (18)

4

ADC - Guerin, M. E., Kordulakova, J., Schaeffer, F., Svetlikova, Z., Buschiazzo, A., Giganti, D., Gicquel, B., Mikusova, K., Jackson, M., and Alzari, P. M. (2007) Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria. J Biol Chem 282, 20705-20714, IF (JCR) 2007=5.581


Citations (65)

5

ADC - Grzegorzewicz, A. E., Pham, H., Gundi, V. A., Scherman, M. S., North, E. J., Hess, T., Jones, V., Gruppo, V., Born, S. E., Kordulakova, J., Chavadi, S. S., Morisseau, C., Lenaerts, A. J., Lee, R. E., McNeil, M. R., and Jackson, M. (2012) Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol 8, 334-341, IF (JCR) 2012=12.948


Citations (155)

VI.3 - The most significant research/artistic/other outputs over the last six years
1

ADC - Sabbah, M., Mendes, V., Vistal, R. G., Dias, D. M., Záhorszká, M., Mikušová, K., Korduláková, J., Coyne, A. G., Blundell, T. L., and Abell, C. (2020) Fragment-based design of Mycobacterium tuberculosis InhA inhibitors. Journal of Medicinal Chemistry 63, 4749-4761, IF (JCR) 2019=6,205                                                                                                  

2

ADM - Farjallah, A., Chiarelli, L. R., Forbak, M., Degiacomi, G., Danel, M., Goncalves, F., Carayon, C., Seguin, C., Fumagalli, M., Zahorszka, M., Vega, E., Abid, S., Grzegorzewicz, A., Jackson, M., Peixoto, A., Kordulakova, J., Pasca, M. R., Lherbet, C., and Chassaing, S. (2021) A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis. ACS Infect Dis 7, 552-565, IF (JCR) 2019=4.614

3

V3 - Chebaiki, M.; Delfourne, E.; Tamhaev, R.; Danoun, S.; Rodriguez, F.; Hoffmann, P.; Grosjean, E.; Goncalves, F.; Azéma-Despeyroux, J.; Pál, A.; Korduláková, J.; Preuilh, N.; Britton, S.; Constant, P.; Marrakchi, H.; Maveyraud, L.; Mourey, L.; Lherbet, C., Discovery of new diaryl ether inhibitors against Mycobacterium tuberculosis targeting the minor portal of InhA. European Journal of Medicinal Chemistry 2023, 259, IF (JCR) 2022=6.7

4

V3 - Karabanovich, G.; Fabianova, V.; Vocat, A.; Dusek, J.; Valaskova, L.; Stolarikova, J.; Kitson, R. R. A.; Pavek, P.; Vavrova, K.; Djaout, K.; Mikusova, K.; Baulard, A. R.; Cole, S. T.; Kordulakova, J.; Roh, J. (2024) Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway. Journal of Medicinal Chemistry 2024, 67 (1), 81-109, IF (JCR) 2022=7.3

5

V3 - Mistretta, M.; Cimino, M.; Campagne, P.; Volant, S.; Kornobis, E.; Hebert, O.; Rochais, C.; Dallemagne, P.; Lecoutey, C.; Tisnerat, C.; Lepailleur, A.; Ayotte, Y.; LaPlante, S. R.; Gangneux, N.; Zahorszka, M.; Kordulakova, J.; Vichier-Guerre, S.; Bonhomme, F.; Pokorny, L.; Albert, M.; Tinevez, J. Y.; Manina, G. (2024) Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy. Nature Communications, 15 (1), 4175, IF (JCR) 2022=16.6

VI.4 - The most significant citations corresponding to the research/artistic/other outputs
1

ADC - Kordulakova, J., Janin, Y. L., Liav, A., Barilone, N., Dos Vultos, T., Rauzier, J., Brennan, P. J., Gicquel, B., and Jackson, M. (2007) Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis. Antimicrob Agents Chemother 51, 3824-3829:

Cit. 2009 Willand, N. - Dirie, B. - Carette, X. - Bifani, P. - Singhal, A. - Desroses, M. - Leroux, F. - Willery, E. - Mathys, V. - Deprez-Poulain, R. - Delcroix, G. - Frenois, F. - Aumercier, M. - Locht, C. - Villeret, V. - Deprez, B. -Baulard, A.R.: Nature Medicine, Vol. 15, No. 5, 2009, s. 537-544

2

ADC - Skovierova, H., Larrouy-Maumus, G., Zhang, J., Kaur, D., Barilone, N., Kordulakova, J., Gilleron, M., Guadagnini, S., Belanova, M., Prevost, M. C., Gicquel, B., Puzo, G., Chatterjee, D., Brennan, P. J., Nigou, J., and Jackson, M. (2009) AftD, a novel essential arabinofuranosyltransferase from mycobacteria. Glycobiology 19, 1235-1247:

Cit. 2014 Kieser, K.J.- Rubin, E.J.: Nature Reviews Microbiology, Vol. 12, No. 8, 2014, s. 550-562

