I. - Basic information

I.1 - Surname

Kupčová

I.2 - Name

Viera

I.3 - Degrees

prof. MUDr. CSc.

I.4 - Year of birth

1951

I.5 - Name of the workplace

III. Department of Internal Medicine, Faculty of Medicine, Comenius University in Bratislava

I.6 - Address of the workplace

Dean's Office of Doctor's Faculty, Comenius University in Špitálska 24, 813 72 Bratislava

I.7 - Position

university teacher – professor

I.8 - E-mail address

kupcova1@uniba.sk

I.9 - Hyperlink to the entry of a person in the Register of university staff

www.portalvs.sk/regzam/detail/3255

I.10 - Name of the study field in which a person works at the university

internal diseases

I.11 - ORCID iD

0000-0002-5264-2916

II. - Higher education and further qualification growth

II.1 - First degree of higher education

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Medicine

II.b - Year

1973

II.c - Study field and programme

Scientific field General Medicine

II.2 - Second degree of higher education

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Medicine

II.b - Year

1975

II.c - Study field and programme

Scientific field General Medicine

II.3 - Third degree of higher education

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Medicine

II.b - Year

1989

II.c - Study field and programme

1989 Internal diseases

II.4 - Associate professor

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Medicine

II.b - Year

1994

II.c - Study field and programme

Internal diseases

II.5 - Professor

II.a - Name of the university or institution

Comenius University in Bratislava, Faculty of Medicine

II.b - Year

2003

II.c - Study field and programme

Internal diseases

II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position	III.b - Institution	III.c - Duration
Secondary doctor and self-employed doctor	Institute of National Health of the City of Bratislava	1975-1980
Assistant, specialized assistant	III. Department of Internal Medicine LFUK and UNB, Comenius University	1981-1993
University teacher-assistant professor	associate professor III.Department of Internal Medicine LFUK and UNB, Comenius University	1994 -2002
University teacher-professor	professor III. Department of Internal Medicine of LFUK and UNB, Comenius University	2003 – present

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other	IV.b - Name of the institution	IV.c - Year
Internal medicine I. st.	Slovak Medical University Bratislava	1980
Internal medicine II. st.	Slovak Medical University Bratislava	1987
Hepatology	Slovak Medical University Bratislava	1999
Clinical Pharmacology– certified course	Slovak Medical University Bratislava	1984
Good clinical practice – clinical trial – certified course	Slovak Medical University Bratislava	2007
Ultrasonography – certified course	P.J.Šafárik University, Faculty of Medicine, Košice	2013

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes

V.1.a - Name of the profile course	V.1.b - Study programme	V.1.c - Degree	V.1.d - Field of study
Internal medicine .	study program Internal Medicine	Level I + II	field of study General Medicine
Internal medicine	study Programme of Internal Medicine	Level III,	Field of Study General Medicine

V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year

V.2.a - Name of the study programme	V.2.b - Degree	V.2.c - Field of study
Internal medicine	III	General medicine

V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year

V.4 - Overview of supervised final theses

V.4.1 - Number of currently supervised theses

V.4.a - Bachelor's (first degree)

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.4.2 - Number of defended theses

V.4.a - Bachelor's (first degree)

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.5 - Overview of other courses taught in the current academic year according to study programmes

V.5.a - Name of the course	V.5.b - Study programme	V.5.c - Degree	V.5.d - Field of study
Internal medicine	study program Internal Medicine	Level III	study. Department of General Medicine
Hepatology	study. program Internal Medicine	Level III	study. Department of General Medicine
Gastroenterology	study. program Internal Medicine	Level III	study. Department of General Medicine

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations

VI.1.1 - Number of the research/artistic/other outputs

VI.1.a - Overall

806

VI.1.b - Over the last six years

VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases

VI.1.a - Overall

73 outputs of Scopus, 60 outputs of Web of Science

VI.1.b - Over the last six years

17 Scopus outputs, 14 Web of Science outputs

VI.1.3 - Number of citations corresponding to the research/artistic/other outputs

VI.1.a - Overall

899

VI.1.b - Over the last six years

373

VI.1.4 - Number of citations registered in the Web of Science or Scopus databases

