Meno a priezvisko:
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Ing. Ján Strnádel, PhD.
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Typ dokumentu:
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Vedecko/umelecko-pedagogická charakteristika osoby
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Názov vysokej školy:
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Univerzita Komenského v Bratislave
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Sídlo vysokej školy:
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Šafárikovo námestie 6, 818 06 Bratislava
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III.a - Zamestnanie-pracovné zaradenie | III.b - Inštitúcia | III.c - Časové vymedzenie |
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vedúci vedecký pracovník | Univerzita Komenského v Bratislave, Jesseniova lekárska fakulta | 2016-doteraz |
Vedecký pracovník | Department of Anesthesiology, University of California San Diego, Gilman Dr. 9500, 92093 La Jollla, United States of America | 2014-2015 |
postdok | Department of Anesthesiology, University of California San Diego, Gilman Dr. 9500, 92093 La Jollla, United States of America | 2011-2014 |
Postgraduálny študent a postdoc | Department of Anesthesiology, University of California San Diego, Gilman Dr. 9500, 92093 La Jollla, United States of America | 2009-2011 |
Postgraduálny študent a postdoc | Laboratoř biologie nádoru, Ústav živočišné fyziologie a genetiky AV ČR, Liběchov, Česká republika | 2004-2008 |
IV.a - Popis aktivity, názov kurzu (ak išlo o kurz), iné | IV.b - Názov inštitúcie | IV.c - Rok |
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Kurz operátora prietokového cytometra | BD Biosciences, San Jose, California, USA | 2009 |
V.1.a - Názov profilového predmetu | V.1.b - Študijný program | V.1.c - Stupeň | V.1.d - Študijný odbor |
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Lekárska biochémia | Všeobecné lekárstvo | I.+II. | Všeobecné lekárstvo |
Lekárska biochémia pre zubné lekárstvo | Zubné lekárdstvo | I.+II. | Zubné lekárstvo |
Seminár k diplomovej práci I, II a III | Všeobecné lekárstvo/General Medicine | I.+II. | Všeobecné lekárstvo |
Diplomová práca a obhajoba diplomovej práce | Všeobecné lekárstvoMedical Biochemistry | I.+II. | Všeobecné lekárstvo |
M.E.S.H - Európska patentová prihláška (2021) č. 19218710.2
M.E.S.H European Patent Application No. 19218710.2 (2021)
Strnadel J, Zahumenska R, Nosal V, Smolar M, Marcinek J, Kalman M, Juhas S, Juhasova J, Studenovska H, Dumortier H, et al. (2020). Generation of ORIONi001-A induced pluripotent stem cell line for in vitro modeling of sporadic form of amyotrophic lateral sclerosis. Stem. Cell Res. 4, 101981
Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park H.W, Bui J, Kelber J, Bouvet M, Guan K.L, Klemke R.L (2017). eIF5A-PEAK1 signaling regulates YAP1/TAZ protein expression and pancreatic cancer cell growth. Cancer Res 77, 1997–2007. (IF=9,122)
Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn A, Glud A.N, Marsala S, Kafka J, Miyanohara A, Kato T, Tadokoro T, Hefferan M.P, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho C.S, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd A.J, Driscoll S.P, Glenn T.D, Pfaff S.L, Klima J, Ciacci J, Curtis E, Gage F.H, Bui J, Yamada K, Muotri A.R, Marsala M. (2018). Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs. Sci Transl Med 10, 1-14. (IF=16,796)
Kertys M, Grendar M, Horak V, Zidekova N, Kupcova Skalnikova H, Mokry J, Halasova E, Strnadel J. (2021). Metabolomic characterisation of progression and spontaneous regression of melanoma in the melanoma-bearing Libechov minipig model. Melanoma research, 31(2), 140–151 (IF=2,750)
