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Meno a priezvisko:
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PharmDr. Dalibor Nakládal, PhD.
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Typ dokumentu:
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Vedecko/umelecko-pedagogická charakteristika osoby
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Názov vysokej školy:
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Univerzita Komenského v Bratislave
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Sídlo vysokej školy:
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Šafárikovo námestie 6, 818 06 Bratislava
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| III.a - Zamestnanie-pracovné zaradenie | III.b - Inštitúcia | III.c - Časové vymedzenie |
|---|---|---|
| vedecký pracovník | Vedecký Park, Univerzita Komenského v Bratislave | september 2022 - |
| odborný asistent | Katedra Fyzikálnej Chémie Liečiv, Farmaceutická Fakulta, Univerzita Komenského v Bratislave | 1.9.2025 - |
| postdoc | University Medical Center Groningen, The Netherlands | 2020-2022 |
| doktorand | Katedra Farmakológie a Toxikológie, Farmaceutická Fakulta, Univerzita Komenského v Bratislave | 2015-2019 |
| PhD student | University Medical Center Groningen, The Netherlands | 2015-2022 |
| IV.a - Popis aktivity, názov kurzu (ak išlo o kurz), iné | IV.b - Názov inštitúcie | IV.c - Rok |
|---|---|---|
| Data Science Specialization | Johns Hopkins University Bloomberg School of Public Health (online course) | 2020 |
| Introduction to Genomic Technologies | Johns Hopkins University Bloomberg School of Public Health (online course) | 2015 |
| Introduction to Computer Science and Programming Using Python | Massachusetts Institute of Technology (online course) | 2015 |
| Data Analysis for Genomics | Harvard School of Public Health (online course) | 2014 |
| Scientific Integrity | University of Groningen, Holandsko | 2016 |
| Techniques in Molecular Biology | University of Groningen, Holandsko | 2016 |
| Cellular Imaging Basic | University of Groningen, Holandsko | 2016 |
| Introduction to Laboratory Animal Science | University of Groningen, Holandsko | 2016 |
| CERTARA: Phoenix Non-linear Mixed Effect Modeling | PAGE Meeting 2015, Crete, Greece | 2015 |
| Human Research Curriculum | Nova Southeastern University, Florida, USA | 2014 |
| V.1.a - Názov profilového predmetu | V.1.b - Študijný program | V.1.c - Stupeň | V.1.d - Študijný odbor |
|---|---|---|---|
| Farmaceutická fyzika | Farmácia | I.+II. | farmácia |
Benedek Halmos; Anouk M. La Rose; Daisey Methorst; Anouk G. Groenen; Dalibor Nakládal; Venetia Bazioti; Mirjam H. Koster; Niels J. Kloosterhuis; Azuwerus van Buiten; Elisabeth M. Schouten et al. (2025) “SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis.” Circulation Research. https://doi.org/10.1161/CIRCRESAHA.124.325103
Lambooy, S., Heida, A., Joschko, C., Nakladal, D., van Buiten, A., Kloosterhuis, N., Huijkman, N., Gerding, A., van de Sluis, B., Henning, R., & Deelman, L. (2023). Selective Hepatic Cbs Knockout Aggravates Liver Damage, Endothelial Dysfunction and ROS Stress in Mice Fed a Western Diet. International Journal of Molecular Sciences, 24(8), Article 8. https://doi.org/10.3390/ijms24087019
Vogelaar, P., Nakladal, D. (shared first authorship), Swart, D., Tkáčiková, Ľ., Tkáčiková, S., van der Graaf, A., Henning, R., & Krenning, G. (2021). Towards prevention of ischemia-reperfusion kidney injury: Pre-clinical evaluation of 6-chromanol derivatives and the lead compound SUL-138. European Journal of Pharmaceutical Sciences, 106033. https://doi.org/10.1016/j.ejps.2021.106033
