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Meno a priezvisko:
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Mgr. Mária Brodňanová, PhD.
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Typ dokumentu:
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Vedecko/umelecko-pedagogická charakteristika osoby
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Názov vysokej školy:
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Univerzita Komenského v Bratislave
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Sídlo vysokej školy:
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Šafárikovo námestie 6, 818 06 Bratislava
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| III.a - Zamestnanie-pracovné zaradenie | III.b - Inštitúcia | III.c - Časové vymedzenie |
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| Vedecko-výskumný pracovník | Jesseniova lekárska fakulta UK | 2021 - |
| Vedecko-výskumný pracovník | Ústav farmakologických a biomolekulárnych vied, Università degli Studi di Milano | 2024 - 2025 |
| IV.a - Popis aktivity, názov kurzu (ak išlo o kurz), iné | IV.b - Názov inštitúcie | IV.c - Rok |
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| IX. Begginers Course in Molecular Diagnostics | Medzinárodná federácia klinickej chémie a laboratórnej medicíny | 2018 |
| ISN Advanced School - New challenges and opportunities in neurochemical studies – novel tools and approaches | Mezinárodní neurochemická spoločnost | 2023 |
| Letná škola lekárskej štatistiky | Jesseniova lekárska fakulta v Martine UK | 2021 |
| Kurz medicínskeho vzdelávania | Jesseniova lekárska fakulta v Martine UK | 2020 |
| V.1.a - Názov profilového predmetu | V.1.b - Študijný program | V.1.c - Stupeň | V.1.d - Študijný odbor |
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| Lekárska chémia 1 | všeobecné lekárstvo | I.+II. | všeobecné lekárstvo |
| Lekárska chémia 2 | všeobecné lekárstvo | I.+II. | všeobecné lekárstvo |
| Lekárska biochémia 1 | všeobecné lekárstvo | I.+II. | všeobecné lekárstvo |
| Lekárska Biochémia 2 | všeobecné lekárstvo | I.+II. | všeobecné lekárstvo |
| Lekárska chémia pre zubné lekárstvo | zubné lekárstvo | I.+II. | zubné lekárstvo |
| Lekárska biochémia pre zubné lekárstvo 1 | zubné lekárstvo | I.+II. | zubné lekárstvo |
| Lekárska biochémia pre zubné lekárstvo 2 | zubné lekárstvo | I.+II. | zubné lekárstvo |
(ADC) Brodnanova, M.; Hatokova, Z.; Evinova, A.; Cibulka, M.; Racay, P. Differential Impact of Imipramine on Thapsigargin- and Tunicamycin-Induced Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Neuroblastoma SH-SY5Y Cells. European Journal of Pharmacology 2021, 902, 174073. https://doi.org/10.1016/j.ejphar.2021.174073. IF (JRC) 2020: 4,432, Q1 – SJR)
Rusmini, P.; Mina, F.; Valenza, M.; Vitali, M.; Ferrari, V.; Tedesco, B.; Casarotto, E.; Cozzi, M.; Chierichetti, M.; Mohamed, A. Pramaggiore, P.; Cornaggia, L.; Milioto, C.; Brodnanova, M.; Magdalena, R.; Koshal, P.; Piccolella, M.; Cristofani, R;, Galbiati, M.; Crippa, V.; Poletti, A. Impairment of lysosomal quality control in Huntington disease. Cell Death Dis. 2025, 16(1): 762. doi: 10.1038/s41419-025-08103-z.
