I. - Basic information

I.1 - Surname

Calkovska

I.2 - Name

Andrea

I.3 - Degrees

Prof., MD, DSc.

I.4 - Year of birth

1965

I.5 - Name of the workplace

Department of Physiology, Jessenius Faculty of Medicine, Comenius University

I.6 - Address of the workplace

Mala Hora 4C, 036 01 Martin, Slovakia

I.7 - Position

Professor

I.8 - E-mail address

andrea.calkovska@uniba.sk

I.9 - Hyperlink to the entry of a person in the Register of university staff

https://www.portalvs.sk/regzam/detail/5344

I.10 - Name of the study field in which a person works at the university

General medicine

I.11 - ORCID iD

https://orcid.org/0000-0003-4113-3005

II. - Higher education and further qualification growth

II.1 - First degree of higher education

II.2 - Second degree of higher education

II.a - Name of the university or institution

Comenius University, Faculty of Medicine in Martin

II.b - Year

1990

II.c - Study field and programme

Comenius University, Jessenius Faculty of Medicine in Bratislava

II.3 - Third degree of higher education

II.a - Name of the university or institution

Comenius University, Jessenius Faculty of Medicine in Bratislava

II.b - Year

1993

II.c - Study field and programme

Normal and Pathological Physiology

II.4 - Associate professor

II.a - Name of the university or institution

Comenius University, Jessenius Faculty of Medicine in Martin

II.b - Year

1998

II.c - Study field and programme

Normal and Pathological Physiology

II.5 - Professor

II.a - Name of the university or institution

Comenius University, Jessenius Faculty of Medicine in Martin

II.b - Year

2006

II.c - Study field and programme

Normal and Pathological Physiology

II.6 - Doctor of Science (DrSc.)

II.a - Name of the university or institution

Slovak Academy of Sciences in Bratislava

II.b - Year

2014

II.c - Study field and programme

Medical Sciences, Normal and Pathological Physiology

III. - Current and previous employment

III.a - Occupation-position	III.b - Institution	III.c - Duration
Assist.Professor	Comenius University, Jessenius Faculty of Medicine in Martin	1994-1998
Assoc.Professor	Comenius University, Jessenius Faculty of Medicine in Martin	1998-2006
Professor	Comenius University, Jessenius Faculty of Medicine in Martin	2006-currently

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other	IV.b - Name of the institution	IV.c - Year
English language state exam	Comenius University in Bratislava	1989
Statistical methods in biomedical research	University of Stockholm, Stockholm	1994
Laboratory animal science	Karolinska Institutet, Stockholm	1994
Optimizing ventilatory care in infants	Karolinska Institutet, Stockholm	1994
Multimedia in medical research and education	Karolinska Institutet, Stockholm	1995
Maternal and fetal physiology	Huddinge University Hospital, Stockholm	1995

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes

V.1.a - Name of the profile course	V.1.b - Study programme	V.1.c - Degree	V.1.d - Field of study
Physiology 1 and 2	General Medicine	I.+II.	General Medicine
Physiology for Dental Medicine 1 and 2	Dental Medicine	III.	Dental Medicine
Seminar for Diploma Thesis 1,2,3; supervisor	General Medicine	I.+II.	General Medicine
Member of state exams committee for Physiology in subject Defence of Diploma Thesis	General Medicine	I.+II.	General Medicine
Supervisor	Normal and Pathological Physiology	III.	General Medicine
Member of state exam committee	Normal and Pathological Physiology	III.	General Medicine

V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year

V.2.a - Name of the study programme	V.2.b - Degree	V.2.c - Field of study
Guarantor of profile subject Physiology 1 and 2	I.+II.	General Medicine
Guarantor of profile subject Physiology for Dental Medicine 1 and 2	I.+II.	Dental Medicine
Guarantor of Normal and Pathological Physiology	III.	General Medicine

V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year

V.3.a - Name of the field of habilitation procedure and inaugural procedure	V.3.b - Study field to which it is assigned
Normal and Pathological Physiology	General Medicine

V.4 - Overview of supervised final theses

V.4.1 - Number of currently supervised theses

V.4.a - Bachelor's (first degree)

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.4.2 - Number of defended theses

V.4.a - Bachelor's (first degree)

V.4.b - Diploma (second degree)

V.4.c - Dissertation (third degree)

V.5 - Overview of other courses taught in the current academic year according to study programmes

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations

VI.1.1 - Number of the research/artistic/other outputs

VI.1.a - Overall

569

VI.1.b - Over the last six years

VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases

VI.1.a - Overall

130

VI.1.b - Over the last six years

VI.1.3 - Number of citations corresponding to the research/artistic/other outputs

VI.1.a - Overall

1560

VI.1.b - Over the last six years

962

VI.1.4 - Number of citations registered in the Web of Science or Scopus databases

VI.1.a - Overall

1319

VI.1.b - Over the last six years

950

VI.1.5 - Number of invited lectures at the international, national level

VI.1.a - Overall

VI.1.b - Over the last six years

VI.2 - The most significant research/artistic/other outputs

Q1 ADC Sun B, Curstedt T, Lindgren G, Franzen B, Alaiya AA, Calkovska A, Robertson B. Biophysical and physiological properties of a modified porcine surfactant enriched with surfactant protein A. Eur Respir J 1997; 10 (9): 1967-1974.