VI.1.a - Overall

597 Scopus responses, 525 Web of Science responses

VI.1.b - Over the last six years

356 Scopus responses, 349 Web of Science responses

VI.1.5 - Number of invited lectures at the international, national level

VI.1.a - Overall

VI.1.b - Over the last six years

VI.2 - The most significant research/artistic/other outputs

Šebeková K, Kupčová V, Schinzel R, Heidland A: Markedly elevated levels of plasma advanced glycation end products in patients with liver cirrhosis – amelioration by liver transplantation

Journal of Hepatology. - Vol. 36, No. 1 (2002), s. 66-71. (IF =4,974; Q1), Citations (120)

van der Ree M, van der Meer A, de Bruijne J, Maan R, van Vliet A, Welzel T, Zeuzem S, Lawitz E, Rodriguez-Torres M, Kupčová V, Wircinska-Drapalo A, Hodges M, Janssen H, Reesink H.: Long-term safety and efficacy of microRNA-targeted therapy in chronic hepatitis C patients

Antiviral Research. - Vol. 111, November (2014), s. 53-59. (IF =3,938; Q1), Citations(158)

Kupčová V, Turecký L, Uhlíková E. The role of oxidative stress in anti-tumor necrosis factor antibody treatment in Crohn´s disease. Current Medicinal Chemistry. - Vol. 19, No. 30 (2012), s. 5226-5231. (IF =4,070; Q1), Citations(6)

Kupčová V, Šperl J, Pannier A, Jordan P, Dougherty F.C, Reigner B. : The effect of severe hepatic impairment on the pharmacokinetics and haematological response of C.E.R.A.Current Medical Research and Opinion. - Vol. 24, No. 7 (2008), s. 1943-1950. (IF =2,596; Q2), Citations (4)

Kupčová V, Arold G, Roepstorff C, Hojbjerre M, Klim S, Haahr H.: Insulin degludec: Pharmacokinetic properties in subjects with hepatic impairment. Clinical Drug Investigation. - Vol. 34, No. 2 (2014), s. 127-133. (IF =1,557; Q3), Citations (35)

Baekdal Tine, Thomsen M, Kupčová V, Hansen C, Anderson T. Pharmacokinetics, safety, and tolerability

of oral semaglutide in subjects with hepatic impairment. Journal of Clinical Pharmacology. - Vol. 58, No.

10 (2018), s. 1314-1323. (IF =2,915; Q2), Citations (63)

Jensen L, Kupčová V, Arold G, Pettersson J, Hjerpsted J: Pharmacokinetics and tolerability of semaglutide

in people with hepatic impairment. Diabetes, Obesity and Metabolism. Vol. 20, No 4 (2018), s. 998-1005.

(IF =6,133; Q1), Citations (39)

VI.3 - The most significant research/artistic/other outputs over the last six years

Kupčová V, Fedelešová M, Bulas J, Kozmonová P, Turecký L: Overview of the pathogenesis, genetic, and non-invasive clinical, biochemical, and scoring methods in the assessment of NAFLD

International journal of environmental research and public health. - Roč. 16, č. 19 (2019), s.1-25. (IF =2,849; Q1), Citations (36)

Kupčová, V, Murín, J, Wimmerová, S, Páterková, M, Turecký, L, Bulas, J:O besity, elevated levels of

fasting plasma glucose and type 2 diabetes are associated with aortic stiffness. – text. –

[recenzované]. – DOI 10.4149/BLL_2023_062. – OA ; WOS CC ; SCO.

In: Bratislava medical journal [textový dokument (print)] [elektronický dokument] . – Bratislava (Slovensko) :

Academic Electronic Press. – ISSN 0006-9248. – ISSN (online) 1336-0345. – Roč. 124, č. 6 (2023), s. 407-

416 [tlačená forma] [online] IF: 1.5, Q2, Citations (1)

Haahr, H, Cieslarová, B, Hingst, J. R, Jiang, S, Kristensen, N. R, Kupčová, V, Norgreen, L, Wagner, F-D. H,

Ignatenko, S: The effect of various degrees of renal or hepatic impairment on the pharmacokinetic

properties of once-weekly insulin icodec. – text. – [recenzované]. – DOI 10.1007/s40262-024-01375-2.

