Research/art/teacher profile of a person
Name and surname:
Mgr. Mária Brodňanová, PhD.
Document type:
Research/art/teacher profile of a person
The name of the university:
Comenius University Bratislava
The seat of the university:
Šafárikovo námestie 6, 818 06 Bratislava

I. - Basic information

I.1 - Surname
Brodňanová
I.2 - Name
Mária
I.3 - Degrees
Mgr., PhD.
I.4 - Year of birth
1993
I.5 - Name of the workplace
Department of Medical Biochemistry JFM CU
I.6 - Address of the workplace
Mala Hora 4D, 03601 Martin
I.7 - Position
scientific researcher
I.8 - E-mail address
maria.brodnanova@uniba.sk
I.9 - Hyperlink to the entry of a person in the Register of university staff
https://www.portalvs.sk/regzam/detail/34332
I.10 - Name of the study field in which a person works at the university
General Medicine
I.11 - ORCID iD
0000-0001-7350-1461

II. - Higher education and further qualification growth

II.1 - First degree of higher education
II.a - Name of the university or institution
Faculty of Natural Sciences CU
II.b - Year
2015
II.c - Study field and programme
Biology
II.2 - Second degree of higher education
II.a - Name of the university or institution
Faculty of Natural Sciences CU
II.b - Year
2017
II.c - Study field and programme
Genetics
II.3 - Third degree of higher education
II.a - Name of the university or institution
Jessenius Faculty of Medicine CU
II.b - Year
2021
II.c - Study field and programme
Medical, Clinical and Pharmaceutical Biochemistry
II.4 - Associate professor
II.5 - Professor
II.6 - Doctor of Science (DrSc.)

III. - Current and previous employment

III.a - Occupation-position III.b - Institution III.c - Duration
Scientific researcher Jessenius Faculty of Medicine CU 2021 -
Scientific researcher Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano 2024 - 2025

IV. - Development of pedagogical, professional, language, digital and other skills

IV.a - Activity description, course name, other IV.b - Name of the institution IV.c - Year
IX. Begginers Course in Molecular Diagnostics International Federation of Clinical Chemistry and Laboratory Medicine 2018
ISN Advanced School - New challenges and opportunities in neurochemical studies – novel tools and approaches International Society for Neurochemistry 2023
Medical Statistics Summer School Jessenius Faculty of Medicine in Martin CU 2021
Medical Education Course Jessenius Faculty of Medicine in Martin CU 2020

V. - Overview of activities within the teaching career at the university

V.1 - Overview of the profile courses taught in the current academic year according to study programmes
V.1.a - Name of the profile course V.1.b - Study programme V.1.c - Degree V.1.d - Field of study
Medical Chemistry 1 General Medicine I.+II. General Medicine
Medical Chemistry 2 General Medicine I.+II. General Medicine
Medical Biochemistry 1 General Medicine I.+II. General Medicine
Medical Biochemistry 2 General Medicine I.+II. General Medicine
Medical Chemistry for Dental Medicine Dentistry, Dental Medicine I.+II. Dentistry, Dental Medicine
Medical Biochemistry for Dental Medicine 1 Dentistry, Dental Medicine I.+II. Dentistry, Dental Medicine
Medical Biochemistry for Dental Medicine 2 Dentistry, Dental Medicine I.+II. Dentistry, Dental Medicine
V.2 - Overview of the responsibility for the delivery, development and quality assurance of the study programme or its part at the university in the current academic year
V.3 - Overview of the responsibility for the development and quality of the field of habilitation procedure and inaugural procedure in the current academic year
V.4 - Overview of supervised final theses
V.4.1 - Number of currently supervised theses
V.4.2 - Number of defended theses
V.5 - Overview of other courses taught in the current academic year according to study programmes

