I. - Basic information

I.1 - Surname

Lehotsky

I.2 - Name

jan

I.3 - Degrees

prof

I.4 - Year of birth

1954

I.5 - Name of the workplace

Comenius University in Bratislava Jessenius Medical Faculty in Martin

I.6 - Address of the workplace

Martin, Mala Hora4c

I.7 - Position

prof

I.8 - E-mail address

jan.lehotsky@uniba.sk

I.9 - Hyperlink to the entry of a person in the Register of university staff

https://www.jfmed.uniba.sk/

I.10 - Name of the study field in which a person works at the university

general medicine

I.11 - ORCID iD

(0000-0002-2408-5745)

II. - Higher education and further qualification growth

II.1 - First degree of higher education

II.a - Name of the university or institution

Comenius University

II.b - Year

1972-77

II.c - Study field and programme

Biochemistry

II.2 - Second degree of higher education

II.a - Name of the university or institution

Comenius University

II.b - Year

1977

II.c - Study field and programme

Biochemistry

II.3 - Third degree of higher education

II.a - Name of the university or institution

Comenius University

II.b - Year

1986

II.c - Study field and programme

Biochemistry

II.4 - Associate professor

II.a - Name of the university or institution

Comenius University

II.b - Year

1990

II.c - Study field and programme

Biochemistry

II.5 - Professor

II.a - Name of the university or institution

Comenius University

II.b - Year

2002

II.c - Study field and programme

Biochemistry

II.6 - Doctor of Science (DrSc.)

II.a - Name of the university or institution

Slovak Academy of Sciences

II.b - Year

2004

II.c - Study field and programme

Biochemistry

III. - Current and previous employment

III.a - Occupation-position	III.b - Institution	III.c - Duration
Slovak Academy of Sciences- science worker	Slovak Academy of Sciences	1977-1979
asistant professor	Comenius University	1980-89
associate professor	Comenius UNiv	1990-2001
professor	Comenius Univ	2002- now

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other	IV.b - Name of the institution	IV.c - Year
Medical chemistry	Comenius Univ	1980- now
Medical Biochemistry	Comenius Univ	1980-now
Pathological Biochemistry	Comenius Univ	2000-now

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes

V.1.a - Name of the profile course	V.1.b - Study programme	V.1.c - Degree	V.1.d - Field of study
Medical chemistry	Medical chemistry	MD	General Medicine
Med Biochemistry	Med Biochem	MD	General Medicine
Pathol Biochemistry	Pathol Biochem	MD	General Medicine

V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year

V.2.a - Name of the study programme	V.2.b - Degree	V.2.c - Field of study
Medical Biochemistry	MD, MDD	General Medicine, Dentistry

V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year

V.3.a - Name of the field of habilitation procedure and inaugural procedure	V.3.b - Study field to which it is assigned
Medical, clinical and pharmaceutical biochemistry	General medicine

V.4 - Overview of supervised final theses

V.4.1 - Number of currently supervised theses

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.4.2 - Number of defended theses

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.5 - Overview of other courses taught in the current academic year according to study programmes

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations

VI.1.1 - Number of the research/artistic/other outputs

VI.1.a - Overall

672

VI.1.b - Over the last six years

29- V2, 5- V3, 15- O2, 8- I3,

VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases

VI.1.a - Overall

ADC - 70, ADD - 30, ADM -9, ADN - 6

VI.1.b - Over the last six years

ADC-9, ADD-3, ADM-2, ADN-3

VI.1.3 - Number of citations corresponding to the research/artistic/other outputs

VI.1.a - Overall

2674

VI.1.b - Over the last six years

350

VI.1.4 - Number of citations registered in the Web of Science or Scopus databases

VI.1.a - Overall

1900

VI.1.b - Over the last six years

230

VI.1.5 - Number of invited lectures at the international, national level

VI.1.a - Overall

VI.1.b - Over the last six years

VI.2 - The most significant research/artistic/other outputs

VEGA 213/12 Project brings a novel insight on the ethiology of CNS damage by neurotoxicant -homocystein as well as on the mechanisms

of ichemicj tolerance and its interference with naturally present toxicant. The pathways of MAP kinases have been described

in the endogenous processes of tolerance evolution by preconditioning. It has been found that homocysteine neurotoxicity is

partially suppressed by ischemic toleranci. The results originally extent the knowledge on the effect of hyperhomocysteinémia

to the phenomenon of ischemic tolerance and can be perspectively utilized in the praxis. The detailed knowledge on this

phenomenon could have a clinical impact to the procedure linked with the short term ischemia or transient ischemic atack.

VEGA 128/16: Project brings a novel insight on the ethiology of CNS damage by neurotoxicant -homocystein as well as on the mechanisms of ichemicj tolerance and its interference with naturally present toxicant. The pathways of MAP kinases have been described

in the endogenous processes of tolerance evolution by preconditioning. It has been found that homocysteine neurotoxicity is

partially suppressed by ischemic toleranci. The results originally extent the knowledge on the effect of hyperhomocysteinémia

to the phenomenon of ischemic tolerance and can be perspectively utilized in the praxis. The detailed knowledge on this

phenomenon could have a clinical impact to the procedure linked with the short term ischemia or transient ischemic atack.

