Research/art/teacher profile of a person
Name and surname:
Ing. Ondrej Cehlár, PhD.
Document type:
Research/art/teacher profile of a person
The name of the university:
Comenius University Bratislava
The seat of the university:
Šafárikovo námestie 6, 818 06 Bratislava

I. - Basic information

I.1 - Surname
Cehlár
I.2 - Name
Ondrej
I.3 - Degrees
Ing., PhD.
I.4 - Year of birth
1984
I.5 - Name of the workplace
Department of pharmaceutical chemistry, Faculty of Pharmacy
I.6 - Address of the workplace
Ulica odbojárov 10, 832 32 Bratislava
I.7 - Position
university teacher -
I.8 - E-mail address
cehlar4@uniba.sk
I.10 - Name of the study field in which a person works at the university
Pharmacy
I.11 - ORCID iD
0000-0002-1996-6812

II. - Higher education and further qualification growth

II.1 - First degree of higher education
II.2 - Second degree of higher education
II.a - Name of the university or institution
Institute of Chemical Technology, Prague
II.b - Year
2008
II.c - Study field and programme
General and applied biochemistry
II.3 - Third degree of higher education
II.a - Name of the university or institution
University of veterinary medicine and pharacy in Košice
II.b - Year
2013
II.c - Study field and programme
Immunology
II.4 - Associate professor
II.5 - Professor
II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position III.b - Institution III.c - Duration
Researcher Axon Neuroscience R&D Services SE 2013-2020
Researcher Neuroimunologický ústav SAV 2013 -

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other IV.b - Name of the institution IV.c - Year
BioExcel workshop on GROMACS and HADDOCK, Bratislava, BioExcel consorcium, SAS computing center 2023
GPU programming in CUDA National supercomputing center 2022

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes
V.1.a - Name of the profile course V.1.b - Study programme V.1.c - Degree V.1.d - Field of study
Pharmaceutical chemistry Pharmacy 2.
V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year
V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year
V.4 - Overview of supervised final theses
V.4.1 - Number of currently supervised theses
V.4.b - Diploma (second degree)
1
V.4.c - Dissertation (third degree)
1
V.4.2 - Number of defended theses
V.4.a - Bachelor's (first degree)
2
V.4.b - Diploma (second degree)
3
V.5 - Overview of other courses taught in the current academic year according to study programmes
V.5.a - Name of the course V.5.b - Study programme V.5.c - Degree V.5.d - Field of study
Molecular basis of drug design Pharmacy 2.
Analysis of drugs Pharmacy 2.

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations
VI.1.1 - Number of the research/artistic/other outputs
VI.1.a - Overall
30
VI.1.b - Over the last six years
16
VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases
VI.1.a - Overall
30
VI.1.b - Over the last six years
16
VI.1.3 - Number of citations corresponding to the research/artistic/other outputs
VI.1.a - Overall
213
VI.1.b - Over the last six years
125
VI.1.4 - Number of citations registered in the Web of Science or Scopus databases
VI.1.a - Overall
213
VI.1.b - Over the last six years
125
VI.1.5 - Number of invited lectures at the international, national level
VI.1.a - Overall
2
VI.1.b - Over the last six years
2
VI.2 - The most significant research/artistic/other outputs
1

Hornakova L, Sinsky J, Janubova M, Mederlyova A, Ivanovova NP, Piestansky J, Kovac A, Galba

J, Skrabana R & Cehlar O (2022) Interaction kinetics reveal distinct properties of conformational

ensembles of three-repeat and four-repeat tau proteins. Febs Lett, doi: 10.1002/1873-3468.14339.

2

Weisova P, Cehlar O, Skrabana R, Zilkova M, Filipcik P, Kovacech B, Prcina M, Wojciakova L,

Fialova L, Smolek T, Kontsekova E, Zilka N & Novak M (2019) Therapeutic antibody targeting

microtubule-binding domain prevents neuronal internalization of extracellular tau via masking

neuron surface proteoglycans. Acta Neuropathol Com 7, doi: 10.1186/S40478-019-0770-Y.

3

Langer A, Bartoschik T, Lüdecke A., Cehlar O, Duhr S, Baaske P & Streicher W (2022) A New

Spectral Shift-Based Method to Characterize Molecular Interactions. Assay Drug Dev Techn, doi:

10.1089/adt.2021.133.