Strnadel J, Zahumenska R, Nosal V, Smolar M, Marcinek J, Kalman M, Juhas S, Juhasova J, Studenovska H, Dumortier H, et al. (2020). Generation of ORIONi001-A induced pluripotent stem cell line for in vitro modeling of sporadic form of amyotrophic lateral sclerosis. Stem. Cell Res. 4, 101981
M.E.S.H - Európska patentová prihláška (2021) č. 19218710.2
M.E.S.H European Patent Application No. 19218710.2 (2021)
Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park H.W, Bui J, Kelber J, Bouvet M, Guan K.L, Klemke R.L (2017). eIF5A-PEAK1 signaling regulates YAP1/TAZ protein expression and pancreatic cancer cell growth. Cancer Res 77, 1997–2007. (IF=9,122)
Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn A, Glud A.N, Marsala S, Kafka J, Miyanohara A, Kato T, Tadokoro T, Hefferan M.P, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho C.S, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd A.J, Driscoll S.P, Glenn T.D, Pfaff S.L, Klima J, Ciacci J, Curtis E, Gage F.H, Bui J, Yamada K, Muotri A.R, Marsala M. (2018). Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs. Sci Transl Med 10, 1-14. (IF=16)
Kertys M, Grendar M, Horak V, Zidekova N, Kupcova Skalnikova H, Mokry J, Halasova E, Strnadel J. (2021). Metabolomic characterisation of progression and spontaneous regression of melanoma in the melanoma-bearing Libechov minipig model. Melanoma research, 31(2), 140–151 (IF=2,750)
Článok/Article: Strnadel, J., Wang, H., Carromeu, C., Miyanohara, A., Fujimura, K., Blahovcova, E., Nosal, V., Skovierova, H., Klemke, R., & Halasova, E. (2018). Transplantation of Human-Induced Pluripotent Stem Cell-Derived Neural Precursors into Early-Stage Zebrafish Embryos. Journal of molecular neuroscience : MN, 65(3), 351–358. https://doi.org/10.1007/s12031-018-1109-z
Citované v/Cited by:
Patton, E. E., Zon, L. I., & Langenau, D. M. (2021). Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials. Nature reviews. Drug discovery, 20(8), 611–628. https://doi.org/10.1038/s41573-021-00210-8 (IF (2020) = 88)
Článok/Article:Fujimura, K., Wright, T., Strnadel, J., Kaushal, S., Metildi, C., Lowy, A. M., Bouvet, M., Kelber, J. A., & Klemke, R. L. (2014). A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer. Cancer research, 74(22), 6671–6681. https://doi.org/10.1158/0008-5472.CAN-14-1031
Citované v/Cited in:
Lopez, M. L., Lo, M., Kung, J. E., Dudkiewicz, M., Jang, G. M., Von Dollen, J., Johnson, J. R., Krogan, N. J., Pawłowski, K., & Jura, N. (2019). PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization. Proceedings of the National Academy of Sciences of the United States of America, 116(31), 15495–15504. https://doi.org/10.1073/pnas.1906360116 (IF (2020) =11,2)
Lee, W. B., Kang, J. S., Choi, W. Y., Zhang, Q., Kim, C. H., Choi, U. Y., Kim-Ha, J., & Kim, Y. J. (2016). Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution. Nature communications, 7, 11322. https://doi.org/10.1038/ncomms11322 (IF (2020) = 14,92)
Článok/Article: Strnadel, J., Choi, S., Fujimura, K., Wang, H., Zhang, W., Wyse, M., Wright, T., Gross, E., Peinado, C., Park, H. W., Bui, J., Kelber, J., Bouvet, M., Guan, K. L., & Klemke, R. L. (2017). eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer research, 77(8), 1997–2007. https://doi.org/10.1158/0008-5472.CAN-16-2594
Citované v/Cited by:
Su, H., Yang, F., Fu, R., Li, X., French, R., Mose, E., Pu, X., Trinh, B., Kumar, A., Liu, J., Antonucci, L., Todoric, J., Liu, Y., Hu, Y., Diaz-Meco, M. T., Moscat, J., Metallo, C. M., Lowy, A. M., Sun, B., & Karin, M. (2021). Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. Cancer cell, 39(5), 678–693.e11. https://doi.org/10.1016/j.ccell.2021.02.016 (IF (2020) = 31,74)
Projekt Biobanka (spoluriešiteľ)/Project Biobank (participant)Integrated Infrastructure Operational Program for the project: Systemic public research infrastructure – Biobank for cancer and rare diseases, ITMS: 313011AFG5, co-financed by the European Regional Development Fund.
