Name and surname:
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Mgr. Jaroslav Tóth, PhD.
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Document type:
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Research/art/teacher profile of a person
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The name of the university:
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Comenius University Bratislava
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The seat of the university:
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Šafárikovo námestie 6, 818 06 Bratislava
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III.a - Occupation-position | III.b - Institution | III.c - Duration |
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University teacher, Assistant Professor, Associate Professor | Comenius University Bratislava, Faculty of Pharmacy | 01.10.1998 – |
IV.a - Activity description, course name, other | IV.b - Name of the institution | IV.c - Year |
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Basics of pedagogy for teachers of medical and pharmaceutical disciplines | Institute for Further Education of Healthcare Workers, Bratislava | 1996 |
International holiday course in German language and culture | Heidelberg University (Ruprecht-Karls-Universität Heidelberg), Germany | 1994 |
General State Language Examination in German Language | State Language School in Košice (Jazyková škola v Košiciach), Kováčska 28 | 1990 |
Summer School of HPLC and GC | Slovak University of Technology in Bratislava, Faculty of Chemical and Food Technology, Institute of Analytical Chemistry | 2004, 2001, 2000 |
V.1.a - Name of the profile course | V.1.b - Study programme | V.1.c - Degree | V.1.d - Field of study |
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Pharmacognosy (1) | Pharmacy | I.+II. | Pharmacy |
Pharmacognosy (2) | Pharmacy | I.+II. | Pharmacy |
Diploma Thesis Preparation (1) | Pharmacy | I.+II. | Pharmacy |
Diploma Thesis Preparation (2) | Pharmacy | I.+II. | Pharmacy |
Diploma Thesis Preparation (3) | Pharmacy | I.+II. | Pharmacy |
V.5.a - Name of the course | V.5.b - Study programme | V.5.c - Degree | V.5.d - Field of study |
---|---|---|---|
Safety of Herbal Medicines and Food Supplements | Pharmacy | I.+II. | Pharmacy |
ADC
Tóth, Jaroslav [UKOFAFG] - Remko, Milan [UKOFAFCH] - Nagy, Milan [UKOFAFG]:
Structural Study of Flavonoids and Their Protonated Forms.
In: Zeitschrift für Naturforschung Section C - A Journal of Biosciences. - Vol. 51, No. 11-12 (1996), s. 784-790. - ISSN 0939-5075
Citations (10)
ADC
Mrlianová, Mária - Tekeľová, Daniela [UKOFAFG] - Felklová, Melanie - Reinöhl, Vilém - Tóth, Jaroslav [UKOFAFG]:
The Influence of the Harvest Cut Height on the Quality of the Herbal Drugs Melissae folium and Melissae herba
Lit. 20 zázn.
In: Planta Medica. - Vol. 68, No. 2 (2002), s. 178-180. - ISSN 0032-0943
Citations (34)
ADC
Speijers, Gerrit - Bottex, Bernard - Dusemund, Birgit - Lugasi, Andrea - Tóth, Jaroslav [UKOFAFG] - Amberg-Müller, Judith - Galli, Corrado L. - Silano, Vittorio - Rietjens, Ivonne M. C. M.:
Safety assessment of botanicals and botanical preparations used as ingredients in food supplements: testing an European Food Safety Authority-tiered approach
Lit. 75 zázn.
In: Molecular Nutrition & Food Research. - Vol. 54, No. 2 (2010), s. 175-185. - ISSN 1613-4125
Citations (29)
ADC
Czigle, Szilvia [UKOFAFG] - Tóth, Jaroslav [KAUT] [UKOFAFG] - Háznagy-Radnai, Erzsébet - Csupor, Dezsö - Jedlinszki, Nikoletta - Tekeľová, Daniela [UKOFAFG]:
Ginkgo biloba food supplements on the European market - Adulteration patterns revealed by quality control of selected samples
In: Planta Medica. - Roč. 84, č. 6-7 (2018), s. 475-482. - ISSN (print) 0032-0943
Citations (38)
ADC
Koutsoulas, Antonios [UKOFAFG] - Čarnecká, Martina - Slanina, Jiří - Tóth, Jaroslav [KAUT] [UKOFAFG] - Slaninová, Iva [KAUT]:
Characterization of Phenolic Compounds and Antiproliferative Effects of Salvia pomifera and Salvia fruticosa Extracts
In: Molecules. - Roč. 24, č. 16 (2019), s. [1-18], art. no. 2921. - ISSN (online) 1420-3049
Citations (36)
V3 / Czigle, Szilvia - Nagy, Milan - Mladěnka, Přemysl - Tóth, Jaroslav : Pharmacokinetic and pharmacodynamic herb-drug interactions—part I. Herbal medicines of the central nervous system. – DOI 10.7717/peerj.16149. – OA ; SCO ; WOS CC ; CCC.
