I. - Basic information

I.1 - Surname

Mego

I.2 - Name

Michal

I.3 - Degrees

MD, DSc

I.4 - Year of birth

1977

I.5 - Name of the workplace

2nd Department of Oncology, Comenius University, Medical Faculty

I.6 - Address of the workplace

Klenova 1, 83101 Bratislava

I.7 - Position

head of department

I.8 - E-mail address

misomego@gmail.com

I.9 - Hyperlink to the entry of a person in the Register of university staff

https://www.portalvs.sk/regzam/detail/3289

I.10 - Name of the study field in which a person works at the university

Oncology

I.11 - ORCID iD

0000-0002-6511-6827

II. - Higher education and further qualification growth

II.1 - First degree of higher education

II.a - Name of the university or institution

Comenius University, Medical Faculty

II.b - Year

1998

II.c - Study field and programme

General Medicine

II.2 - Second degree of higher education

II.a - Name of the university or institution

Comenius University, Medical Faculty

II.b - Year

2001

II.c - Study field and programme

General Medicine

II.3 - Third degree of higher education

II.a - Name of the university or institution

Comenius University, Medical Faculty

II.b - Year

2006

II.c - Study field and programme

Oncology

II.4 - Associate professor

II.a - Name of the university or institution

Comenius University, Medical Faculty

II.b - Year

2011

II.c - Study field and programme

Oncology

II.5 - Professor

II.a - Name of the university or institution

Comenius University, Medical Faculty

II.b - Year

2017

II.c - Study field and programme

Oncology

II.6 - Doctor of Science (DrSc.)

II.a - Name of the university or institution

Slovak Academy of Sciences

II.b - Year

2017

II.c - Study field and programme

Oncology

III. - Current and previous employment

III.a - Occupation-position	III.b - Institution	III.c - Duration
Head of Department	Comenius University, Medical Faculty	since 2017

IV. - Development of pedagogical, professional, language, digital and other skills

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes

V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year

V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year

V.3.a - Name of the field of habilitation procedure and inaugural procedure	V.3.b - Study field to which it is assigned
Clinical Oncology	General Medicine

V.4 - Overview of supervised final theses

V.4.1 - Number of currently supervised theses

V.4.2 - Number of defended theses

V.5 - Overview of other courses taught in the current academic year according to study programmes

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations

VI.1.1 - Number of the research/artistic/other outputs

VI.1.a - Overall

226

VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases

VI.1.3 - Number of citations corresponding to the research/artistic/other outputs

VI.1.4 - Number of citations registered in the Web of Science or Scopus databases

VI.1.a - Overall

4756

VI.1.5 - Number of invited lectures at the international, national level

VI.1.a - Overall

VI.2 - The most significant research/artistic/other outputs

Antonelli L, Ardizzone D, Tachibana I, Adra N, Cary C, Hugar L, Sexton WJ, Bagrodia A, Mego M, Daneshmand S, Nicolai N, Nazzani S, Giannatempo P, Franza A, Heidenreich A, Paffenholz P, Saoud R, Eggener S, Ho M, Oswald N, Olson K, Tryakin A, Fedyanin M, Naoun N, Javaud C, Cazzaniga W, Nicol D, Gerdtsson A, Tandstad T, Fizazi K, Fankhauser CD; EAU-YAU Penile and Testis Cancer Working Group. Risk Factors for Relapse in Nonseminomatous Testicular Cancer After Postchemotherapy Retroperitoneal Lymph Node Dissection With Viable Residual Cancer. J Clin Oncol. 2023 Dec 1;41(34):5296-5305. doi: 10.1200/JCO.23.00443. Epub 2023 Sep 1. PMID: 37656935.

Mego M, Danis R, Chovanec J, Jurisova S, Bystricky B, Porsok S, Konkolovsky P, Vaclav V, Wagnerova M, Streško M, Brezinova B, Rečková M, Sutekova D, Pazderova N, Novisedlakova M, Zomborska E, Ciernikova S, Svetlovska D, Drgona L. Randomized double-blind, placebo-controlled multicenter phase III study of prevention of irinotecan-induced diarrhea by a probiotic mixture containing Bifidobacterium BB-12^®Lactobacillus rhamnosus LGG^® in colorectal cancer patients. Front Oncol. 2023 Aug 4;13:1168654. doi: 10.3389/fonc.2023.1168654. PMID: 37601667; PMCID: PMC10438450.

Lesko P, Chovanec M, Mego M. Biomarkers of disease recurrence in stage I testicular germ cell tumours. Nat Rev Urol. 2022 Nov;19(11):637-658. doi: 10.1038/s41585-022-00624-y. Epub 2022 Aug 26. PMID: 36028719.