(ADC) Cibulka, M.; Brodnanova, M.; Grendar, M.; Grofik, M.; Kurca, E.; Pilchova, I.; Osina, O.; Tatarkova, Z.; Dobrota, D.; Kolisek, M. SNPs Rs11240569, Rs708727, and Rs823156 in SLC41A1 Do Not Discriminate Between Slovak Patients with Idiopathic Parkinson’s Disease and Healthy Controls: Statistics and Machine-Learning Evidence. IJMS 2019, 20 (19), 4688. IF (JRC) 2018: 4,183
(V3) Evinova, A.; Hatokova, Z.; Tatarkova, Z.; Brodnanova, M.; Dibdiakova, K.; Racay, P. Endoplasmic Reticulum Stress Induces Mitochondrial Dysfunction but Not Mitochondrial Unfolded Protein Response in SH-SY5Y Cells. Mol Cell Biochem 2022, 477 (3), 965–975. https://doi.org/10.1007/s11010-021-04344-6. IF (JRC) 2021: 3,842
(V3) Cibulka, M.; Brodnanova, M.; Grendar, M.; Necpal, J.; Benetin, J.; Han, V.; Kurca, E.; Nosal, V.; Skorvanek, M.; Vesely, B.; Stanclova, A.; Lasabova, Z.; Pös, Z.; Szemes, T.; Stuchlik, S.; Grofik, M.; Kolisek, M. Alzheimer’s Disease-Associated SNP Rs708727 in SLC41A1 May Increase Risk for Parkinson’s Disease: Report from Enlarged Slovak Study. IJMS 2022, 23 (3), 1604. https://doi.org/10.3390/ijms23031604. IF (JRC) 2021: 6,208
(ADC) Brodnanova, M.; Hatokova, Z.; Evinova, A.; Cibulka, M.; Racay, P. Differential Impact of Imipramine on Thapsigargin- and Tunicamycin-Induced Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Neuroblastoma SH-SY5Y Cells. European Journal of Pharmacology 2021, 902, 174073. https://doi.org/10.1016/j.ejphar.2021.174073. IF (JRC) 2020: 4,432, Q1 – SJR)
Rusmini, P.; Mina, F.; Valenza, M.; Vitali, M.; Ferrari, V.; Tedesco, B.; Casarotto, E.; Cozzi, M.; Chierichetti, M.; Mohamed, A. Pramaggiore, P.; Cornaggia, L.; Milioto, C.; Brodnanova, M.; Magdalena, R.; Koshal, P.; Piccolella, M.; Cristofani, R;, Galbiati, M.; Crippa, V.; Poletti, A. Impairment of lysosomal quality control in Huntington disease. Cell Death Dis. 2025, 16(1): 762. doi: 10.1038/s41419-025-08103-z.
(ADC) Cibulka, M.; Brodnanova, M.; Grendar, M.; Grofik, M.; Kurca, E.; Pilchova, I.; Osina, O.; Tatarkova, Z.; Dobrota, D.; Kolisek, M. SNPs Rs11240569, Rs708727, and Rs823156 in SLC41A1 Do Not Discriminate Between Slovak Patients with Idiopathic Parkinson’s Disease and Healthy Controls: Statistics and Machine-Learning Evidence. IJMS 2019, 20 (19), 4688. IF (JRC) 2018: 4,183
(V3) Evinova, A.; Hatokova, Z.; Tatarkova, Z.; Brodnanova, M.; Dibdiakova, K.; Racay, P. Endoplasmic Reticulum Stress Induces Mitochondrial Dysfunction but Not Mitochondrial Unfolded Protein Response in SH-SY5Y Cells. Mol Cell Biochem 2022, 477 (3), 965–975. https://doi.org/10.1007/s11010-021-04344-6. IF (JRC) 2021: 3,842
(V3) Cibulka, M.; Brodnanova, M.; Grendar, M.; Necpal, J.; Benetin, J.; Han, V.; Kurca, E.; Nosal, V.; Skorvanek, M.; Vesely, B.; Stanclova, A.; Lasabova, Z.; Pös, Z.; Szemes, T.; Stuchlik, S.; Grofik, M.; Kolisek, M. Alzheimer’s Disease-Associated SNP Rs708727 in SLC41A1 May Increase Risk for Parkinson’s Disease: Report from Enlarged Slovak Study. IJMS 2022, 23 (3), 1604. https://doi.org/10.3390/ijms23031604. IF (JRC) 2021: 6,208
Evinova, A.; Hatokova, Z.; Tatarkova, Z.; Brodnanova, M.; Dibdiakova, K.; Racay, P. Endoplasmic Reticulum Stress Induces Mitochondrial Dysfunction but Not Mitochondrial Unfolded Protein Response in SH-SY5Y Cells. Mol Cell Biochem 2022, 477 (3), 965–975. https://doi.org/10.1007/s11010-021-04344-6.
