I. - Basic information

I.1 - Surname

Imrich

I.2 - Name

Richard

I.3 - Degrees

doc. MUDr. DrSc.

I.4 - Year of birth

1974

I.5 - Name of the workplace

Institute of Physiology, Faculty of Medicine

I.6 - Address of the workplace

Sasinkova 4, Bratislava

I.7 - Position

university teacher - associated professor

I.8 - E-mail address

imrich6@uniba.sk

I.9 - Hyperlink to the entry of a person in the Register of university staff

https://www.portalvs.sk/regzam/detail/22248

I.10 - Name of the study field in which a person works at the university

Normal and pathological physiology

I.11 - ORCID iD

0000-0002-1747-7150

II. - Higher education and further qualification growth

II.1 - First degree of higher education

II.a - Name of the university or institution

Faculty of Medicine, Comenius University Bratislava

II.b - Year

1998

II.c - Study field and programme

General medicine

II.2 - Second degree of higher education

II.a - Name of the university or institution

Faculty of Medicine, Comenius University Bratislava

II.b - Year

2001

II.c - Study field and programme

General medicine

II.3 - Third degree of higher education

II.a - Name of the university or institution

Slovak Academy of Sciences

II.b - Year

2003

II.c - Study field and programme

Normal and pathological physiology

II.4 - Associate professor

II.a - Name of the university or institution

Faculty of Medicine, Comenius University Bratislava

II.b - Year

2017

II.c - Study field and programme

Normal and pathological physiology

II.5 - Professor

II.6 - Doctor of Science (DrSc.)

II.a - Name of the university or institution

Slovak Academy of Sciences

II.b - Year

2014

II.c - Study field and programme

Normal and pathological physiology

III. - Current and previous employment

III.a - Occupation-position	III.b - Institution	III.c - Duration
researcher	Institute of Experimental Endocrinology, now Biomedical Research Center	2001-continues
center coordinator, general director (2017-2022)	National Institute of Rheumatic Diseases	2012-2023
university teacher - associated professor	Faculty of Medicine, Comenius University Bratislava	2014-2017
university teacher - associated professor	Faculty of Medicine, Slovak Medical University Bratislava	2019-2023
university teacher - associated professor	Faculty of Medicine, Comenius University Bratislava	2023-continues

IV. - Development of pedagogical, professional, language, digital and other skills

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes

V.1.a - Name of the profile course	V.1.b - Study programme	V.1.c - Degree	V.1.d - Field of study
Physiology	General medicine	I.	General medicine
Physiology	Dentistry	I.	Dentistry

V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year

V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year

V.4 - Overview of supervised final theses

V.4.1 - Number of currently supervised theses

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.4.2 - Number of defended theses

V.5 - Overview of other courses taught in the current academic year according to study programmes

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations

VI.1.1 - Number of the research/artistic/other outputs

VI.1.a - Overall

126

VI.1.b - Over the last six years

VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases

VI.1.a - Overall

126

VI.1.b - Over the last six years

VI.1.3 - Number of citations corresponding to the research/artistic/other outputs

VI.1.a - Overall

2508

VI.1.b - Over the last six years

1095

VI.1.4 - Number of citations registered in the Web of Science or Scopus databases

VI.1.a - Overall

2508

VI.1.b - Over the last six years

1095

VI.1.5 - Number of invited lectures at the international, national level

VI.1.a - Overall

VI.1.b - Over the last six years

VI.2 - The most significant research/artistic/other outputs

Ranganath LR, Psarelli EE, Arnoux JB, Braconi D, Briggs M, Bröijersén A, Loftus N, Bygott H, Cox TF, Davison AS, Dillon JP, Fisher M, FitzGerald R, Genovese F, Glasova H, Hall AK, Hughes AT, Hughes JH, Imrich R, Jarvis JC, Khedr M, Laan D, Le Quan Sang KH, Luangrath E, Lukáčová O, Milan AM, Mistry A, Mlynáriková V, Norman BP, Olsson B, Rhodes NP, Rovenský J, Rudebeck M, Santucci A, Shweihdi E, Scott C, Sedláková J, Sireau N, Stančík R, Szamosi J, Taylor S, van Kan C, Vinjamuri S, Vrtíková E, Webb C, West E, Záňová E, Zatkova A, Gallagher JA.Efficacy and safety of once-daily nitisinone for patients with alkaptonuria (SONIA 2): an international, multicentre, open-label, randomised controlled trial. Lancet Diabetes Endocrinol. 2020 Sep;8(9):762-772.

Ranganath LR, Milan AM, Hughes AT, Davison AS, M K, Norman BP, Bou-Gharios G, Gallagher JA, Imrich R, Arnoux JB, Rudebeck M, Olsson B. Determinants of tyrosinaemia during nitisinone therapy in alkaptonuria. Sci Rep. 2022 Sep 27;12(1):16083

Imrich R, Sedláková J, Úlehlová M, Gornall M, Jackson R, Olsson B, Rudebeck M, Gallagher J, Lukáčová O, Mlynáriková V, Stančík R, Vrtíková E, Záňová E, Zaťková A, Arnoux JB, Rovenský J, Luangrath E, Bygott H, Khedr M, Ranganath LR.Radiological evolution of spinal disease in alkaptonuria and the effect of nitisinone. RMD Open. 2022 Oct;8(2):e002422.

