Research/art/teacher profile of a person
Name and surname:
doc. RNDr. Tatiana Betáková, DrSc.
Document type:
Research/art/teacher profile of a person
The name of the university:
Comenius University Bratislava
The seat of the university:
Šafárikovo námestie 6, 818 06 Bratislava

I. - Basic information

I.1 - Surname
Betáková
I.2 - Name
Tatiana
I.3 - Degrees
doc., RNDr., DrSc.
I.4 - Year of birth
1963
I.5 - Name of the workplace
Comenius University in Bratislava, Faculty of Natural Sciences, Depertment of Microbiology and Virology
I.6 - Address of the workplace
Mlynská dolina, Ilkovičova 6, 84215 Bratislava
I.7 - Position
Associate professor
I.8 - E-mail address
betakova7@uniba.sk
I.9 - Hyperlink to the entry of a person in the Register of university staff
https://www.portalvs.sk/regzam/detail/25857
I.10 - Name of the study field in which a person works at the university
Biology
I.11 - ORCID iD
https://orcid.org/0000-0003-1095-8258

II. - Higher education and further qualification growth

II.1 - First degree of higher education
II.2 - Second degree of higher education
II.a - Name of the university or institution
Commenius University in Bratislava, Faculty of Natural Sciences
II.b - Year
1987
II.c - Study field and programme
Biochemistry
II.3 - Third degree of higher education
II.a - Name of the university or institution
Slovak Academy of Sciences
II.b - Year
1993
II.c - Study field and programme
Virology
II.4 - Associate professor
II.a - Name of the university or institution
Commenius University in Bratislava, Faculty of Natural Sciences
II.b - Year
2020
II.c - Study field and programme
Microbiology
II.5 - Professor
II.6 - Doctor of Science (DrSc.)
II.a - Name of the university or institution
Slovac Academy of Sciences
II.b - Year
2015
II.c - Study field and programme
Virology

III. - Current and previous employment

III.a - Occupation-position III.b - Institution III.c - Duration
Laboratory technician Institute of Virology SAS 1987-1993
Scientist Institute of Virology SAS 1993-2015
Principal investigator Biomedical Research Center of SAS 2015 - up to now
Assistant professor Faculty of Natural Sciences 2016-2021
Associate professor Faculty of Natural Sciences 2021- up to now

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other IV.b - Name of the institution IV.c - Year
State English exam Academy Language Institute Bratislava 2003
Special state English exam Academy Language Institute Bratislava 2004
1-2027 Workshop - Good laboratory practice Slovak Medical University in Bratislava 2013
1-4086 Workshop - Actualization and requirements for good laboratory practice Slovak Medical University in Bratislava 2014
Certificate 1376/2023 - Protection of animals used for scientific or educational purposes "retraining" Institute for the Education of Veterinary Doctors 2023

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes
V.1.a - Name of the profile course V.1.b - Study programme V.1.c - Degree V.1.d - Field of study
Virology Biological chemistry I. Biology
Immunology Biological chemistry I. Biology
Biosynthesis of viruses Virology II. Biology
Structure, morphogenesis and taxonomy of viruses Biology, biological chemistry I. Biology
Oncogenic viruses and antiviral therapy biology, biological chemistry II. Biology
Selected chapters from virology biology, biological chemistry II. Biology
Biosynthesisi of viruses - laboratory practices Biology II. Biology
V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year
V.2.a - Name of the study programme V.2.b - Degree V.2.c - Field of study
Microbiology and virology II. Biology
Microbiology and virology III. internal Biology
Microbiology and virology III.external Biology
Microbiology and virology I. Biology
V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year
V.4 - Overview of supervised final theses
V.4.1 - Number of currently supervised theses
V.4.a - Bachelor's (first degree)
1
V.4.b - Diploma (second degree)
1
V.4.c - Dissertation (third degree)
1
V.4.2 - Number of defended theses
V.4.a - Bachelor's (first degree)
7
V.4.b - Diploma (second degree)
10
V.4.c - Dissertation (third degree)
9
V.5 - Overview of other courses taught in the current academic year according to study programmes
V.5.a - Name of the course V.5.b - Study programme V.5.c - Degree V.5.d - Field of study
Current problems in biology 1 Biology, Medical biology II. Biology
Biotechnology in microbiology and virology Biology, medical biology II. Biology
Immunological aspects of host-pathogen interaction Biology, medical biology II. Biology

