Research/art/teacher profile of a person
Name and surname:
doc. Ing. Mária Chomová, PhD.
Document type:
Research/art/teacher profile of a person
The name of the university:
Comenius University Bratislava
The seat of the university:
Šafárikovo námestie 6, 818 06 Bratislava

I. - Basic information

I.1 - Surname
Chomova
I.2 - Name
Maria
I.3 - Degrees
assoc.prof., Ing., PhD.
I.4 - Year of birth
1965
I.5 - Name of the workplace
Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry
I.6 - Address of the workplace
Sasinkova 2, 811 08 Bratislava
I.7 - Position
associate professor
I.8 - E-mail address
maria.chomova@fmed.uniba.sk
I.9 - Hyperlink to the entry of a person in the Register of university staff
https://www.portalvs.sk/regzam/detail/5784
I.10 - Name of the study field in which a person works at the university
General Medicine
I.11 - ORCID iD
0000-0002-8045-869X

II. - Higher education and further qualification growth

II.1 - First degree of higher education
II.2 - Second degree of higher education
II.a - Name of the university or institution
Slovak University of Technology -Faculty of Chemical and Food Technology in Bratislava
II.b - Year
1987
II.c - Study field and programme
Technology of production and processing polymers
II.3 - Third degree of higher education
II.a - Name of the university or institution
Jessenius Faculty of Medicine Comenius University in Martin
II.b - Year
2010
II.c - Study field and programme
Medical, Clinical and Pharmaceutical Biochemistry
II.4 - Associate professor
II.a - Name of the university or institution
Jessenius Faculty of Medicine Comenius University in Martin
II.b - Year
2020
II.c - Study field and programme
Medical, Clinical and Pharmaceutical Biochemistry
II.5 - Professor
II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position III.b - Institution III.c - Duration
associate professor Faculty of Medicine, Bratislava 2021 - until now
University Teacher Faculty of Medicine Comenius University in Bratislava 2010-2020
Specialist AescuLab - laboratory of Clinical Biochemistry, Prague, Czech Republic 2005-2005
Specialist University Hospital in Martin 1995 - 2004
Specialist Veterinary and Food Institute in Dolny Kubin 1989 - 1995
Office Clerk District National Committee in Dolny Kubin 1987 - 1988

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other IV.b - Name of the institution IV.c - Year
Specialised study and exam - Laboratory Methods in Clinical Biochemistry Slovak Postgradual Academy of Medicine in Bratislava 2000

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes
V.1.a - Name of the profile course V.1.b - Study programme V.1.c - Degree V.1.d - Field of study
Medical Chemistry General Medicine I. +II. General Medicine
Medical Chemistry Dentistry I.+II. Denistry
Medical Biochemistry General Medicine I.+II. General Medicine
Medical Biochemistry Dentistry I.+II. Dentistry
V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year
V.2.a - Name of the study programme V.2.b - Degree V.2.c - Field of study
Basic Principles of Biochemistry for Biophysics I. Physic, Faculty of Mathematics, Physics and Informatics Comenius University in Bratislava
V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year
V.4 - Overview of supervised final theses
V.4.1 - Number of currently supervised theses
V.4.c - Dissertation (third degree)
2
V.4.2 - Number of defended theses
V.4.a - Bachelor's (first degree)
1
V.4.b - Diploma (second degree)
5
V.5 - Overview of other courses taught in the current academic year according to study programmes
V.5.a - Name of the course V.5.b - Study programme V.5.c - Degree V.5.d - Field of study
Basic Principles of Chemistry in living systems for Biophysics Biomedicínska fyzika/všeobecné lekárstvo, Fakulta matematiky, fyziky a informatiky Univerzity Komenského/Biophysics/General Medicine, Faculty of Mathematics, Physics and Informatics Comenius University in Bratislava I. Biophysics/General Medicine, Faculty of Mathematics, Physics and Informatics Comenius University in Bratislava
Basic Principles of Biochemistry for Biophysics, Faculty of Mathematics, Physics and Informatics Comenius University in Bratislava Biophysics I. Physic, General Medicine, Faculty of Mathematics, Physics and Informatics Comenius University in Bratislava
New Trends in Clinical Biochemistry Accredited Study Programmes in Ph.D. Study, General Medicine I. General Medicine and Dentistry