Nakladal, D., Lambooy, S. P. H., Mišúth, S., Čepcová, D., Joschko, C. P., van Buiten, A., Goris, M., Hoogstra-Berends, F., Kloosterhuis, N. J., Huijkman, N., van de Sluis, B., Diercks, G. F., Buikema, J. H., Henning, R. H., & Deelman, L. E. (2022). Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 36(4), e22260. https://doi.org/10.1096/fj.202101550R
Lambooy, S. P. H., Bidadkosh, A., Nakladal, D., van Buiten, A., Girgis, R. A. T., van der Graaf, A. C., … Deelman, L. E. (2017). The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits Progression of Kidney Damage in Type 2 Diabetes Mellitus in Mice. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-11582-6
Feenstra, L., Chatre, L., Bernay, B., Pontin, J., Mastik, M. F., Van Buiten, A., Nakládal, D., Star, B. S., Hillebrands, J., & Krenning, G. (2025). Calciprotein particle‐induced calcium overload triggers mitochondrial dysfunction in endothelial cells. The Journal of Physiology, JP287656. https://doi.org/10.1113/JP287656
Nakládal, D., Oerlemans, R., Molitorisová, M., Chomaničová, N., Zorkócy, G., Yoseif, C., Van Der Graaf, A. C., Stuchlík, S., Krenning, G., Groves, M. R., Heeres, A., Levarski, Z., Kyselovič, J., Henning, R. H., & Deelman, L. E. (2025). New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase. SLAS Discovery, 32, 100234. https://doi.org/10.1016/j.slasd.2025.100234
Nakládal, D. (2022). Drug development and new targets for redox disturbances in experimental vascular disease: [Dissertation Thesis, University of Groningen]. https://doi.org/10.33612/diss.233870509
Nakladal, D., Sijbesma, J. W. A., Visser, L. M., Tietge, U. J. F., Slart, R. H. J. A., Deelman, L. E., Henning, R. H., Hillebrands, J. L., & Buikema, H. (2021). Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats. Vascular Pharmacology, 106945. https://doi.org/10.1016/j.vph.2021.106945
Nakladal, D., Buikema, H., Romero, A. R., Lambooy, S. P. H., Bouma, J., Krenning, G., … Deelman, L. E. (2019). The (R)-enantiomer of the 6-chromanol derivate SUL-121 improves renal graft perfusion via antagonism of the α1-adrenoceptor. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-018-36788-0
Sijbesma, J. W. A., Van Waarde, A., Kristensen, S., Kion, I., Tietge, U. J. F., Hillebrands, J.-L., Bulthuis, M. L. C., Buikema, H., Nakladal, D., Westerterp, M., Liu, F., Boersma, H. H., Dierckx, R. A. J. O., & Slart, R. H. J. A. (2023). Characterization of a novel model for atherosclerosis imaging: The apolipoprotein E-deficient rat. EJNMMI Research, 13(1), 106. https://doi.org/10.1186/s13550-023-01055-5
Rodriguez, R. D., Huizing, E., Ünlü, Ç., Simonis, F. F. J., Bokkers, R. P. H., De Vries, J.-P. P. M., Schuurmann, R. C. L., Nakladal, D., Buikema, H., Hillebrands, J.-L., & Leuvenink, H. G. D. (2023). Validation of an ex vivo Flow Model Including Magnetic Resonance Imaging to Study the Effects of Endovascular Treatments on the Arterial Wall. Journal of Vascular Research, 60(1), 1–11. https://doi.org/10.1159/000529115
Jorna, Lysanne M., Dalibor Nakládal, Johannes N. Van Heuveln, Diederik E. Van Der Feen, Quint A. J. Hagdorn, Guido P. L. Bossers, Annemieke Van Oosten, Michel Weij, Ludmila Tkáčiková, Soňa Tkáčiková, Robert H. Henning, Martin C. Harmsen, Rolf M. F. Berger, and Guido Krenning. 2025. “SUL-150 Limits Vascular Remodeling and Ventricular Failure in Pulmonary Arterial Hypertension.” International Journal of Molecular Sciences 26(15):7181. doi:10.3390/ijms26157181.
