Research/art/teacher profile of a person
Name and surname:
Mgr. Stanislav Huszár, PhD.
Document type:
Research/art/teacher profile of a person
The name of the university:
Comenius University Bratislava
The seat of the university:
Šafárikovo námestie 6, 818 06 Bratislava

I. - Basic information

I.1 - Surname
Huszár
I.2 - Name
Stanislav
I.3 - Degrees
Mgr., PhD.
I.4 - Year of birth
1985
I.5 - Name of the workplace
Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava
I.6 - Address of the workplace
Faculty of Natural Sciences, Comenius University in Bratislava, Mlynská dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia
I.7 - Position
Assistant professor
I.8 - E-mail address
stanislav.huszar@uniba.sk
I.9 - Hyperlink to the entry of a person in the Register of university staff
https://www.portalvs.sk/regzam/detail/15960
I.10 - Name of the study field in which a person works at the university
Chemistry
I.11 - ORCID iD
0000-0001-7463-1532

II. - Higher education and further qualification growth

II.1 - First degree of higher education
II.a - Name of the university or institution
Faculty of Natural Sciences, Comenius University in Bratislava
II.b - Year
2008
II.c - Study field and programme
Chemistry, Chemistry
II.2 - Second degree of higher education
II.a - Name of the university or institution
Faculty of Natural Sciences, Comenius University in Bratislava
II.b - Year
2011
II.c - Study field and programme
Chemistry, Biochemistry
II.3 - Third degree of higher education
II.a - Name of the university or institution
Faculty of Natural Sciences, Comenius University in Bratislava
II.b - Year
2016
II.c - Study field and programme
Chemistry, Biochemistry
II.4 - Associate professor
II.5 - Professor
II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position III.b - Institution III.c - Duration
Assistant professor Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava 2016 - present

IV. - Development of pedagogical, professional, language, digital and other skills

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes
V.1.a - Name of the profile course V.1.b - Study programme V.1.c - Degree V.1.d - Field of study
Bachelor Thesis in Biochemistry (2) Biochemistry I. Chemistry
Biochemistry and Cell Biology Advanced Laboratory Practices Biochemistry II. Chemistry
Methods in Biochemistry Biochemistry I. Chemistry
V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year
V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year
V.4 - Overview of supervised final theses
V.4.1 - Number of currently supervised theses
V.4.a - Bachelor's (first degree)
2
V.4.b - Diploma (second degree)
1
V.4.c - Dissertation (third degree)
0
V.4.2 - Number of defended theses
V.4.a - Bachelor's (first degree)
8
V.4.b - Diploma (second degree)
3
V.4.c - Dissertation (third degree)
0
V.5 - Overview of other courses taught in the current academic year according to study programmes
V.5.a - Name of the course V.5.b - Study programme V.5.c - Degree V.5.d - Field of study
Optional laboratory practice in biochemistry and molecular biology Biochemistry II. Chemistry
Biochemistry and Cell Biology Laboratory Practices Biochemistry I. Chemistry
Perspectives in Biochemistry Biochemistry, Biology I. Chemistry
Bachelor Thesis in Biochemistry (1) Biochemistry I. Chemistry

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations
VI.1.1 - Number of the research/artistic/other outputs
VI.1.a - Overall
24
VI.1.b - Over the last six years
10
VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases
VI.1.a - Overall
14
VI.1.b - Over the last six years
6
VI.1.3 - Number of citations corresponding to the research/artistic/other outputs
VI.1.a - Overall
654
VI.1.b - Over the last six years
464
VI.1.4 - Number of citations registered in the Web of Science or Scopus databases
VI.1.a - Overall
654
VI.1.b - Over the last six years
464
VI.1.5 - Number of invited lectures at the international, national level
VI.1.a - Overall
0
VI.1.b - Over the last six years
0
VI.2 - The most significant research/artistic/other outputs
1

Savková, K., Huszár, S., Baráth, P., Pakanová, Z., Kozmon, S., Vancová, M., Tesařová, M., Blaško, J., Kaliňák, M., Singh, V., Korduláková, J., and Mikušová, K. (2021) An ABC transporter Wzm–Wzt catalyzes translocation of lipid-linked galactan across the plasma membrane in mycobacteria. Proc. Natl. Acad. Sci. 118, e2023663118, IF (JCR) 2019=9.412


Citations (4) 

2

Huszár, S., Singh, V., Polčicová, A., Baráth, P., Belén Barrio, M., Lagrange, S., Leblanc, V., Nacy, C. A., Mizrahi, V., and Mikušová, K. (2017) N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 61, 1–16, IF (JCR) 2017=4.255


Citations (19)

3

Brecik, M., Centárová, I., Mukherjee, R., Kolly, G. S., Huszár, S., Bobovská, A., Kilacsková, E., Mokošová, V., Svetlíková, Z., Šarkan, M., Neres, J., Korduláková, J., Cole, S. T., and Mikušová, K. (2015) DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization. ACS Chem. Biol. 10, 1631–1636, IF (JCR) 2015=5.090