Q1 ADC Calkovska A, Sun B, Curstedt T, Renheim G, Robertson B. Combined effects of high-frequency ventilation and surfactant treatment in experimental meconium aspiration syndrome. Acta Anaesthesiol Scand 1999; 43 (2): 135-145.

Q1 ADC Kopincova J, Calkovska A.Meconium-induced inflammation and surfactant inactivation: specifics of molecular mechanisms. Pediatric Res 2016, 79 (4): 514-521.

Q1 ADC Nova Z, Skovierova H, Strnadel J, Halasova E, Calkovska A. Short-term versus long-term culture of A549 cells for evaluating the effects of lipopolysaccharide on oxidative stress, surfactant proteins and cathelicidin LL-37. Int J Mol Sci 2020; 21 (3): 1-17, art. no. 1148

Q1 ADC Calkovska A, Haegerstrand-Bjorkman M, Curstedt T.Restoration of surfactant activity by polymyxin B in lipopolysaccharide - potentiated injury of immature rabbit lungs. In: Scientific Reports [elektronický dokument]. - Roč. 11, č. 1 (2021), s. [1-8], art. no. 22 [online]. - ISSN (online) 2045-2322

VI.3 - The most significant research/artistic/other outputs over the last six years

Q1 ADC/V3 Calkovska A, Haegerstrand-Bjorkman M, Curstedt T.Restoration of surfactant activity by polymyxin B in lipopolysaccharide - potentiated injury of immature rabbit lungs. In: Scientific Reports [elektronický dokument]. - Roč. 11, č. 1 (2021), s. [1-8], art. no. 22 [online]. - ISSN (online) 2045-2322

Q1 ADC/V3 Kolomaznik M, Mikolka P, Hanusrichterova J, Kosutova P, Matasova K jr., Mokrsa D, Calkovska A. N-Acetylcysteine in Mechanically Ventilated Rats with Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome [elektronický dokument] : the Effect of Intravenous Dose on Oxidative Damage and Inflammation In: Biomedicines - Roč. 9, č. 12 (2021), s. [1-13], art. no. 1885 [online]. - ISSN (online) 2227-9059

Q1 ADC/V3 Kosutova P, Kolomaznik M, Calkovska A, Mokra D, Mikolka P. Nitric-Oxide-Releasing Dexamethasone Derivative NCX-1005 Improves Lung Function and Attenuates Inflammation in Experimental Lavage-Induced ARDS. Pharmaceutics 2021; 13(12):2092. doi: 10.3390/pharmaceutics13122092.

Q1 ADC/V3 Mikolka P, Kronqvist N, Haegerstrand-Björkman M, Jaudzems K, Kosutova P, Kolomaznik M, Saluri M, Landreh M, Calkovska A, Curstedt T, Johansson J. Synthetic surfactant with a combined SP-B and SP-C analogue is efficient in rabbit models of adult and neonatal respiratory distress syndrome. In: Translational Research 2023: S1931-5244(23)00127-5. doi: 10.1016/j.trsl.2023.07.009.

Q1 ADC/V3 Alonso-Ojembarrena A, Ehrhardt H, Cetinkaya M, Lavizzari A, Szczapa T, Sartorius V, Rocha G, Sindelar R, Wald M, Heiring C, Soukka H, Danhaive O, Roehr CC, Cucerea M, Calkovska A, Dimitriou G, Barzilay B, Klingenberg C, Schulzke S, Plavka R, Tameliene R, O'Donnell CPF, van Kaam AH; ESPR Pulmonary Research Consortium. Use of neonatal lung ultrasound in European neonatal units: a survey by the European Society of Paediatric Research. Arch Dis Child Fetal Neonatal Ed. 2024 Oct 18;109(6):660-664. doi: 10.1136/archdischild-2024-327068.

