Research/art/teacher profile of a person
Name and surname:
MUDr. Michal Cibulka, PhD.
Document type:
Research/art/teacher profile of a person
The name of the university:
Comenius University Bratislava
The seat of the university:
Šafárikovo námestie 6, 818 06 Bratislava

I. - Basic information

I.1 - Surname
Cibulka
I.2 - Name
Michal
I.3 - Degrees
MUDr., PhD.
I.4 - Year of birth
17.7.1991
I.5 - Name of the workplace
Department of medical biochemistry
I.6 - Address of the workplace
Malá hora 4D
I.7 - Position
Assistant
I.8 - E-mail address
michal.cibulka@uniba.sk
I.9 - Hyperlink to the entry of a person in the Register of university staff
https://www.portalvs.sk/regzam/detail/33248?mode=full&do=filterForm-submit&name=Michal&surname=Cibulka&university=701000000&faculty=701080000&sort=surname&employment_state=yes&filter=Vyh%C4%BEada%C5%A5
I.10 - Name of the study field in which a person works at the university
General Medicine

II. - Higher education and further qualification growth

II.1 - First degree of higher education
II.2 - Second degree of higher education
II.a - Name of the university or institution
Comenius University Bratislava
II.b - Year
2016
II.c - Study field and programme
General medicine
II.3 - Third degree of higher education
II.a - Name of the university or institution
Comenius University Bratislava
II.b - Year
2020
II.c - Study field and programme
Medical, clinical and pharmaceutical biochemistry
II.4 - Associate professor
II.5 - Professor
II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position III.b - Institution III.c - Duration
Assistant Department of Medical Biochemistry 2024 - ongoing
Doctor University Hospital Martin 2019 - ongoing

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other IV.b - Name of the institution IV.c - Year
Course "English for Medical Sciences C1 - Unicert III" Jessenius Faculty of Medicine 2016-2017
9th Begginer´s Course in Molecular Diagnostics Jessenius Faculty of Medicine, IFCC 2018
Medical education course Jessenius Faculty of Medicine 2020

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes
V.1.a - Name of the profile course V.1.b - Study programme V.1.c - Degree V.1.d - Field of study
Medical Biochemistry General Medicine Joined 1st and 2nd General Medicine
Clinical Biochemistry General Medicine Joined 1st and 2nd General Medicine
Clinical Chemistry General Medicine Joined 1st and 2nd General Medicine
V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year
V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year
V.4 - Overview of supervised final theses
V.4.1 - Number of currently supervised theses
V.4.2 - Number of defended theses
V.5 - Overview of other courses taught in the current academic year according to study programmes

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations
VI.1.1 - Number of the research/artistic/other outputs
VI.1.a - Overall
60
VI.1.b - Over the last six years
41
VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases
VI.1.a - Overall
15
VI.1.b - Over the last six years
13
VI.1.3 - Number of citations corresponding to the research/artistic/other outputs
VI.1.a - Overall
73
VI.1.b - Over the last six years
69
VI.1.4 - Number of citations registered in the Web of Science or Scopus databases
VI.1.a - Overall
94
VI.1.b - Over the last six years
88
VI.1.5 - Number of invited lectures at the international, national level
VI.1.a - Overall
3
VI.1.b - Over the last six years
3
VI.2 - The most significant research/artistic/other outputs
1

Kolisek M, Sponder G, Pilchova I, Cibulka M, Tatarkova Z, Werner T, Racay P. Magnesium Extravaganza: A Critical Compendium of Current Research into Cellular Mg2+ Transporters Other than TRPM6/7. Rev Physiol Biochem Pharmacol. 2019;176:65-105. doi: 10.1007/112_2018_15. PMID: 30406297.

2

Cibulka M, Brodnanova M, Grendar M, Necpal J, Benetin J, Han V, Kurca E, Nosal V, Skorvanek M, Vesely B, Stanclova A, Lasabova Z, Pös Z, Szemes T, Stuchlik S, Grofik M, Kolisek M. Alzheimer's Disease-Associated SNP rs708727 in SLC41A1 May Increase Risk for Parkinson's Disease: Report from Enlarged Slovak Study. Int J Mol Sci. 2022 Jan 29;23(3):1604. doi: 10.3390/ijms23031604. PMID: 35163527; PMCID: PMC8835868.

3

Cibulka M, Brodnanova M, Grendar M, Grofik M, Kurca E, Pilchova I, Osina O, Tatarkova Z, Dobrota D, Kolisek M. SNPs rs11240569, rs708727, and rs823156 in SLC41A1 Do Not Discriminate Between Slovak Patients with Idiopathic Parkinson's Disease and Healthy Controls: Statistics and Machine-Learning Evidence. Int J Mol Sci. 2019 Sep 21;20(19):4688. doi: 10.3390/ijms20194688. PMID: 31546642; PMCID: PMC6801379.