VI. - Overview of the research/artistic/other outputs

VI.1 - Overview of the research/artistic/other outputs and the corresponding citations
VI.1.1 - Number of the research/artistic/other outputs
VI.1.a - Overall
59
VI.1.b - Over the last six years
47
VI.1.2 - Number of the research/artistic/other outputs registered in the Web of Science or Scopus databases
VI.1.a - Overall
22
VI.1.b - Over the last six years
20
VI.1.3 - Number of citations corresponding to the research/artistic/other outputs
VI.1.a - Overall
29
VI.1.b - Over the last six years
29
VI.1.4 - Number of citations registered in the Web of Science or Scopus databases
VI.1.a - Overall
50
VI.1.b - Over the last six years
50
VI.1.5 - Number of invited lectures at the international, national level
VI.1.a - Overall
0
VI.1.b - Over the last six years
0
VI.2 - The most significant research/artistic/other outputs
1

Brodnanova, M.; Hatokova, Z.; Evinova, A.; Cibulka, M.; Racay, P. Differential Impact of Imipramine on Thapsigargin- and Tunicamycin-Induced Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Neuroblastoma SH-SY5Y Cells. European Journal of Pharmacology 2021, 902, 174073. https://doi.org/10.1016/j.ejphar.2021.174073. IF (JRC) 2020: 4,432, Q1 – SJR) Citations (12)

2

Rusmini, P.; Mina, F.; Valenza, M.; Vitali, M.; Ferrari, V.; Tedesco, B.; Casarotto, E.; Cozzi, M.; Chierichetti, M.; Mohamed, A. Pramaggiore, P.; Cornaggia, L.; Milioto, C.; Brodnanova, M.; Magdalena, R.; Koshal, P.; Piccolella, M.; Cristofani, R;, Galbiati, M.; Crippa, V.; Poletti, A. Impairment of lysosomal quality control in Huntington disease. Cell Death Dis. 2025, 16(1): 762. doi: 10.1038/s41419-025-08103-z.

3

Cibulka, M.; Brodnanova, M.; Grendar, M.; Grofik, M.; Kurca, E.; Pilchova, I.; Osina, O.; Tatarkova, Z.; Dobrota, D.; Kolisek, M. SNPs Rs11240569, Rs708727, and Rs823156 in SLC41A1 Do Not Discriminate Between Slovak Patients with Idiopathic Parkinson’s Disease and Healthy Controls: Statistics and Machine-Learning Evidence. IJMS 2019, 20 (19), 4688. IF (JRC) 2018: 4,183, Citations (11)

4

Evinova, A.; Hatokova, Z.; Tatarkova, Z.; Brodnanova, M.; Dibdiakova, K.; Racay, P. Endoplasmic Reticulum Stress Induces Mitochondrial Dysfunction but Not Mitochondrial Unfolded Protein Response in SH-SY5Y Cells. Mol Cell Biochem 2022, 477 (3), 965–975. https://doi.org/10.1007/s11010-021-04344-6. IF (JRC) 2021: 3,842, Citations (10)

5

Cibulka, M.; Brodnanova, M.; Grendar, M.; Necpal, J.; Benetin, J.; Han, V.; Kurca, E.; Nosal, V.; Skorvanek, M.; Vesely, B.; Stanclova, A.; Lasabova, Z.; Pös, Z.; Szemes, T.; Stuchlik, S.; Grofik, M.; Kolisek, M. Alzheimer’s Disease-Associated SNP Rs708727 in SLC41A1 May Increase Risk for Parkinson’s Disease: Report from Enlarged Slovak Study. IJMS 2022, 23 (3), 1604. https://doi.org/10.3390/ijms23031604. IF (JRC) 2021: 6,208, Citations (10)

VI.3 - The most significant research/artistic/other outputs over the last six years
1

(ADC) Brodnanova, M.; Hatokova, Z.; Evinova, A.; Cibulka, M.; Racay, P. Differential Impact of Imipramine on Thapsigargin- and Tunicamycin-Induced Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Neuroblastoma SH-SY5Y Cells. European Journal of Pharmacology 2021, 902, 174073. https://doi.org/10.1016/j.ejphar.2021.174073. IF (JRC) 2020: 4,432, Q1 – SJR)

