Research/art/teacher profile of a person
Name and surname:
doc. Ing. Helena Gbelcová, PhD.
Document type:
Research/art/teacher profile of a person
The name of the university:
Comenius University Bratislava
The seat of the university:
Šafárikovo námestie 6, 818 06 Bratislava

I. - Basic information

I.1 - Surname
Gbelcová
I.2 - Name
Helena
I.3 - Degrees
Doc., Ing., Ph.D.
I.4 - Year of birth
1982
I.5 - Name of the workplace
Institute of Medical Biology, Genetics and Clinical Genetics, Facukty of Medicine, Comenius University in Bratislava
I.6 - Address of the workplace
Špitálska 24, 842 15 Bratislava 1
I.7 - Position
University Teacher - Associate Professor
I.8 - E-mail address
helena.gbelcova@fmed.uniba.sk
I.9 - Hyperlink to the entry of a person in the Register of university staff
www.portalvs.sk/regzam/detail/5829
I.10 - Name of the study field in which a person works at the university
General Medicine, Dental Medicine, Biomedical Physics
I.11 - ORCID iD
0000-0003-1644-109X

II. - Higher education and further qualification growth

II.1 - First degree of higher education
II.a - Name of the university or institution
Slovak University of Technology in Bratislava, Faculty of chemical and food technology
II.b - Year
2003
II.c - Study field and programme
Food and Biochemical technology
II.2 - Second degree of higher education
II.a - Name of the university or institution
Slovak University of Technology in Bratislava, Faculty of chemical and food technology
II.b - Year
2005
II.c - Study field and programme
Biochemistry and Biotechnology
II.3 - Third degree of higher education
II.a - Name of the university or institution
Univeristy of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology
II.b - Year
2009
II.c - Study field and programme
Microbiology
II.4 - Associate professor
II.a - Name of the university or institution
Palacký University Olomouc, Faculty of Science
II.b - Year
2019
II.c - Study field and programme
Molecular and Cell Biology
II.5 - Professor
II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position III.b - Institution III.c - Duration
Assocciate Professor Institute of Medical Biology, Genetics and Clinical Genetics, Comenius University in Bratislava from 2020
Assistant professor Institute of Medical Biology, Genetics and Clinical Genetics, Comenius University in Bratislava 2011-2013, 2015-2020
Assistant professor Faculty of Food and Biochemical Technology, Univeristy of Chemistry and Technology, Prague 2013-2015
Assistant professor Faculty of chemical and food technology, Slovak University of Technology in Bratislava 2009-2010

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other IV.b - Name of the institution IV.c - Year
Scientific Qualification Level IIa – Biology Slovak Academy of Sciences, Bratislava 2016
Multiplex PCR Course TATAA Biocenter AB, Göteborg, Sweden 2015
Intellectual Property Course, accredited by the Ministry of Education of the Slovak Republic Industrial property Office of the Slovak Republik, Banská Bystrica 2013

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes
V.1.a - Name of the profile course V.1.b - Study programme V.1.c - Degree V.1.d - Field of study
Biológia a humánna genetika 1 Všeobecné lekárstvo I.+II Všeobecné lekárstvo
Biológia a humánna genetika 2 Všeobecné lekárstvo I.+II Všeobecné lekárstvo
Biology and Human Genetics 1 General Medicine I.+II Všeobecné lekárstvo
Biology and Human Genetics 2 General Medicine I.+II Všeobecné lekárstvo
Biológia a humánna genetika 1 Zubné lekárstvo I.+II Všeobecné lekárstvo
Biológia a humánna genetika 2 Zubné lekárstvo I.+II Všeobecné lekárstvo
Biology and Human Genetics 1 Dentistry I.+II Všeobecné lekárstvo
Biology and Human Genetics 2 Dentistry I.+II Všeobecné lekárstvo
Medical biology Biomedical physics I. Physics
Molecular biology Biomedical physics I. Physics
V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year
V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year
V.4 - Overview of supervised final theses
V.4.1 - Number of currently supervised theses
V.4.a - Bachelor's (first degree)
0
V.4.b - Diploma (second degree)
1
V.4.c - Dissertation (third degree)
7
V.4.2 - Number of defended theses
V.4.a - Bachelor's (first degree)
0
V.4.b - Diploma (second degree)
15
V.4.c - Dissertation (third degree)
0
V.5 - Overview of other courses taught in the current academic year according to study programmes
V.5.a - Name of the course V.5.b - Study programme V.5.c - Degree V.5.d - Field of study
New Trends in Medical Biology and Clinical Genetics Medical Biology and Clinical Genetics III. General Medicine