Citations (126)

4

Makarov, V., Neres, J., Hartkoorn, R. C., Ryabova, O. B., Kazakova, E., Šarkan, M., Huszár, S., Piton, J., Kolly, G. S., Vocat, A., Conroy, T. M., Mikušová, K., and Cole, S. T. (2015) The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 59, 4446–4452, IF (JCR) 2015=4.415


Citations (68)

5

Wang, F., Sambandan, D., Halder, R., Wang, J., Batt, S. M., Weinrick, B., Ahmad, I., Yang, P., Zhang, Y., Kim, J., Hassani, M., Huszar, S., Trefzer, C., Ma, Z., Kaneko, T., Mdluli, K. E., Franzblau, S., Chatterjee, A. K., Johnsson, K., Mikusova, K., Besra, G. S., Futterer, K., Robbins, S. H., Barnes, S. W., Walker, J. R., Jacobs, W. R., and Schultz, P. G. (2013) Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc. Natl. Acad. Sci. 110, E2510–E2517, IF (JCR) 2013=9.809


Citations (188)

VI.3 - The most significant research/artistic/other outputs over the last six years
1

Savková, K., Huszár, S., Baráth, P., Pakanová, Z., Kozmon, S., Vancová, M., Tesařová, M., Blaško, J., Kaliňák, M., Singh, V., Korduláková, J., and Mikušová, K. (2021) An ABC transporter Wzm–Wzt catalyzes translocation of lipid-linked galactan across the plasma membrane in mycobacteria. Proc. Natl. Acad. Sci. 118, e2023663118, IF (JCR) 2019=9.412


Citations (4) 

2

Huszár, S., Chibale, K., and Singh, V. (2020) The quest for the holy grail: new antitubercular chemical entities, targets and strategies. Drug Discov. Today. 00, 1–9, IF (JCR) 2019=7.321


Citations (42) 

3

Karabanovich, G., Dušek, J., Savková, K., Pavliš, O., Pávková, I., Korábečný, J., Kučera, T., Kočová Vlčková, H., Huszár, S., Konyariková, Z., Konečná, K., Jand’ourek, O., Stolaříková, J., Korduláková, J., Vávrová, K., Pávek, P., Klimešová, V., Hrabálek, A., Mikušová, K., and Roh, J. (2019) Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β- d -ribofuranose 2′-Oxidase . J. Med. Chem. 62, 8115–8139, IF (JRC) 2019=6.205


Citations (38)

4

Chiarelli, L. R., Mori, G., Orena, B. S., Esposito, M., Lane, T., de Jesus Lopes Ribeiro, A. L., Degiacomi, G., Zemanová, J., Szádocka, S., Huszár, S., Palčeková, Z., Manfredi, M., Gosetti, F., Lelièvre, J., Ballell, L., Kazakova, E., Makarov, V., Marengo, E., Mikusova, K., Cole, S. T., Riccardi, G., Ekins, S., and Pasca, M. R. (2018) A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK. Sci. Rep. 8, 3187, IF (JRC) 2018=4.011


Citations (35)

5

Huszár, S., Singh, V., Polčicová, A., Baráth, P., Belén Barrio, M., Lagrange, S., Leblanc, V., Nacy, C. A., Mizrahi, V., and Mikušová, K. (2017) N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 61, 1–16, IF (JCR) 2017=4.255


Citations (19)

VI.4 - The most significant citations corresponding to the research/artistic/other outputs
1

Wang, F., Sambandan, D., Halder, R., Wang, J., Batt, S. M., Weinrick, B., Ahmad, I., Yang, P., Zhang, Y., Kim, J., Hassani, M., Huszar, S., Trefzer, C., Ma, Z., Kaneko, T., Mdluli, K. E., Franzblau, S., Chatterjee, A. K., Johnsson, K., Mikusova, K., Besra, G. S., Futterer, K., Robbins, S. H., Barnes, S. W., Walker, J. R., Jacobs, W. R., and Schultz, P. G. (2013) Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc. Natl. Acad. Sci. 110, E2510–E2517;

Cit.: Trivedi, A., Mavi, P. S., Bhatt, D., and Kumar, A. (2016) Thiol reductive stress induces cellulose-anchored biofilm formation in Mycobacterium tuberculosis. Nat. Commun. 7, 11392

2

Wang, F., Sambandan, D., Halder, R., Wang, J., Batt, S. M., Weinrick, B., Ahmad, I., Yang, P., Zhang, Y., Kim, J., Hassani, M., Huszar, S., Trefzer, C., Ma, Z., Kaneko, T., Mdluli, K. E., Franzblau, S., Chatterjee, A. K., Johnsson, K., Mikusova, K., Besra, G. S., Futterer, K., Robbins, S. H., Barnes, S. W., Walker, J. R., Jacobs, W. R., and Schultz, P. G. (2013) Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc. Natl. Acad. Sci. 110, E2510–E2517;