2

Rusmini, P.; Mina, F.; Valenza, M.; Vitali, M.; Ferrari, V.; Tedesco, B.; Casarotto, E.; Cozzi, M.; Chierichetti, M.; Mohamed, A. Pramaggiore, P.; Cornaggia, L.; Milioto, C.; Brodnanova, M.; Magdalena, R.; Koshal, P.; Piccolella, M.; Cristofani, R;, Galbiati, M.; Crippa, V.; Poletti, A. Impairment of lysosomal quality control in Huntington disease. Cell Death Dis. 2025, 16(1): 762. doi: 10.1038/s41419-025-08103-z.

3

(ADC) Cibulka, M.; Brodnanova, M.; Grendar, M.; Grofik, M.; Kurca, E.; Pilchova, I.; Osina, O.; Tatarkova, Z.; Dobrota, D.; Kolisek, M. SNPs Rs11240569, Rs708727, and Rs823156 in SLC41A1 Do Not Discriminate Between Slovak Patients with Idiopathic Parkinson’s Disease and Healthy Controls: Statistics and Machine-Learning Evidence. IJMS 2019, 20 (19), 4688. IF (JRC) 2018: 4,183

4

(V3) Evinova, A.; Hatokova, Z.; Tatarkova, Z.; Brodnanova, M.; Dibdiakova, K.; Racay, P. Endoplasmic Reticulum Stress Induces Mitochondrial Dysfunction but Not Mitochondrial Unfolded Protein Response in SH-SY5Y Cells. Mol Cell Biochem 2022, 477 (3), 965–975. https://doi.org/10.1007/s11010-021-04344-6. IF (JRC) 2021: 3,842

5

(V3) Cibulka, M.; Brodnanova, M.; Grendar, M.; Necpal, J.; Benetin, J.; Han, V.; Kurca, E.; Nosal, V.; Skorvanek, M.; Vesely, B.; Stanclova, A.; Lasabova, Z.; Pös, Z.; Szemes, T.; Stuchlik, S.; Grofik, M.; Kolisek, M. Alzheimer’s Disease-Associated SNP Rs708727 in SLC41A1 May Increase Risk for Parkinson’s Disease: Report from Enlarged Slovak Study. IJMS 2022, 23 (3), 1604. https://doi.org/10.3390/ijms23031604. IF (JRC) 2021: 6,208

VI.4 - The most significant citations corresponding to the research/artistic/other outputs
1

Evinova, A.; Hatokova, Z.; Tatarkova, Z.; Brodnanova, M.; Dibdiakova, K.; Racay, P. Endoplasmic Reticulum Stress Induces Mitochondrial Dysfunction but Not Mitochondrial Unfolded Protein Response in SH-SY5Y Cells. Mol Cell Biochem 2022, 477 (3), 965–975. https://doi.org/10.1007/s11010-021-04344-6.

Li, M.; Tang, S.; Velkov, T.; Shen, J.; Dai, C. Copper exposure induces mitochondrial dysfunction and hepatotoxicity via the induction of oxidative stress and PERK/ATF4 -mediated endoplasmic reticulum stress. Environ Pollut. 2024, 1:352:124145. doi: 10.1016/j.envpol.2024.124145.

Zhang, S.; Chen, L.; Chen, T.; Zhang, Y.; Ma, J.; Ji, H.; Guo, C.; Xiao, Z.; Li, J.; Niu, P. Transcriptome Evidence Reveals Mitochondrial Unfolded Protein Response Participate in SH-SY5Y Cells Exposed to Manganese. J. Integr. Neurosci. 2022, 21 (5). https://doi.org/10.31083/j.jin2105127.