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations
VI.1.1 - Number of the research/artistic/other outputs
VI.1.a - Overall
99
VI.1.b - Over the last six years
36
VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases
VI.1.a - Overall
24
VI.1.b - Over the last six years
11
VI.1.3 - Number of citations corresponding to the research/artistic/other outputs
VI.1.a - Overall
365
VI.1.b - Over the last six years
187
VI.1.4 - Number of citations registered in the Web of Science or Scopus databases
VI.1.a - Overall
365
VI.1.b - Over the last six years
187
VI.1.5 - Number of invited lectures at the international, national level
VI.1.a - Overall
2
VI.1.b - Over the last six years
1
VI.2 - The most significant research/artistic/other outputs
1

https://app.crepc.sk/?fn=detailBiblioForm&sid=8D0EECA6BDE4F42E79FC869F4E

The authors of the publication document the impact of ischemia-reperfusion injury on calcium uptake and mitochondrial function in the central nervous system. The observed significant reduction in the capacity of mitochondria to accumulate calcium, despite an unchanged rate of calcium uptake, as well as the inhibited enzymatic activities of respiratory complexes I and IV during ischemia and reperfusion, create favorable conditions for the progression of degenerative processes and ischemic neuronal damage.

2

https://app.crepc.sk/?fn=detailBiblioForm&sid=CF36523E57698E50E20ADC7133

The authors emphasize that reoxygenation following ischemia-reperfusion (IR) injury can exacerbate brain damage due to the neurotoxic effects of changes in membrane phospholipids and the accumulation of lipid oxidation products. Plasma and mitochondrial membranes are key mediators of stress signals induced by IR. Understanding these processes may lead to the development of new therapeutic agents that stabilize neuronal membranes and support cell survival.

3

https://app.crepc.sk/?fn=detailBiblioForm&sid=986F61172A08876C59D951F0D0

Research indicates that diabetes can cause mitochondrial dysfunction in the brain, leading to neurological complications such as stroke and Alzheimer's disease. Administration of fish oil can partially mitigate these negative effects, suggesting potential for new therapeutic approaches and dietary supplements for diabetics. However, further research is needed to fully understand the effects of fish oil on brain function in diabetics.

4

https://app.crepc.sk/?fn=detailBiblioForm&sid=49DF912496E3F1EA379EA24E6B

The author provides a comprehensive overview of the latest insights into molecular events in the brains of diabetics. The focus is on glucose and insulin uptake in the brain, the action of insulin in the brain, and the role of the brain in regulating glucose homeostasis. The publication also discusses the potential contribution of mitochondria to diabetes-induced brain damage, which is crucial for understanding energy metabolism and proper brain function.

5

https://app.crepc.sk/?fn=detailBiblioForm&sid=0446DCEE7C6F4765D6B5BAEEE0

The authors investigated the relationship between type 2 diabetes mellitus (T2DM) and the properties of Na,K-ATPase in the kidneys of obese ZDF rats. It was found that Na,K-ATPase activity in the renal cortex is higher in ZDF rats regardless of the severity of diabetes, which may be due to increased glucose load. Increased lipid peroxidation did not affect Na,K-ATPase activity. This research helps to better understand how diabetes affects kidney function, which may contribute to the development of new treatment methods to protect the kidneys in patients with T2DM.

VI.3 - The most significant research/artistic/other outputs over the last six years
1

V3: Radosinska D, Gaal Kovalcikova A, Gardlik R, Chomova M, Snurikova D, Radosinska J, Vrbjar N. Oxidative Stress Markers and Na,K-ATPase Enzyme Kinetics Are Altered in the Cerebellum of Zucker Diabetic Fatty fa/fa Rats: A Comparison with Lean fa/+ and Wistar Rats. Biology (Basel). 2024, Indikátor časopisu:Q1, IF=3,6

2

V3: Vrbjar N, Jasenovec T, Kollarova M, Snurikova D, Chomova M, Radosinska D, Shawkatova I, Tothova L, Radosinska J. Na,K-ATPase Kinetics and Oxidative Stress in Kidneys of Zucker Diabetic Fatty (fa/fa) Rats Depending on the Diabetes Severity-Comparison with Lean (fa/+) and Wistar Rats. Biology (Basel). 2022. Indikátor časopisu: Q1, IF =4,2

