Detection of Murine Herpesvirus 68 (MHV-68) in Dermacentor reticulatus Ticks; https://link.springer.com/article/10.1007/s00248-015-0622-7

Murine Gammaherpesvirus (MHV-68) Transforms Cultured Cells in vitro; https://www.karger.com/Article/FullText/370071

Cells transformed by murine herpesvirus 68(MHV-68) release compounds with transforming and transformed phenotype suppressing activity resembling growth factors; https://pdfs.semanticscholar.org/560e/4f429b74752eedf092bf30bf0e2ae2a2c393.pdf?_ga=2.29403263.172385128.1603872715-1623526796.1603872715

Transformation of Cells by Photoinactivated Murine Gamma-Herpesvirus 68 during Nonproductive and Quiescent Infection; https://www.karger.com/Article/Fulltext/479373

Murine herpesvirus-68-related growth factors treatment correlates with decrease of p53 and HIF-1α protein levels; https://doi.org/10.1093/femspd/ftad004

Murine herpesvirus-68-related growth factors treatment correlates with decrease of p53 and HIF-1α protein levels; https://doi.org/10.1093/femspd/ftad004

Transformation of Cells by Photoinactivated Murine Gamma-Herpesvirus 68 during Nonproductive and Quiescent Infection; https://www.karger.com/Article/Fulltext/479373

Transforming Activity of Murine Herpesvirus 68 Putative Growth Factor is Related to the Ability to Change Cytoskeletal Structure; https://www.karger.com/Article/Fulltext/453067

Optimization of the Microscopic Method of Observing of the Oleogel Structure; https://app.scilit.net/publications/b47135d14d2163cfe814f355f18aa742

Spheroids as 3D Cell Models for Testing of_Drugs; https://www.researchgate.net/publication/373378357

Detection of Murine Herpesvirus 68 (MHV-68) in Dermacentor reticulatus Ticks. [o1] 2016 - Rubel, F. - Brugger, K. - Pfeffer, M. - Chitimia-Dobler, L. - Didyk, Y.M. - Leverenz, S. - Dautel, H. - Kahl, O. - In: Ticks and Tick-borne Diseases, Vol. 7, No. 1, 2016 ; s. 224-233 ; SCI ; SCOPUS

Cells transformed by murine herpesvirus 68(MHV-68) release compounds with transforming and transformed phenotype suppressing activity resembling growth factors. [o1] 2018 - Cimpean, A.M. - Lalošević, D. - Lalošević, V. - Banović, P. - Raica, M. - Alexandru Mederle, O. - In: In Vivo, Vol. 32, No. 4, 2018 ; s. 791-798 ; SCI

Transformation of Cells by Photoinactivated Murine Gamma-Herpesvirus 68 during Nonproductive and Quiescent Infection. [o1] 2019 - Wiehe, A. - O'brien, J.M. - Senge, M.O. - In: Photochemical and Photobiological Sciences, Vol. 18, No. 11, 2019 ; s. 2565-2612 ; SCI

Murine Gammaherpesvirus (MHV-68) Transforms Cultured Cells in vitro. [o2] 2020 - Mistríková, J. - Briestenská, K. - In: Acta Virologica, Vol. 64, No. 2, 2020 ; s. 167-176 ; SCI ; SCOPUS

Recombinant herpesviruses as tools for the study of herpesvirus biology. [o1] 2016 - Stutzman-Rodriguez, K. - Rovnak, J. - VandeWoude, S. - Troyer, R.M. - In: Virology, Vol. 498, November, 2016 ; s. 23-30 ; SCOPUS

VEGA 1/0146/23: Study of drugs based on glycosaminoglycans, sulfated heteropolysaccharides and live bacterial strains with antiproliferative and immunomodulatory properties in vitro and in vivo (01/23 - 12/26), principal investigator of the project.

The aim of the project is to monitor the phagocytic activity of macrophages by increasing the production of GcMAF protein in the body by using drugs prepared on the basis of glycosaminoglycans, sulfated heteropolysaccharides and live bacterial strains. In the research we will study the antiproliferative, antitumor and immunomodulatory effects of these substances. The essence of the immunomodulatory effect of substances based on glycosaminoglycans-low molecular weight chondroitin sulphate and fucoidan-sulphated heteropolysaccharide containing fucose and galactosamine is the in vivo increase of GcMAF protein production by inhibition of nagalase activity. Initially, we will start testing substances on 2D and 3D cell cultures. Following targeted subcutaneous administration of tumor cells to laboratory mice, we will monitor the effect of the oral drug on progression as well as inhibition of xenografts formed. We anticipate that experimental studies will bring medically significant markers to GcMAF immunotherapy.

KEGA 008UK-4/2019: Integration of interactive electronic textbooks and e-learning processes in the teaching of immunology and virology (01/19 – 12/21), principal investigator of the project. The output of the submitted project will be interactive electronic textbooks from virology in English and a manual of methods and procedures from immunology and molecular biology of viruses, as well as teaching texts of basic virological methods in printed form. Interactive electronic textbooks will be introduced in the processes of teaching immunology and virology in integration with e-learning systems.

VEGA 1/0061/18: The analysis of bioactive substances associated with Murine herpesvirus with antiproliferative andimmunomodulatory properties in vitro and in vivo (01/18 – 12/21), principal investigator of the project. The project represents an original study devoted to the biological and immunological characterization of bioactive compounds associated with the virus MHV-68, which is referred to as MHGF-68 In spite of intensive studies of MHV-68, no attention has been hitherto paid to substances resembling growth factors associated with this virus. We characterize the selected fraction of MHGF-68 with antiproliferative effects in vitro on different cell lines and in vivo in a model of athymic mice. The obtained results suggest the possible application of MHGF-68 in the treatment or prevention of cancer associoated with herpesvirus.

APVV-0621-12: Murine herpesvirus, a producent of substances exhibiting immunomodulatory and antiproliferative properties (10/2013 – 09/2017), head of the co-resolving organization. The project was focused on the study and characterization of MHV-68-induced substances with immunomodulatory and antiproliferative properties. The results of the project contribute to elucidating the potential therapeutic use of M3 protein and MHGF-68 and to a better understanding of chronic infection of people with gHVs. In particular, it is possible to specifically modulate the binding of chemokines to recombinant M3 proteins desired in the treatment of immune response disorders and the real possibility to use MHGF68 and tumor lines to expand knowledge of the mechanisms of viral cell transformation.