VI.4 - The most significant citations corresponding to the research/artistic/other outputs

[o1] 2000 Greenough, A.: Expanded use of surfactant replacement therapy. In: European Journal of Pediatrics, roč. 159, č. 9, 2000, s. 635-640 na prácu/cited work Calkovska A, Sun B, Curstedt T, Renheim G, Robertson B. Combined effects of high-frequency ventilation and surfactant treatment in experimental meconium aspiration syndrome In: Acta Anesthesiologica Scandinavica. - Roč. 43, č. 2 (1999), s. 135-145. - ISSN 0001-5172 Naša práca bola citovaná poprednou svetovou pediatričkou a neonatologičkou profesorkou Anne Greenough z King´s College London/Our article was cited by excellent world-known pediatrician and neonatologist professor Anne Greenough from King´s College London

[o1] 2017 Salaets, T. - Gie, A. - Tack, B. - Deprest, J. - Toelen, J.: Current Pharmaceutical Design, roč. 23, č. 38, 2017, s. 5887-5901 na prácu/cited work Calkovska A, Linderholm B, Haegerstrand-Björkman M, Pioselli B, Pelizzi N, Johansson J, Curstedt T. Phospholipid Composition in Synthetic Surfactants Is Important for Tidal Volumes and Alveolar Stability in Surfactant-Treated Preterm Newborn Rabbits In: Neonatology. - Roč. 109, č. 3 (2016), s. 177-185. - ISSN 1661-7800 Našu prácu cituje skupina autorov, ktorí sú známi vysoko hodnotenými publikáciami na tému akútneho poškodenia pľúc a modelovaním respiračných ochorení/Our study was cited by a group of authors known for their key publications in the field of acute lung injury and modeling of respiratory diseases

[o1] 2020 Autilio, C. - Echaide, M. - Dell'orto, V. - Perez-Gil, J. - De Luca, D.: Therapeutic Hypothermia and Temperature Management, roč. 10, č. 3, 2020, s. 186-189 na prácu/cited work Kopincova J, Calkovska A. Meconium-induced inflammation and surfactant inactivation: specifics of molecular mechanisms. In: Pediatric Research. - Roč. 79, č. 4 (2016), s. 514-521. - ISSN 0031-3998 Práca bola citovaná skupinou okolo Pérez-Gil a De Luca, ktorí patria medzi popredných vedcov v oblasti pľúcneho surfaktantu/Our study was cited by group of Pérez-Gil and De Luca, who belong to excellent scientists in pulmonary surfactant

[o1] 2021 Da Silva, E. - Vogel, U. - Hougaard, K. S. - Pérez-Gil, J. - Zuo, Y. Y. - Sorli, J. B.: Current Research in Toxicology, roč. 2, 2021, s. 225-236 na prácu/cited work Kopincova J, Calkovska A. Meconium-induced inflammation and surfactant inactivation: specifics of molecular mechanisms. In: Pediatric Research. - Roč. 79, č. 4 (2016), s. 514-521. - ISSN 0031-3998 Práca bola citovaná skupinou okolo Pérez-Gil a Zuo, ktorí patria medzi popredných vedcov v oblasti pľúcneho surfaktantu/Our study was cited by group of Pérez-Gil and Zuo, who belong to excellent scientists in pulmonary surfactant

[o1] 2021 Zyrianova, T. - Lopez, B. - Liao, A. - Gu, C. - Wong, L. - Ottolia, M. - Olcese, R. - Schwingshackl, A.: American Journal of Respiratory Cell and Molecular Biology, roč. 64, č. 2, 2021, s. 224-234 na prácu/cited work Nova Z, Skovierova H, Calkovska A. Alveolar-Capillary Membrane-Related Pulmonary Cells as a Target in Endotoxin-Induced Acute Lung Injury. In: International journal of molecular sciences - Roč. 20, č. 4 (2019), s. [1-20] [online]. - ISSN (online) 1422-0067 Ide o citáciu v časopise s vysokým ratingom, pričom práca sa týka opisu novej funkcie receptorov pri infekcii s účasťou LPS/Our work was cited in higly-rated journal, in the article on newly discovered function of receptors included in LPS signalling

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years

VEGA 1/0097/23 Dvojitý inzult a poškodenie pľúc: klinicky relevantný model pre testovanie účinku exogénneho surfaktantu?/Double-hit lung injury: clinically relevant model for testing the effect of an exogenous surfactant? 1.1.2023 - 31.12.2026, zodpovedná riešiteľka/principal investigator https://www.minedu.sk/rozpis-dotacii-na-nove-a-pokracujuce-projekty-vega-na-rok-2023/

APVV-17-0250 Pľúcny surfaktant ako modulátor odpovede organizmu na expozíciu endotoxínu: efekty a mechanizmy/ Pulmonary surfactant as a modulator of body´s response to endotoxin exposure: effects and mechanisms, 1.8.2018 - 30.6.2022, zodpovedná riešiteľka/principal investigator https://www.jfmed.uniba.sk/fileadmin/jlf/Dekanat/Sekretariat/Hodnotiace_spravy_VVC/Hodnotiaca_sprava_urovne_VVC_2019_VR_JLF_UK.pdf