Hernández-Camacho, Juan D., Michel Bernier, Guillermo López-Lluch, and Plácido Navas. 2018. “Coenzyme Q10 Supplementation in Aging and Disease.” Frontiers in Physiology 9:44. doi: 10.3389/fphys.2018.00044.
Vývoj inovatívnych liečiv cieliacich biochémiu síry (TREATSULF), APVV-23-0178, 2024-2026, hlavný riešiteľ
High-throughput skríning pre objav nových liečiv upravujúcich narušený metabolizmus síry v diabetickej nefropatii a rakovine hrubého čreva, VEGA 1/0619/24, 2024-2026, hlavný riešiteľ
Discovery and development of new drugs for treatment of diabetic kidney disease: counteracting transsulfuration deficiency to improve defense against oxidative stress, APVV PP-MSCA2022-0001 (Marie Skłodowska-Curie Actions Seal of Excellence), 2022-2024, hlavný riešiteľ
Discovery and development of new drugs for treatment of diabetic kidney disease: counteracting transsulfuration deficiency to improve defense against oxidative stress, Slovak Academic and Scientific Programme (SASPRO2) 3333/03/02, 2022-2025, research fellow.
European Lead Factory program (2021-2022): Ultra-High-Throughput-Screening of large academic/commercial library for the discovery of allosteric modulators of Cystathionine-β-synthase. PivotPark Screening Center in Oss, the Netherlands; Bio:ascent, Scotland.
| VII.a - Aktivita, funkcia | VII.b - Názov inštitúcie, grémia | VII.c - Časové vymedzenia pôsobenia |
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| Komisia pre organizovanie aktivít PhD študentov | PhD student committee, Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Holandsko | 2020-2022 |
| VIII.a - Názov inštitúcie | VIII.b - Sídlo inštitúcie | VIII.c - Obdobie trvania pôsobenia/pobytu (uviesť dátum odkedy dokedy trval pobyt) | VIII.d - Mobilitná schéma, pracovný kontrakt, iné (popísať) |
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| Nova Southeastern University | Davie, Florida, USA | 1.1.2014 - 30.6.2014 | Národný Štipendijný Program Slovenskej Republiky, SAIA |
| Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Holandsko | Groningen, Holandsko | 01.09.2018 - 31.08.2019 | Národný Štipendijný Program Slovenskej Republiky, SAIA |
Rigorózne konanie
30/10/2015 – 26/03/2018 Farmaceutická fakulta, študijný program Farmácia, práca: The (R)-enantiomer of the 6-chromanol derivate SUL-121 counteracts renal vasoconstriction by antagonism of the α1-adrenoceptor
Ocenenia
01/01/2022 – 31/12/2022 Top Downloaded Article
The FASEB Journal (Federation of American Societies for Experimental Biology, Wiley), article: Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia
05/05/2022 Marie Skłodowska-Curie Actions Seal of Excellence 101062114
Submitted under the Horizon Europe Marie Skłodowska-Curie Actions call HORIZON-MSCA-2021-PF-01-01 — MSCA Postdoctoral Fellowships 2021. Project proposal (unfunded): Discovery and development of new drugs for treatment of diabetic kidney disease: counteracting transsulfuration deficiency to improve defense against oxidative stress.
24/11/2018 Best 1-minute PhD thesis pitch
Drug Development Game: Experimental Section, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology
17/11/2015 Academic Acknowledgement from the Rector of Comenius University
Outstanding Diploma Thesis: Blood-Based Genomic Signature For Autism Spectrum Disorders
17/09/2015 EPHAR Poster Award
Conference: 65th Czech-Slovak Pharmacology Days in Prague, The Federation of European Pharmacological Societies; Poster: Blood-Based Genomic Signature for Autism Spectrum Disorders
19/10/2015 Slovak Patient award for most liked article
University Cup in writing articles for patient audiences (public outreach). Article: Autism: Diagnosis and available supplementary therapies