Ji, Y.; Jiang, Q.; Chen, B.; Chen, X.; Li, A.; Shen, D.; Shen Y.; Liu, H.; Qian, X.; Yao, X.;, Sun, H. Endoplasmic reticulum stress and unfolded protein response: Roles in skeletal muscle atrophy. Biochem Pharmacol. 2025, 234:116799. doi: 10.1016/j.bcp.2025.116799.

Xiong, C.; Tang Y.; Li F.; Ye, Y.; Li, X.; Lin, J.; Dai, S. 3,3'-Diindolylmethane inhibits the proliferation of esophageal squamous cell carcinoma cells via downregulation of STIM1. 2024, 28(2): 339. doi: 10.3892/ol.2024.14473.

Liskova, M; Evinova, A.; Guzikova, J.; Hudak, L.; Pokusa, M.; Kotulova, L.; Racay, P. Impact of tauroursodeoxycholic acid and 4-phenylbutyric acid on mitochondrial functions and morphology of SH-SY5Y cells. Gen Physiol Biophys. 2025, 44(4): 275-287. doi: 10.4149/gpb_2025017.

2

Cibulka, M.; Brodnanova, M.; Grendar, M.; Necpal, J.; Benetin, J.; Han, V.; Kurca, E.; Nosal, V.; Skorvanek, M.; Vesely, B.; Stanclova, A.; Lasabova, Z.; Pös, Z.; Szemes, T.; Stuchlik, S.; Grofik, M.; Kolisek, M. Alzheimer’s Disease-Associated SNP Rs708727 in SLC41A1 May Increase Risk for Parkinson’s Disease: Report from Enlarged Slovak Study. IJMS 2022, 23 (3), 1604.

Zhang, Y.; Li, X.; Ren, K.-D.; Peng, J.; Luo, X. Restoration of Metal Homeostasis: A Potential Strategy against Neurodegenerative Diseases. Ageing Res. Rev. 2023, 87. https://doi.org/10.1016/j.arr.2023.101931.

Nemoto, T.; Tagashira, H.; Kita, T.; Kita, S.; Iwamoto, T. Functional Characteristics and Therapeutic Potential of SLC41 Transporters. J. Pharmacol. Sci. 2023, 151 (2), 88–92. https://doi.org/10.1016/j.jphs.2022.12.003.

Yang, Y.; Chen, S.; Zhang L.; Zhang, G.; Liu, Y.; Li, Y.; Zou, L.; Meng, L.; Tian, Y.; Dai, L.; Xiong, M.; Pan, L.; Xiong, J.; Chen, L.; Hou, H.; Yu, Z.; Zhang, Z. The PM20D1-NADA pathway protects against Parkinson's disease. Cell Death Differ. 2024, 31(11):1545-1560. doi: 10.1038/s41418-024-01356-9.

Cibulka, M.; Brodnanova, M.; Halasova, E.; Kurca, E.; Kolisek, M.; Grofik, M. The Role of Magnesium in Parkinson's Disease: Status Quo and Implications for Future Research. Int J Mol Sci. 2024, 25(15): 8425. doi: 10.3390/ijms25158425.

Yang, Z.; Zheng, Y.; Zhang, L.; Zhao, J.; Xu, W.; Wu, H.; Xie, T.; Ding, Y. Screening the Best Risk Model and Susceptibility SNPs for Chronic Obstructive Pulmonary Disease (COPD) Based on Machine Learning Algorithms. Int J Chron Obstruct Pulmon Dis. 2024, 5:19:2397-2414. doi: 10.2147/COPD.S478634.

3

Brodnanova, M.; Hatokova, Z.; Evinova, A.; Cibulka, M.; Racay, P. Differential Impact of Imipramine on Thapsigargin- and Tunicamycin-Induced Endoplasmic Reticulum Stress and Mitochondrial Dysfunction in Neuroblastoma SH-SY5Y Cells. European Journal of Pharmacology 2021, 902, 174073. https://doi.org/10.1016/j.ejphar.2021.174073.

