ADM  Vedecké práce v zahraničných časopisoch registrovaných v databázach Web of Science alebo SCOPUS

Factors Influencing Persistence of Diphtheria Immunity and Immune Response to a Booster Dose in Healthy Slovak Adults

Authors: Marek Petráš, Vladimír Oleár, Milica Molitorisová, et al.

Published in 2019, Vaccines [online], Vol. 7, no 4 (2019), p. 1-9, art. no.139

AKK-UKOFA-5214 A+

Počet ohlasov: 5

Key outcomes

Booster immunisation against diphtheria in adults carried out with bivalent tetanus-diphtheria vaccines produced a protective immune response dependent on persistent levels of diphtheria antibodies prior to the booster dose. The persistence of antibody levels is the key predictor of seroprotection achievement correlating with time since the last vaccination.

Therefore, two-dose vaccination should be considered, in an emergency, in recipients with the last dose received >34 years earlier. Based on our data, we can further anticipate a higher increase in diphtheria antibodies more often in non-smokers and in adults without statin treatment. If these factors have any clinical impact on protection against diphtheria is yet to be established.

V3 Vedecký výstup publikačnej činnosti z časopisu:

Has Mutual Recognition in the EU Failed?-A Legal-Empirical Analysis on the Example of Food Supplements Containing Botanicals and Other Bioactive Substances

Authors: Warda, Roman (Korešpondenčný autor) (33.334%) - Purnhagen, K. (Autor) (33.333%) - Molitorisová, Milica (Autor) [UKOFAG] (33.333%)

– text, tab. – [recenzované]. – DOI 10.1007/s10603-024-09571-0. – OA ; SCO ; WOS CC.

In: Journal of consumer policy [textový dokument (print)] : consumer issues in law, economics and behavioural sciences. – New York (USA): Springer Nature. Springer. – ISSN 0168-7034. – ISSN (online) 1573-0700. – Roč. 47, č. 3 (2024), s. 425-443 [tlačená forma]

AKK-UKOFA-5214 A

Key outcomes

Our research highlighted the fragmentation of food supplement regulation at the EMS level regarding the responsible authorities’ legislative frameworks and regulatory practices. It also endorsed the claim that the functionality of mutual recognition is dependent on EMS acceptance and illustrated that mutual recognition of food supplements is not accepted by EMS and hence not functional as a governance mode in practice. We assume that the fragmentation of the regulation of food supplements in the EU is associated with the dysfunctionality of mutual recognition of food supplements at the EU level. Strengthening the harmonization of food supplement regulation could enhance access to safe food supplements and the free movement of goods throughout the EU. Improved secondary legislation on product safety databases or communication procedures between authorities should be considered. Initiatives such as the BELFRIT project demonstrate that this is explicitly desired by EMS. Continued research in this area, with a focus on the involvement of other EU countries and an inclusion of new participants, e.g., business operators, food supplement quality and safety laboratories, consumers, and others, could initiate a deep revision and acceleration of the food supplement harmonization by all relevant stakeholders.

ACD Kapitoly vo vysokoškolských učebniciach vydané v domácich vydavateľstvách

Etické otázky v súčasnej vakcinológii

Authors: Glasová, Helena (Author) (50%) - Molitorisová, Milica (Author)

In: Kapitoly z vakcinológie 1 [textový dokument (print)] . – 1 vyd. – Banská Bystrica : PRO, 2014. – ISBN 978-80-89057-52-8, s. 259-281

Počet všetkých autorov: 2

[kapitola]

ADN Vedecké práce v domácich časopisoch registrovaných v databázach Web of Science alebo SCOPUS

Počet výstupov: 2

Support of medication adherence by community pharmacists in Czech and Slovak Republics: a questionnaire survey study

Authors: Milica Molitorisová, Iveta Waczulíková, Jana Kotlářová... [et al.]

Published in 2018, European Pharmaceutical Journal [online], Vol 65, No 1 (2018), p. 15-23; SCOPUS

Počet ohlasov: 2

Key outcomes

Intervention of pharmacists in medication adherence can meaningfully contribute to achieving therapeutic outcomes. Exploring the real-life readiness and opportunities of pharmacists may result in the adoption of measures, which could be seen through improvement of patients ́ adherence to pharmacotherapy.