VEGA 230/20 Protective role of vitamin D in the development of EAE, animal model of SM, defined by neurologic scores and changes in the proteomic profile and levels o f neurotrometabolites analyzed by MRS. Lower levels of vitamin D in patients serum with SM.

Quocient of light chain of immunoglobulines ?-fLC in liquor and serum has a diagnostic characteristics with high sensitivity,

suitable also for routine praxis. We found association of HLA-DRB1 and DQB1 allel and genotype polymorphisms with the

onset of diseases and progression of disability( EDSS scores).Allele DRB1*07 is positive and DRB1*15/15 a DQB1*03/*03

are clinically negative prognostic factors. Polymorphisms of genes for vitamín D associate with HLA complex (rs703842 in

CYP27B1). We have optimalized process of dealbuminization for proteomic analysis of plasma a by metabolomic and MRS

studies we have indentified level changes of metabolites of Krebs cycle , amino acids and changes in glutamate index and

GABA.

VI.3 - The most significant research/artistic/other outputs over the last six years

VEGA project 274/23 : Project includes experiments which describe complex effect of modifiable risk factors - neurotoxic substances in

combination with cerebral ischemic-reperfusion damageon laboratory animals and impact of this combination on

manifestation of functional, vascular changes and neurodegenerative processes. Study of molecular,

biochemical, spectroskopic and immunohistologic changes induced by risk factors and their combination with

cerebral ischemia with the aim to identify ethiologic mechanisms perspectively utilizable in human praxis.

APVV project 15/107: Integrating translational and clinical research which by biological and molecular approach enables a more

detailed understanding of the role of vitamine D and other markers in relation to the development and

progression of sclerosis multiplex. By application of

this approach, from the level of animal model of SM - experimental allergic encephalomyelitis to clinically

diagnosed group of SM patients, to improve patients stratification, identification of predisposed individuals,

personalization of the prevention and therapy.

Characterization of origin and progression of demyelinization prognosis in correlation with the plasma level of

vitamine D or its metabolites. Determination of linkage and validity of genetic markers and gene polymorphisms

in correlation to

the disease progression. Analysis of the influence of vitamine D and its derivatives on genetic DNA modifications

and micro RNA

expression in model and in patients with various disability progression (MSSS scores). By proteomic and MR

and MRS analyses to

quantify damage and to understand in more details the role of vitamine D and its derivatives in the disease

VI.4 - The most significant citations corresponding to the research/artistic/other outputs

ADC_022 / Škovierová, Henrieta (Autor) [UKOLJ110A] (25%) - Vidomanová, Eva (Autor) [UKOLJ110A] (15%) - Mahmood, Silvia (Autor) (15%) - Pálešová, Janka (Autor) [Interný doktorand] [UKOLJ111] (10%) - Drgová, Anna (Autor) [UKOLJ111] (10%) - Červeňová, Tatiana (Autor) (5%) - Halašová, Erika (Autor) [UKOLJ120] (10%) - Lehotský, Ján (Autor) [UKOLJ111] (10%): The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health. – DOI 10.3390/ijms17101733. – CCC ; SCO ; WOS CC ; SCIE.

In: International journal of molecular sciences [textový dokument (print)] [elektronický dokument] . – Bazilej (Švajčiarsko) : Multidisciplinary Digital Publishing Institute. – ISSN 1661-6596. – ISSN (online) 1422-0067. – Roč. 17, č. 10 (2016), art. no. 1733, s. [1-18] [online] [tlačená forma]

Počet všetkých autorov: 8

[článok]

Lit.: 112

[OV 180 Lekárske, farmaceutické a nelekárske zdravotnícke vedy]

Indikátor časopisu:

IF: 3,226 - 2016

SNIP: 1,157 - 2016

SJR: 1,235 - 2016

CiteScore: 5,4 - 2016

Kvartil Q (2016):

JIF - Biochemistry & molecular biology - Q2 JIF - Chemistry, multidisciplinary - Q2

Cited : 304

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

APVV -15/107 - Role of vitamine D and other markers in the progression of multiple

sclerosis

VEGA 274/23- Effect of neurotoxicants as risk factors on the onset and progression of CNS vascular disorders

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VII.a - Activity, position	VII.b - Name of the institution, board	VII.c - Duration
COST EU - DC BMBC	European Union	2002-2014

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution	VIII.b - Address of the institution	VIII.c - Duration (indicate the duration of stay)	VIII.d - Mobility scheme, employment contract, other (describe)
Catholic University Leuven, Belgium	Leuven, Belgium	1990-91, 1993, 1996, 1998	NATO research grant, National belgium grant

IX. - Other relevant facts

Date of last update

2025-01-27

Name and surname:	prof. RNDr. Ján Lehotský, DrSc.
Document type:	Research/art/teacher profile of a person
The name of the university:	Comenius University Bratislava
The seat of the university:	Šafárikovo námestie 6, 818 06 Bratislava