3

V3: Chomova M. Toward the Decipherment of Molecular Interactions in the Diabetic Brain. Biomedicines. 2022. Indikátor časopisu: JCI - Biochemistry & molecular biology - Q2 , IF= 4,7

4

V3: Kollárová, M. - Chomová, M. - Radošinská, D - Tóthová, Ľ - Shawkatová, I - Radošinská, J: ZDF (fa/fa) rats show increasing heterogeneity in main parameters during ageing, as confirmed by biometrics, oxidative stress markers and MMP activity. In: Experimental Physiology Roč. 107, č. 11, s. 1326-1338, 2022 . Indikátor časopisu: JCI - Physiology - Q2, IF=2,7

5

ADC: Kľačanová K, Kovaľská M, Chomová M, Pilchová I, Tatarková Z, Kaplan P, Racay P: Global brain ischemia in rats is associated with mitochondrial release and downregulation of Mfn2 in the cerebral cortex, but not the hippocampus. In: International Journal of Molecular Medicine. - Roč. 43, č. 6, s. 2420-2428. 2019. Indikátor časopisu: IF (JCR) 2019=3,098.

VI.4 - The most significant citations corresponding to the research/artistic/other outputs
1

https://app.crepc.sk/?fn=detailBiblioForm&sid=8D0EECA6BDE4F42E79FC869F4E

[o1] 2010 Ten, V.S.-Yao, J. - Ratner, V.- Sosunov, et al.,In: Journal of Neuroscience. – Roč. 30, č. 6 (2010), WOS, SCOPUS

[o1] 2010 Nilakantan, V. - Liang, H. L. - Rajesh, S. et al., In: Free Radical Research. – Roč. 44, č. 7 (2010), WOS, SCOPUS

[o1] 2012 Hütterman, M. - Helling, S- Sanderson, T. H. et al., In: Biochimica et Biophysica Acta - Bioenergetics – Roč. 1817, č. 4, WOS, SCOPUS

[o1] 2013 Wang, R. - Tu, J- Zhang, Q. et al., In: Hippocampus – Roč. 23, č. 7 , WOS, SCOPUS

[o1] 2018 Burstein, S. R. - Kim, H. J- Fels, J. A. et al., In: Biochimica et Biophysica Acta - Bioenergetics – Roč. 1859, č. 6, WOS, SCOPUS

2

https://app.crepc.sk/?fn=detailBiblioForm&sid=CF36523E57698E50E20ADC7133

[o1] 2019 Wen, L. - Liu, L. - Li, J.F. et al., In: Brain research bulletin– Roč. 146, WOS, SCOPUS

[o1] 2021 Zhang, G. - Wang, Q. - Su, D. - Xie, Y. In: Frontiers in neurology– Roč. 11, WOS, SCOPUS

[o1] 2023 Guo, Q. - Du, A. - Wang, J. - Wang, L. et al., In: Frontiers in Bioscience - Landmark– Roč. 28, č. 8, WOS, SCOPUS

[o1] 2023 Liu, X.-Y., Li, Q.-S., Yang, W.-H., ... Yuan, Q.-W., Sui, R.-B. In: In Vitro Cellular and Developmental Biology - Animal - Roč. 59, č.3, SCOPUS, WOS

[o1] 2024 Wei, J. - Zhang, M.-Wang, X. et al., In: European Journal of Pharmacology - Roč. 979, č. 176853 -SCOPUS, WOS

3

https://app.crepc.sk/?fn=detailBiblioForm&sid=986F61172A08876C59D951F0D0

[o1] 2020 Lopez-Malo, D. - Arnal, E. - Miranda, M. et al., In: Diabetes: Oxidative Stress and Dietary Antioxidants, pp. 161-168. – 1 vyd. Elsevier, WOS, SCOPUS

[o1] 2020 Zhang, T. - Zheng, H. - Fan, K. et al., In: Metabolic Brain Disease– Roč. 35, č. 7, WOS, SCOPUS

[o1] 2022 Jolivalt, C.G. - Aghanoori, M.R. - Navarro-Diaz, M.C. et al., In: Journal of Diabetes Research, 2022, WOS, SCOPUS