The pharmaceutical care is developing towards the improvement of medication adherence in both countries, the Czech Republic and Slovakia, assuming a medium degree of adherence support. Further progress may be observed in strengthening the pharmacists’ personnel capacities, and accelerated mainly using information technologies.

ADM  Vedecké práce v zahraničných časopisoch registrovaných v databázach Web of Science alebo SCOPUS

Factors Influencing Persistence of Diphtheria Immunity and Immune Response to a Booster Dose in Healthy Slovak Adults

Authors: Marek Petráš, Vladimír Oleár, Milica Molitorisová, et al.

Published in 2019, Vaccines [online], Vol. 7, no 4 (2019), p. 1-9, art. no.139

AKK-UKOFA-5214 A+

Počet ohlasov: 5

Key outcomes

Booster immunisation against diphtheria in adults carried out with bivalent tetanus-diphtheria vaccines produced a protective immune response dependent on persistent levels of diphtheria antibodies prior to the booster dose. The persistence of antibody levels is the key predictor of seroprotection achievement correlating with time since the last vaccination.

Therefore, two-dose vaccination should be considered, in an emergency, in recipients with the last dose received >34 years earlier. Based on our data, we can further anticipate a higher increase in diphtheria antibodies more often in non-smokers and in adults without statin treatment. If these factors have any clinical impact on protection against diphtheria is yet to be established.

V3 Vedecký výstup publikačnej činnosti z časopisu:

Has Mutual Recognition in the EU Failed?-A Legal-Empirical Analysis on the Example of Food Supplements Containing Botanicals and Other Bioactive Substances

Authors: Warda, Roman (Korešpondenčný autor) (33.334%) - Purnhagen, K. (Autor) (33.333%) - Molitorisová, Milica (Autor) [UKOFAG] (33.333%)

– text, tab. – [recenzované]. – DOI 10.1007/s10603-024-09571-0. – OA ; SCO ; WOS CC.

In: Journal of consumer policy [textový dokument (print)] : consumer issues in law, economics and behavioural sciences. – New York (USA): Springer Nature. Springer. – ISSN 0168-7034. – ISSN (online) 1573-0700. – Roč. 47, č. 3 (2024), s. 425-443 [tlačená forma]

AKK-UKOFA-5214 A

Key outcomes

Our research highlighted the fragmentation of food supplement regulation at the EMS level regarding the responsible authorities’ legislative frameworks and regulatory practices. It also endorsed the claim that the functionality of mutual recognition is dependent on EMS acceptance and illustrated that mutual recognition of food supplements is not accepted by EMS and hence not functional as a governance mode in practice. We assume that the fragmentation of the regulation of food supplements in the EU is associated with the dysfunctionality of mutual recognition of food supplements at the EU level. Strengthening the harmonization of food supplement regulation could enhance access to safe food supplements and the free movement of goods throughout the EU. Improved secondary legislation on product safety databases or communication procedures between authorities should be considered. Initiatives such as the BELFRIT project demonstrate that this is explicitly desired by EMS. Continued research in this area, with a focus on the involvement of other EU countries and an inclusion of new participants, e.g., business operators, food supplement quality and safety laboratories, consumers, and others, could initiate a deep revision and acceleration of the food supplement harmonization by all relevant stakeholders.

ADN Vedecké práce v domácich časopisoch registrovaných v databázach Web of Science alebo SCOPUS

Characterization of bioactive substances MHGF-68 on tumour cell lines with LiveFlow In Vitro Technology

Autori: Nováková, Eva (Autor) [UKOPRBMV] (30%) - Macková, K. (Autor) (3%) - Molitorisová, Milica (Autor) [UKOFAG] (10%) - Šupolíková, Miroslava (Korešpondenčný autor) [UKOPRBMV] (40%):

Published in 2021, European Pharmaceutical Journal 68(1): 000010247820200021DOI: 10.2478/afpuc-2020-0021. License CC BY-NC-ND 3.0