Asensi-Cantó, A.; López-Abellán, M. D.; Castillo-Guardiola, V.; Hurtado, A. M.; Martínez-Penella, M.; Luengo-Gil, G.; Conesa-Zamora, P. Antitumoral Effects of Tricyclic Antidepressants: Beyond Neuropathic Pain Treatment. Cancers 2022, 14 (13), 3248. https://doi.org/10.3390/cancers14133248.

Evinova, A.; Baranovicova, E.; Hajduchova, D.; Dibdiakova, K.; Baranova, I.; Racay P.; Strnadel, J.; Pecova, E.; Halasova E.; Pokusa, M. The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson's disease model using SH-SY5Y cells depends on their differentiation state. J Bioenerg Biomembr. 2024, 56(4):347-360. doi: 10.1007/s10863-024-10018-x.

Umano, A.; Fang, K.; Qu, Z.; Scaglione, J.; Altinok, J.; Treadway, C.; Wick, E.; Paulakonis, E.; Karunanayake, C.; Chou, S.; Bardakjian, T.; Gonzalez-Alegre, P.; Page, R.; Schisler, J.; Brown, N.; Yan, D.; Scaglione, K. The molecular basis of spinocerebellar ataxia type 48 caused by a de novo mutation in the ubiquitin ligase CHIP. J Biol Chem. 2022, 298(5):101899. doi: 10.1016/j.jbc.2022.101899.

Lusa, W.; Rozpędek-Kamińska, W.; Siwecka, N.; Galita, G.; Majsterek, I.; Kucharska, E. Small‑molecule PKR‑like Endoplasmic Reticulum Kinase Inhibitors as a Novel Targeted Therapy for Parkinson’s Disease. Mol. Med. Rep. 2023, 27 (5), 1–15. https://doi.org/10.3892/mmr.2023.12989.

Talati, M. N.; Vemireddy, S.; Seelam, S. D.; Halmuthur. M, S. K. Synthesis and Immunomodulatory Activity of Novel Amino Acid Analogues of Fluoxetine. Synth. Commun. 2023, 53 (10), 731–743. https://doi.org/10.1080/00397911.2023.2196024.

4

Cibulka, M.; Brodnanova, M.; Grendar, M.; Grofik, M.; Kurca, E.; Pilchova, I.; Osina, O.; Tatarkova, Z.; Dobrota, D.; Kolisek, M. SNPs Rs11240569, Rs708727, and Rs823156 in SLC41A1 Do Not Discriminate Between Slovak Patients with Idiopathic Parkinson’s Disease and Healthy Controls: Statistics and Machine-Learning Evidence. IJMS 2019, 20 (19), 4688.

Mei, J.; Desrosiers, C.; Frasnelli, J. Machine Learning for the Diagnosis of Parkinson’s Disease: A Review of Literature. Front. Aging Neurosci. 2021, 13. https://doi.org/10.3389/fnagi.2021.633752.

Rana, A.; Dumka, A.; Singh, R.; Panda, M. K.; Priyadarshi, N.; Twala, B. Imperative Role of Machine Learning Algorithm for Detection of Parkinson’s Disease: Review, Challenges and Recommendations. Diagnostics 2022, 12 (8). https://doi.org/10.3390/diagnostics12082003.

Rana, A.; Dumka, A.; Singh, R.; Rashid, M.; Ahmad, N.; Panda, M. K. An Efficient Machine Learning Approach for Diagnosing Parkinson’s Disease by Utilizing Voice Features. Electron. Switz. 2022, 11 (22). https://doi.org/10.3390/electronics11223782.

Rana, A.; Dumka, A.; Singh, R.; Panda, M. K.; Priyadarshi, N. A Computerized Analysis with Machine Learning Techniques for the Diagnosis of Parkinson’s Disease: Past Studies and Future Perspectives. Diagnostics 2022, 12 (11). https://doi.org/10.3390/diagnostics12112708.