Li, M.; Tang, S.; Velkov, T.; Shen, J.; Dai, C. Copper exposure induces mitochondrial dysfunction and hepatotoxicity via the induction of oxidative stress and PERK/ATF4 -mediated endoplasmic reticulum stress. Environ Pollut. 2024, 1:352:124145. doi: 10.1016/j.envpol.2024.124145.
Zhang, S.; Chen, L.; Chen, T.; Zhang, Y.; Ma, J.; Ji, H.; Guo, C.; Xiao, Z.; Li, J.; Niu, P. Transcriptome Evidence Reveals Mitochondrial Unfolded Protein Response Participate in SH-SY5Y Cells Exposed to Manganese. J. Integr. Neurosci. 2022, 21 (5). https://doi.org/10.31083/j.jin2105127.
Ji, Y.; Jiang, Q.; Chen, B.; Chen, X.; Li, A.; Shen, D.; Shen Y.; Liu, H.; Qian, X.; Yao, X.;, Sun, H. Endoplasmic reticulum stress and unfolded protein response: Roles in skeletal muscle atrophy. Biochem Pharmacol. 2025, 234:116799. doi: 10.1016/j.bcp.2025.116799.
Xiong, C.; Tang Y.; Li F.; Ye, Y.; Li, X.; Lin, J.; Dai, S. 3,3'-Diindolylmethane inhibits the proliferation of esophageal squamous cell carcinoma cells via downregulation of STIM1. 2024, 28(2): 339. doi: 10.3892/ol.2024.14473.
Liskova, M; Evinova, A.; Guzikova, J.; Hudak, L.; Pokusa, M.; Kotulova, L.; Racay, P. Impact of tauroursodeoxycholic acid and 4-phenylbutyric acid on mitochondrial functions and morphology of SH-SY5Y cells. Gen Physiol Biophys. 2025, 44(4): 275-287. doi: 10.4149/gpb_2025017.
Cibulka, M.; Brodnanova, M.; Grendar, M.; Necpal, J.; Benetin, J.; Han, V.; Kurca, E.; Nosal, V.; Skorvanek, M.; Vesely, B.; Stanclova, A.; Lasabova, Z.; Pös, Z.; Szemes, T.; Stuchlik, S.; Grofik, M.; Kolisek, M. Alzheimer’s Disease-Associated SNP Rs708727 in SLC41A1 May Increase Risk for Parkinson’s Disease: Report from Enlarged Slovak Study. IJMS 2022, 23 (3), 1604.
Zhang, Y.; Li, X.; Ren, K.-D.; Peng, J.; Luo, X. Restoration of Metal Homeostasis: A Potential Strategy against Neurodegenerative Diseases. Ageing Res. Rev. 2023, 87. https://doi.org/10.1016/j.arr.2023.101931.
Nemoto, T.; Tagashira, H.; Kita, T.; Kita, S.; Iwamoto, T. Functional Characteristics and Therapeutic Potential of SLC41 Transporters. J. Pharmacol. Sci. 2023, 151 (2), 88–92. https://doi.org/10.1016/j.jphs.2022.12.003.
Yang, Y.; Chen, S.; Zhang L.; Zhang, G.; Liu, Y.; Li, Y.; Zou, L.; Meng, L.; Tian, Y.; Dai, L.; Xiong, M.; Pan, L.; Xiong, J.; Chen, L.; Hou, H.; Yu, Z.; Zhang, Z. The PM20D1-NADA pathway protects against Parkinson's disease. Cell Death Differ. 2024, 31(11):1545-1560. doi: 10.1038/s41418-024-01356-9.
Cibulka, M.; Brodnanova, M.; Halasova, E.; Kurca, E.; Kolisek, M.; Grofik, M. The Role of Magnesium in Parkinson's Disease: Status Quo and Implications for Future Research. Int J Mol Sci. 2024, 25(15): 8425. doi: 10.3390/ijms25158425.
Yang, Z.; Zheng, Y.; Zhang, L.; Zhao, J.; Xu, W.; Wu, H.; Xie, T.; Ding, Y. Screening the Best Risk Model and Susceptibility SNPs for Chronic Obstructive Pulmonary Disease (COPD) Based on Machine Learning Algorithms. Int J Chron Obstruct Pulmon Dis. 2024, 5:19:2397-2414. doi: 10.2147/COPD.S478634.