Timmerman DM, Eleveld TF, Sriram S, Dorssers LCJ, Gillis AJM, Schmidtova S, Kalavska K, van de Werken HJG, Oing C, Honecker F, Mego M, Looijenga LHJ. Chromosome 3p25.3 Gain Is Associated With Cisplatin Resistance and Is an Independent Predictor of Poor Outcome in Male Malignant Germ Cell Tumors. J Clin Oncol. 2022 Sep 10;40(26):3077-3087. doi: 10.1200/JCO.21.02809. Epub 2022 Apr 20. PMID: 35442716; PMCID: PMC9462533.

VI.3 - The most significant research/artistic/other outputs over the last six years

Mego M, Svetlovska D, Reckova M, Angelis D, Kalavska K, Obertova J, Palacka P, Rejlekova K, Sycova-Mila Z, Chovanec M, Mardiak J. Gemcitabine, carboplatin and veliparib in multiple relapsed/refractory germ cell tumours: The GCT-SK-004 phase II trial. Invest New Drugs. 2021 Dec;39(6):1664-1670. doi: 10.1007/s10637-021-01130-5. Epub 2021 May 29. PMID: 34052929.

Kucerova L, Fekiacova A, Udvorkova N, Malcharkova P, Blahova V, Jochova S, Kalavska K, Cierna Z, Mego M. Mirvetuximab Soravtansine Induces Potent Cytotoxicity and Bystander Effect in Cisplatin-Resistant Germ Cell Tumor Cells. Cells. 2025 Feb 15;14(4):287. doi: 10.3390/cells14040287. PMID: 39996761; PMCID: PMC11853988.

VI.4 - The most significant citations corresponding to the research/artistic/other outputs

Mego, Michal 35% - Rečková, Mária - Obertová, Jana - Syčová - Milá, Zuzana - Brozmanová, K. -Mardiak, Jozef 35%: Increased cardiotoxicity of sorafenib in sunitinib - pretreated patients with metastatic renal cell carcinoma. Annals of Oncology. - Vol. 18, No. 11 (2007), s. 1906-1907 Ohlasy (26): [o1] 2009 Cho, D.C. - Puzanov, I. - regan, M.M. - Schwarzberg, T. - Seery, V. - Liu, V. - Bhatt, R. - Koon, H. - Mier, J.W. - Sosman, J.A: - Atkins, M.B. - McDermott, D.F.: Journal of Immunotherapy, vol. 32, no. 2, 2009, s. 181-185 - SCI ;SCOPUS [o1] 2009 Baker, S.D. - Hu, S.: Clinical Pharmacology and Therapeutics, vol. 85, no. 2, 2009, s. 208-211 - SCI ; SCOPUS [o1] 2009 Orphanos, G.S. - Ioannidis, G.N. - Ardavanis, A.G.: Acta Oncologica, vol. 48, no. 7, 2009, s. 964-970 - SCI ; SCOPUS [o1] 2009 Wong, M.K.K. - Jarkowski III, A.: Pharmacotherapy, vol. 29, no. 4, 2009, s. 473-478 - SCI ; SCOPUS [o1] 2009 Grant, S.K.: Cellular and Molecular Life Sciences, vol. 66, no. 7, 2009, s. 1163-1177 - SCI ; SCOPUS [o1] 2010 Nowis, D. - Maczewski, M. - Mackiewicz, U. - Kujawa, M. - Ratajska, A. - Wieckowski, M.R. - Wilczynski, G.M. - Malinowkska, M. - Bil, J. - Salwa, P. - Bugajski, M. - Wojcik, C. - Sinskij, M. - Abramczyk, P. - Winiarska, M. -Dabrowska-Iwanicka, A. - Duszynski, J. - Jakóbisiak, M. - Golab, J.: American Journal of Pathology, vol. 176, no. 6, 2010, s. 2658-2668 - SCI ; SCOPUS [o1] 2010 Kamada, P. - Dudek, A.Z.: Cancer Investigation, vol. 28, no. 5, 2010, s. 501-504 - SCI ; SCOPUS [o1] 2010 Staehler, M. - Haseke, N. - Zilinberg, K. - Stadler, T. - Stief, C.G.: Urologia Internationalis, vol. 84, no. 1, 2010, s. 119-121 - SCI ; SCOPUS [o1] 2010 Raschi, E. - Vasina, V. - Ursino, M.G. - Boriani, G. - Martoni, A. - de Ponti, F.: Pharmacology Therapeutics, vol. 125, no. 2, 2010, s. 196-218 - SCI ; SCOPUS [o1] 2011 Jarkowski, A. - Glode, A.E. - Spangenthal, E.J. - Wong, M.K.K.: Pharmacotherapy, vol. 31, no. 1, 2011, s. 62-75 - SCI ; SCOPUS