In: Clinical pharmacokinetics [textový dokument (print)] [elektronický dokument] . – Auckland (Veľká

Británia) : Springer Nature. Adis. – ISSN 0312-5963. – ISSN (online) 1179-1926. – Roč. 63, č. 6 (2024), s.

819-830 [tlačená forma] [online], IF 4,6

Skladaný Ľ, Oltman M, Fraňková S, Dražilová S, Husa P, Šperl J, Hejda V, Urbánek P, Adamcová-Selčanová S, Janičko M, Kristian P, Kupčová V, Rác M, Schréter I, Virág L, Liptáková A, Ondrášová M, Jarčuška P. Chronic hepatitis C virus infection in the Czech Republic and Slovakia: an analysis of patient and virus characteristics. International Journal of Public Health. – Vol. 65, No. 9 (2020), s. 1723-1735. (IF = 3,380; Q1)

Czerniak R, Cieslarová B, Kupčová V, Rosario M, Lock R, Dong Ch, Dukes G. The effect of hepatic impairment on the pharmacokinetics of intravenously administered felcisetrag (TAK-954). Journal of Clinical Pharmacology. – Vol. 62, No 8 (2022), s. 1006-1017. (IF =2.9; Q2)

Bulas, J, Páterková, M, Kupčová, V, Gašpar, Ľ, Wimmer, G, Murín, J:C entral systolic blood pressure

increases with aortic stiffness. – text. – DOI 10.4149/BLL_2019_150. – SCO ; WOS CC.

In: Bratislava medical journal [elektronický dokument] . – Bratislava (Slovensko) : Academic Electronic

Press. – ISSN 0006-9248. – ISSN (online) 1336-0345. – Roč. 120, č. 12 (2019), s. 894-898 [tlačená forma]

[online], IF 1,2, Q3, Citations (7)

Szántová, M, Skladaný, Ľ, Janičko, M, O. M, Dražilová, S, Belovičová, M, Zima, M, Kupčová, V, Adamcová

Selčanová, S, Koller, T, Rác, M, Jakabovičová, M, Hlavatá, T, Jursová, X, Ďurkovičová, Z, Szamosová, M,

Jarčuška, P, Mojto, V, Vorličková, M: Questionnaire for risk factors of alcoholic and nonalcoholic fatty

liver disease. – text. – [recenzované]. – DOI 10.4149/BLL_2022_079. – sign UPJS MSEP 034490.I n:

Bratislava medical journal [textový dokument (print)] [elektronický dokument] . – Bratislava (Slovensko) :

Academic Electronic Press. – ISSN 0006-9248. – ISSN (online) 1336-0345. – Roč. 123, č. 7 (2022), s. 496-

504 [tlačená forma] [online], IF 1,5, Q4

Kupčová, V, Turecký, L: Hereditárna hemochromatóza z pohľadu klinika - prehľad a vlastné

skúsenosti = Hereditary hemochromatosis at a insight of clinician - overview and own experiences. – text,

graf., tab. – [recenzované]. – SCO.

In: Lekársky obzor [textový dokument (print)] [elektronický dokument] . – Bratislava (Slovensko) : Herba,

Bratislava (Slovensko) : Slovenská zdravotnícka univerzita v Bratislave. – ISSN 0457-4214. – ISSN

(zrušené) 0322-9203. – Roč. 71, č. 11 (2022), s. 443-457 [tlačená forma] [online]

VI.4 - The most significant citations corresponding to the research/artistic/other outputs

Šebeková K, Kupčová V, Schinzel R, Heidland A: Markedly elevated levels of plasma advanced glycation end products in patients with liver cirrhosis – amelioration by liver transplantation.

Journal of Hepatology. - Vol. 36, No. 1 (2002), s. 66-71.

Cited in: Smit, A.J, Lutgers H. L.: Current Medicinal Chemistry, vol. 11, No. 20, 2004, s. 2767-2784. Citations (120)

Kupčová V, Turecký L, Uhlíková E. The role of oxidative stress in anti-tumor necrosis factor antibody treatment in Crohn´s disease. Current Medicinal Chemistry. - Vol. 19, No. 30 (2012), s. 5226-5231. Citations (6)

Cited in: Tratenšek, Armando - Locatelli, Igor - Grabnar, Iztok - Drobne, David - Vovk, Tomaž.