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations
VI.1.1 - Number of the research/artistic/other outputs
VI.1.a - Overall
208
VI.1.b - Over the last six years
34
VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases
VI.1.a - Overall
55
VI.1.b - Over the last six years
7
VI.1.3 - Number of citations corresponding to the research/artistic/other outputs
VI.1.a - Overall
0
VI.1.b - Over the last six years
0
VI.1.4 - Number of citations registered in the Web of Science or Scopus databases
VI.1.a - Overall
989
VI.1.b - Over the last six years
239
VI.1.5 - Number of invited lectures at the international, national level
VI.1.a - Overall
0
VI.1.b - Over the last six years
0
VI.2 - The most significant research/artistic/other outputs
1

Influenza A virus replication is inhibited in IFN-λ2 and IFN-λ3 transfected or stimulated cells. Antiviral Res. 2010 Dec;88(3):329-33. doi: 10.1016/j.antiviral.2010.10.005.

2

Differences in conductance of M2 proton channels of two influenza viruses at low and high pH. J Physiol. 2003 Jan 15;546(Pt 2):427-38. doi: 10.1113/jphysiol.2002.028910.

3


The NB protein is an integral component of the membrane of influenza B virus. J Gen Virol. 1996 Nov;77 ( Pt 11):2689-94. doi: 10.1099/0022-1317-77-11-2689.

4

Preparation of monoclonal-antibodies for the diagnosis of influenza-a infection using different immunization protocols. J Immunol Methods. 1995 Mar 13;180(1):107-16. doi: 10.1016/0022-1759(94)00307-i.

5

Cytokines Induced During Influenza Virus Infection. Curr Pharm Des. 2017;23(18):2616-2622.

doi: 10.2174/1381612823666170316123736.                                            

VI.3 - The most significant research/artistic/other outputs over the last six years
1

Changes in the Expression of Proteins Associated with Neurodegeneration in the Brains of Mice after Infection with Influenza A Virus with Wild Type and Truncated NS1. Int J Mol Sci. 2024 Feb 20;25(5):2460. doi: 10.3390/ijms25052460.

2

Hypoxia alters the immune response in mouse peritoneal macrophages infected with influenza a virus with truncated NS1 protein. Cytokine 2023 Apr:164:156138. doi: 10.1016/j.cyto.2023.156138.

3

Comparison of cytokine profiles induced by nonlethal and lethal doses of influenza A virus in mice. Exp Ther Med. 2019 Dec;18(6):4397-4405. doi: 10.3892/etm.2019.8096. 

4

Conserved methionine 165 of matrix protein contributes to the nuclear import and is essential for influenza A virus replication. Švančarová P, Betáková T. Virol J. 2018 Dec 3;15(1):187. doi: 10.1186/s12985-018-1056-x.

5

Pandemics of the 21st Century: The Risk Factor for Obese People.2022 VIRUSES-BASEL 14(1). DOI 10.3390/v14010025

VI.4 - The most significant citations corresponding to the research/artistic/other outputs
1

Hutchinson, EC; Charles, PD; Hester, SS; Thomas, B; Trudgian, D; Martinez-Alonso, M; Fodor, E Conserved and host-specific features of influenza virion architecture NATURE COMMUNICATIONS Volume: 5 Article Number: 4816 , 2014, Cited: BETÁKOVÁ, Tatiana - NERMUT, M.V. - HAY, A.J. The NB protein is an integral component of the membrane of influenza B virus. In Journal of General Virology, 1996, vol. 77, no.11, p. 2689-2694. 

2

Schnell JR, Chou JJ : Structure and mechanism of the M2 proton channel of influenza A virus : NATURE  Volume: 451  Issue: 7178  Pages: 591-U12  Published: JAN 31 2008. Cited: BETÁKOVÁ, Tatiana - ČIAMPOR, Fedor - HAY, A.J. Influence of residue 44 on the activity of the M2 proton channel of influenza A virus. In Journal of General Virology. - Society for General Microbiology, 2005, vol.86, no., p.181-184. 