Mego, Michal - Masi, Sendural A. - Cristofanilli, Massimo : Molecular mechanisms of metastasis in breast cancer - clinical applications. Nature Reviews - Clinical Oncology. - Vol. 7, No. 12 (2010), s. 693-701 Ohlasy (47): [o1] 2011 Hanash, S.M. - Baik, C. - Kallioniemi, O.: Nature Reviews Clinical Oncology, vol. 8, no. 3, 2011, s. 142-150 - SCI ; SCOPUS [o1] 2011 Chaffer, C.L. - Weinberg, R.A.: Science, vol. 331, no. 6024, 2011, s. 1559-1564 - SCI ; SCOPUS [o1] 2011 Serrano, M.J. - Nadal, R. - Lorente, J.A. - Salido, M. - Rodriguez, R. - Rodriguez, M. - Macia, M. - Sanchez-Rovira, P. - Corominas, J.M. - Gonzalez, L. - Vera, L. - Albanell, J. - Sole, F.: Ann als of Oncology, vol. 22, no. 9, 2011,s. 2150-2151 - SCI ; SCOPUS [o1] 2011 Lecharpentier, A. - Vielh, P. - Perez-Moreno, P. - Planchard, D. - Soria, J.C. - Farace, F.: British Journal of Cancer, vol. 105, no. 9, 2011, s. 1338-1341 - SCI ; SCOPUS [o1] 2011 Pecot, C.V. - Bischoff, F.Z. - Mayer, J.A. - Wong, K.L. - Pham, T. - Bottsford-Miller, Stone, R.L. - Lin, Y.G. - Jaladurgam, P. - Roh, J.W. - Goodman, B.W. - Merritt, W.M. - Pircher, T.J. - Mikolajczyk, S.D. - Nick, A.M. - Celestino,J. - Eng, C. - Ellis, L.M. - Deavers, M.T. - Sood, A.K.: Cancer Discovery, vol. 1, no. 7, 2011, s. 580-586 - SCI ; SCOPUS [o1] 2012 Pierga, J.Y. - Hajage, D. - Bachelot, T. - Delaloge, S. - Brain, E. - Campone, M. - Dieras, V. - Rolland, E. - Mignot, L. - Mathiot, C. - Bidard, F.C.: Annals of Oncology, vol. 23, no. 3, 2012, s. 618-624 - SCI ; SCOPUS [o1] 2012 Mordant, P. - Loriot, Y. - Lahon, B. - Castie, Y. - Leseche, G. - Soria, J.C. - Massard, C. - Deutsch, E.: Cancer Treatment Reviews, vol. 38, no. 2, 2012, s. 101-110 - SCI ; SCOPUS [o1] 2012 Nadal, R. - Fernandez, A. - Sanchez-Rovira, P. - Salido, M. - Rodriguez, M. - Garcia-Puche, J.L. - Maciá, M. - Corominas, J.M. - Delgado-Rodriguez, M. - Conzales, L. - Albanell, J. - Fernandez, M. - Solé, F. - Lorente, J.A.: BreastCancer Research, vol. 14, no. 3, art no. R71, 2012, s. [nn] - SCI ; SCOPUS [o1] 2012 Foroni, C. - Broggini, M. - Generali, D. - Damia, G.: Cancer Treatment Reviews, vol. 38, no. 6, 2012, s. 689-697 - SCI ; SCOPUS [o1] 2012 Liu, Z. - Zhang, B. - Liu, K. - Ding, Z. - Hu, X.: Plos One, vol. 7, no. 7, art. no. e40480, 2012, s. [nn] - SCI ; SCOPUS

Mego, Michal 20% - De Giorgi, Ugo - Dawood, Shahenaah - Wang, Xuemei - Valero, Vicente - Andreoupolou, Eleni - Handy, Beverly - Ueno, Naoto T. - Reuben, James M. - Cristofanilli, Massimo : Characterization of metastatic breast cancerpatients with nondetectable circulating tumor cells In: International Journal of Cancer. - Vol. 129, No. 2 (2011), s. 417-423 Ohlasy (26): [o1] 2011 Gradilone, A. - Raimondi, C. - Nicolazzo, C. - Petracca, A. - Gandini, O. - Vincenzi, B. - Naso, G. - Agliano, A.M. - Cortesi, E. - Gazzaniga, P.: Journal of Cellular and Molecular Medicine, vol. 15, no. 5, 2011, s. 1066-1070 - SCI