Oxidative stress-related biomarkers as promising indicators of inflammatory bowel disease activity:

A systematic review and meta-analysis [elektronický dokument]. DOI 10.1016/j.redox.2024.103380 In:

Redox Biology: An official Journal of the Society for Redox Biology and Medicine and the Society for Free

Radical Research-Europe. Amsterdam: Elsevier, 2024, Roč. 77, art. no. 103380 [online]. ISSN (online)

2213-2317. - SCO ; WOS CC ; SCIE, s. art. no. 103380

Kupčová V, Šperl J, Pannier A, Jordan P, Dougherty F. C, Reigner B. : The effect of severe hepatic impairment on the pharmacokinetics and haematological response of C.E.R.A. Current Medical Research and Opinion. - Vol. 24, No. 7 (2008), s. 1943-1950.

Cited in: El-Komy M.H, Widness J.A, Veng-Pedersen P.: Drug Metabolism and Disposition, Vol. 39, No. 4, 2011, s. 603-609. Citations (4)

Kupčová V, Fedelešová M, Bulas J, Kozmonová P, Turecký L: Overview of the pathogenesis, genetic, and non-invasive clinical, biochemical, and scoring methods in the assessment of NAFLD

International journal of environmental research and public health. - Roč. 16, č. 19 (2019), s. 1-25.

Cirted in: Pereira L.M.M, de Medeiros F.J.E.M, Baccin M.V.J, da Silva G, de Oliveira F.A. Jr,

de Almeida F.É.J.B, Silva A.S, da Costa-Silva J.H, de Brito A.J.L.: Plos One, Vol. 15, No. 8, 2020, art. No. e0237360. Citations (36)

Kupčová V, Arold G, Roepstorff C, Hojbjerre M, Klim S, Haahr H.: Insulin degludec: Pharmacokinetic properties in subjects with hepatic impairment. Clinical Drug Investigation. - Vol. 34, No. 2 (2014), s. 127-133.

Cited in: Ghosal S, Sinha B, Gangopadhyay K.K.: Diabetes and Metabolic Syndrome: Clinical Research and Reviews, Vol. 10, No 3, 2016, s. 161-165. Citations (35)

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

Principal investigator: Scientific grant agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic: VEGA MŠSR and SAS: Grant research task no. 1/0826/18: Liver steatofibrosis and metabolic syndrome in relation to cardiovascular disease. Project duration: 2018 – 2020

Co-investigator: Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic: VEGA MŠSR and SAS: Grant research task no. 1/0807/18: Central systolic pressure in optimization of hypertension treatment. Zodp. Principal investigator: Doc. MUDr. Jozef Bulas, CSc. Project duration from 2018 – 2020

Co-investigator: Grant of the Ministry of Health of the Slovak Republic: Ministry of Health of the Slovak Republic 2018_33-LFUK-7: The role of extracellular DNA in the pathogenesis of metabolic complications of obesity. Zodp. Principal investigator: Roman Gardlík, MD, PhD. Project duration from 2019-2020

Representative of the zodp. Principal investigator: Scientific grant agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic. VEGA MŠSR and SAS: Grant research task no. 1/0649/21: Elucidation of pathogenesis of chronic liver diseases by studying neutrophil extracellular traps and circulating DNA. Zodp. Principal investigator: MUDr. Roman Gardlík, PhD. Project duration from 2021 – 2023

Co-investigator: Research and Development Agency. APVV-21-0370: The role of extracellular DNA and neutrophil extracellular traps in the pathogenesis of chronic liver diseases. Zodp. Principal investigator: Roman Gardlík, MD, PhD. Project duration from 2022-2025

International bilateral project between LFUK Bratislava, SR and Horphag Res., Ltd, Geneva, Switzerland. The effect of French oak wood extract (Rshoeit^R ) on the liver regeneration process in non-alcoholic fatty liver disease. Zodp. researchers: Prof. RNDr. Jana Muchová, PhD, Prof. MUDr. Ladislav Turecký, CSc. – Institute of Chemistry, Biochemistry and Clinical Biochemistry, LFUK Bratislava, Prof. MUDr. Viera Kupčová, CSc. – III. Department of Internal Medicine LFUK and UNB Bratislava. Start of the project in 2024. Approved by the Ethics Committee of the FNsP academic Dérera, Limbová no. 5 on 27.6.2023. Decision No. 23/2023

