I. - Basic information

I.1 - Surname

Samec

I.2 - Name

Marek

I.3 - Degrees

RNDr., Ph.D.

I.4 - Year of birth

1991

I.5 - Name of the workplace

Department of Medical Biology JFM CU

I.6 - Address of the workplace

Mala Hora 4C, 036 01 Martin, Slovakia

I.7 - Position

assistant professor

I.8 - E-mail address

marek.samec@uniba.sk

I.9 - Hyperlink to the entry of a person in the Register of university staff

https://www.portalvs.sk/regzam/detail/34268

I.10 - Name of the study field in which a person works at the university

general medicine

I.11 - ORCID iD

https://orcid.org/0000-0002-2545-7694

II. - Higher education and further qualification growth

II.1 - First degree of higher education

II.a - Name of the university or institution

Fakulty of natural sciences Comenius University Bratislava

II.b - Year

2014

II.c - Study field and programme

biology

II.2 - Second degree of higher education

II.a - Name of the university or institution

Fakulty of natural sciences Comenius University Bratislava

II.b - Year

2016

II.c - Study field and programme

molecular biology

II.3 - Third degree of higher education

II.a - Name of the university or institution

Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin

II.b - Year

2021

II.c - Study field and programme

gynecology and obstetrics

II.4 - Associate professor

II.5 - Professor

II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position	III.b - Institution	III.c - Duration
research scientist	Biomedical centre Martin JFM CU	2021 - 2022
research scientist	Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Department of Pathological Physiology	2022-2023
assistant professor	Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin, Department of Medical Biology	2023-present

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other	IV.b - Name of the institution	IV.c - Year
English language test for doctors, doctoral students and others interested in an English language certificate.	Academy of education Martin	2017
Methodology of scientific work	Jessenius faculty of medicine Comenius University Bratislava	2018
workshop focused on wellfare of animals used for experimental and educational purposes	Institute of veterinary education	2019
Skills in medical education	Jessenius faculty of medicine Comenius University Bratislava	2022
education for manipulation with toxic compounds	agency for industrial medicine JFM CU	2022

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes

V.1.a - Name of the profile course	V.1.b - Study programme	V.1.c - Degree	V.1.d - Field of study
Medical Biology 1	General Medicine	I.+II.	General Medicine
Medical Biology 2	General Medicine	I.+II.	General Medicine
Diploma Thesis 1,2,3	General medicine	I.+II.	General Medicine
Diploma Thesis and Diploma Thesis Defence	General medicine	I.+II.	General medicine
Medical biology and genetics	Nursing	I.	Nursing
Medical biology	Public Health	I.	Public Health
Medical biology and genetics	Midwifery	I.	Midwifery
Clinical genetics	Midwifery	I.	Midwifery

V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year

V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year

V.4 - Overview of supervised final theses

V.4.1 - Number of currently supervised theses

V.4.a - Bachelor's (first degree)

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.4.2 - Number of defended theses

V.4.a - Bachelor's (first degree)

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.5 - Overview of other courses taught in the current academic year according to study programmes

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations

VI.1.1 - Number of the research/artistic/other outputs

VI.1.a - Overall

113

VI.1.b - Over the last six years

112

VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases

VI.1.a - Overall

VI.1.b - Over the last six years

VI.1.3 - Number of citations corresponding to the research/artistic/other outputs

VI.1.a - Overall

3595

VI.1.b - Over the last six years

3595

VI.1.4 - Number of citations registered in the Web of Science or Scopus databases

VI.1.a - Overall

2567

VI.1.b - Over the last six years

2567

VI.1.5 - Number of invited lectures at the international, national level

VI.2 - The most significant research/artistic/other outputs

Abu Samaan TM, Samec M, Liskova A, Kubatka P, Büsselberg D. Paclitaxel's Mechanistic and Clinical Effects on Breast Cancer. Biomolecules. 2019 Nov 27;9(12):789. doi: 10.3390/biom9120789. PMID: 31783552; PMCID: PMC6995578. In: Biomolecules [elektronický dokument]. - Roč. 9, č. 12 (2019), s. [1-22], art. no. 789 [online]. - ISSN (print) 2218-273X; IF (JCR) 2019=4.082

Samec M, Liskova A, Koklesova L, Samuel SM, Zhai K, Buhrmann C, Varghese E, Abotaleb M, Qaradakhi T, Zulli A, Kello M, Mojzis J, Zubor P, Kwon TK, Shakibaei M, Büsselberg D, Sarria GR, Golubnitschaja O, Kubatka P. Flavonoids against the Warburg phenotype-concepts of predictive, preventive and personalised medicine to cut the Gordian knot of cancer cell metabolism. EPMA J. 2020 Jul 30;11(3):377-398. doi: 10.1007/s13167-020-00217-y. PMID: 32843908; PMCID: PMC7429635. In: EPMA Journal. - Roč. 11, č. 3 (2020), s. 377-398. - ISSN (print) 1878-5077; IF (JCR) 2020=6,543

Kubatka P, Uramova S, Kello M, Kajo K, Samec M, Jasek K, Vybohova D, Liskova A, Mojzis J, Adamkov M, Zubor P, Smejkal K, Svajdlenka E, Solar P, Samuel SM, Zulli A, Kassayova M, Lasabova Z, Kwon TK, Pec M, Danko J, Büsselberg D. Anticancer Activities of Thymus vulgaris L. in Experimental Breast Carcinoma in Vivo and in Vitro. Int J Mol Sci. 2019 Apr 9;20(7):1749. doi: 10.3390/ijms20071749. PMID: 30970626; PMCID: PMC6479806. In: International journal of molecular sciences [elektronický dokument]. - Roč. 20, č. 7 (2019), s. [1-29] [online].

