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Name and surname:
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PharmDr. Dalibor Nakládal, PhD.
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Document type:
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Research/art/teacher profile of a person
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The name of the university:
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Comenius University Bratislava
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The seat of the university:
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Šafárikovo námestie 6, 818 06 Bratislava
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| III.a - Occupation-position | III.b - Institution | III.c - Duration |
|---|---|---|
| scientific researcher | Science Park, Comenius University in Bratislava | september 2022 - |
| postdoc | University Medical Center Groningen, The Netherlands | 2020-2022 |
| PhD student | Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University in Bratislava | 2015-2019 |
| PhD student | University Medical Center Groningen, The Netherlands | 2015-2022 |
Benedek Halmos; Anouk M. La Rose; Daisey Methorst; Anouk G. Groenen; Dalibor Nakládal; Venetia Bazioti; Mirjam H. Koster; Niels J. Kloosterhuis; Azuwerus van Buiten; Elisabeth M. Schouten et al. (2025) “SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis.” Circulation Research. https://doi.org/10.1161/CIRCRESAHA.124.325103
Lambooy, S., Heida, A., Joschko, C., Nakladal, D., van Buiten, A., Kloosterhuis, N., Huijkman, N., Gerding, A., van de Sluis, B., Henning, R., & Deelman, L. (2023). Selective Hepatic Cbs Knockout Aggravates Liver Damage, Endothelial Dysfunction and ROS Stress in Mice Fed a Western Diet. International Journal of Molecular Sciences, 24(8), Article 8. https://doi.org/10.3390/ijms24087019
Vogelaar, P., Nakladal, D. (shared first authorship), Swart, D., Tkáčiková, Ľ., Tkáčiková, S., van der Graaf, A., Henning, R., & Krenning, G. (2021). Towards prevention of ischemia-reperfusion kidney injury: Pre-clinical evaluation of 6-chromanol derivatives and the lead compound SUL-138. European Journal of Pharmaceutical Sciences, 106033. https://doi.org/10.1016/j.ejps.2021.106033
Nakladal, D., Lambooy, S. P. H., Mišúth, S., Čepcová, D., Joschko, C. P., van Buiten, A., Goris, M., Hoogstra-Berends, F., Kloosterhuis, N. J., Huijkman, N., van de Sluis, B., Diercks, G. F., Buikema, J. H., Henning, R. H., & Deelman, L. E. (2022). Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemia. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, 36(4), e22260. https://doi.org/10.1096/fj.202101550R
Lambooy, S. P. H., Bidadkosh, A., Nakladal, D., van Buiten, A., Girgis, R. A. T., van der Graaf, A. C., … Deelman, L. E. (2017). The Novel Compound Sul-121 Preserves Endothelial Function and Inhibits Progression of Kidney Damage in Type 2 Diabetes Mellitus in Mice. Scientific Reports, 7(1). https://doi.org/10.1038/s41598-017-11582-6
Feenstra, L., Chatre, L., Bernay, B., Pontin, J., Mastik, M. F., Van Buiten, A., Nakládal, D., Star, B. S., Hillebrands, J., & Krenning, G. (2025). Calciprotein particle‐induced calcium overload triggers mitochondrial dysfunction in endothelial cells. The Journal of Physiology, JP287656. https://doi.org/10.1113/JP287656
Nakládal, D., Oerlemans, R., Molitorisová, M., Chomaničová, N., Zorkócy, G., Yoseif, C., Van Der Graaf, A. C., Stuchlík, S., Krenning, G., Groves, M. R., Heeres, A., Levarski, Z., Kyselovič, J., Henning, R. H., & Deelman, L. E. (2025). New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase. SLAS Discovery, 32, 100234. https://doi.org/10.1016/j.slasd.2025.100234
Nakládal, D. (2022). Drug development and new targets for redox disturbances in experimental vascular disease: [Dissertation Thesis, University of Groningen]. https://doi.org/10.33612/diss.233870509
Nakladal, D., Sijbesma, J. W. A., Visser, L. M., Tietge, U. J. F., Slart, R. H. J. A., Deelman, L. E., Henning, R. H., Hillebrands, J. L., & Buikema, H. (2021). Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats. Vascular Pharmacology, 106945. https://doi.org/10.1016/j.vph.2021.106945
Nakladal, D., Buikema, H., Romero, A. R., Lambooy, S. P. H., Bouma, J., Krenning, G., … Deelman, L. E. (2019). The (R)-enantiomer of the 6-chromanol derivate SUL-121 improves renal graft perfusion via antagonism of the α1-adrenoceptor. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-018-36788-0
Sijbesma, J. W. A., Van Waarde, A., Kristensen, S., Kion, I., Tietge, U. J. F., Hillebrands, J.-L., Bulthuis, M. L. C., Buikema, H., Nakladal, D., Westerterp, M., Liu, F., Boersma, H. H., Dierckx, R. A. J. O., & Slart, R. H. J. A. (2023). Characterization of a novel model for atherosclerosis imaging: The apolipoprotein E-deficient rat. EJNMMI Research, 13(1), 106. https://doi.org/10.1186/s13550-023-01055-5
Rodriguez, R. D., Huizing, E., Ünlü, Ç., Simonis, F. F. J., Bokkers, R. P. H., De Vries, J.-P. P. M., Schuurmann, R. C. L., Nakladal, D., Buikema, H., Hillebrands, J.-L., & Leuvenink, H. G. D. (2023). Validation of an ex vivo Flow Model Including Magnetic Resonance Imaging to Study the Effects of Endovascular Treatments on the Arterial Wall. Journal of Vascular Research, 60(1), 1–11. https://doi.org/10.1159/000529115
Hernández-Camacho, Juan D., Michel Bernier, Guillermo López-Lluch, and Plácido Navas. 2018. “Coenzyme Q10 Supplementation in Aging and Disease.” Frontiers in Physiology 9:44. doi: 10.3389/fphys.2018.00044.
Advancing innovative treatments targeting sulfur biochemistry (TREATSULF), APVV-23-0178, 2024-2026, principal investigator
High-throughput screening for the discovery of new drugs rescuing impaired sulfur metabolism in diabetic nephropathy and colon cancer, VEGA 1/0619/24, 2024-2026, principal investigator.
Discovery and development of new drugs for treatment of diabetic kidney disease: counteracting transsulfuration deficiency to improve defense against oxidative stress, APVV PP-MSCA2022-0001 (Marie Skłodowska-Curie Actions Seal of Excellence), 2022-2024, principal investigator
Discovery and development of new drugs for treatment of diabetic kidney disease: counteracting transsulfuration deficiency to improve defense against oxidative stress, Slovak Academic and Scientific Programme (SASPRO2) 3333/03/02, 2022-2025, research fellow.
European Lead Factory program (2021-2022): Ultra-High-Throughput-Screening of large academic/commercial library for the discovery of allosteric modulators of Cystathionine-β-synthase. PivotPark Screening Center in Oss, the Netherlands; Bio:ascent, Scotland.