In: PeerJ : Peerj INC. – ISSN (online) 2167-8359. – Roč. 11, č. November 15 (2023), art. no. e16149, s. [1-51]
Citations (3)
V3 / Chrastina, Martin - Poništ, Silvester - Tóth, Jaroslav - Czigle, Szilvia - Pašková, Ľudmila - Vyletelová, Veronika - Švík, Karol - Bauerová, Katarína : Combination Therapy of Carnosic Acid and Methotrexate Effectively Suppressed the Inflammatory Markers and Oxidative Stress in Experimental Arthritis. – DOI 10.3390/molecules27207115. – WOS CC ; SCO ; MEDLINE® ; CCC ; SCIE ; OA.
In: Molecules : Multidisciplinary Digital Publishing Institute. – ISSN (online) 1420-3049. – Roč. 27, č. 20 (2022), art. no. 7115, s. [1-16]
Citations (1)
V3 / Mammari, Nour - Albert, Quentin - Devocelle, Marc - Kenda, Maša - Kočevar Glavač, Nina - Sollner Dolenc, Marija - Mercolini, Laura - Tóth, Jaroslav - Nagy, Milan - Czigle, Szilvia - Varbanov, Mihayl : Natural Products for the Prevention and Treatment of Common Cold and Viral Respiratory Infections. – DOI 10.3390/ph16050662. – OA ; CCC ; SCO ; WOS CC.
In: Pharmaceuticals : Multidisciplinary Digital Publishing Institute. – ISSN (online) 1424-8247. – Roč. 16, č. 5 (2023), art. no. 662, s. [1-25]
Citations (8)
ADC
Barkociová, Michaela [UKOFAFG] - Tóth, Jaroslav [KAUT] [UKOFAFG] - Sutor, Katarzyna - Drobnicka, Natalia - Wybraniec, Slawomir - Dudík, Boris [UKOFABM] - Bilková, Andrea [UKOFABM] - Czigle, Szilvia [KAUT] [UKOFAFG]:
Betalains in Edible Fruits of Three Cactaceae Taxa – Epiphyllum, Hylocereus, and Opuntia – Their LC-MS/MS and FTIR Identification and Biological Activities Evaluation [elektronický dokument]
In: Plants-Basel [elektronický dokument]. - Roč. 10, č. 12 (2021), s. [1-15], art. no. 2669 [online]. - ISSN (online) 2223-7747
Citations (11)
V3
Czigle, Szilvia [KAUT] [UKOFAFG] - Bittner Fialová, Silvia [UKOFAFG] - Tóth, Jaroslav [UKOFAFG] - Mučaji, Pavel [UKOFAFG] - Nagy, Milan [UKOFAFG]:
Treatment of Gastrointestinal Disorders-Plants and Potential Mechanisms of Action of Their Constituents
In: Molecules. - Roč. 27, č. 9 (2022), s. [1-35], art. no. 2881. - ISSN (online) 1420-3049
Citations (14)
ADC
Volleková, Anna - Košťálová, Daniela - Kettmann, Viktor - Tóth, Jaroslav [UKOFAFG]:
Antifungal activity of Mahonia aquifolium extract and its major protoberberine alkaloids
In: Phytotherapy Research. - Vol. 17, No. 7 (2003), s. 834-837. - ISSN 0951-418X
Citations (105)
ADC
Tekeľová, Daniela [UKOFAFG] - Zemková, E. - Tóth, Jaroslav [UKOFAFG] - Repčák, Miroslav [UKOEXRP]:
Quantitative changes of dianthrones, hyperforin and flavonoids content in the flower ontogenesis of Hypericum perforatum
In: Planta Medica. - Vol. 66, No. 8 (2000), s. 778-780. - ISSN 0032-0943
Citations (71)
ADC
Miadoková, Eva [UKOPRBGEs] - Mašterová, Irena - Vlčková, Viera [UKOPRBGE] - Dúhová, Viola [UKOPRBGE] - Tóth, Jaroslav [UKOFAFG]:
Antimutagenic potential of homoisoflavonoids from Muscari racemosum
In: Journal of Ethnopharmacology. - Vol. 81, No. 3 (2002), s. 381-386. - ISSN 0378-8741
Citations (51)
ADE
Čerňáková, Marta - Košťálová, Daniela - Kettmann, Viktor - Poldová, Miriam - Tóth, Jaroslav [UKOFAFG] - Dřímal, Ján:
Potential Antimutagenic Activity of Berberine, a Constituent of Mahonia aquifolium
In: BMC Complementary and Alternative Medicine. - Vol. 2, No. 2 (2002), s. 1-6
Citations (46)
AED
Tóth, Jaroslav [UKOFAFG] - Mrlianová, Mária - Tekeľová, Daniela [UKOFAFG] - Koreňová, Marcela [UKOFAHO]:
Rosmarinic Acid - An Important Phenolic Active Compound of Lemon balm (Melissa officinalis L.)