Mego, Michal 50% - Mani, Sandurai A. 5% - Lee, Bang-Ning 5% - Li, Changping 5% - Ewans, Kurt W. 5% - Cohen, Evan N. 5% - Gao, Hui 5% - Jackson, Summer A. 2% - Giordano, Antonio 3% - Hortobagyi, Gabriel N. 5% - Cristofanilli, Massimo 3% - Lucci,Anthony 2% - Reuben, James M. 5%: Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy International Journal of Cancer. - Vol. 130, No. 4 (2012), s. 808-816 Ohlasy (21): [o1] 2011 Strati, A. - Markou, A. - Parisi, C. - Politaki, E. - Mavroudis, D. - Georgoilias, V. - Lianidou, E.: BMC Cancer, vol. 11, art. no. 422, 2011, s. [nn] - SCI [o1] 2011 Bednarz-Knoll, N. - Alix-Panabieres, C. - Pantel, K.: Breast Cancer Research, vol. 13, no. 6, art. no. 228, 2011, s. [nn] - SCI [o1] 2011 Kallergi, G. - Papadaki, M.A. - Politaki, E. - Mavroudis, D. - Georgoulias, V. - Agelaki, S.: Breast Cancer Research, vol. 13, no. 3, art. no. R59, 2011, s. [nn] - SCI [o1] 2012 Bednarz-Knoll, N. - Alix-Panabieres, C. - Pantel, K.: Cancer and Metastasis Reviews, vol. 31, no. 3-4, SI, 2012, s. 673-687 - SCI ; SCOPUS [o1] 2012 Bonnomet, A. - Syne, L. - Brysse, A. - Feyereisen, E. - Thompson, E.W. - Noel, A. - Foidart, J.M. - Birembaut, P. - Polette, M. - Gilles, C.: Oncogene, vol. 31, no. 33, 2012, s. 3741-3753 - SCI [o1] 2012 Gonzales-Angulo, A.M. - Iwamoto, T. - Liu, S. - Chen, H.Q. - Do, K.A. - Hortobagy, G.N. - Mills, G.B. - Meric-Bernstam, F. - Symmans, W.F. - Pusztai, L.: Clinical Cancer Research, vol. 18, no. 4, 2012, s. 1109-1119 - SCI [o1] 2012 Gorges, T.M. - Tinhofer, I. - Drosch, M. - Röse, L. - Zollner, T.M. - Krahn, T. - von Ahsen, O.: BMC Cancer, vol. 12, art. no. 178, 2012, s. [nn] - SCI ; SCOPUS [o1] 2012 Mitra, R. - Chao, O. - Urasaki, Y. - Goodman, O.B. - Le, T.T.: BMC Cancer, vol. 12, art. no. 540, 2012, s. [nn] - SCI ; SCOPUS [o1] 2013 Kang, Y. - Pantel, K.: Cancer Cell, vol. 23, no. 5, 2013, s. 573-581 - SCI ; SCOPUS [o1] 2013 Tsai, J.H. - Yang, J.: Genes and Development, vol. 27, no. 20, 2013, s. 2192-2206 - SCI ; SCOPUS