Brodnanova, M.; Hatokova, Z.; Evinova, A.; Cibulka, M.; Racay, P. Differential Impact of Imipramine on Thapsigargin- and Tunicamycin-Induced Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Neuroblastoma SH-SY5Y Cells. European Journal of Pharmacology 2021, 902, 174073. https://doi.org/10.1016/j.ejphar.2021.174073.
Asensi-Cantó, A.; López-Abellán, M. D.; Castillo-Guardiola, V.; Hurtado, A. M.; Martínez-Penella, M.; Luengo-Gil, G.; Conesa-Zamora, P. Antitumoral Effects of Tricyclic Antidepressants: Beyond Neuropathic Pain Treatment. Cancers 2022, 14 (13), 3248. https://doi.org/10.3390/cancers14133248.
Evinova, A.; Baranovicova, E.; Hajduchova, D.; Dibdiakova, K.; Baranova, I.; Racay P.; Strnadel, J.; Pecova, E.; Halasova E.; Pokusa, M. The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson's disease model using SH-SY5Y cells depends on their differentiation state. J Bioenerg Biomembr. 2024, 56(4):347-360. doi: 10.1007/s10863-024-10018-x.
Umano, A.; Fang, K.; Qu, Z.; Scaglione, J.; Altinok, J.; Treadway, C.; Wick, E.; Paulakonis, E.; Karunanayake, C.; Chou, S.; Bardakjian, T.; Gonzalez-Alegre, P.; Page, R.; Schisler, J.; Brown, N.; Yan, D.; Scaglione, K. The molecular basis of spinocerebellar ataxia type 48 caused by a de novo mutation in the ubiquitin ligase CHIP. J Biol Chem. 2022, 298(5):101899. doi: 10.1016/j.jbc.2022.101899.
Lusa, W.; Rozpędek-Kamińska, W.; Siwecka, N.; Galita, G.; Majsterek, I.; Kucharska, E. Small‑molecule PKR‑like Endoplasmic Reticulum Kinase Inhibitors as a Novel Targeted Therapy for Parkinson’s Disease. Mol. Med. Rep. 2023, 27 (5), 1–15. https://doi.org/10.3892/mmr.2023.12989.
Talati, M. N.; Vemireddy, S.; Seelam, S. D.; Halmuthur. M, S. K. Synthesis and Immunomodulatory Activity of Novel Amino Acid Analogues of Fluoxetine. Synth. Commun. 2023, 53 (10), 731–743. https://doi.org/10.1080/00397911.2023.2196024.
Cibulka, M.; Brodnanova, M.; Grendar, M.; Grofik, M.; Kurca, E.; Pilchova, I.; Osina, O.; Tatarkova, Z.; Dobrota, D.; Kolisek, M. SNPs Rs11240569, Rs708727, and Rs823156 in SLC41A1 Do Not Discriminate Between Slovak Patients with Idiopathic Parkinson’s Disease and Healthy Controls: Statistics and Machine-Learning Evidence. IJMS 2019, 20 (19), 4688.
Mei, J.; Desrosiers, C.; Frasnelli, J. Machine Learning for the Diagnosis of Parkinson’s Disease: A Review of Literature. Front. Aging Neurosci. 2021, 13. https://doi.org/10.3389/fnagi.2021.633752.
Rana, A.; Dumka, A.; Singh, R.; Panda, M. K.; Priyadarshi, N.; Twala, B. Imperative Role of Machine Learning Algorithm for Detection of Parkinson’s Disease: Review, Challenges and Recommendations. Diagnostics 2022, 12 (8). https://doi.org/10.3390/diagnostics12082003.
Rana, A.; Dumka, A.; Singh, R.; Rashid, M.; Ahmad, N.; Panda, M. K. An Efficient Machine Learning Approach for Diagnosing Parkinson’s Disease by Utilizing Voice Features. Electron. Switz. 2022, 11 (22). https://doi.org/10.3390/electronics11223782.
Rana, A.; Dumka, A.; Singh, R.; Panda, M. K.; Priyadarshi, N. A Computerized Analysis with Machine Learning Techniques for the Diagnosis of Parkinson’s Disease: Past Studies and Future Perspectives. Diagnostics 2022, 12 (11). https://doi.org/10.3390/diagnostics12112708.
