I. - Basic information

I.1 - Surname

Kučerová

I.2 - Name

Lucia

I.3 - Degrees

MSc, DSc

I.4 - Year of birth

1973

I.5 - Name of the workplace

Translational Research Unit, 2nd Oncology Clinic, Medical Faculty, Comenius University

I.6 - Address of the workplace

Klenová 1, 833 10 Bratislava - Nové Mesto

I.7 - Position

research scientist

I.8 - E-mail address

lucia.kucerova@fmed.uniba.sk

I.10 - Name of the study field in which a person works at the university

experimental oncology, cellular biology

I.11 - ORCID iD

0000-0002-6407-6659

II. - Higher education and further qualification growth

II.1 - First degree of higher education

II.a - Name of the university or institution

Faculty of Natural Sciences, Comenius University

II.b - Year

1994

II.c - Study field and programme

Biochemistry

II.2 - Second degree of higher education

II.a - Name of the university or institution

Faculty of Natural Sciences, Comenius University

II.b - Year

1996

II.c - Study field and programme

Biochemistry

II.3 - Third degree of higher education

II.a - Name of the university or institution

Faculty of Medicine, Comenius University

II.b - Year

1999

II.c - Study field and programme

Oncology

II.4 - Associate professor

II.5 - Professor

II.6 - Doctor of Science (DrSc.)

II.a - Name of the university or institution

Scientific Board, Slovak Academy of Sciences

II.b - Year

2018

II.c - Study field and programme

Biological Sciences

III. - Current and previous employment

III.a - Occupation-position	III.b - Institution	III.c - Duration
Independent researcher	Cancer Research Institute SAS	1999-2015
Principal investigator - senior researcher	Cancer Research Institute, Biomedical Research Center SAS	2016-present
Research scientist	Translational Research Unit, 2nd Oncology Clinic, Medical Faculty, Comenius University	2022-present
Senior research manager	Glycostem BV, Oss, the Netherlands	2019-2023

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other	IV.b - Name of the institution	IV.c - Year
State exam English language C1, 12.1.1994	Faculty of Natural Sciences, Comenius University	1994

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes

V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year

V.2.a - Name of the study programme	V.2.b - Degree	V.2.c - Field of study
Oncology	III.	General Medicine

V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year

V.4 - Overview of supervised final theses

V.4.1 - Number of currently supervised theses

V.4.a - Bachelor's (first degree)

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.4.2 - Number of defended theses

V.4.a - Bachelor's (first degree)

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.5 - Overview of other courses taught in the current academic year according to study programmes

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations

VI.1.1 - Number of the research/artistic/other outputs

VI.1.a - Overall

196

VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases

VI.1.a - Overall

VI.1.b - Over the last six years

VI.1.3 - Number of citations corresponding to the research/artistic/other outputs

VI.1.a - Overall

2873

VI.1.b - Over the last six years

1256

VI.1.4 - Number of citations registered in the Web of Science or Scopus databases

VI.1.a - Overall

1395

VI.1.5 - Number of invited lectures at the international, national level

VI.1.a - Overall

VI.1.b - Over the last six years

VI.2 - The most significant research/artistic/other outputs

Adipose tissue-derived human mesenchymal stem cells mediated prodrug cancer gene therapy, Authors: Kucerova, Lucia; Altanerova, Veronika; Matuskova, Miroslava; ... Altaner, Cestmir; Published:Jul 2007 in Cancer Research, DOI: 10.1158/0008-5472.CAN-06-4024

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene. Mikula, M; Schreiber, M; Husak, Z, Kucerova, L; Ruth, J ; Wieser, R ; Zatloukal, K ; Beug, H ; Wagner, EF; Baccarini, M. )Published:Apr 2001 in The EMBO Journal, DOI: 10.1093/EMBOJ/20.8.1952

Tumor cell behaviour modulation by mesenchymal stromal cells. Kucerova, Lucia; Matuskova, Miroslava; Hlubinova, Kristina; ... Altaner, Cestmir; Published:May 2010 in Molecular Cancer, DOI: 10.1186/1476-4598-9-129

Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice. Kucerova, Lucia; Matuskova, Miroslava; Pastorakova, Andrea; ... Altaner, Cestmir; Published:Oct 2008 in Journal of Gene Medicine, DOI: 10.1002/JGM.1239

Altered features and increased chemosensitivity of human breast cancer cells mediated by adipose tissue-derived mesenchymal stromal cells. Kucerova, Lucia; Skolekova, Svetlana; Matuskova, Miroslava; ... Kozovska, Zuzana; Published: 2013 in BMC Cancer

VI.3 - The most significant research/artistic/other outputs over the last six years

Chemotherapy-triggered changes in stromal compartment drive tumor invasiveness and progression of breast cancer. Plava, Jana; Burikova, Monika; Cihova, Marina; ... Kucerova, Lucia, Miklikova, Svetlana; Published: Sep 2021 in Journal of Experimental & Clinical Cancer Research, DOI: 10.1186/S13046-021-02087-2

Genetic Engineering of Natural Killer Cells for Enhanced Antitumor Function, Mantesso, Simone; Geerts, Dirk; Spanholtz, Jan; Kucerova, Lucia, Published: Dec 2020 in Frontiers in Immunology, DOI: 10.3389/FIMMU.2020.607131

