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Name and surname:
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PharmDr. Vladimír Garaj, PhD.
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Document type:
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Research/art/teacher profile of a person
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The name of the university:
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Comenius University Bratislava
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The seat of the university:
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Šafárikovo námestie 6, 818 06 Bratislava
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| III.a - Occupation-position | III.b - Institution | III.c - Duration |
|---|---|---|
| pharmacist assistant | Pharmacy Medovka in Myjava | 2000 - 2001 |
| university teacher | Faculty of Pharmacy, Comenius University in Bratislava | 2001 - till now |
| IV.a - Activity description, course name, other | IV.b - Name of the institution | IV.c - Year |
|---|---|---|
| INTERNATIONAL TRAINING FOR ACADEMIC STAFF - ENHANCING THE TEACHING MOBILITY EXPERIENCE | Eötvös Loránd University | 2021 |
| V.1.a - Name of the profile course | V.1.b - Study programme | V.1.c - Degree | V.1.d - Field of study |
|---|---|---|---|
| Pharmaceutical chemistry | pharmacy | 2. | |
| Pharmaceutical chemistry | pharmaceutical chemistry | 3. |
| V.5.a - Name of the course | V.5.b - Study programme | V.5.c - Degree | V.5.d - Field of study |
|---|---|---|---|
| Molecular basis of drug development | pharmacy | 2. | |
| Drug analysis | pharmacy | 2. |
10.1016/j.snb.2019.127646
10.1016/j.snb.2019.127646
10.1002/chir.23255
10.3390/ijms23010231
10.3390/SYM12050849
10.1002/ardp.202400889
10.1016/j.jchromb.2024.124067
https://doi.org/10.1016/j.ejmech.2018.11.017
10.1039/d0cs00547a
VEGA 1/0825/25 - head investigator
In vitro, in silico and in cellulo search for efficient small molecule drug targeting tau protein in the pathogenesis of
Alzheimer's disease
The fact that the only disease modifying therapy for Alzheimer's disease being expensive biological therapy with
anti amyloid B antibodies represents a significant burden for the healthcare systems worldwide. Therefore the
obtainment of small molecule inhibitor of tau pathology may be a groundbreaking scientific and pharmaceutical
result. In this project we aim to find a small molecule inhibitor of tau pathology out of libraries of available
molecules using molecular docking, characterize its interaction and test its efficacy both in vitro and in cellulo .
We will use the biophysical methods for characterization of interactions between protein- small molecule - SPR,
MST, MS and NMR ; together with the monitoring of tau aggregation reaction and testing of molecules added to
tau FRET reporter cells. The best lead compounds will be further improved for higher affinity and better selectivity
and ADMET properties.
https://www.minedu.sk/data/att/3f1/33338.354be4.xlsx
VEGA 1/0743/13 - head investigator
VEGA 1/0039/12 - coinvestigator
VEGA 1/0084/10 - coinvestigator
VEGA 1/4301/07 - coinvestigator
COST CM0602 - coinvestigator
| VII.a - Activity, position | VII.b - Name of the institution, board | VII.c - Duration |
|---|---|---|
| editor | European Pharmaceutical Journal | 2014 - till now |
| editor | All Life Methods | 2023 - 2024 |
| VIII.a - Name of the institution | VIII.b - Address of the institution | VIII.c - Duration (indicate the duration of stay) | VIII.d - Mobility scheme, employment contract, other (describe) |
|---|---|---|---|
| UNIVERSIDAD DE CASTILLA-LA MANCHA | Av. Dr. Jose Maria Sánchez Ibáñez, s/n, 02071 Albacete, Španielsko | 28. 6. - 5. 7. 2024 | Blended Intensive Programme (BIP) titled: “Drug Discovery and Development” |
| Universitá degli studi di Messina | Viale Stagno d'Alcontres, 31 - 98166 MESSINA | 27. 9. - 1. 10. 2021 | Erasmus+ STA |
| George Emil Palade University of Medicine, Pharmacy, Science and Technology of Targu Mures | Gheorghe Marinescu Street 38, Targu Mureș, 540142, ROMANIA | 3. - 7. 10. 2016 | Erasmus+ STA |