Cibulka, M.; Brodnanova, M.; Grendar, M.; Necpal, J.; Benetin, J.; Han, V.; Kurca, E.; Nosal, V.; Skorvanek, M.; Vesely, B.; Stanclova, A.; Lasabova, Z.; Pös, Z.; Szemes, T.; Stuchlik, S.; Grofik, M.; Kolisek, M. Alzheimer’s Disease-Associated SNP Rs708727 in SLC41A1 May Increase Risk for Parkinson’s Disease: Report from Enlarged Slovak Study. Int. J. Mol. Sci. 2022, 23 (3). https://doi.org/10.3390/ijms23031604.

5

Cibulka, M.; Brodnanova, M.; Halasova, E.; Kurca, E.; Kolisek, M.; Grofik, M. The Role of Magnesium in Parkinson's Disease: Status Quo and Implications for Future Research. Int J Mol Sci. 2024, 25(15):8425. doi: 10.3390/ijms25158425.

Graves, N.; Jaafar, A.; Gambin, Y.; Sierecki, E. Divalent and Trivalent Metallic Ions Differentially Affect Alpha-Synuclein Aggregation. ACS Chem Neurosci. 2025, 16(18):3497-3512. doi: 10.1021/acschemneuro.5c00160.

Guk, J.; Lokominienė, R.; Jatužis D. Use of nutritional supplements and other complementary medicine methods among patients with Parkinson's disease in Lithuania. Front Neurol. 2025, 7:16:1581590. doi: 10.3389/fneur.2025.1581590.

Khan, M.; Zhou, Q.; Guo, J.; Liu L.; Hu, R. Integrated LIBS-Raman spectroscopy coupled with explainable machine learning for biochemical characterization of melanoma. Spectrochim Acta A Mol Biomol Spectrosc. 2026, 9:353:127576. doi: 10.1016/j.saa.2026.127576.

Weiye, Z.; Xudan, W.; He, Q.; Hongtao, T.; Xun, Q. The Role of Magnesium in Liver Cirrhosis. Portal Hypertens. Cirrhosis. 2025, doi: 10.1002/poh2.70007.

Mohammad, F. Role of Homocysteine and water-soluble vitamins in Parkinson's disease: A case-control study in Iraq. Biosci. Appl. Res. 2025, doi: 10.21608/jbaar.2025.412305.

VI.5 - Participation in conducting (leading) the most important research projects or art projects over the last six years
1

Identification of components of magnesium homeostasis and study of the regulation in blood-brain barrier cells Project VEGA 1/0039/23. Realization: 2023 -2025. investigator

2

Determination of mitochondrial fitness in the diagnostics and prediction of Parkinson's disease. Project APVV-19-0222. Realization: 2020-2024. Total budget: 220 000 €; investigator

3

The role of the STAT3 signalling pathway in the regulation of the Na + / Mg2 + promoter of the SLC41A1 exchanger: from inflammation to Parkinson’s disease. Project VEGA 1/0554/19. Realization: 2019-2021. investigator

4

The impact of changes in expression of gene encoding magnesium transporter on cell response mechanisms in different models of endoplasmic reticulum stress. Project VEGA 1/0277/18. Realization: 2018-2021. investigator

5

The role of cellular organelles and their interactions in process of protein synthesis, modification and degradation in relation to ischemia-induced delayed neuronal death. Project APVV-16-0033. Realization: 2017-2021. Total budget: 210 000 €; investigator

VII. - Overview of organizational experience related to higher education and research/artistic/other activities

VIII. - Overview of international mobilities and visits oriented on education and research/artistic/other activities in the given field of study

VIII.a - Name of the institution VIII.b - Address of the institution VIII.c - Duration (indicate the duration of stay) VIII.d - Mobility scheme, employment contract, other (describe)
Università degli Studi di Milano Via Festa del Perdono 7 - 20122 Milano 1.6.2024 - 30.11.2025 Pracovný kontrakt na inštitúte Dipartimento di Scienze Farmacologiche e Biomolecolari Rodolfo Paoletti

IX. - Other relevant facts

Date of last update
2026-02-28