I. - Basic information

I.1 - Surname

Pastorek

I.2 - Name

Michal

I.3 - Degrees

MSc., PhD.

I.4 - Year of birth

1986

I.5 - Name of the workplace

Institute of Molecular Biomedicine, Medical Faculty, Comenius University in Bratislava

I.6 - Address of the workplace

Sasinkova 4, 811 08, Bratislava

I.7 - Position

researcher

I.8 - E-mail address

michal.pastorek@imbm.sk

I.9 - Hyperlink to the entry of a person in the Register of university staff

https://www.portalvs.sk/regzam/detail/30009

I.10 - Name of the study field in which a person works at the university

Normal and pathological physiology

I.11 - ORCID iD

0000-0003-1987-5459

II. - Higher education and further qualification growth

II.1 - First degree of higher education

II.a - Name of the university or institution

Faculty of Natural Sciences, Comenius University, Bratislava

II.b - Year

2007

II.c - Study field and programme

Molecular biology

II.2 - Second degree of higher education

II.a - Name of the university or institution

Faculty of Natural Sciences, Comenius University in Bratislava

II.b - Year

2009

II.c - Study field and programme

Molecular biology

II.3 - Third degree of higher education

II.a - Name of the university or institution

Faculty of Medicine, Comenius University in Bratislava

II.b - Year

2014

II.c - Study field and programme

Oncology

II.4 - Associate professor

II.5 - Professor

II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position	III.b - Institution	III.c - Duration
researcher	Institute of Molecular Biomedicine, Medical Faculty, Comenius University in Bratislava	2018-
researcher	Regional Centre for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic	2015-2018
researcher	Centre for Molecular Medicine, Slovak Academy of Sciences, Bratislava	2014-2015

IV. - Development of pedagogical, professional, language, digital and other skills

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes

V.1.a - Name of the profile course	V.1.b - Study programme	V.1.c - Degree	V.1.d - Field of study
Basics of theoretical and experimental medicine	Biology	I.	Biology
Introduction to science	General medicine	II.	General medicine

V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year

V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year

V.4 - Overview of supervised final theses

V.4.1 - Number of currently supervised theses

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.4.2 - Number of defended theses

V.4.a - Bachelor's (first degree)

V.5 - Overview of other courses taught in the current academic year according to study programmes

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations

VI.1.1 - Number of the research/artistic/other outputs

VI.1.a - Overall

VI.1.b - Over the last six years

VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases

VI.1.a - Overall

VI.1.b - Over the last six years

VI.1.3 - Number of citations corresponding to the research/artistic/other outputs

VI.1.a - Overall

298

VI.1.b - Over the last six years

183

VI.1.4 - Number of citations registered in the Web of Science or Scopus databases

VI.1.a - Overall

298

VI.1.b - Over the last six years

183

VI.1.5 - Number of invited lectures at the international, national level

VI.2 - The most significant research/artistic/other outputs

Pastorek M, Muller P, Coates PJ, Vojtesek B. Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition. Plos One. 2018 Aug;13(8)

Pastorek M, Simko V, Takacova M, Barathova M, Bartosova M, Hunakova L, Sedlakova O, Hudecova S, Krizanova O, Dequiedt F, Pastorekova S, Sedlak J. Sulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy. Int J Oncol. 2015 Jul;47(1):51-60.

Gibadulinova A, Pastorek M, Filipcik P, Radvak P, Csaderova L, Vojtesek B, et al. Cancer-associated S100P protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance. Oncotarget. 2016 Apr;7(16):22508-22.

Vidlickova I, Dequiedt F, Jelenska L, Sedlakova O, Pastorek M, Stuchlik S, et al. Apoptosis -induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy. BMC Cancer. 2016 Mar 19;16:239.

Maronek M, Gromova B, Liptak R, Konecna B, Pastorek M, Cechova B, et al. Extracellular DNA Correlates with Intestinal Inflammation in Chemically Induced Colitis in Mice. Cells. 2021 Jan 6;10(1):81.

VI.3 - The most significant research/artistic/other outputs over the last six years

Pastorek M, Muller P, Coates PJ, Vojtesek B. Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition. Plos One. 2018 Aug;13(8)

Matoulkova E, Sommerova L, Pastorek M, Vojtesek B, Hrstka R. Regulation of AGR2 expression via 3'UTR shortening. Exp Cell Res. 2017 Jul 1;356(1):40-47.

Maronek M, Gromova B, Liptak R, Konecna B, Pastorek M, Cechova B, et al. Extracellular DNA Correlates with Intestinal Inflammation in Chemically Induced Colitis in Mice. Cells. 2021 Jan 6;10(1):81.

VI.4 - The most significant citations corresponding to the research/artistic/other outputs

Anwar MM, Shalaby M, Embaby AM, Saeed H, Agwa MM, Hussein A. Prodigiosin/PU-H71 as a novel potential combined therapy for triple negative breast cancer (TNBC): preclinical insights. Sci Rep. 2020 Sep 7;10(1):14706.

Sita G, Hrelia P, Graziosi A, Morroni F. Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment. Nutrients. 2018 Nov 14;10(11):1755.

Güttler A, Eiselt Y, Funtan A, Thiel A, Petrenko M, Keßler J, Thondorf I, Paschke R, Vordermark D, Bache M. Betulin Sulfonamides as Carbonic Anhydrase Inhibitors and Anticancer Agents in Breast Cancer Cells. Int J Mol Sci. 2021 Aug 16;22(16):8808. doi: 10.3390/ijms22168808. PMID: 34445506; PMCID: PMC8395940.

Cong Y, Cui Y, Wang S, Jiang L, Cao J, Zhu S, Birkin E, Lane J, Ruge F, Jiang WG, Qiao G. Calcium-Binding Protein S100P Promotes Tumor Progression but Enhances Chemosensitivity in Breast Cancer. Front Oncol. 2020 Sep 15;10:566302.

Janning M, Müller V, Vettorazzi E, Cubas-Cordova M, Gensch V, Ben-Batalla I, Zu Eulenburg C, Schem C, Fasching PA, Schnappauf B, Karn T, Fehm T, Just M, Kühn T, Holms F, Overkamp F, Krabisch P, Rack B, Denkert C, Untch M, Tesch H, Rezai M, Kittel K, Pantel K, Bokemeyer C, Loibl S, von Minckwitz G, Loges S. Evaluation of soluble carbonic anhydrase IX as predictive marker for efficacy of bevacizumab: A biomarker analysis from the geparquinto phase III neoadjuvant breast cancer trial. Int J Cancer. 2019 Aug 1;145(3):857-868.

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

APVV-PP-COVID-20-0016

Neutrophils and their extracellular traps in COVID-19

1/0716/20

Causes and effects of NETosis in sterile inflammation - flow cytometry analysis

APVV-18-0366

The role of NETosis in the etiopathogenesis of rheumatoid arthritis

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution	VIII.b - Address of the institution	VIII.c - Duration (indicate the duration of stay)	VIII.d - Mobility scheme, employment contract, other (describe)
Molecular Biology Unit, Faculty of Agronomy, Gembloux, Belgium, Laboratory of Franck Dequiedt	Faculty of Agronomy, Gembloux, Belgium	2009

IX. - Other relevant facts

Date of last update

2022-01-14

Name and surname:	doc. Mgr. Michal Pastorek, PhD.
Document type:	Research/art/teacher profile of a person
The name of the university:	Comenius University Bratislava
The seat of the university:	Šafárikovo námestie 6, 818 06 Bratislava