- ISSN (online) 1422-0067; IF (JCR) 2019=4,556

Kubatka P, Kello M, Kajo K, Samec M, Jasek K, Vybohova D, Uramova S, Liskova A, Sadlonova V, Koklesova L, Murin R, Adamkov M, Smejkal K, Svajdlenka E, Solar P, Samuel SM, Kassayova M, Kwon TK, Zubor P, Pec M, Danko J, Büsselberg D, Mojzis J. Chemopreventive and Therapeutic Efficacy of Cinnamomum zeylanicum L. Bark in Experimental Breast Carcinoma: Mechanistic In Vivo and In Vitro Analyses. Molecules. 2020 Mar 19;25(6):1399. doi: 10.3390/molecules25061399. PMID: 32204409; PMCID: PMC7144360. In: Molecules [elektronický dokument]. - Roč. 25, č. 6 (2020), s. [1-32], art. no. 1399 [online]. - ISSN (online); IF (JCR) 2020=4,412

Liskova A, Samec M, Koklesova L, Samuel SM, Zhai K, Al-Ishaq RK, Abotaleb M, Nosal V, Kajo K, Ashrafizadeh M, Zarrabi A, Brockmueller A, Shakibaei M, Sabaka P, Mozos I, Ullrich D, Prosecky R, La Rocca G, Caprnda M, Büsselberg D, Rodrigo L, Kruzliak P, Kubatka P. Flavonoids against the SARS-CoV-2 induced inflammatory storm. Biomed Pharmacother. 2021 Jun;138:111430. doi: 10.1016/j.biopha.2021.111430. Epub 2021 Feb 25. PMID: 33662680; PMCID: PMC7906511. In: Biomedicine & Pharmacotherapy [elektronický dokument]. - Roč. 138 (2021), s. [1-12], art. no. 111430

[print]. - ISSN (print) 0753-3322; IF (JCR) 2020=6.530

Soltysova A, Dvorska D, Kajabova VH, Pecimonova M, Cepcekova K, Ficek A, Demkova L, Buocikova V, Babal P, Juras I, Janikova K, Kasubova I, Samec M, Brany D, Lyskova D, Valaskova J, Dankova Z, Smolkova B, Furdova A. Uncovering accurate prognostic markers for high-risk uveal melanoma through DNA methylation profiling. Clin Transl Med. 2023 Jul;13(7):e1317. doi: 10.1002/ctm2.1317. PMID: 37478301; PMCID: PMC10361544.In: Clinical and translational medicine [elektronický dokument]. - Roč. 13, č. 7 (2023), s. [1-7], art. no. e1317 [online]. - ISSN (online) 2001-1326: IF (JCR) 2022=8.55

Lucansky V, Samec M, Burjanivova T, Lukacova E, Kolkova Z, Holubekova V, Turyova E, Hornakova A, Zaborsky T, Podlesniy P, Reizigova L, Dankova Z, Novakova E, Pecova R, Calkovska A, Halasova E. Comparison of the methods for isolation and detection of SARS-CoV-2 RNA in municipal wastewater. Front Public Health. 2023 Mar 7;11:1116636. doi: 10.3389/fpubh.2023.1116636. PMID: 36960362; PMCID: PMC10028190. In: Frontiers in Public Health [elektronický dokument]. - Roč. 11, č. March (2023), s. [1-12], art. no. 1116636 [online]. - ISSN (print) 2296-2565: IF (JCR) 2022=6.46

Baranová I, Samec M, Dvorská D, Šťastný I, Janíková K, Kašubová I, Hornáková A, Lukáčová E, Kapinová A, Biringer K, Halašová E, Danková Z. Droplet digital PCR analysis of CDH13 methylation status in Slovak women with invasive ductal breast cancer. Sci Rep. 2024 Jun 26;14(1):14700. doi: 10.1038/s41598-024-65580-6. PMID: 38926485; PMCID: PMC11208553.

Kunc P, Pokusa M, Hajduchova D, Fabry J, Samec M, Neuschlova M, Pecova R. Biomarkers Reflecting the Severity of Bronchial Asthma in Children. J Asthma Allergy. 2024 Nov 29;17:1227-1237. doi: 10.2147/JAA.S486958. PMID: 39628472; PMCID: PMC11614579.

Lukacova E, Hanzlikova Z, Podlesnyi P, Sedlackova T, Szemes T, Grendar M, Samec M, Hurtova T, Malicherova B, Leskova K, Budis J, Burjanivova T. Novel liquid biopsy CNV biomarkers in malignant melanoma. Sci Rep. 2024 Jul 9;14(1):15786. doi: 10.1038/s41598-024-65928-y. PMID: 38982214; PMCID: PMC11233564.