Permanent Pro-Tumorigenic Shift in Adipose Tissue-Derived Mesenchymal Stromal Cells Induced by Breast Malignancy. Plava, Jana; Cihova, Marina; Burikova, Monika; ... Kucerova, Lucia, Miklikova, Svetlana; Published: Feb 2020 in Cells, DOI: 10.3390/CELLS9020480

Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer. Plava, Jana; Cihova, Marina; Burikova, Monika; ... Kucerova, Lucia, Miklikova, Svetlana; Published: Mar 2019 in Molecular Cancer, DOI: 10.1186/S12943-019-0960-Z

SCHMIDTOVÁ, Silvia - UDVORKOVÁ, Natália - ČIERNA, Zuzana - HORAK, Samuel - KAĽAVSKÁ, Katarína - CHOVANEC, Michal - ROJIKOVÁ, Lucia - VULEVOVÁ, Miriam - KUČEROVÁ, Lucia* - MEGO, Michal*. Effect of the PARP inhibitor veliparib on germ cell tumor cell lines. In Oncology Letters, 2022, vol.24, no. 5, art. no. 392. (2021: 3.111 - IF, Q3 - JCR, 0.639 - SJR, Q3 - SJR). Typ: ADMA

VI.4 - The most significant citations corresponding to the research/artistic/other outputs

The work was cited more then 2873 times, Hirsch index H=26.Publication: Kucerova L et al., Tumor cell behaviour modulation by mesenchymal stromal cells. Mol Cancer. 2010 May 28;9:129. doi: 10.1186/1476-4598-9-129. Cited in: Di Franco S et al., Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery. Nat Commun. 2021 Aug 18;12(1):5006. doi: 10.1038/s41467-021-25333-9.

Publication: Kucerova L et al., Tumor cell behaviour modulation by mesenchymal stromal cells. Mol Cancer. 2010 May 28;9:129. doi: 10.1186/1476-4598-9-129. Cited in: Ridge SM et al., Mesenchymal stem cells: key players in cancer progression. Mol Cancer. 2017 Feb 1;16(1):31. doi: 10.1186/s12943-017-0597-8

Publication: Kucerova L et al., Adipose tissue-derived human mesenchymal stem cells mediated prodrug cancer gene therapy. Cancer Res. 2007 Jul 1;67(13):6304-13. doi: 10.1158/0008-5472. Cited in: Yin Z et al., Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy. Mol Cancer. 2018 Dec 28;17(1):178. doi: 10.1186/s12943-018-0926-6.

Publication: Kucerova L et al., Adipose tissue-derived human mesenchymal stem cells mediated prodrug cancer gene therapy. Cancer Res. 2007 Jul 1;67(13):6304-13. doi: 10.1158/0008-5472. Cited in: Srifa W et al., Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice. Nat Commun. 2020 May 18;11(1):2470. doi: 10.1038/s41467-020-16065-3

Publication: Kucerova & Skolekova, Tumor microenvironment and the role of mesenchymal stromal cells. Neoplasma. 2013;60(1):1-10. doi: 10.4149/neo_2013_001. Cited in: Daunys S et al., 3D Tumor Spheroid Models for In Vitro Therapeutic Screening of Nanoparticles. Adv Exp Med Biol. 2021;1295:243-270. doi: 10.1007/978-3-030-58174-9_11.

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

7th Joint Transnational Call for Proposals of the EuroNanomed Initiative in EuroNanoMed II Projekt INNOCENT, 2017-2020, Consortium coordinator/coinvestigator since 2018

APVV-16-0178 Mechanizmus tolerancie indukovanej mezenchýmovými stromálnymi bunkami voči protinádorovej liečbe a cielená terapeutická intervencia v nádorových bunkách karcinómu prsníka, (2016-2021) Principal investigator

APVV-16-0010 Identifikácia a validácia signálnych dráh asociovaných s cirkulujúcimi nádorovými bunkami pri karcinóme prsníka, (2016-21) Zodpovedný riešiteľ: prof. MUDr. Michal Mego, DrSc., Principal investigator CRI BMC SAS

APVV-15-0697 Úloha CA IX v adaptácii na nádorové mikroprostredie a v rezistencii na protinádorovú terapiu: molekulárne mechanizmy a klinické implikácie, (2015-2020) Co- investigator CRI BMC SAS

APVV-21-0158 Identification of new treatment options in refractory testicular germ cell tumors, (2021-2025) Co- investigator

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VII.a - Activity, position	VII.b - Name of the institution, board	VII.c - Duration
Member of the dosctoral study program, oncoolgy 7.1.15	Comenius University in Bratislava, Faculty of Medicine	2016-present
Member of the Board for the PhD theses defense	Comenius University in Bratislava, Faculty of Medicine	2016-present
Member VEGA, Meber of the Comission VEGA nr. 9 for medical and pharmaceutical sciences	Slovak Academy of Sciences	2014-2018
Scientific board member	Cancer Resrarch Institute SAS	2011-2015

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

IX. - Other relevant facts

Date of last update

2024-04-26

Name and surname:	Mgr. Lucia Kučerová, DrSc.
Document type:	Research/art/teacher profile of a person
The name of the university:	Comenius University Bratislava
The seat of the university:	Šafárikovo námestie 6, 818 06 Bratislava