VEGA 1/0004/21 Syntetický surfaktant s analógmi surfaktantových proteínov SP-B a SP-C a protizápalová terapia v experimentálnom syndróme akútnej respiračnej tiesne (ARDS)/ Synthetic surfactant with surfactant proteins SP-B and SP-C analogues and anti-inflammatory therapy in experimental acute respiratory distress syndrome (ARDS), 2021-2024, zástupkyňa zodp.riešiteľa/deputy of principal investigator https://www.jfmed.uniba.sk/fileadmin/jlf/Dekanat/referat-pre-vedecko-vyskumnu-cinnost/Projekty/VEGA.pdf

VEGA 1/0055/19 Pľúcny surfaktant ako súčasť obranných mechanizmov respiračného systému: využitie troch modelov/ Pulmonary surfactant as a part of the defense mechanisms of the respiratory system: use of three models, 2019-2022, zodpovedná riešiteľka/ principal investigator https://www.jfmed.uniba.sk/fileadmin/jlf/Dekanat/Sekretariat/Hodnotiace_spravy_VVC/Hodnotiaca_sprava_urovne_VVC_2019_VR_JLF_UK.pdf

VEGA 1/0356/18 Vplyv experimentálne vyvolaného poškodenia pľúc na extrapulmonálne orgány/The influence of experimentally-induced lung injury on extrapulmonary organs, 2018-2021, členka rieš.kolektívu/member of research team https://www.jfmed.uniba.sk/fileadmin/jlf/Dekanat/Sekretariat/Hodnotiace_spravy_VVC/Hodnotiaca_sprava_urovne_VVC_2018_VR_JLF_UK.pdf

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VII.a - Activity, position	VII.b - Name of the institution, board	VII.c - Duration
Member of organizing committee	ORPHEUS workshop: „PhD study from student views“ organized by JFM CU in Martin under auspicies of organisation for PhD.study in Europe,	11.-13.10.2012
Co-chair of organising committee	Bilateral conference of Serbian Physiological Society and Slovak Physiological Society, ″Cardiovascular and neurophysiological research – from scientific truth via friendship to the art“, Kovačica, Serbia	June 2013
Member of international scientific committee	3rd Congress of Physiological Sciences of Serbia with International Participation: Molecular and Integrative basis of Health and Disease: Transdisciplinary Approach. Beograd, Serbia,	29.-31. 10. 2014
Chief organizer	International Symposium „Pulmonary surfactant: from molecule to function“ during Joint meeting of Federation of European Physiological Societies and Hungarian Physiological Society, Budapest	August 2014
Member of international organizing committee	Bilateral Slovak-Serbian Conference on Physiology, Smolenice	Bilateral Slovak-Serbian Conference on Physiology, Smolenice
Member of international organizing committee	Congress of Federation of European Physiological Societies, Vienna	September 2017
Co-organizer of the symposium of Ethical committee IUPS	Congress of International Union of Physiological Sciences, Beijing, China	May 2022

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution	VIII.b - Address of the institution	VIII.c - Duration (indicate the duration of stay)	VIII.d - Mobility scheme, employment contract, other (describe)
Karolinska Institutet, Surfactant Research Laboratory	Solna, Stockholm, Sweden	1994-1995, 16 months	post-doc, travel grant of European Respiratory Society
Karolinska Institutet, Surfactant Research Laboratory	Solna, Stockholm, Švédsko/Sweden	2000-2001, 13 months	post-doc, travel grant of European Respôiratory Society
Karolinska Institutet, Surfactant Research Laboratory and Uppsala University	Solna, Stockholm and Uppsala, Sweden	2009-2010, 12 months	Visiting scientist by invitation of institution
Karolinska Institutet, Surfactant Research Laboratory	Solna, Stockholm, Sweden	Repeteadly - short-term study stays; 2007, 2015, 2016, 2017	Scientific cooperation with publication outputs

IX. - Other relevant facts

IX.a - If relevant, other activities related to higher education or research/artistic/other activities are mentioned

President of Slovak Physiological Society; Member of Scandinavian Physiological Society; Chair of Ethical Committee of IUPS; Representative of Slovakia in Federation of European Physiological Societies (FEPS); Member of Scientific Boards of Medical Faculties of Košice, Bratislava, Olomouc, Comenius University, Ministry of Health SR and other institutions; Comenius University; Member of Committee of Slovak Academy of Sciences for scientific qualifications

Date of last update

2025-01-03

Name and surname:	prof. MUDr. Andrea Čalkovská, DrSc.
Document type:	Research/art/teacher profile of a person
The name of the university:	Comenius University Bratislava
The seat of the university:	Šafárikovo námestie 6, 818 06 Bratislava