Mego, Michal - De Giorgi, U. - Broglio, K. - Dawood, S. - Valero, Vicente - Andreopoulou, E. - Handy, B. - Reuben, James M. - Cristofanilli, Massimo : Circulating tumour cells are associated with increased risk of venous thromboembolism inmetastatic breast cancer patients British Journal of Cancer. - Vol. 101, No. 11 (2009), s. 1813-1816 Ohlasy (11): [o1] 2010 Matrone, M.A. - Whipple, R.A. - Balzer, E.M. - Martin, S.S.: Cancer Research, vol. 70, no. 20, 2010, s. 7737-7741 - SCI ; SCOPUS [o1] 2011 Lianidou, E.S. - Markou, A.: Clinical Chemistry and Laboratory Medicine, vol. 49, no. 10, 2011, s. 1579-1590 - SCI ; SCOPUS [o1] 2011 Cajfinger, F. - Debourdeau, P. - Drouet, L. - Durant, C. - Elalamy, I. - Farge-Bancel, D.: Onkologie, vol. 13, no. 12, 2011, s. 789-796 - SCI ; SCOPUS [o1] 2012 Medioni, J. - Guastalla, J.P. - Drouet, L.: Bulletin du Cancer, vol. 99, no. 2, 2012, s. 199-210 - SCI [o1] 2012 Custodio, A. - Lopez-Farre, A.J. - Zamorano-Leon, J.J. - Mateos-Caceres, P.J. - Macaya, C. - Caldes, T. - de la Hoya, M. - Olivera, E. - Puente, J. - Diaz-Rubio, E. - Perez-Segura, P.: Journal of Cancer Research and ClinicalOncology, vol. 138, no. 5, 2012, s. 867-875 - SCI [o1] 2012 Bobek, V.: Anti-Cancer Agents in Medicinal Chemistry, vol. 12, no. 6, 2012, s. 580-588 - SCOPUS [o1] 2012 Médioni, J. - Guastalla, J.P. - Drouet, L.: Bulletin du Cancer, vol. 99, no. 2, 2012, s. 199-210 - SCOPUS [o1] 2012 Siegal, D.M. - Garcia, D.: Journal of Thrombosis and Haemostasis, vol. 10, no. 11, 2012, s. 2230-2241 - SCI [o1] 2012 Gary, T. - Belaj, K. - Steidl, K. - Pichler, M. - Eisner, F. - Stoger, H. - Hafner, F. - Froehlich, H. - Samonigg, H. - Pilger, E. - Brodmann, M.: British Journal of Cancer, vol. 107, no. 8, 2012, s. 1244-1248 - SCI [o1] 2013 Serra, R. - Buffone, G. - Montemurro, R. - de Franciscis, S.: Surgery Today, vol. 43, no. 1, 2013, s. 100-102 - SCI

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

Grant VEGA 1/0071/24 Štúdium vplyvu črevného mikrobiomu na liečbu a prognózu pacientov s testikulárnymi nádromi z germinatívnych buniek. Zodpovedný riešiteľ: prof.MUDr. Michal Mego, DrSc.

APVV-20-0158 Identification of new treatment options in refractory testicular germ cell tumors. Zodpovedný riešiteľ: prof.MUDr. Michal Mego, DrSc.

Grant VEGA 1/0349/21 Inhibícia karbonickej anhydrázy IX (CA IX) ako nástroj prekonania rezistencie voči cisplatine u refraktérnych testikulárnych nádorov zo zárodočných buniek. Zodpovedný riešiteľ: RNDr. Ing. Katarína Káľavská, PhD.

Grant VEGA 2/0124/21 Identifikácia potenciálnych terapeutických cieľov asociovaných s rezistenciou voči cisplatine u nádorov zo žĺtkového vaku. Zodpovedný riešiteľ: Ing. Silvia Schmidtová, PhD.

Grant APVV-21-0197. Preprogramovanie mikroprostredia duktálneho adenokarcinómu pankreasu voči imunoterapii. Zodpovedný riešiteľ: Mgr. Božena Smolková, PhD.

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

IX. - Other relevant facts

IX.a - If relevant, other activities related to higher education or research/artistic/other activities are mentioned

“Crystal Wing” in Medicine and Science category (prestigious national award for outstanding achievements, 2017) Prize of the Minister of Education of Slovakia for Science and Technology (2019) State decoration “Rad Ľudovíta Štúra” for the advancement of science in Slovakia awarded by the President of the Slovak Republic Zuzana Čaputová (2022) Silver Medal “Propter Merit” Slovak Medical Society, (2024) Esset Science Award “Public Prize” (2024) 2013 Young Investigator Travel Grant Award (2nd Prize), 9th International symposium, Minimal Residual Cancer, September 26-28, 2013, Paris, France 2011 Prize of the Minister of Education of Slovakia for Science and Technology for 2011 2009 American Association for Cancer Research, Translational Research Scholar-in-Training Award, San Antonio, December 9-13th, TX, USA 2009 Best Poster Award, 7th International symposium, Minimal Residual Cancer, September 16-18, 2009, Athens, Greece 2008 UICC American Cancer Society International Fellowship for Beginning Investigators, ACSBI Award ACS /08/ 006 2006 European Society of Medical Oncology Best Exam Award 2001 Academic Award of the Head of Comenius University 2000 Academic Award of the Head of Comenius University 1998 1st place at International Student Scientific Conference in Pilsen, Czech Republic Patenty 2011 WO2011112903 - Quantitative RT-PCR detection for genes involved in epithelial mesenchymal transition in peripheral blood of breast cancer patients PCT/US2011/028049 2013 Patent pending: Method for in vivo isolation of circulating tumor cells from peripheral blood II. onkologická klinika od roku 2007

Name and surname:	prof. MUDr. Michal Mego, DrSc.
Document type:	Research/art/teacher profile of a person
The name of the university:	Comenius University Bratislava
The seat of the university:	Šafárikovo námestie 6, 818 06 Bratislava