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VII.a - Activity, position	VII.b - Name of the institution, board	VII.c - Duration
Member of the Examining Committee of State Final Examinations in Internal Medicine	Faculty of Medicine, Comenius University	1996 - present
'Member of the committee for the defense of diploma theses	Faculty of Medicine, Comenius University Bratislava	2018 – present
Member of the committee for the defense of dissertations	Faculty of Medicine, Comenius University Bratislava	1994 - present
Member of the Commission for the Defense of Habilitation Theses	Faculty of Medicine, Comenius University Bratislava	1994 - present
Member of the committee for the defense of dissertations	Pavol Jozef Šafárik University, Košice	2003 - present
'Member of the commission for defense of habilitation theses	Pavol Jozef Šafárik University, Košice	2003 - present
'Member of the Commission for Inaugural Proceedings	Pavol Jozef Šafárik University, Košice	2003 - present
Member of the audition committee for the post of associate professor and professor (appointed by the Rector of Pavol Jozef Šafárik University)	Pavol Jozef Šafárik University, Košice	2020 until now
Member of the Examining Committee for Attestations in Internal Medicine	Faculty of Medicine, Comenius University Bratislava	2019 - until now
Member of the examining committee for attestations in gastroenterology	Faculty of Medicine, Comenius University Bratislava	2019 - present

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution	VIII.b - Address of the institution	VIII.c - Duration (indicate the duration of stay)	VIII.d - Mobility scheme, employment contract, other (describe)
University Clinic Eppendorf	Hamburg	1994 (2 months)	Educational stay in the field of liver transplantation - contract within DAAD
University Clinic Eppendorf,	Hamburg	1997 (1 month)	Educational stay in the field of liver transplantation – contact person – Prof. Broelsch MD, Clinic of Transplant Surgery
University Hospital of Essen	Essen	1997 (1 month )	Educational stay in the field of liver transplantation – contact person Prof. Burdelski MD, Paediatric Clinic of Transplant Surgery
Faculty of Medicine - University of Naples	Naples	2001 (1 month)	contact person - teachers, Faculty of Medicine, University of Naples - Erasmus – teacher mobility within LFUK Bratislava

IX. - Other relevant facts

IX.a - If relevant, other activities related to higher education or research/artistic/other activities are mentioned

2001 - SLS Bronze medal

2003 - Honorable mention of SLS

2002 - Bronze medal of the Faculty of Medicine, Comenius University

2011 - SLS Silver Medal

2011 - Gold medal of the Faculty of Medicine, Comenius University in Bratislava

2019 - Commemorative gold medal to the 100th anniversary Anniversary of the Faculty of Medicine of Comenius University in Bratislava

2023 - Honorary membership of SHS

1985 - Award of the Slovak Hepatological Society for the most important publication in the field of hepatology

1988 - Award of the Slovak Hepatological Society for the most important work in the field of hepatology

2010 - Award of the Slovak Hepatological Society for the most important work in the field of hepatology

2005 - 2nd place Prize for work presented at an international event: Falk symposium No 146: Gut-Liver interactions. Basic and clinical concepts, Insbruck

2007 - Finished in 1st place Prize for work presented at the event with international participation: XXXI Czech and Slovak Gastroenterological and Hepatological Congress with international participation Brno

2019 - 3rd place Award for presented work at EASL event with international participation (10. Symposium on portal hypertension in B. Bystrica

Member of the Committee of the Slovak Hepatological Society from 1994 to 2022

Honorary member of the committee of the Slovak Hepatological Society from 2023 until now

Member of the Slovak Gastroenterological Society

Member of the Slovak Internist Society

Member of the Slovak Associationof Atherosclerosis

Member of the editorial board of the journal Trends in Hepatology

Member of the editorial board of the journal Current Clinical Practice

Date of last update

2024-04-27

Name and surname:	prof. MUDr. Viera Kupčová, CSc.
Document type:	Research/art/teacher profile of a person
The name of the university:	Comenius University Bratislava
The seat of the university:	Šafárikovo námestie 6, 818 06 Bratislava