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations
VI.1.1 - Number of the research/artistic/other outputs
VI.1.a - Overall
146
VI.1.b - Over the last six years
61
VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases
VI.1.a - Overall
44
VI.1.b - Over the last six years
19
VI.1.3 - Number of citations corresponding to the research/artistic/other outputs
VI.1.a - Overall
1211
VI.1.b - Over the last six years
905
VI.1.4 - Number of citations registered in the Web of Science or Scopus databases
VI.1.a - Overall
1206
VI.1.b - Over the last six years
900
VI.1.5 - Number of invited lectures at the international, national level
VI.1.a - Overall
1
VI.1.b - Over the last six years
0
VI.2 - The most significant research/artistic/other outputs
1

Darmostuk, Mariia - Rimpelová, Silvie - Gbelcová, Helena - Ruml, Tomáš: Current approaches in SELEX: An update to aptamer selection technology, Biotechnology Advances. -Vol. 33, No. 6 (2015), s. 1141-1161. -ISSN 0734-9750, IF (JCR) 2015=9,848, 501 citations.

2

Gbelcová, Helena -Leníček, Martin - Zelenka, Jaroslav - Knejzlík, Zdeněk - Dvořáková, Gabriela - Zadinová, Marie - Poučková, Pavla - Kudla, Michal - Balaž, Peter - Ruml,Tomáš - Vítek, Libor: Differences in antitumor effects of various statins on human pancreatic cancerInternational Journal of Cancer. -Vol. 122, No. 6 (2008), s. 1214-1221. -ISSN 0020-7136, IF (JCR) 2008=4,734, 97 citations.

3

Vítek, Libor - Gbelcová, Helena - Muchová, Lucie - Váňová, Kateřina - Zelenka, Jaroslav - Koníčková, Renata - Šuk, Jakub - Zadinová, Marie -Knezlík, Zdeněk - Ahmad, Shakil - Fujisawa, Takeshi - Ahmed, Asif - Ruml, Tomáš: Antiproliferative effects of carbon monoxide on pancreatic cancer, Digestive and Liver Disease. -Vol. 46, No. 4 (2014), s. 369-375. -ISSN 1590-8658, IF (JCR) 2014=2,963, 84 citations.

4

Kirakci, Kaplan - Kubát, Pavel - Kučeráková, Monika - Šícha, Václav - Gbelcová, Helena - Lovecká, Petra - Grznárová, Petra - Ruml, Tomáš - Lang, Kamil : Water-soluble octahedralmolybdenum cluster compounds Na-2[Mo6I8(N-3)(6)] and Na-2[Mo6I8(NCS)(6)]: Syntheses, luminescence, and in vitro studies, Inorganica Chimica Acta. - Vol. 441 (2016), s. 42-49. -ISSN 0020-1693, IF (JCR) 2016=2,002, 66 citations.

5

D ́ Acunto, Walter Cosimo - Gbelcová, Helena - Festa, Michela -Ruml, Tomáš : The complex understanding of Annexin A1 phosphorylation, Cellular Signalling. -Vol.26, No. 1 (2014), s. 173-178. ISSN 0898-6568, IF (JCR) 2014=4,315, 57 citations.

VI.3 - The most significant research/artistic/other outputs over the last six years
1

D'Acunto CW, Kaplánek R, Gbelcová H, Kejík Z, Bříza T, Vasina L, Havlík M, Ruml T, Král V. Metallomics for Alzheimer's disease treatment: Use of new generation of chelators combining metal-cation binding and transport properties. Eur J Med Chem. 2018, 25;150:140-155, 20 citaions.

2

Sersenová D, Machala Z, Repiská V, Gbelcová H. Selective Apoptotic Effect of Plasma Activated Liquids on Human Cancer Cell Lines. Molecules. 2021 Jul 13;26(14):4254, 17 citations.

3

Víglaš J, Dobiasová S, Viktorová J, Ruml T, Repiská V, Olejníková P, Gbelcová H. Peptaibol-Containing Extracts of Trichoderma atroviride and the Fight against Resistant Microorganisms and Cancer Cells. Molecules. 2021 Oct 4;26(19):6025, 9 citations.

4

Rimpelová S, Kolář M, Strnad H, Ruml T, Vítek L, Gbelcová H. Comparison of Transcriptomic Profiles of MiaPaCa-2 Pancreatic Cancer Cells Treated with Different Statins. Molecules. 2021 Jun 9;26(12):3528, 5 citations.