[o1] 2022 Yumi Noronha, N. - da Silva Rodrigues, G. - Harumi Yonehara Noma, I. et al., In: Frontiers in endocrinology – Roč. 13, WOS, SCOPUS

[o1] 2023 Bulut, F. - Adam, M. - Ozgen, A. et al., In: Behavioural Brain Research – Roč. 452, WOS, SCOPUS

4

https://app.crepc.sk/?fn=detailBiblioForm&sid=49DF912496E3F1EA379EA24E6B

[o1] 2022 Henn, R. E. - Noureldein, M.H. - Elzinga, S.E. et al., In: Neurobiology of Disease – Roč. 170, WOS, SCOPUS

[o1] 2023 Sanz, F.J - Martínez-Carrión, G - Solana-Manrique, C. et al In: Journal of Experimental Zoology Part A: Ecological and Integrative Physiology – Roč. 339, č. 8, s. 697-705, WOS, SCOPUS

[o1] 2024 Lanzillotta, Ch - Tramutola, A - Lanzillotta, S et al., In: Redox Biology – Roč. 73 art. no. 103221, WOS, SCOPUS

5

https://app.crepc.sk/?fn=detailBiblioForm&sid=0446DCEE7C6F4765D6B5BAEEE0

[o1] 2023 Chae, S.Y. - Kim, Y. - Park, Ch. W. In: Antioxidants– Roč. 12, č. 12 art. no. 2083 , WOS, SCOPUS

[o1] 2024 Hu, H. - Liang, W.- Ding, G. In: Trends in Endocrinology and Metabolism – Roč. 35, č. 2, s. 142-150, WOS, SCOPUS

[o1] 2025 Mou, L.-Fu, Z.-Wang, T.B. et al., In: Frontiers in Immunology -Roč. 16, č.1555310, SCOPUS

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years
1

Vega 1/0019/24 Obesity and Diabetes Mellitus as Risk Factors for Accelerated Brain Aging and Development of Diabetic Encephalopathies. Project Duration: 2024-2027. The aim of the project is to study the cellular mechanisms and signaling pathways leading to changes in neuronal proteostasis, dysfunction of the chaperone network, and the emergence of proteotoxic stress. Focusing on the mechanisms of protein quality control under conditions of obesity, diabetes mellitus (DM), and aging, combined with subcellular analysis in vivo on an animal rodent model of type 2 DM and ex vivo on neuronal cultures in various brain regions, will allow for a better understanding of the processes occurring in the aging and diabetic brain.

2

VEGA 1/0314/19 Contribution of Diabetes Mellitus to Brain Neurodegeneration. Principal Investigator. Project Duration: 2019-2022. The aim of the project is a multi-level analysis (in vivo, ex vivo) at the cellular and subcellular levels in sensitive brain structures, focused on understanding the molecular pathways occurring in the diabetic and aging brain.

3

EU Project from the Cross-border Cooperation Program SR-AT - Interreg, Nutriaging V-014; Nutrition and Healthy Aging. Co-investigator. Project Duration: 2016-2021. The aim of the project is to search for markers of "healthy aging" in experimental animal and cell models (Bratislava) and in a human study with seniors living in facilities for the elderly (Vienna). It evaluates the impact of lifestyle - dietary habits and physical activity - on the mental and physical condition of the seniors.

4

VEGA 1/0349/16 Molecular Mechanisms of Diabetes Mellitus-Induced Neurodegenerative Changes. Deputy Principal Investigator. Project Duration: 2016-2018. The project was aimed at identifying and analyzing biochemical changes in the cerebral diabetic cortex and hippocampus of rats in terms of mitochondrial function, oxidative stress, changes in the cellular proteome, signaling pathways, and activation of apoptosis.

5

VEGA 1/0109/16 The Effect of Gender on the Oxidative State of Patients with Atherogenic and Non-Atherogenic Dyslipoproteinemia. Co-investigator. Project Duration: 2016-2018. The project was aimed at determining the sex differences in the extent of endothelial damage in experimental groups of dyslipoproteinemia (hyperlipoproteinemia and normolipemia), the extent of oxidative damage to lipids, and the performance of the organism's antioxidant defense.

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

IX. - Other relevant facts

Date of last update
2025-04-10