4

Sponder G, Abdulhanan N, Fröhlich N, Mastrototaro L, Aschenbach JR, Röntgen M, Pilchova I, Cibulka M, Racay P, Kolisek M. Overexpression of Na+/Mg2+ exchanger SLC41A1 attenuates pro-survival signaling. Oncotarget. 2017 Dec 22;9(4):5084-5104. doi: 10.18632/oncotarget.23598. PMID: 29435164; PMCID: PMC5797035.

5

Cibulka M, Brodnanova M, Halasova E, Kurca E, Kolisek M, Grofik M. The Role of Magnesium in Parkinson's Disease: Status Quo and Implications for Future Research. Int J Mol Sci. 2024 Aug 1;25(15):8425. doi: 10.3390/ijms25158425. PMID: 39125993; PMCID: PMC11312984.

VI.3 - The most significant research/artistic/other outputs over the last six years
1

Cibulka M, Brodnanova M, Halasova E, Kurca E, Kolisek M, Grofik M. The Role of Magnesium in Parkinson's Disease: Status Quo and Implications for Future Research. Int J Mol Sci. 2024 Aug 1;25(15):8425. doi: 10.3390/ijms25158425. PMID: 39125993; PMCID: PMC11312984.

2

Cibulka M, Brodnanova M, Grendar M, Necpal J, Benetin J, Han V, Kurca E, Nosal V, Skorvanek M, Vesely B, Stanclova A, Lasabova Z, Pös Z, Szemes T, Stuchlik S, Grofik M, Kolisek M. Alzheimer's Disease-Associated SNP rs708727 in SLC41A1 May Increase Risk for Parkinson's Disease: Report from Enlarged Slovak Study. Int J Mol Sci. 2022 Jan 29;23(3):1604. doi: 10.3390/ijms23031604. PMID: 35163527; PMCID: PMC8835868.

3

Cibulka M, Brodnanova M, Grendar M, Grofik M, Kurca E, Pilchova I, Osina O, Tatarkova Z, Dobrota D, Kolisek M. SNPs rs11240569, rs708727, and rs823156 in SLC41A1 Do Not Discriminate Between Slovak Patients with Idiopathic Parkinson's Disease and Healthy Controls: Statistics and Machine-Learning Evidence. Int J Mol Sci. 2019 Sep 21;20(19):4688. doi: 10.3390/ijms20194688. PMID: 31546642; PMCID: PMC6801379.

4

Grofik M, Cibulka M, Oleksakova J, Sivak S, Cierny D, Tatarkova Z, Grendar M, Nosal V, Ruzinak R, Kurca E, Kolisek M. Oxidative stress parameters and their relation to motor subtype of Parkinson's disease and levodopa treatment status. Gen Physiol Biophys. 2023 Jan;42(1):77-85. doi: 10.4149/gpb_2022051. PMID: 36705307.

5

Werner T, Kolisek M, Vormann J, Pilchova I, Grendar M, Struharnanska E, Cibulka M. Assessment of bioavailability of Mg from Mg citrate and Mg oxide by measuring urinary excretion in Mg-saturated subjects. Magnes Res. 2019 Aug 1;32(3):63-71. doi: 10.1684/mrh.2019.0457. PMID: 32162607.

VI.4 - The most significant citations corresponding to the research/artistic/other outputs
1

Fan R, Peng X, Xie L, Dong K, Ma D, Xu W, Shi X, Zhang S, Chen J, Yu X, Yang Y. Importance of Bmal1 in Alzheimer's disease and associated aging-related diseases: Mechanisms and interventions. Aging Cell. 2022 Oct;21(10):e13704. doi: 10.1111/acel.13704. Epub 2022 Sep 3. PMID: 36056774; PMCID: PMC9577946.


Cited research:

Cibulka M, Brodnanova M, Grendar M, Necpal J, Benetin J, Han V, Kurca E, Nosal V, Skorvanek M, Vesely B, Stanclova A, Lasabova Z, Pös Z, Szemes T, Stuchlik S, Grofik M, Kolisek M. Alzheimer's Disease-Associated SNP rs708727 in SLC41A1 May Increase Risk for Parkinson's Disease: Report from Enlarged Slovak Study. Int J Mol Sci. 2022 Jan 29;23(3):1604. doi: 10.3390/ijms23031604. PMID: 35163527; PMCID: PMC8835868.

2

Asensi-Cantó A, López-Abellán MD, Castillo-Guardiola V, Hurtado AM, Martínez-Penella M, Luengo-Gil G, Conesa-Zamora P. Antitumoral Effects of Tricyclic Antidepressants: Beyond Neuropathic Pain Treatment. Cancers (Basel). 2022 Jul 1;14(13):3248. doi: 10.3390/cancers14133248. PMID: 35805019; PMCID: PMC9265090.


