I. - Basic information

I.1 - Surname

Čeháková

I.2 - Name

Michaela

I.3 - Degrees

RNDr., PhD.

I.4 - Year of birth

1988

I.5 - Name of the workplace

Institute of Medical Biology, Genetics, and Clinical Genetics, Faculty of Medicine, Comenius University

I.6 - Address of the workplace

Sasinkova 4, 811 08 Bratislava

I.7 - Position

assistant lecturer, research scientist

I.8 - E-mail address

michaela.debreova@fmed.uniba.sk

I.9 - Hyperlink to the entry of a person in the Register of university staff

https://ais2.uniba.sk/ais/servlets/WebUIServlet?appClassName=ais.gui.lz.LZ020App&kodAplikacie=LZ020&uiLang=SK&viewer=web

I.10 - Name of the study field in which a person works at the university

biology

I.11 - ORCID iD

0000-0001-9530-6499

II. - Higher education and further qualification growth

II.1 - First degree of higher education

II.a - Name of the university or institution

Faculty of Natural Sciences, Comenius University

II.b - Year

2007-2010

II.c - Study field and programme

biology

II.2 - Second degree of higher education

II.a - Name of the university or institution

Faculty of Natural Sciences, Comenius University

II.b - Year

2010-2012

II.c - Study field and programme

biology, genetics

II.3 - Third degree of higher education

II.a - Name of the university or institution

Faculty of Medicine, Comenius University

II.b - Year

2012-2016

II.c - Study field and programme

oncology

II.4 - Associate professor

II.5 - Professor

II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position	III.b - Institution	III.c - Duration
assistant lecturer, research scientist	Institute of Medical Biology, Genetics, and Clinical Genetics, Faculty of Medicine, Comenius University	1.7.2023-30.6.2024, 1.3.2022-30.6.2025
Research Scientist	National Institute of Rheumatic Diseases, Nábrežie I. Krasku č. 4, 921 12 Piešťany	07/2020-05/2023
Project Management Analyst	IQVIA RDS Slovakia, Vajnorská 100/B, 831 04 Bratislava	08/2019-06/2020
Laboratory Diagnostician	Medirex, a.s., Galvaniho 17/C, 820 16 Bratislava	04/2018-07/2019
PostDoctoral Research Scientist	Institute of Virology, Biomedical Research Centre, SAS, Dúbravská cesta 9, 845 05 Bratislava	06/2016-04/2018

IV. - Development of pedagogical, professional, language, digital and other skills

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes

V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year

V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year

V.4 - Overview of supervised final theses

V.4.1 - Number of currently supervised theses

V.4.2 - Number of defended theses

V.5 - Overview of other courses taught in the current academic year according to study programmes

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations

VI.1.1 - Number of the research/artistic/other outputs

VI.1.a - Overall

VI.1.b - Over the last six years

VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases

VI.1.a - Overall

VI.1.b - Over the last six years

VI.1.3 - Number of citations corresponding to the research/artistic/other outputs

VI.1.4 - Number of citations registered in the Web of Science or Scopus databases

VI.1.a - Overall

231

VI.1.b - Over the last six years

184

VI.1.5 - Number of invited lectures at the international, national level

VI.2 - The most significant research/artistic/other outputs

Cehakova M, Ivanisova D, Strecanska M, Plava J, Varchulova Novakova Z, Nicodemou A, Harsanyi S, Culenova M, Bernatova S, Danisovic L. Rheumatoid Synovial Fluid and Acidic Extracellular pH Modulate the Immunomodulatory Activity of Urine-Derived Stem Cells. Int J Mol Sci. 2023 Nov 1;24(21):15856. doi: 10.3390/ijms242115856. PMID: 37958839; PMCID: PMC10648750.

Nicodemou A, Bernátová S, Čeháková M, Danišovič Ľ. Emerging Roles of Mesenchymal Stem/Stromal-Cell-Derived Extracellular Vesicles in Cancer Therapy. Pharmaceutics. 2023 May 10;15(5):1453. doi: 10.3390/pharmaceutics15051453. PMID: 37242693; PMCID: PMC10221697.

Strecanska M, Danisovic L, Ziaran S, Cehakova M. The Role of Extracellular Matrix and Hydrogels in Mesenchymal Stem Cell Chondrogenesis and Cartilage Regeneration. Life (Basel). 2022 Dec 9;12(12):2066. doi: 10.3390/life12122066. PMID: 36556431; PMCID: PMC9784885.

Csöbönyeiová M, Beerová N, Klein M, Debreová-Čeháková M, Danišovič Ľ. Cell-Based and Selected Cell-Free Therapies for Myocardial Infarction: How Do They Compare to the Current Treatment Options? Int J Mol Sci. 2022 Sep 7;23(18):10314. doi: 10.3390/ijms231810314. PMID: 36142245; PMCID: PMC9499607.