3

Hutchinson, EC; Charles, PD ; Hester, SS ; Thomas, B; Trudgian, D; Martinez-Alonso, M; Fodor, E Conserved and host-specific features of influenza virion architecture  NATURE COMMUNICATIONS  Volume: 5  Article Number: 4816 , 2014. Cited : BETÁKOVÁ, Tatiana - NERMUT, M.V. - HAY, A.J. The NB protein is an integral component of the membrane of influenza B virus. In Journal of General Virology, 1996, vol. 77, no.11, p. 2689-2694. 

4

Amanda L Stouffer 1, Rudresh Acharya, David Salom, Anna S Levine, Luigi Di Costanzo, Cinque S Soto, Valentina Tereshko, Vikas Nanda, Steven Stayrook, William F DeGrado Structural basis for the function and inhibition of an influenza virus proton channel.  NATURE   Volume: 451   Issue: 7178   Pages: 596-U13;   doi: 10.1038/nature06528. Cited: Betakova, T., Ciampor, F. & Hay, A. J. Influence of residue 44 on the activity of the M2 proton channel of influenza A virus. J. Gen. Virol. 86, 181–184 (2005)

5

Wei, H.T. - Wang, S. - Chen, Q.H. - Chen, Y.H. - Chi, X.J. - Zhang, L.F. - Huang, S.L. - Gao, G.F. - Chen, J.L. Suppression of Interferon Lambda Signaling by SOCS-1 Results in Their Excessive Production during Influenza Virus Infection. PLOS PATHOGENS, 2014, vol. 10. No. 1. Article Number: e1003845, doi: 10.1371/journal.ppat.1003845. Cited: Svetlikova D, Kabat P, Ohradanova A, Pastorek J, Betakova T (2010) Influenza A virus replication is inhibited in IFN-lambda2 and IFN-lambda3 transfected or stimulated cells. Antiviral Res 88: 329–333.

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years
1

VEGA 2/0014/16 The role of cytokines/chemokines in the immune response to influenza A infection. 2016-2019 principal investigator. 

The main aim of this project is to study innate immune response to influenza virus and role ov NS1 protein.   

2

VEGA 2/0031/20 Influence of NS1 protein and influenza virus load on the pathogenesis and innate immune response in brains, hearts and spleens of infected mice. 2020-2023 Principal investigator.                                                                                                                                                                                                                        The main aim of this project is to investigate the spread of low virulent and high virulent influenza viruses into the brain, heart and spleen of infected mice and compare immune responses induced in these organs. 

3

VEGA 2/0014/24 The immune cell subsets and apoptosis in response to influenza A virus. 2024-2027. Principal investigator.

The aims of this project are study the development of immune cells subpopulations in the primary site of infection (lungs) and in secondary sites of infection (different organs);  determinate the role of apoptosis in immune cells, and  clarify the role of the NS1 protein in the development of immune cell subpopulations and in the introduction of apoptosis in these cells after infection with IAV. 

4

                                                                                                                      

5

       

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VII.a - Activity, position VII.b - Name of the institution, board VII.c - Duration
Member of Committee VEGA for medical and pharmacological science (9) Ministry of Education, Science, Research and Sport of the Slovak Republic and Slovak Academy of Sciences 2008-2016
Member of special commision for virology Comenius University in Bratislava, Faculty of Natural Sciences from 2005
Member of doctoral (DSc) dissertation defence committee for Virology - 010621 Ministry of Education, Science, Research and Sport of the Slovak Republic 2016 - 2021
member of the Crisis Staff of Comenius University in Bratislava Comenius University in Bratislava in Bratislava 2020 -2021
Member of Committee of the Biology Section Comenius University in Bratislava, Faculty of Natural Sciences From 2022

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution VIII.b - Address of the institution VIII.c - Duration (indicate the duration of stay) VIII.d - Mobility scheme, employment contract, other (describe)
National Institute for Medical Research London, UK 1.9.1993-31.12.1993 FEMS a Royal society grant
National Institute for Medical Research London, UK 1.3.1994-30.6.1994 British Council
National Institute for Medical Research London, UK 1.11.1994-30.6.1996 grant Welcome trust
National Institute of Health Bethesda, USA 1.7.1996-30.6.1999 NIH, USA
National Institute for Medical Research London, UK 1.7.1999-31.7.2002 NIMR, UK

IX. - Other relevant facts

IX.a - If relevant, other activities related to higher education or research/artistic/other activities are mentioned

Since I am working at Faculty of Natural Sciences only few years, my publications are not available in database CREPC.

Date of last update
2024-06-03