5

Aetiology of clefts / Gbelcová, Helena [Author, 100%], p. 22-27

Genetic of orofacial clefts / Gbelcová, Helena [Author, 50%] ; Repiská, Vanda [Author, 50%], p 28-44

In:Clefts (print)] / Bánsky, Roman [editor] ; Bernadič, Marián [Recenzent] ; Koller, Ján [Recenzent] ; Měšťák, Jan [Recenzent] ; Stanko, Peter [Recenzent] ; Delaire, Jean [Recenzent]. – 2. edition. – Bratislava (Slovensko) : SAP - Slovak Academic Press, 2023. – ISBN 978-80-8265-004-7


VI.4 - The most significant citations corresponding to the research/artistic/other outputs
1

Gbelcová, H., Leníček, M., Zelenka, J., Knejzlík, Z., Dvořáková, G., Zadinová, M., Poučková, P., Kudla, M., Balaž, P., Ruml, T., Vítek, L.: Differences in antitumor effects of various statins on human pancreatic cancer, In: International Journal of Cancer. - Vol. 122, No. 6 (2008), s. 1214-1221. - ISSN 0020-7136. IF (JCR) 2008=4,734.

Citácia: Jakobisiak, M., Golab, J.: Statins can modulate effectiveness of antitumor therapeutic modalities, 2010, Medicinal Research Reviews 30(1), pp. 102-135 (CiteScore 9,45).

2

Gbelcová, H., Rimpelová, S., Ruml, T., Fenclová, M., Kosek, V., Hajšlová, J., Strnad, H., Kolář, M., Vítek, L.: Variability in statin-induced changes in gene expression profiles of pancreatic cancer. In: Scientific Reports - Vol. 7 (2017), Art. No. 44219 [11 s.] [online]. - ISSN 2045-2322. IF (JCR) 2017=4,122.

Citácia: Mira, E., Carmona-Rodríguez, L., Pérez-Villamil, B. et al. SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α. Nature Communications, 2018, 9(1), 575 (CiteScore 12,30).

3

Darmostuk, M., Rimpelová, S., Gbelcová, H., Ruml, T.: Current approaches in SELEX: An update to aptamer selection technology. In: Biotechnology Advances. - Vol.33, No. 6 (2015), s. 1141-1161. - ISSN 0734-9750. IF (JCR) 2015=9,848.

Citácia: Spicer, C.D., Pashuck, E.T., Stevens, M.M. Achieving Controlled Biomolecule-Biomaterial Conjugation. Chemical Reviews. 2018, 118(16), pp. 7702-7743 (CiteScore 51,08).

4

Darmostuk, M., Rimpelová, S., Gbelcová, H., Ruml, T.: Current approaches in SELEX: An update to aptamer selection technology. In: Biotechnology Advances. - Vol.33, No. 6 (2015), s. 1141-1161. - ISSN 0734-9750. IF (JCR) 2015=9,848.

Citácia: Medlock, J., Das, A.A.K., Madden, L.A., Allsup, D.J., Paunov, V.N.: Cancer bioimprinting and cell shape recognition for diagnosis and targeted treatment. In:Chemical Society Reviews, vol. 46, no. 16, 2017, s. 5110-5127 (CiteScore 39,42).

5

Vítek, Libor - Gbelcová, Helena - Muchová, Lucie - Váňová, Kateřina - Zelenka, Jaroslav - Koníčková, Renata - Šuk, Jakub - Zadinová, Marie -Knezlík, Zdeněk - Ahmad,Shakil - Fujisawa, Takeshi - Ahmed, Asif - Ruml, Tomáš: Antiproliferative effects of carbon monoxide on pancreatic cancer, Digestive and Liver Disease. -Vol. 46, No. 4 (2014), s. 369-375. -ISSN 1590-8658, IF (JCR) 2014=2,963.

Citácia: Mira, E., Carmona-Rodríguez, L., Pérez-Villamil, B. et al. SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α. Nature Communications, 2018, 9(1), 575 (CiteScore 12,30).

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years
1

VEGA 1/0405/22 - Sensitization of prostate cancer cells by statins (2022 – 2025) - principal investigator.

Patients with prostate cancer used statins to treat hypercholesterolemia appear to respond better to chemotherapy. Therefore, the aim of the project is to study of the mechanisms of pleiotropic effects of statins on the processes of inhibition of cancer cell growth with the potential for their targeted use in the adjuvant treatment of prostate cancer.

2

APVV 22-0247 - Plasma-liquid interactions and the effects/applications of plasma activated water to in medicine and agriculture (2022-2027) -principal investigator for FM UC.

Continuation of the APVV-17-0382 project from the years 2018 - 2022, which currently unites more than eight working groups, while the task of our research group is to verify the non-irritating effects of activated plasma solutions on healthy skin cells.

3

Visegrad Fund 22010090 - Modulation of multidrug resistance and post-treatment regeneration stimulated by natural compounds (2020-2022), principal investigator for SR.

The aim of the project is to initiate and develop official international cooperation between the Faculty of Food and Biochemical Technology, the University of Chemical Technology in Prague, the Medical Faculty of Comenius University in Bratislava and the Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged. During internships of students and university teachers and researchers, we study the problems of bacterial multidrug resistance, tumours multidrug resistance and tissue regeneration, we also exchange methodological experiences and approaches to research.