Debreova M, Culenova M, Smolinska V, Nicodemou A, Csobonyeiova M, Danisovic L. Rheumatoid arthritis: From synovium biology to cell-based therapy. Cytotherapy. 2022 Apr;24(4):365-375. doi: 10.1016/j.jcyt.2021.10.003. Epub 2022 Jan 26. PMID: 35090806.

Culenova M, Nicodemou A, Novakova ZV, Debreova M, Smolinská V, Bernatova S, Ivanisova D, Novotna O, Vasicek J, Varga I, Ziaran S, Danisovic L. Isolation, Culture and Comprehensive Characterization of Biological Properties of Human Urine-Derived Stem Cells. Int J Mol Sci. 2021 Nov 19;22(22):12503. doi: 10.3390/ijms222212503. PMID: 34830384; PMCID: PMC8624597.

VI.3 - The most significant research/artistic/other outputs over the last six years

VI.4 - The most significant citations corresponding to the research/artistic/other outputs

Sun H, Guo Y, Wang H, Yin A, Hu J, Yuan T, Zhou S, Xu W, Wei P, Yin S, Liu P, Guo X, Tang Y, Yan Y, Luo Z, Wang M, Liang Q, Wu P, Zhang A, Zhou Z, Chen Y, Li Y, Li J, Shan J, Zhou W. Gut commensal Parabacteroides distasonis alleviates inflammatory arthritis. Gut. 2023 Sep;72(9):1664-1677. doi: 10.1136/gutjnl-2022-327756. Epub 2023 Jan 5. PMID: 36604114.

Chang TH, Wu CS, Chiou SH, Chang CH, Liao HJ. Adipose-Derived Stem Cell Exosomes as a Novel Anti-Inflammatory Agent and the Current Therapeutic Targets for Rheumatoid Arthritis. Biomedicines. 2022 Jul 18;10(7):1725. doi: 10.3390/biomedicines10071725. PMID: 35885030; PMCID: PMC9312519.

Liu P, Mao Y, Xie Y, Wei J, Yao J. Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential. Stem Cell Res Ther. 2022 Jul 26;13(1):356. doi: 10.1186/s13287-022-03041-5. PMID: 35883127; PMCID: PMC9327386.

Huang RL, Li Q, Ma JX, Atala A, Zhang Y. Body fluid-derived stem cells - an untapped stem cell source in genitourinary regeneration. Nat Rev Urol. 2023 Dec;20(12):739-761. doi: 10.1038/s41585-023-00787-2. Epub 2023 Jul 6. PMID: 37414959.

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

2023 – 2026 Principal investigator VEGA (1/0281/23): The effect of various environmental stress factors on improvement of the biological potential of mesenchymal stromal cells for application in autologous therapy and tissue engineering

The mesenchymal stromal cells (MSC) application shows promising results, therefore intensive research is currently underway generating outputs for cell therapies and tissue engineering. Even if MSC have low immunogenicity autologous cells are still preferred in clinical practice. The MSC biological properties are compromised with advanced age as well as disease status of the donor. Aged individuals often with advanced disease stages are target population for cell-based therapies/regeneration of damaged tissues. It is therefore essential to develop effective strategies to stimulate the impaired biological potential of autologous MSC. Thus, the presented project focuses on the comprehensive characterization of various approaches of external MSC stimulation (hypoxia, heat shock, etc.) leading to an increase in their biological activity for application in cell-based therapy. It also analyzes the behavior of stimulated MSC after seeding on scaffold (in vitro and in vivo) for potential use in tissue engineering.

2020 – 2023 Co-investigator: Biobank for cancer and rare diseases (ITMS2014+: 313011AFG5)

The project is entirely oriented towards building a modern, efficient and systematic method of biobanking in Slovakia, which represents one of the basic pillars of excellent biomedical research.

Due to the fact that this is a project with strategic importance in the field of biomedicine, academic workplaces, research centers and parks and health institutions that have biomedicine in their programs were integrated into the project, and it is assumed that the highest quality scientific and research capacities with sufficient infrastructural security. In all its specific objectives, the project supports the integration, optimization and further development of research infrastructure, including international scientific and technical cooperation, which is a key element in the implementation of individual project activities.

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

IX. - Other relevant facts

Date of last update

2024-04-30

Name and surname:	RNDr. Michaela Čeháková, PhD.
Document type:	Research/art/teacher profile of a person
The name of the university:	Comenius University Bratislava
The seat of the university:	Šafárikovo námestie 6, 818 06 Bratislava