4

Kovacech B, Fialova L, Filipcik P, Skrabana R, Zilkova M, Paulenka-Ivanovova N, Kovac A, Palova D, Rolkova GP, Tomkova K, Csokova NT, Markova K, Skrabanova M, Sinska K, Basheer N, Majerova P, Hanes J, Parrak V, Prcina M, Cehlar O, Cente M, Piestansky J, Fresser M, Novak M, Slavikova M, Borsova K, Cabanova V, Brejova B, Vinař T, Nosek J, Klempa B, Eyer L, Hönig V, Palus M, Ruzek D, Vyhlidalova T, Strakova P, Mrazkova B, Zudova D, Koubkova G, Novosadova V, Prochazka J, Sedlacek R, Zilka N & Kontsekova E (2022) Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern. eBioMedicine 76, doi: 10.1016/j.ebiom.2022.103818.

5

Novak P, Cehlar O, Skrabana R & Novak M (2018) Tau Conformation as a Target for Disease-Modifying Therapy: The Role of Truncation. J Alzheimers Dis 64, S535-S546, doi: 10.3233/Jad-179942.

VI.3 - The most significant research/artistic/other outputs over the last six years
1

Hornakova L, Sinsky J, Janubova M, Mederlyova A, Ivanovova NP, Piestansky J, Kovac A, Galba

J, Skrabana R & Cehlar O (2022) Interaction kinetics reveal distinct properties of conformational

ensembles of three-repeat and four-repeat tau proteins. Febs Lett, doi: 10.1002/1873-3468.14339.

2

Weisova P, Cehlar O, Skrabana R, Zilkova M, Filipcik P, Kovacech B, Prcina M, Wojciakova L,

Fialova L, Smolek T, Kontsekova E, Zilka N & Novak M (2019) Therapeutic antibody targeting

microtubule-binding domain prevents neuronal internalization of extracellular tau via masking

neuron surface proteoglycans. Acta Neuropathol Com 7, doi: 10.1186/S40478-019-0770-Y.

3

Langer A, Bartoschik T, Lüdecke A., Cehlar O, Duhr S, Baaske P & Streicher W (2022) A New

Spectral Shift-Based Method to Characterize Molecular Interactions. Assay Drug Dev Techn, doi:

10.1089/adt.2021.133.

4

Kovacech B, Fialova L, Filipcik P, Skrabana R, Zilkova M, Paulenka-Ivanovova N, Kovac A, Palova D, Rolkova GP, Tomkova K, Csokova NT, Markova K, Skrabanova M, Sinska K, Basheer N, Majerova P, Hanes J, Parrak V, Prcina M, Cehlar O, Cente M, Piestansky J, Fresser M, Novak M, Slavikova M, Borsova K, Cabanova V, Brejova B, Vinař T, Nosek J, Klempa B, Eyer L, Hönig V, Palus M, Ruzek D, Vyhlidalova T, Strakova P, Mrazkova B, Zudova D, Koubkova G, Novosadova V, Prochazka J, Sedlacek R, Zilka N & Kontsekova E (2022) Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern. eBioMedicine 76, doi: 10.1016/j.ebiom.2022.103818.

5

Zilkova, M.; Nolle, A.; Kovacech, B.; ....; Cehlar, O.; Rolkova, G. P.; Maderova, D.; Novak, M.; Zilka, N.; Hoozemans, J. J. M. Humanized Tau Antibodies Promote Tau Uptake by Human Microglia without Any Increase of Inflammation. acta neuropathol commun 2020, 8 (1), 74. https://doi.org/10.1186/s40478-020-00948-z.

VI.4 - The most significant citations corresponding to the research/artistic/other outputs
1

citing Hornakova et al. 2022:

He, X.; Man, V. H.; Gao, J.; Wang, J. Investigation of the Structure of Full-Length Tau Proteins with Coarse-Grained and All-Atom Molecular Dynamics Simulations. ACS Chem. Neurosci. 2023, 14 (2), 209–217. https://doi.org/10.1021/acschemneuro.2c00381.

2

citing Weisova et al. 2019:

Readhead, B.; Klang, E.; Gisladottir, U.; Vandromme, M.; Li, L.; Quiroz, Y. T.; Arboleda-Velasquez, J. F.; Dudley, J. T.; Tatonetti, N. P.; Glicksberg, B. S.; Reiman, E. M. Heparin Treatment Is Associated with a Delayed Diagnosis of Alzheimer’s Dementia in Electronic Health Records from Two Large United States Health Systems. Mol Psychiatry 2024. https://doi.org/10.1038/s41380-024-02757-5.

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years
1

Vega 2/0125/23

Aggregation prone conformation of protein tau targetable by specific antibodies - Principal investigator

2

COST CA21160

Non-globular proteins in the era of Machine Learning (ML4NGP) - member of management comittee for Slovakia

3

 APVV -21-0479

Small ordered motifs in regulation of pathophysiology of disordered protein tau - team member

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

IX. - Other relevant facts

Date of last update
2025-02-05