Cant HEO, Chatzidaki I, Olsson B, Rudebeck M, Arnoux JB, Imrich R, Eddowes LA, Ranganath LR. Improving the clinical accuracy and flexibility of the Alkaptonuria severity score index. JIMD Rep. 2022 May 10;63(4):361-370.

Olsson B, Ranganath L, Arnoux JB, Imrich R, Milan A, Rudebeck M. Effects of a protein-restricted diet on body weight and serum tyrosine concentrations in patients with alkaptonuria. JIMD Rep. 2021 Nov 9;63(1):41-49.

VI.3 - The most significant research/artistic/other outputs over the last six years

VI.4 - The most significant citations corresponding to the research/artistic/other outputs

Kurdiova T, Balaz M, Vician M, Maderova D, Vlcek M, Valkovic L, Srbecky M, Imrich R, Kyselovicova O, Belan V, Jelok I, Wolfrum C, Klimes I, Krssak M, Zemkova E, Gasperikova D, Ukropec J, Ukropcova B.Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies. J Physiol. 2014 Mar 1;592(5):1091-107. 311 citácií

Radikova Z, Koska J, Huckova M, Ksinantova L, Imrich R, Vigas M, Trnovec T, Langer P, Sebokova E, Klimes I.Insulin sensitivity indices: a proposal of cut-off points for simple identification of insulin-resistant subjects. Exp Clin Endocrinol Diabetes. 2006 May;114(5):249-56. 131 citácií

Goldstein DS, Holmes C, Bentho O, Sato T, Moak J, Sharabi Y, Imrich R, Conant S, Eldadah BA. Biomarkers to detect central dopamine deficiency and distinguish Parkinson disease from multiple system atrophy. Parkinsonism Relat Disord. 2008 Dec;14(8):600-7. 137 citácií

Ranganath LR, Milan AM, Hughes AT, Dutton JJ, Fitzgerald R, Briggs MC, Bygott H, Psarelli EE, Cox TF, Gallagher JA, Jarvis JC, van Kan C, Hall AK, Laan D, Olsson B, Szamosi J, Rudebeck M, Kullenberg T, Cronlund A, Svensson L, Junestrand C, Ayoob H, Timmis OG, Sireau N, Le Quan Sang KH, Genovese F, Braconi D, Santucci A, Nemethova M, Zatkova A, McCaffrey J, Christensen P, Ross G, Imrich R, Rovensky J. Suitability Of Nitisinone In Alkaptonuria 1 (SONIA 1): an international, multicentre, randomised, open-label, no-treatment controlled, parallel-group, dose-response study to investigate the effect of once daily nitisinone on 24-h urinary homogentisic acid excretion in patients with alkaptonuria after 4 weeks of treatment. Ann Rheum Dis. 2016 Feb;75(2):362-7. 107 citácií

Bertok T, Klukova L, Sediva A, Kasák P, Semak V, Micusik M, Omastova M, Chovanová L, Vlček M, Imrich R, Vikartovska A, Tkac J.Ultrasensitive impedimetric lectin biosensors with efficient antifouling properties applied in glycoprofiling of human serum samples. Anal Chem. 2013 Aug 6;85(15):7324-32. 80 citácií

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

FP7-HEALTH-2013-INNOVATION-1 Clinical Development of Nitisinone for Alkaptonuria (DevelopAKUre) 2012-2019, EudraCT 2012-005340-24, EudraCT 2013-001633-41, koordinátor centra

APVV-15-0228 Sclerosis multiplex - Úloha mitochondriálnej dysfunkcie v inzulinovej rezistencii, Multiple sclerosis - The role of mitochondrial dysfunction in insulin resistance. ClinicalTrials.gov Identifier: NCT03052595, zodpovedný riešiteľ, 2015-2019

MZ-2018/37-LFUK-11 The use of GLP-1 analogs in the multiple sclerosis treatment (MSGLP) 2018-2021, ClinicalTrials.gov Identifier: NCT01444833, spoluriešiteľ

APVV-21-0261 Účinky GLP-1 analógu na sclerosis multiplex, Effects of GLP-1 Analog on Multiple Sclerosis (GAMS) 2022-2026

ERA4Health, Fostering a European Research Area for Health Research (HORIZON-HLTH-2022-DISEASE-03), INSTITUTO DE SALUD CARLOS III (ISCIII), Spain, 2022-2029, Role: Co-investigator

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution	VIII.b - Address of the institution	VIII.c - Duration (indicate the duration of stay)	VIII.d - Mobility scheme, employment contract, other (describe)
Free University of Brussels	Brusel, Belgicko	01/2004-05/2004	Grant EULAR
National Institutes of Health	Bethesda, MD, USA	01/2005-01/2008	NIH visiting fellow
National Institutes of Health	Bethesda, MD, USA	01/2008-01/2015	NIH Guest Researchers

IX. - Other relevant facts

Date of last update

2024-05-02

Name and surname:	doc. MUDr. Richard Imrich, DrSc.
Document type:	Research/art/teacher profile of a person
The name of the university:	Comenius University Bratislava
The seat of the university:	Šafárikovo námestie 6, 818 06 Bratislava