Hlavný riešiteľ: Projekt APVV-17-0037, názov projektu: Vývoj nových in vitro modelov pre amyotrofickú laterálnu sklerózu a testovanie bezpečnosti neurálnych prekurzorov odvodených z ľudských indukovaných pluripotentných kmeňových buniek/The pricipal investigator of
Project APVV, No.:APVV-17-0037, name of the project: Development of novel in vitro models for amyotrophic lateral sclerosis and testing the safety of human induced pluripotent stem cell-derived neural precursors
Project No.: APVV-21-0372 Title: Development of XenoPig – a large, orthotopic xenograft animal model for modeling human pancreatic cancer, Agency: The Slovak Research and Development Agency Duration: (2021-2026)
Position: Principal Investigator
Projekt VEGA 1/0279/18, názov projektu: Využitie novovyvinutých 3D nádorových in vitro modelov pri testovaní aktivovaných nanočastíc inhibujúcich opravné mechanizmy DNA
The principal investigator of the Project VEGA 1/0279/18, project title: The use of de novo developed 3D cancer cell in vitro models in testing of activated nanoparticles, inhibiting DNA repair mechanism.
Projek č.APVV-21-0372 Názov:: Development of XenoPig – a large, orthotopic xenograft animal model for modeling human pancreatic cancer, Agentúra: The Slovak Research and Development Agency Duration: (2021-2026)
Pozícia: Hlavný riešiteľ
Project No.: APVV-21-0372 Title: Development of XenoPig – a large, orthotopic xenograft animal model for modeling human pancreatic cancer, Agency: The Slovak Research and Development Agency Duration: (2021-2026)
Position: Principal Investigator
VII.a - Aktivita, funkcia | VII.b - Názov inštitúcie, grémia | VII.c - Časové vymedzenia pôsobenia |
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Metodológia vedeckej práce/ Methodology of scientific work course | Univerzita Komenského v Bratislave, Jesseniova lekárska fakulta Comenius university in Bratislava, Jessenius faculty of Medicine in Martin | 2019-now |
Student'sscientific activities/Študentská vedecká a odborná činnosť | Univerzita Komenského v Bratislave, Jesseniova lekárska fakulta Comenius university in Bratislava, Jessenius faculty of Medicine in Martin | 2019-doteraz/ 2019-now |
VIII.a - Názov inštitúcie | VIII.b - Sídlo inštitúcie | VIII.c - Obdobie trvania pôsobenia/pobytu (uviesť dátum odkedy dokedy trval pobyt) | VIII.d - Mobilitná schéma, pracovný kontrakt, iné (popísať) |
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Kalifornská univerzita v San Diegu, CA, USA/ University of California, San Diego, CA, USA | 9500 Gilman Dr., La Jolla, CA 92093, Spojené štáty americké/ 9500 Gilman Dr., La Jolla, CA 92093, United States | 2009-2015 | pracovný kontrakt/work contract |
Zavedenie metódy 3D kultivácie a reprogramovania somatických buniek do indukovaných pluripotentných kmeňových buniek na Jesseniovej lekárskej fakulte v Martine/ Establishment of 3D culture technology and technology of somatic cell reprogramming into induced pluripotent stem cells at Jessenius Faculty of Medicine in Martin (www.biomedmartin.sk Laboratory of flow cytometry, cell phenotyping and engineering)