AKK-UKOFA-5214 B

Key outcomes

As part of experimental research, growth factor-like substances associated with MHV-68, named MHGF-68, were discovered in our laboratory. MHGF-68 activity was manifested by the ability to alter cell morphology, that is, normal phenotype to transformed, resp. suppresses the transformed phenotype of tumour cells. The aim of the experiments was to monitor the effect of MHGF-68 on the change of the cell actin cytoskeleton in the tumour cell line Hepa1c1c7, as well as the normal cell line NIH3T3, and compare conventional stationary cultivation and dynamic cultivation conditions using a LiveFlow system (In Vitro Technologies). LiveFlow is an advanced system to test the impact of different compounds on the cell cultures, which allows simulation of in vivo conditions thanks to continuous flow of cultivation medium. MHGF-68 was prepared with the infection of BHK-21 cells with MHV-68 virus under non-permissive conditions (41°C). After dynamic cultivation with MHGF-68, we observed changes in morphology on Hepa1c1c7 cells. In cells cultured in a dynamic environment, we observed more pronounced changes in cell morphology in comparison with cells cultured statically. We observed no changes in the cytoskeletal structures in the NIH 3T3 cell line affected by MHGF-68 in both types of cultivation. The advantage of LiveFlow in comparison to in vivo testing is that the experiments performed in this system are less time and money consuming. Dynamic cultivation in the LiveFlow system is suitable for optimizing experiments before testing substances in vivo.

Factors Influencing Persistence of Diphtheria Immunity and Immune Response to a Booster Dose in Healthy Slovak Adults

Autori: Marek Petráš, Vladimír Oleár, Milica Molitorisová, a spol.

Vydané 2019, Vaccines [elektronický dokument]. - Roč. 7, č. 4 (2019), s. 1-9, art. no.139 [online]

Kľúčové ohlasy: 5

2024 [01/20] / GBR - Srivastava, Varshita - Godara, Priya - Jena, Sudip Prasad - Naik, Biswajit - Singh, Satyendra - Prajapati, Vijay Kumar - Prusty, Dhaneswar. Peptide-ligand conjugate based immunotherapeutic approach for targeted dismissal of non-structural protein 1 of dengue virus: A novel therapeutic solution for mild and severe dengue infections [elektronický dokument]. DOI 10.1016/j.ijbiomac.2024.129562 In: International Journal of Biological Macromolecules: Structure, Function and Interactions. Oxford: Elsevier, 2024, Roč. 260, č. Part 2, art. no. 129562, s. [1-17] [tlačená forma] [online]. ISSN 0141-8130. ISSN (online) 1879-0003. - SCO ; CCC ; WOS CC ; SCIE, s. [1 - 17]

2024 [01/20] / CHE - Papagiannis, Dimitrios - Thireos, Eleftherios - Mariolis, Anargiros - Katsioulis, Antonios - Lampropoulos, Ioannis Ch - Tsiaousi, Ioanna - Gartzonika, Kostantina - Malliaraki, Niki - Malli, Foteini - Rouka, Erasmia C. - Marinos, Georgios - Symvoulakis, Emmanouil K. - Rachiotis, Georgios - Gourgoulianis, Konstantinos I. Diphtheria and Tetanus Immunity Status among Greek Adults: Results from a Nationwide Seroprevalence Study [elektronický dokument]. DOI 10.3390/vaccines12040378 In: Vaccines. Basel: Multidisciplinary Digital Publishing Institute, 2024, Roč. 12, č. 4, Article number 378 [online]. ISSN (online) 2076-393X. - SCO ; WOS CC

2022 [01/20] / CHE - Ferrara, Pietro - Gianfredi, Vincenza - Tomaselli, Venera - Polosa, Riccardo. The Effect of Smoking on Humoral Response to COVID-19 Vaccines: A Systematic Review of Epidemiological Studies [elektronický dokument]. DOI 10.3390/vaccines10020303 In: Vaccines. Basel: Multidisciplinary Digital Publishing Institute, 2022, Roč. 10, č. 2, art. no. 303 [online]. ISSN (online) 2076-393X. - SCO ; WOS CC ; SCIE

2021 [01/20] / POL - Lesichkova, S. - Mihailova, S. - Mihaylova, A. - Gesheva, N. - Yankova, P. - Naumova, E. Age-related dynamics in post-vaccine antibody immune response to diphtheria and tetanus toxoid in bulgarian subjects [elektronický dokument]. DOI 10.2478/amb-2021-0007 In: Acta Medica Bulgarica. Varšava:

De Gruyter Poland, 2021, Roč. 48, č. 1, 46-52 [tlačená forma] [online]. ISSN 0324-1750. ISSN (online) 2719-5384. - SCO, s. 46 - 52

2021 [01/20] / CUB - Torres-Rives, Bárbara - Martínez-Téllez, Goitybell - Matarán-Valdés, Minerva - Osorio-Ilas, Lisi - Vilches-Lescaille, Daysi - Rodríguez-Pelier, Cira - Zúñiga-Rosales, Yaíma - Collazo-Mesa, Teresa. Tetanus and diphtheria antitoxin levels related to the hla-b27 allele in cuban patients with non-infectious anterior uveitis [elektronický dokument] In: VacciMonitor. Havana: Instituto Finlay, 2021, Roč. 30, č. 1, 10-17 [tlačená forma] [online]. ISSN 1025028X. ISSN (online) 10250298. - SCO, s. 10 - 17

Support of medication adherence by community pharmacists in Czech and Slovak Republics: a

questionnaire survey study

Autori Milica Molitorisová , Iveta Waczulíková, Jana Kotlářová... [a spol.]

Publikované 2018, European Pharmaceutical Journal [online]. - Roč. 65, č. 1 (2018), s. 15-23; SCOPUS

Kľúčové ohlasy: 2

2024 [01/20] / NZL - Limenh, Liknaw Workie - Tessema, Tewodros Ayalew - Simegn, Wudneh - Ayenew, Wondim - Bayleyegn, Zemenu Wube - Sendekie, Ashenafi Kibret - Chanie, Gashaw Sisay - Fenta, Eneyew Talie - Beyna, Alemante Tafese - Kasahun, Asmamaw Emagn. Patients’ Preference for Pharmaceutical Dosage Forms: Does It Affect Medication Adherence? A Cross-Sectional Study in Community Pharmacies [elektronický dokument]. DOI 10.2147/PPA.S456117 In: Patient Preference and Adherence. Auckland: Dove Medical Press, 2024, č. 18, s. 753-766 [online]. ISSN (online) 1177-889X. - SCO ; OA ; WOS CC ; SCIE, s. 753 - 766

2020 [01/12] / NZL - Parente, Marco - Pignata, Irene - Gnavi, Roberto - Spadea, Teresa - Di Martino, Mirko - Baratta, Francesca - Brusa, Paola. Assessment of non-adherence to oral metformin and atorvastatin therapies: A cross-sectional survey in piedmont (Italy) [elektronický dokument]. DOI 10.2147/PPA.S226206 In: Patient Preference and Adherence. Auckland: Dove Medical Press, 2020, Roč. 14, č. 14

Projekt: APVV

• Číslo projektu: APVV-20-0158
• Názov projektu: "Identification of new treatment options in refractory testicular germcell tumors".
• Zodpovedný riešiteľ: LF UK v Bratislave/ Koordinátor: prof. MUDr. Michal Mego, DrSc.
• Spoluriešiteľ: FaF UK, Katedra galenickej farmácie
• Doba riešenia projektu: 07/2021 – 06/2025                                                                  
• Celková ročná hodinová kapacita projektu za rok 2023: 0,- FaFUK
• - pedagogickí pracovníci katedry: 150 h M. Molitorisová

• Anotácia: Testicular germ cell tumors (TGCTs) are the most common tumors in young males with increasing incidence in Slovakia and resemble the clinical and biological characteristics of a model for the cure of cancer. Nonetheless, a small proportion of patients does not have a durable complete remission with initial cisplatin-based chemotherapy. Only 20–40% of them can be cured with the use of platinum-containing standard-dose or high-dose salvage chemotherapy with autologous stem cell transplantation. Patients who fail to be cured after second-line salvage therapy have an extremely poor prognosis and long-term survival had been documented in <5%. Numerous new treatment regimens, including targeted and biological therapies, have been evaluated in patients with refractory TGCT, however, with very limited efficacy. The aim of this project is to identify new therapeutic targets in chemorefractory disease using high-throughput methods of molecular biology through translational research and to identify new drugs that overcomes cisplatin resistance.