Cibulka, M.; Brodnanova, M.; Grendar, M.; Necpal, J.; Benetin, J.; Han, V.; Kurca, E.; Nosal, V.; Skorvanek, M.; Vesely, B.; Stanclova, A.; Lasabova, Z.; Pös, Z.; Szemes, T.; Stuchlik, S.; Grofik, M.; Kolisek, M. Alzheimer’s Disease-Associated SNP Rs708727 in SLC41A1 May Increase Risk for Parkinson’s Disease: Report from Enlarged Slovak Study. Int. J. Mol. Sci. 2022, 23 (3). https://doi.org/10.3390/ijms23031604.
Cibulka, M.; Brodnanova, M.; Halasova, E.; Kurca, E.; Kolisek, M.; Grofik, M. The Role of Magnesium in Parkinson's Disease: Status Quo and Implications for Future Research. Int J Mol Sci. 2024, 25(15):8425. doi: 10.3390/ijms25158425.
Graves, N.; Jaafar, A.; Gambin, Y.; Sierecki, E. Divalent and Trivalent Metallic Ions Differentially Affect Alpha-Synuclein Aggregation. ACS Chem Neurosci. 2025, 16(18):3497-3512. doi: 10.1021/acschemneuro.5c00160.
Guk, J.; Lokominienė, R.; Jatužis D. Use of nutritional supplements and other complementary medicine methods among patients with Parkinson's disease in Lithuania. Front Neurol. 2025, 7:16:1581590. doi: 10.3389/fneur.2025.1581590.
Khan, M.; Zhou, Q.; Guo, J.; Liu L.; Hu, R. Integrated LIBS-Raman spectroscopy coupled with explainable machine learning for biochemical characterization of melanoma. Spectrochim Acta A Mol Biomol Spectrosc. 2026, 9:353:127576. doi: 10.1016/j.saa.2026.127576.
Weiye, Z.; Xudan, W.; He, Q.; Hongtao, T.; Xun, Q. The Role of Magnesium in Liver Cirrhosis. Portal Hypertens. Cirrhosis. 2025, doi: 10.1002/poh2.70007.
Mohammad, F. Role of Homocysteine and water-soluble vitamins in Parkinson's disease: A case-control study in Iraq. Biosci. Appl. Res. 2025, doi: 10.21608/jbaar.2025.412305.
Identifikácia komponentov horčíkovej homeostázy a štúdium ich regulácie v bunkách hemato-encefalickej bariéry. Projekt VEGA 1/0039/23. Realizované: 2023-2025. člen rieš. kolektívu
Stanovenie mitochondriálneho fitness v diagnostike a predikcii Parkinsonovej choroby. Projekt APVV-19-0222. Realizované: 2020-2024. Celkový rozpočet: 220 000 €; člen rieš. kolektívu
Úloha STAT3 signálnej dráhy v regulácii promótora Na+/Mg2+ výmenníka SLC41A1: od zápalu k Parkinsonovej chorobe. Projekt VEGA 1/0554/19. Realizované: 2019-2021. člen rieš. kolektívu
Vplyv zmien expresie génov pre horčíkové transportéry na mechanizmy bunkovej odozvy v rôznych modeloch stresu endoplazmatického retikula. Projekt VEGA 1/0277/18. Realizované: 2018-2021. člen rieš. kolektívu
Úloha vnútrobunkových organel a ich interakcií v procese syntézy, modifikácii a degradácii bielkovín vo vzťahu k ischémiou indukovanej oneskorenej smrti neurónov. Projekt APVV-16-0033. Realizované: 2017-2021. Celkový rozpočet: 210 000 €; člen rieš. kolektívu
| VIII.a - Názov inštitúcie | VIII.b - Sídlo inštitúcie | VIII.c - Obdobie trvania pôsobenia/pobytu (uviesť dátum odkedy dokedy trval pobyt) | VIII.d - Mobilitná schéma, pracovný kontrakt, iné (popísať) |
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| Università degli Studi di Milano | Via Festa del Perdono 7 - 20122 Milano | 1.6.2024 - 30.11.2025 | Pracovný kontrakt na inštitúte Dipartimento di Scienze Farmacologiche e Biomolecolari Rodolfo Paoletti |