In: Acta Facultatis Pharmaceuticae Universitatis Comenianae, roč. 50. - Bratislava : Univerzita Komenského, 2003. - S. 139-146. - ISBN 80-223-1879-5
URL: http://www.fpharm.uniba.sk/Dokumenty/Acta_Facultatis/L/Pharm-15%20Tóth%20J-Mrlianová%20M-Tekeľová%20D-Koreňová%20M.pdf
Citations (55)
ADF
Košťálová, Daniela - Tekeľová, Daniela [UKOFAFG] - Czigle, Szilvia [UKOFAFG] - Tóth, Jaroslav [UKOFAFG] - Mrlianová, Mária - Lalkovič, Štefan:
Porovnanie obsahu flavonoidov vo vybraných HVL a výživových doplnkoch s obsahom Ginkgo biloba L.
In: Farmaceutický obzor. - Roč. 74, č. 5 (2005), s. 119-123. - ISSN 0014-8172
Citations (4):
[o1] 2009 Beek, T.A. van - Montoro, P.: Journal of Chromatography A, Roč. 1216, č. 11, 2009, s. 2032 - SCOPUS
Project abbreviation: OEMONOM
Project type: ERASMUS+ KA203 Strategic partnership
Project number: 2020-1-CZ01-KA203-078218
Project name: Open access Educational Materials on Naturally Occurring Molecules - sources, biological activity and use
„Open access Educational Materials On Naturally Occurring Molecules - sources, biological activity and use (OEMONOM)“
Main investigator: Prof. Přemysl Mladěnka, Pharm.D., Ph.D.,
Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic
Co-investigator: Jaroslav Tóth
Project Summary:
Natural compounds have always attracted interest due to their potential effects on human being. Their use is widespread and is rather rising due to false belief that they are always better and safer than conventional drugs. This belief is often the background for companies producing preparations containing such compounds. Hence, the major aim of this project is to prepare comprehensible, free and easily accessible materials reporting both positive and negative aspects of natural compounds used for several commonly used indications (infections, menopause and gynaecological problems, benign prostatic hyperplasia, cough, cardiovascular diseases, CNS, skin and GIT disorders), as well as of vitamins and sympathomimetics, according to the most recent scientific evidence. Special materials will be also prepared for their interactions with conventional drugs.
The novelty and strength of this material will be based on several aspects:
1. They will be freely available,
2. There will be three versions, one for professionals in the form of open access publications, one for students of biomedical disciplines and one for laypersons, both latter as attractive e-learning material in Moodle platform. In particular, in the current situation in the World, the need for a quality and easily accessible e-learning materials is apparent.
3. Materials for students and laypeople will be prepared in English and 8 native languages of participating universities (Czech, French, German, Hungarian, Italian, Portuguese, Slovak and Slovene),
4. Materials will be prepared by common work of experts from different fields (pharmacologists, pharmacognostics, toxicologists, microbiologists, analytical chemists and E-learning experts).
The team is well balanced not only from the scientific point of view, but it also encompasses collegues with solid experiences in a similar e-learning project (e.g. TOX-OER project, www.toxoer.com) as well as many young and talented colleagues.