Cited research:

Brodnanova M, Hatokova Z, Evinova A, Cibulka M, Racay P. Differential impact of imipramine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells. Eur J Pharmacol. 2021 Jul 5;902:174073. doi: 10.1016/j.ejphar.2021.174073. Epub 2021 Mar 31. PMID: 33798597.

3

Jomova K, Makova M, Alomar SY, Alwasel SH, Nepovimova E, Kuca K, Rhodes CJ, Valko M. Essential metals in health and disease. Chem Biol Interact. 2022 Nov 1;367:110173. doi: 10.1016/j.cbi.2022.110173. Epub 2022 Sep 22. PMID: 36152810.


Cited research:

Kolisek M, Sponder G, Pilchova I, Cibulka M, Tatarkova Z, Werner T, Racay P. Magnesium Extravaganza: A Critical Compendium of Current Research into Cellular Mg2+ Transporters Other than TRPM6/7. Rev Physiol Biochem Pharmacol. 2019;176:65-105. doi: 10.1007/112_2018_15. PMID: 30406297.

4

Rodelo-Haad C, Pendón-Ruiz de Mier MV, Díaz-Tocados JM, Martin-Malo A, Santamaria R, Muñoz-Castañeda JR, Rodríguez M. The Role of Disturbed Mg Homeostasis in Chronic Kidney Disease Comorbidities. Front Cell Dev Biol. 2020 Nov 12;8:543099. doi: 10.3389/fcell.2020.543099. PMID: 33282857; PMCID: PMC7688914.


Cited research:

Kolisek M, Sponder G, Pilchova I, Cibulka M, Tatarkova Z, Werner T, Racay P. Magnesium Extravaganza: A Critical Compendium of Current Research into Cellular Mg2+ Transporters Other than TRPM6/7. Rev Physiol Biochem Pharmacol. 2019;176:65-105. doi: 10.1007/112_2018_15. PMID: 30406297.

5

Dominguez L, Veronese N, Barbagallo M. Magnesium and Hypertension in Old Age. Nutrients. 2020 Dec 31;13(1):139. doi: 10.3390/nu13010139. PMID: 33396570; PMCID: PMC7823889.


Cited research:

Sponder G, Abdulhanan N, Fröhlich N, Mastrototaro L, Aschenbach JR, Röntgen M, Pilchova I, Cibulka M, Racay P, Kolisek M. Overexpression of Na+/Mg2+ exchanger SLC41A1 attenuates pro-survival signaling. Oncotarget. 2017 Dec 22;9(4):5084-5104. doi: 10.18632/oncotarget.23598. PMID: 29435164; PMCID: PMC5797035.

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years
1

APVV-19-0222 "Determination of mitochondrial fitness in the diagnosis and prediction of Parkinson's disease."


Task: Member of the research team


Brief description:


The idiopathic form is the most common form of Parkinson's disease (iPD) with typical onset in older age. Currently, the diagnosis of iPD is based on a battery of neurological examinations and the patient's positive response to treatment. Currently, no reliable biomarker of iPD is clinically available. Progressive deterioration of mitochondrial homeostasis in dopaminergic neurons of the substantia nigra is typical of PD, and its severity could be proportional to the stage and complexity of the disease. We hypothesize that the level of complex multiparametric mitochondrial fitness (MiF) in leukocytes of iPD patients correlates with the stage of iPD and the rate of its progression. To test our hypothesis, we designed a longitudinal cohort study including 60 iPD patients (early stage: 30, advanced stage: 30) and 60 sex- and age-matched controls. The study will be conducted over 2 years and samples will be collected at 0, 12 and 24 months. The multiparametric MiF will be determined at each time point and will be correlated with the clinical picture of each patient individually. The results of the study should lead to the following: 1) development of a clinically applicable algorithm for the multiparametric determination of MiF in iPD; 2) determination of the metabolomic profile of bile acids in iPD plasma and leukocytes of iPD; 3) determination of the apoptotic profile and pro-survival signaling in leukocytes of iPD patients.

2

VEGA 1/0039/23 "Identification of components of magnesium homeostasis and study of their regulation in blood-brain barrier cells."


Task: Principal investigator


Brief description:

Magnesium is one of the key factors in many cellular processes. For example, it plays an important role in mitochondrial and energy homeostasis or the regulation of cell metabolism. Impaired magnesium homeostasis plays a significant role in the pathogenesis of major neuropsychiatric and neurodegenerative diseases. Magnesium entry into the brain is regulated by the blood-brain barrier. However, it is unclear which transport systems are involved in the passage of magnesium across the blood-brain barrier and how magnesium entry into the brain is regulated. The aim of the present project is therefore to analyse the known transport and regulatory systems involved in magnesium transport in the periphery, both in terms of their physical presence in cells of the blood-brain barrier and in terms of their regulation by magnesium itself, glucose and insulin. The main contribution of the project will be to obtain basal data on the mechanism and regulation of magnesium transfer to the central nervous system.

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

IX. - Other relevant facts

Date of last update
2025-01-31