3

ADC - Guerin, M. E., Kordulakova, J., Alzari, P. M., Brennan, P. J., and Jackson, M. (2010) Molecular basis of phosphatidyl-myo-inositol mannoside biosynthesis and regulation in mycobacteria. J Biol Chem 285, 33577-33583:

Cit. 2020 Dulberger, C.L. - Rubin, E.J. - Boutte, C.C.: Nature Reviews Microbiology, Vol. 18, No. 1, 2020, s. 47-59

4

ADC - Brown, J. R., North, E. J., Hurdle, J. G., Morisseau, C., Scarborough, J. S., Sun, D., Kordulakova, J., Scherman, M. S., Jones, V., Grzegorzewicz, A., Crew, R. M., Jackson, M., McNeil, M. R., and Lee, R. E. (2011) The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorg Med Chem 19, 5585-5595:

Cit. 2019 Beddoe, R.H. - Andrews, K.G. - Magne, V. - Cuthbertson, J.D. - Saska, J. - Shannon-Little, A.L. - Shanahan, S.E. - Sneddon, H.F. - Denton, R.M.: Science, Vol. 365, No. 6456, 2019, s. 910

5

ADC - Grzegorzewicz, A. E., Pham, H., Gundi, V. A., Scherman, M. S., North, E. J., Hess, T., Jones, V., Gruppo, V., Born, S. E., Kordulakova, J., Chavadi, S. S., Morisseau, C., Lenaerts, A. J., Lee, R. E., McNeil, M. R., and Jackson, M. (2012) Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol 8, 334-341:

Cit. 2013 Zumla, A. - Nahid, P. - Cole, S.T.: Nature Reviews Drug Discovery, Vol. 12, No. 5, 2013, s. 388-404

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years
1

Grant APVV-19-0189: Activation of drugs against tuberculosis (2020 – 2024) - solving 3D structures of selected activating enzymes and characterization of mechanisms of activation/metabolism of ethionamide, rifampicin and pretomanide; principal investigator

2

Grant VEGA 1/0301/18: Investigation of the mechanism of action of antimycobacterial inhibitors (2018 – 2021) - development of a new methodology for the investigation of mechanisms of action of new antimycobacterial compounds; principal investigator

3

Grant VEGA 1/0284/15: Activation of thioamide and thiourea antituberculotics in mycobacteria (2015 – 2017) - functional characterization of mycobacterial monooxygenase EthA and investigation of alternative processes of activation of selected antituberculotics; principal investigator

4

Grant APVV-15-0515: (2016 – 2020) –Topological aspects of biosynthesis of mycobacterial arabinogalactan - functional characterization of selected mycobacterial ABC transporters; co-investigator

5

Grant MŠ SR, 0395/2016: Design, synthesis and study of the mechanism of action of new original heterocyclic compounds that have activity against latent tuberculosis (2017 – 2019) - revealing the mechanisms of action of potent antimycobacterial inhibitors; co-investigator

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VII.a - Activity, position VII.b - Name of the institution, board VII.c - Duration
Member of the Board for the Doctoral Study Program "Biochemistry" Faculty of Natural Sciences, Comenius University in Bratislava 2014 - till now
Member of the state exam committee for Biochemistry master's degree Faculty of Natural Sciences, Comenius University in Bratislava 2014 - till now
Member of the state exam committee for Biochemistry bachelor's degree Faculty of Natural Sciences, Comenius University in Bratislava 2014 - till now
Member of the VEGA Evaluation Committee for Medical and Pharmaceutical Sciences Ministry of Education of the SR 2016 - till now

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution VIII.b - Address of the institution VIII.c - Duration (indicate the duration of stay) VIII.d - Mobility scheme, employment contract, other (describe)
Microbiology, Immunology, and Pathology Department, Colorado State University, Fort Collins, USA Colorado State University, Fort Collins, Colorado 80523 USA May - July 1999 Work on the project within the MSc. study, based on the invitation from dr. D. Chatterjee
Mycobacterial Genetics Unit, Institut Pasteur, Paris, France 25-28 Rue du Dr Roux, 75015 Paris, France April - December 2001 Work on the project within the PhD. study, based on the invitation from prof. Mary Jackson
Mycobacterial Genetics Unit, Institut Pasteur, Paris, France 25-28 Rue du Dr Roux, 75015 Paris, France June - July 2002 Work on the project within the PhD. study, awarded by French goverment fellowship
Microbiology, Immunology, and Pathology Department, Colorado State University, Fort Collins, USA Colorado State University, Fort Collins, Colorado 80523 USA January - March 2003 Work on the project within the PhD. study, based on the invitation from dr. M. McNeil
Mycobacterial Genetics Unit, Institut Pasteur, Paris, France 25-28 Rue du Dr Roux, 75015 Paris, France May 2004 - December 2006 Postdoctoral stay, awarded by Heiser fellowship (The New York Community Trust)

IX. - Other relevant facts

Date of last update
2022-03-09