https://portal.faf.cuni.cz/OEMONOM/SK/Home/
https://portal.faf.cuni.cz/OEMONOM/EN/Home/
Grant VEGA 2/0115/19
„Nové prístupy k liečbe kachexie, zápalu a oxidačného stresu v experimentálnej artritíde: Účinok rôznych rastlinných extraktov z olivových listov, Rhodiola rosea, Tribulus terrestris a extra panenského olivového oleja“
„New approaches to the treatment of cachexia, inflammation and oxidative stress in experimental arthritis: The effect of various plant extracts of olive leaves, Rhodiola rosea, Tribulus terrestris and extra virgin olive oil"
Main investigator: PharmDr. Silvester Poništ, PhD.,
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine (CEM) of the Slovak Academy of Sciences (SAS), Bratislava, Slovakia
Co-investigator: Jaroslav Tóth
Summary:
Rheumatoid cachexia leads to muscle weakness, and loss of functional capacity, and is thought to accelerate morbidity and mortality in rheumatoid arthritis (RA). Adjuvant arthritis (AA) is a model of RA that involves cachexia and also leads to changes in body composition similar to those of RA patients. Our project will examine the relationship between basic arthritic parameters, inflammation, oxidative stress, lipid profile, hunger hormones and satiety. For this purpose, we use AA induced in Lewis rats. Three different plant extracts from olive leaves, Rhodiola rosea, Tribulus terrestris and virgin olive oil alone and in combination with methotrexate are used to reduce cachexia, inflammation and oxidative stress. These plant extracts and virgin olive oil have several biological effects (anti-inflammatory, antioxidant, adaptogenic, anabolic, etc.) and may be beneficial as adjunctive therapy to standard antirheumatic drugs in reducing arthritic cachexia.
Grant APVV-15-0308
„Molekulárno-farmakologické prístupy k inovatívnej terapii reumatoidnej artritídy hodnotenej v experimentálnych podmienkach in vivo a in vitro.“
„Molecular-pharmacological approaches to innovative therapy of rheumatoid arthritis evaluated under experimental conditions in vivo and in vitro.“
Main investigator: PharmDr. K. Bauerová, DrSc.,
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine (CEM) of the Slovak Academy of Sciences (SAS), Bratislava, Slovakia
Co-investigator: Jaroslav Tóth
Project aims:
https://www.crp.gov.sk/apvv-15-0308/
Grant VEGA 1/0359/18
„Možnosti ovplyvnenia niektorých významných faktorov v etiopatogenéze diabetu 2. typu rastlinnými extraktmi"
„Possibilities of influencing some important factors in the etiopathogenesis of type 2 diabetes by plant extracts"
Main investigator: prof. PharmDr. Pavel Mučaji, PhD.,
Faculty of Pharmacy, Comenius University in Bratislava, Slovakia
Co-investigator: Jaroslav Tóth
Grant VEGA 2/0044/15
„Výskum ovplyvnenia zápalu, chronickej autoimunitnej reakcie a redoxnej regulácie organizmu v experimentálnej artritíde použitím nových látok pre adjuvantnú terapiu reumatoidnej artritídy“
"Study of the influence of inflammation, chronic autoimmune response and redox regulation of the organism in experimental arthritis using new agents for the adjuvant therapy of rheumatoid arthritis"
Main investigator: PharmDr. K. Bauerová, DrSc.,
Institute of Experimental Pharmacology and Toxicology, Centre of Experimental Medicine (CEM) of the Slovak Academy of Sciences (SAS), Bratislava, Slovakia
Co-investigator: Jaroslav Tóth
Summary:
The project aims to reveal the unknown mechanisms of etiopathogenesis of RA, up to the level of expression of important Nrf2 and NF-kappa B genes involved in the regulation of inflammation and redox balance of the organism. For this purpose, we will use an experimental model of RA, namely adjuvant arthritis (AA) induced in Lewis rats. We will characterize the development of AA with parameters describing immunological, oxidative and inflammatory processes. In this model, in combination with the acute model (carrageenan-induced inflammation) and cell culture (BV-2 mouse microglia stimulated with inflammation), we will also evaluate the antirheumatic effect of substances not previously studied in adjuvant arthritis in rats (antioxidants: astaxanthin, troloxolocarnoz selected phytochemicals and extracts, punic acid, Lactobacillus plantarum strain LS / 07). The most effective substances of the individual groups are then selected in combination with a basal antirheumatic drug - methotrexate. The expected benefit is an increase in the efficacy of methotrexate without increasing the risk of side effects.