4

MZSR 2018/40-LKUK-14 - SYNCYTÍN-1 as a new marker for pre-eclampsia (2018-2021), the second leading cause of death in pregnant women, principal investigator.

The treatment of pre-eclampsia is based on the prevention and the symptoms' management, therefore screening of risk patients and early diagnosis of the developing preeclampsia are essential for reduction of the risk of the negative effects on the mother and fetus. During preeclampsia, ERVW-1 expression and production of syncytin-1 (one of the main regulators of processes during the trophoblast formation and differentiation) are changed. The aim of the project is to characterize the genetic variability of ERVW-1 in order to find a link between genetic variants and changes in expression of this gene, or between the types and complications of preeclampsia in patients. Identifying such DNA variants would widen and refine the diagnostic possibilities of preeclampsia. In the international context, we have so far managed to point out the importance of a minimum number of samples from one placenta, as gene expression within the placenta varies significantly.

5

VEGA 1/0168/18 - The study of the preeclampsia etiology –the second most frequent cause of the pregnant women mortality (2018-2021), principal investigator.

The aim of the project is the characterization of etiology of preeclampsia with focus on genetic variability of syncytin gene (ERVW-1) with the intention of finding associations between genetic sequence variants, and the expression of this gene, or placental pathological processes during preeclampsia. The identification of such sequence variants or gene expression by wholegenome DNA microchip would expand and clarify the diagnostic possibilities of preeclampsia.

6

APVV-17-0382 -  Interaction of cold plasma with water, the effects of plasma activated water to biological, systems and

their uses in medicine and agriculture (2018 - 2022), investigator.

The main objective of project is to investigate the interaction of the electrical discharges generating cold plasma wih water (or aqueous solutions) where the so-called plasma activated water (PAW) is created. The PAW has multiple uses in biology and

medicine, food preservation and agriculture. During the project, the new and improve established in-situ methods of plasmawater interface diagnostics are tested, the generation, lifespan and storage of PAW are tested and its chemical composition is analyzed, depending on the different experimental parameters and storage conditions. The important part of project is examining the interaction of plasma with water and the effects of PAW on various biological systems (biomolecules, organic molecules, bacteria, yeast, human cancer and non-cancerous cells) for a deeper understanding of basic mechanisms. Based on the understanding of plasma-

water interaction mechanisms and interaction with selected biological systems, it is possible to use PAWs with different compositions for different biomedical, food and agricultural applications and we would like to optimize generation of a specific PAW for each type of use.

7

APVV-15-0217- The molecular mechanisms of the statins effect on inhibition, proliferation and differentiation of selected stem and tumour cells and their application in regenerative medicine (2016-2020), investigator.

During their clinical use of statins as the hypolipidemic, it was defined a number of positive side-effects, such as prevention of coronary heart disease, stroke prevention and anti-proliferative effect on a variety of experimental tumour models, as well as the fact, that statins can inhibit or promote the differentiation of cell. We pointed out possible mechanisms of the effect of statins on the inhibition of tumor cell proliferation and induction of stem cell differentiation, which we believe will contribute to a more precise regulation of controlled differentiation and to the elimination of possible transformation of stem cells into tumor cells.

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution VIII.b - Address of the institution VIII.c - Duration (indicate the duration of stay) VIII.d - Mobility scheme, employment contract, other (describe)
Univeristy of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology Technická 5, Dejvice, 166 28 Praha 6, Česko 28.8.2012 - 9.9.2012 scientific research stay
Univeristy of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology Technická 5, Dejvice, 166 28 Praha 6, Česko 16.7.2018 - 14.9.2018 scientific research stay
Univeristy of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology Technická 5, Dejvice, 166 28 Praha 6, Česko 9.1.2019 - 14.2.2019 scientific research stay
Univeristy of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology Technická 5, Dejvice, 166 28 Praha 6, Česko 9.1.2019 - 14.2.2019 scientific research stay
Univeristy of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology Technická 5, Dejvice, 166 28 Praha 6, Česko 2.1.2020 - 19.2.2020 scientific research stay
Univeristy of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology Technická 5, Dejvice, 166 28 Praha 6, Česko 20.7.2020 - 20.9.2020 scientific research stay

IX. - Other relevant facts

IX.a - If relevant, other activities related to higher education or research/artistic/other activities are mentioned

Participation in the leading of students within foreign cooperation - 2015 - Sarah Aliko, undergraduate student, The University of Edinburgh, UK, 2015 - Anita Parricchi, PhD student, Università degli Studi di Genova, Italy. The cooperating with universities in the Czech Republic has been realized since the time of my doctoral studies (UCT Prague, UP Olomouc). Under the Visegrad Fund, cooperating with the Faculty of

Medicine of the University of Szeged in Hungary has been started in 2020.

Date of last update
2024-04-20