Cit.: Kavvas, E. S., Catoiu, E., Mih, N., Yurkovich, J. T., Seif, Y., Dillon, N., Heckmann, D., Anand, A., Yang, L., Nizet, V., Monk, J. M., and Palsson, B. O. (2018) Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance. Nat. Commun. 9, 4306

3

Brecik, M., Centárová, I., Mukherjee, R., Kolly, G. S., Huszár, S., Bobovská, A., Kilacsková, E., Mokošová, V., Svetlíková, Z., Šarkan, M., Neres, J., Korduláková, J., Cole, S. T., and Mikušová, K. (2015) DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization. ACS Chem. Biol. 10, 1631–1636;

Cit.: Warrier, T., Kapilashrami, K., Argyrou, A., Ioerger, T. R., Little, D., Murphye, K. C., Nandakumar, M., Park, S., Gold, B., Mi, J., Zhang, T., Meiler, E., Rees, M., Somersan-Karakaya, S., Francisco, E. P. De, Martinez-Hoyos, M., Burns-Huang, K., Roberts, J., Ling, Y., Rhee, K. Y., Mendoza-Losana, A., Luo, M., and Nathan, C. F. (2016) N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U. S. A. 113, E4523–E4530

4

Wang, F., Sambandan, D., Halder, R., Wang, J., Batt, S. M., Weinrick, B., Ahmad, I., Yang, P., Zhang, Y., Kim, J., Hassani, M., Huszar, S., Trefzer, C., Ma, Z., Kaneko, T., Mdluli, K. E., Franzblau, S., Chatterjee, A. K., Johnsson, K., Mikusova, K., Besra, G. S., Futterer, K., Robbins, S. H., Barnes, S. W., Walker, J. R., Jacobs, W. R., and Schultz, P. G. (2013) Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proc. Natl. Acad. Sci. 110, E2510–E2517;

Cit.: Richter, A., Rudolph, I., Möllmann, U., Voigt, K., Chung, C., Singh, O. M. P., Rees, M., Mendoza-Losana, A., Bates, R., Ballell, L., Batt, S., Veerapen, N., Fütterer, K., Besra, G., Imming, P., and Argyrou, A. (2018) Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1. Sci. Rep. 8, 13473

5

Brecik, M., Centárová, I., Mukherjee, R., Kolly, G. S., Huszár, S., Bobovská, A., Kilacsková, E., Mokošová, V., Svetlíková, Z., Šarkan, M., Neres, J., Korduláková, J., Cole, S. T., and Mikušová, K. (2015) DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization. ACS Chem. Biol. 10, 1631–1636;

Cit.: Richter, A., Rudolph, I., Möllmann, U., Voigt, K., Chung, C., Singh, O. M. P., Rees, M., Mendoza-Losana, A., Bates, R., Ballell, L., Batt, S., Veerapen, N., Fütterer, K., Besra, G., Imming, P., and Argyrou, A. (2018) Novel insight into the reaction of nitro, nitroso and hydroxylamino benzothiazinones and of benzoxacinones with Mycobacterium tuberculosis DprE1. Sci. Rep. 8, 13473

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years
1

Grant APVV-19-0189 (2020 - 2024): Activation of drugs against tuberculosis - solving 3D structures of selected activating enzymes and characterization of mechanisms of activation/metabolism of ethionamide, rifampicin and pretomanide; co-investigator

2

Grant VEGA 1/0781/19 (2019 - 2022): The study of the electron transport chain in Mycobacterium tuberculosis and Diplonema papillatum - development and optimization of new methodologies for monitoring of Mycobacterium tuberculosis and a Diplonema papillatum electron transport chain complexes. Purification and biochemical characterization of mycobacterial cytochrome bd oxidase; principal investigator

3

Grant VEGA 1/0301/18 (2018 - 2021): Investigation of the mechanism of action of antimycobacterial inhibitors - development of a new methodology for the investigation of mechanisms of action of new antimycobacterial compounds; co-investigator

4

Grant APVV-15-0515 (2016 - 2020): Topological aspects of mycobacterial arabinogalactan biosynthesis - functional characterization of selected mycobacterial ABC transporters; co-investigator

5

Grant VEGA 1/0441/15 (2015 - 2017): Biochemical characterization of mycobacterial proteins WecA and MraY - potential targets for antituberculosis drugs; co-investigator

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution VIII.b - Address of the institution VIII.c - Duration (indicate the duration of stay) VIII.d - Mobility scheme, employment contract, other (describe)
Drug Discovery and Development Centre (H3D), University of Cape Town Rondebosch 7701, Cape Town, Western Cape, South Africa October - December 2018 Intership - construction of mycobacterial knockdown strians by CRISPR-Cas
Drug Discovery and Development Centre (H3D), University of Cape Town Rondebosch 7701, Cape Town, Western Cape, South Africa June 2019 - March 2020 Postdoctoral fellowship

IX. - Other relevant facts