VEGA 213/12 Project brings a novel insight on the ethiology of CNS damage by neurotoxicant -homocystein

as well as on the mechanisms

of ichemicj tolerance and its interference with naturally present toxicant. The pathways of MAP kinases have

been described

in the endogenous processes of tolerance evolution by preconditioning. It has been found that homocysteine

neurotoxicity is

partially suppressed by ischemic toleranci. The results originally extent the knowledge on the effect of

hyperhomocysteinémia

to the phenomenon of ischemic tolerance and can be perspectively utilized in the praxis. The detailed

knowledge on this

phenomenon could have a clinical impact to the procedure linked with the short term ischemia or transient

ischemic atack.

VEGA 128/16: Project brings a novel insight on the ethiology of CNS damage by neurotoxicant -

homocystein as well as on the mechanisms of ichemicj tolerance and its interference with naturally present

toxicant. The pathways of MAP kinases have been described

in the endogenous processes of tolerance evolution by preconditioning. It has been found that homocysteine

neurotoxicity is

partially suppressed by ischemic toleranci. The results originally extent the knowledge on the effect of

hyperhomocysteinémia

to the phenomenon of ischemic tolerance and can be perspectively utilized in the praxis. The detailed

knowledge on this

phenomenon could have a clinical impact to the procedure linked with the short term ischemia or transient

ischemic atack

VEGA 230/20 Protective role of vitamin D in the development of EAE, animal model of SM, defined by

neurologic scores and changes in the proteomic profile and levels o f neurotrometabolites analyzed by

MRS. Lower levels of vitamin D in patients serum with SM.

Quocient of light chain of immunoglobulines ?-fLC in liquor and serum has a diagnostic characteristics with

high sensitivity,

suitable also for routine praxis. We found association of HLA-DRB1 and DQB1 allel and genotype

polymorphisms with the

onset of diseases and progression of disability( EDSS scores).Allele DRB1*07 is positive and DRB1*15/15 a

DQB1*03/*03

are clinically negative prognostic factors. Polymorphisms of genes for vitamín D associate with HLA

complex (rs703842 in

CYP27B1). We have optimalized process of dealbuminization for proteomic analysis of plasma a by

metabolomic and MRS

studies we have indentified level changes of metabolites of Krebs cycle , amino acids and changes in

glutamate

VEGA project 274/23 : Project includes experiments which describe complex effect of modifiable risk factors

- neurotoxic substances in

combination with cerebral ischemic-reperfusion damageon laboratory animals and impact of this

combination on

manifestation of functional, vascular changes and neurodegenerative processes. Study of molecular,

biochemical, spectroskopic and immunohistologic changes induced by risk factors and their combination

with

cerebral ischemia with the aim to identify ethiologic mechanisms perspectively utilizable in human praxis.

APVV project 15/107: Integrating translational and clinical research which by biological and molecular

approach enables a more

detailed understanding of the role of vitamine D and other markers in relation to the development and

progression of sclerosis multiplex. By application of

this approach, from the level of animal model of SM - experimental allergic encephalomyelitis to clinically

diagnosed group of SM patients, to improve patients stratification, identification of predisposed individuals,

personalization of the prevention and therapy.

Characterization of origin and progression of demyelinization prognosis in correlation with the plasma level

of

vitamine D or its metabolites. Determination of linkage and validity of genetic markers and gene

polymorphisms

in correlation to

the disease progression. Analysis of the influence of vitamine D and its derivatives on genetic DNA

modifications

and micro RNA

expression in model and in patients with various disability progression (MSSS scores). By proteomic and

MR

and MRS analyses to

quantify damage and to understand in more details the role of vitamine D and its derivatives in the disease

ADC_022 / Škovierová, Henrieta (Autor) [UKOLJ110A] (25%) - Vidomanová, Eva (Autor) [UKOLJ110A]

(15%) - Mahmood, Silvia (Autor) (15%) - Pálešová, Janka (Autor) [Interný doktorand] [UKOLJ111] (10%) -

Drgová, Anna (Autor) [UKOLJ111] (10%) - Červeňová, Tatiana (Autor) (5%) - Halašová, Erika (Autor)

[UKOLJ120] (10%) - Lehotský, Ján (Autor) [UKOLJ111] (10%): The Molecular and Cellular Effect of

Homocysteine Metabolism Imbalance on Human Health. – DOI 10.3390/ijms17101733. – CCC ; SCO ;

WOS CC ; SCIE.

In: International journal of molecular sciences [textový dokument (print)] [elektronický dokument] . – Bazilej

(Švajčiarsko) : Multidisciplinary Digital Publishing Institute. – ISSN 1661-6596. – ISSN (online) 1422-0067. –

Roč. 17, č. 10 (2016), art. no. 1733, s. [1-18] [online] [tlačená forma]

Počet všetkých autorov: 8

[článok]

Lit.: 112

[OV 180 Lekárske, farmaceutické a nelekárske zdravotnícke vedy]

Indikátor časopisu:

IF: 3,226 - 2016

SNIP: 1,157 - 2016

SJR: 1,235 - 2016

CiteScore: 5,4 - 2016

Kvartil Q (2016):

JIF - Biochemistry & molecular biology - Q2 JIF - Chemistry, multidisciplinary - Q2

Cited : 304

APVV -15/107 - Role of vitamine D and other markers in the progression of multiple

sclerosis

VEGA 274/23- Effect of neurotoxicants as risk factors on the onset and progression of CNS vascular

disorders