VI.3 - The most significant research/artistic/other outputs over the last six years

- ISSN (online) 1422-0067; IF (JCR) 2019=4,556

[print]. - ISSN (print) 0753-3322; IF (JCR) 2020=6.530

VI.4 - The most significant citations corresponding to the research/artistic/other outputs

Abu Samaan, T. M., Samec, M., Liskova, A., Kubatka, P., & Büsselberg, D. (2019). Paclitaxel’s mechanistic and clinical effects on breast cancer. Biomolecules, 9(12), 789.

[o1] 2021 Barbolina, M. V.: Pharmacological Research, roč. 168, 2021, čl. č. 105585 - SCI ; SCOPUS; IF=7,6

Jasek, K., Kubatka, P., Samec, M., Liskova, A., Smejkal, K., Vybohova, D., ... & Büsselberg, D. (2019). DNA methylation status in cancer disease: modulations by plant-derived natural compounds and dietary interventions. Biomolecules, 9(7), 289.

[o1] 2020 Ashrafizadeh, M. - Zarrabi, A. - Hashemipour, M. - Vosough, M. - Najafi, M. - Shahinozzaman, M. - Hushmandi, K. - Khan, H. - Mirzaei, H.: Pharmacological Research, roč. 160, 2020, čl. č. 105199 - SCI ; SCOPUS; IF=7,6

Varghese, E., Samuel, S. M., Líšková, A., Samec, M., Kubatka, P., & Büsselberg, D. (2020). Targeting glucose metabolism to overcome resistance to anticancer chemotherapy in breast cancer. Cancers, 12(8), 2252.

[o1] 2021 Wang, L. - Zhang, S. - Wang, X.: Frontiers in Oncology, roč. 10, 2021, čl. č. 602416 - SCI ; SCOPUS; IF=6,2

Kubatka, P., Uramova, S., Kello, M., Kajo, K., Samec, M., Jasek, K., ... & Büsselberg, D. (2019). Anticancer activities of Thymus vulgaris L. in experimental breast carcinoma in vivo and in vitro. International journal of molecular sciences, 20(7), 1749.

[o1] 2021 Sheremetyewa, A. S. - Napsheva, A. M. - Durnova, N. A.: Pharmacy and Pharmacology - Farmatsiya I, roč. 9, č. 6, 2021, s. 476-484 – SCI; IF=3,39

Samec, M., et al. "Flavonoids targeting HIF-1: Implications on cancer metabolism." Cancers 13.1 (2021): 130.

[o1] 2021 Guo, K. - Feng, Y. - Zheng, X. - Sun, L. - Wasan, H. S. - Ruan, S. - Shen, M.: Frontiers in Oncology, roč. 11, 2021, čl. č. 644134 - SCI ; SCOPUS; IF=6,2

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

VEGA: 1/0124/17 - member of the research team - Gene regulation and clonal evolution in the prediction of functional-mutational changes of primary and metastatic breast cancer as an early predictor of the initiation, progression, dissemination, and chemotherapeutic resistance of the disease (prof. MUDr. Pavol Zubor, PhD, DrSc, FRSM)

VEGA: 1/0199/17-member of the research team- Determination of the molecular basis of the methylator phenotype in selected types of cancer (doc. RNDr Zuzana Dankova, PhD.)

VEGA: 1/0136/19- member of the research team-Evaluation of antineoplastic effects of plant functional foods in mammary carcinogenesis (prof. RNDr. Peter Kubatka, PhD.)

VEGA:1-0261-22/- member of the research team-Preparation of molecular tools for visualization of SARS-CoV-2 virus entry into a permissive cell and their use for imaging with high-resolution 3D microscopy in real time and in a live cell (RNDr. Vincent Lúčanský, PhD.)

VEGA: 1/0024/23/-member of the research team- Monitoring of selected biomarkers and the role of airway afferent nerve endings in the pathogenesis of post-covid cough (prof. MUDr. Renáta Péčová, PhD., MPH.)

Stipendium for excellent researchers R2 R4: 09I03-03-V04-00217 (Grant leader)- Evaluating the anticancer effect of Empagliflozin as an SGLT2 inhibitor on the panel of different CRC cell lines (RNDr. Marek Samec, PhD.)

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution	VIII.b - Address of the institution	VIII.c - Duration (indicate the duration of stay)	VIII.d - Mobility scheme, employment contract, other (describe)
Institut de Recherche en Infectiologie de Montpellier IRIM UMR9004 – CNRS DR13 / Université de Montpellier	1919 route de Mende 34293 MONTPELLIER cedex 5	May 1- June 29	Scientific research internship funded by Campus France

IX. - Other relevant facts

Date of last update

2025-02-26

Name and surname:	RNDr. Marek Samec, PhD.
Document type:	Research/art/teacher profile of a person
The name of the university:	Comenius University Bratislava
The seat of the university:	Šafárikovo námestie 6, 818 06 Bratislava