Kovác L, Gbelská I, Poliachová V, Subík J, Kovácová V: Membrane mutants: a yeast mutant with a lesion in phosphatidylserine biosynthesis.

Eur J Biochem. 1980 Vol.:2,pages:491-501.

Gbelská Y, Subík J, Svoboda A, Goffeau A, Kovác L Intramitochondrial ATP and cell functions: yeast cells depleted of intramitochondrial ATP lose the ability to grow and multiply. Eur J Biochem. 1983 Vol.:130, No.:2, Pages:281-286. 

Gbelska Y, Krijger JJ, Breunig KD.Evolution of gene families: the multidrug resistance transporter genes in five related yeast species.FEMS Yeast Res. 2006 Vo.:6, No.:3, Pages:345-355. 

Hodurova Z, Ferreira L, Sánchez-Juanes F, Dominguez A, Gbelska:Cytosolic proteome of Kluyveromyces lactis affected by the multidrug resistance regulating transcription factor KlPdr1p.J Proteomics. 2012 Vol.:75 No.:17, Pages:5316-5326.  

Culakova H, Dzugasova V, Valencikova R, Gbelska Y, Subik J.:Stress response and expression of fluconazole resistance associated genes in the pathogenic yeast Candida glabrata deleted in the CgPDR16 gene .J.Microbiol Res. 2015 Vol.:174, Pages:17-23. 

Betinova V., Toth Hervay N., Elias D., Horvathova A., Gbelska Y.: The UPC2 gene in Kluyveromyces lactis stress adaptation. Folia Microbiol (Praha) 2022 Aug; 67(4):641-647 doi: 10.1007/s12223-022-00968-3

Konecna A, Toth Hervay N, Bencova A, Morvova M Jr, Sikurova L, Jancikova I, Gaskova D, Gbelska Y.Erg6 gene is essential for stress adaptation in Kluyveromyces lactis.FEMS Microbiol Lett. 2018 Vol.:365, No.:23. doi: 10.1093/femsle/fny265.

Jancikova I., Zahumensky J, Gbelska Y., Gaskova D: Differences in the arrangement of the Pdr5p multidrug transporter binding pocket of Saccharomyces cerevisiae and Kluyveromyces lactis. FEMS Yeast Research (2017) Vol.:17, No.:7,doi:10.1093/femsyr/fox073.

Bencova A, Goffa E, Morvova M, Valachovic M, Griač P, Toth Hervay N, Gbelska Y.The Absence of PDR16 Gene Restricts the Overexpression of CaSNQ2 Gene in the Presence of Fluconazole in Candida albicans. Mycopathologia. 2020 Vol.:185, No.:3, Pages:455-465. doi: 10.1007/s11046-020-00459-4. 

Toth Hervay N, Bencova A, Valachovic M, Morvova M, Gbelska Y.UPC2 gene deletion modifies sterol homeostasis and susceptibility to metabolic inhibitors in Kluyveromyces lactis.Yeast. 2020 Vol.:37, No.:12, Pages:647-657. doi: 10.1002/yea.3527. 

Main N., Kim K.S., Holmes-Hampton G., Singh A.,Rouault T.A.: Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis. 2019 Haematologica 104 (9) 1756-1767. IF 7.53, Q1. Doi:10.3324/haematol.2018.214320.

Bhattacharya S., Oliveira N.K., Savitt A.G., Silva V.K.A., Krausert R.B., Ghebrehiwet B. Fries B.c.: Low glucose mediated Fluconazole Tolerance in Cryptococcus neoformans. Journal of Fungi, Vol. 7, No. 6, 2021; doi:10.3390/jof7060489; IF 5,724 

Li H., Zhao F., Cao F., Teng M., Yang Y., Qui L. Mitochondrial dysfunction-based cardiotoxicity and neurotoxicity induced by pyraclostrobin in zebrafish larvae. 2019. Environmental Pollution. Vol.: 251, Pages: 203-211. IF: 5.95. Q1. Doi:10.1016/j.envpol.2019.04.122.

Hernando-Amado S., Blanco P., Alcalde-Rico M., Corona F., Reales-Calderon J.A., Sanchez M.B., Martinez J.L.: Multidrug efflux pumps as main players in intrinsic and acquired resistance to antimicrobials. 2016 Drug Resistance Updates Vol. 28, Pages: 13-27. IF 11.65. Q1. Doi::10.1016/jdrup.2016.06007.

Staniszewska M., Kuryk L., Gryciuk A., Kawalec J., Rogalska M., Baran J., Lukowska-Chojnacka E., Kowalkewska A: In vitro anti-Candida activity and action mode of benzoxazole derivatives. Molecules, Vol. 26, No. 16, 2021. doi: 103390/molecules 26165008. IF 4,927

Finding of novel specifi targets for antifungal active compounds. Grant project VEGA 1/0697/18, duration 01/2018-12/2021, project leader in the participating organization. Project is aimed on the progress in the therapy of human fingal infections, which is limited due to the structural relatedness of the cell f the host and the fungal pathogen. Another problem is the increasing resistance of pathogenic fungi to available antifungals. The main target of antifungal compounds is the biosynthesis of ergosterol, the main sterol in fungal cell membrane. Methods of reverse genetics will be used to find novel targets in the ergosterol biosynthetic pathway. The viability and physiological properties of the constructed deletion mutants will show the antifungal activity of novel biologically active structures.

Defense mechanisms of microbial and animal cells in reducing their sensitivity to plant defensive compounds. Project APVV 19-0094, duration 07/2020 - 06/2024, project leader in the participating organization..The proposed project is aimed at an intensive research of the effects of selected defensive substances of plant origin and their semisynthetic analogues on the proliferation and metabolism of neoplastically transformed mammalian cells and eukaryotic and prokaryotic microbial cells. The research will be based on our previous activities focused on analogues of plant quinolizidines and indolizidines, catechins, natural isothiocyanates. Essential oils, seed oils, and phytosterols will also be employed. The project will be based on both commercially available substances and their semisynthetic substances analogues prepared by organic chemists at FCHPT STU. Following objectives, representing the stages of the project, were defined for the project implementation: 1. Determination of effectiveness of plant quinolizidines, indolizidines and their analogues on growth, viability and life cycle of bacteria, yeasts filamentous fungi and neoplastically transformed mammalian cells in relation to MDR. 2. Investigation of the ability of plant catechins to modulate the multidrug resistance in bacteria, yeasts filamentous fungi and neoplastically transformed mammalian cells. 3. Study of the ability of plant and synthetically prepared isothiocyanates to modulate multidrug resistance in unicellular microbial and neoplastically transformed mammalian cells. 4. Analysis of the ability of plant essential and seed oils to modulate multidrug resistance and secondary metabolism in microorganisms described above. 5.Investigation of effects of phytosterols on fungal cells and neoplastically transformed mammalian cells in relationship to the activation of cell defense systems

Fungal adaptive mechanisms - first step in the antifungal drug ´s resistance. Grant project VEGA 1/0388/22, duration 01/2022 - 12/2025. member of the research team. Sucessful therapy of life-threatening mycoses depends on the defense mechanisms of the pathogen and the host. Due to the similarity between the pathogen and host eukaryotic cells and the increase in the resistance offungal cells the treatnebt of fungal infections is limited. The first response of fugi to antifungal compounds is the induction of adaptive response to stress conditions. Te aim of the project is to reveal the mein transcription factors and their targat genes associated with regulatory mechanisms of adaptive responses in fungal cells. The study will contribute to deeper understanding of stress mechanisms andtheir relationship to fungal mechanisms of resistance.