Grant VEGA 1/02262/22
„Antimikróbne účinky malých molekúl rastlín a ich extraktov"
„Antimicrobial effects of small molecules of plants and their extracts"
Main investigator: prof. PharmDr. Pavel Mučaji, PhD.,
Faculty of Pharmacy, Comenius University in Bratislava, Slovakia
Co-investigator: Jaroslav Tóth
VII.a - Activity, position | VII.b - Name of the institution, board | VII.c - Duration |
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Vice Dean for Faculty's Development, for Cooperation with Practice, and for Information Technology; Member of the Scientific Board of the Faculty (ex officio); Chairman of the Quality Council of the Faculty (ex officio); Member of the Quality Council of the University (ex officio); Member of the editorial board of the magazine "Our University" ["Naša univerzita"] (ex officio) | Comenius University Bratislava, Faculty of Pharmacy | 12. 3. 2013 – 11. 3. 2021 |
Independent researcher (Scientific qualification level IIa) | Slovak Academy of Sciences | Acquired 8. 12. 2009 |
Nominated member (national expert): EFSA Scientific Cooperation (ESCO) Working Group on Botanicals and Botanical Preparations | European Food Safety Authority (EFSA) – Scientific Committee, Parma, Italy | 2007 – 2009 |
Invited member (external expert): Working Group on Botanicals in Food | European Food Safety Authority (EFSA) – ANS (Scientific Panel on Food Additives and Nutrient Sources Added to Food), Parma, Italy | 2012 – 2013 |
Study Counsellor of the Master's degree programme Pharmacy in English language, member of the Pedagogical Commission | Comenius University Bratislava, Faculty of Pharmacy | Since 2007 – current |
Member of the National Expert Scientific Group of the National Focal Point for Cooperation with the European Food Safety Authority (EFSA) | Ministry of Agriculture and Rural Development of the Slovak Republic | Since 2007 – current |
Alternate member (nominated by the Slovak Republic): Committee on Herbal Medicinal Products (HMPC) | European Medicines Agency (EMA), Committee on Herbal Medicinal Products (HMPC), Amsterdam, The Netherlands | Since 2022 – current |
Member | Comenius University Bratislava, Faculty of Pharmacy – Ethics Committee for Biomedical Research | Since 2014 – current |
Member of the Academic Senate of the Faculty (FPharm CU) (2002 – 2013; 2023 – current); Secretary of the Academic Senate (2004 – 2010); Chairman of the Staff Chamber / Vice-Chairman of the Academic Senate (2010 – 2013) | Comenius University Bratislava, Faculty of Pharmacy – Academic Senate of the Faculty | 2002 – 2013; 2023 – current |
Member (representing the Faculty) | Council of Higher Education Institutions of the Slovak Republic | 2009 – current |
VIII.a - Name of the institution | VIII.b - Address of the institution | VIII.c - Duration (indicate the duration of stay) | VIII.d - Mobility scheme, employment contract, other (describe) |
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Heidelberg University (Ruprecht-Karls-Universität Heidelberg), Institute of Pharmaceutical Biology | Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany | 1. 10. 1996 – 30. 9. 1998 (2 years) | Scholarship of the DAAD (Deutscher Akademischer Austauschdienst / German Academic Exchange Service) |
Deutsches Krebsforschungszentrum Heidelberg (DKFZ) / German Cancer Research Center | Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany | 16. 01. 2008 – 14. 02. 2008 (1 month) | European Social Fund (ESF) project scholarship |
Deutsches Krebsforschungszentrum Heidelberg (DKFZ) / German Cancer Research Center | Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany | 1. 10. 2001 – 21. 12. 2001 (3 months) | Comenius University Bratislava travel grant for PhD. students' mobility |
Charles University, Faculty of Pharmacy | Akademika Heyrovského 1203, CZ-500 05 Hradec Králové | 15. 5. 2001 – 8. 6. 2001 (1 month) | CEEPUS (Central European Exchange Program for University Studies) travel grant |
Summer (German-Czech-Slovak) Academy | Czech Academy of Sciences, Prague, Czech Republic; Schloss Neubeuern (castle), Germany | 2001; 1998; 1997 (three times per 2 weeks) | Scholarship of the DAAD (Deutscher Akademischer Austauschdienst / German Academic Exchange Service) and the DFG (Deutsche Forschungsgemeinschaft / German Research Foundation) |
Popularization of science: regular guest on live television, interviews and podcasts for radio and daily press on the subject of medicinal plants, natural remedies, (traditional) herbal medicinal products, herbal/botanical food supplements.
Since 2007 – current: member of the editorial board of the professional magazine "Medicinal Plants" ["Liečivé rastliny / Léčivé rostliny"]
Membership in professional societies:
Since 1996 – current: Slovak Pharmaceutical Society at the Slovak Medical Association;
Since 1996 – current: Slovak Chemical Society.