Name and surname:
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RNDr. Milan Zvarík, PhD.
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Document type:
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Research/art/teacher profile of a person
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The name of the university:
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Comenius University Bratislava
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The seat of the university:
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Šafárikovo námestie 6, 818 06 Bratislava
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III.a - Occupation-position | III.b - Institution | III.c - Duration |
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Assistant professor | Comenius University in Bratislava, Faculty of Mathematics, Physics and Informatics | 2013-present |
IV.a - Activity description, course name, other | IV.b - Name of the institution | IV.c - Year |
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Defending of degree Rerum Naturalium Doctor | Prírodovedecká fakulta UPJŠ v Košiciach | 2010 |
V.1.a - Name of the profile course | V.1.b - Study programme | V.1.c - Degree | V.1.d - Field of study |
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Methods of Biosignal Processing and Medical Imaging Computer Graphic (1) | Biomedical Physics | II. | Physics |
Experimental Methods in Medical Physics (1) | Biomedical Physics | II. | Physics |
Special Practical in Biomedical Physics (1, 2) | Biomedical Physics | II. | Physics |
V.5.a - Name of the course | V.5.b - Study programme | V.5.c - Degree | V.5.d - Field of study |
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Text and Data Sets Processing | Biomedical Physics | I. | Physics |
Biophysics | Biomedical Physics | I. | Physics |
Biomedical Physics | I. | Physics | |
Biomedical Physics | II. | Physics | |
Biomedical Physics | II. | Biomedical Physics | |
Medical Biology | I. | Biology |
Zvarík, M., Martinický, D., Hunáková, Ľ., Lajdová, I., Šikurová, L. (2013). Fluorescence characteristics of human urine from normal individuals and ovarian cancer patients. Neoplasma. Vol 60, No. 5, s. 533-537.
Šikurová, L., Bališ, P., Zvarík, M. (2011). Penetration of laser light through red blood cell ghosts. Journal of Photochemistry and Photobiology B: Biology. Vol. 103, No. 3, s. 230-233.
Lešková, A., Zvarík, M., Araya, T., Giehl, R. (2019). Nickel Toxicity Targets Cell Wall-Related Processes and PIN2-Mediated Auxin Transport to Inhibit Root Elongation and Gravitropic Responses in Arabidopsis. Plant & cell physiology., Vol 61, No. 3, s. 519-535.
Zvarík, M., Martinický, D., Hunáková, Ľ., Šikurová, L. 2015, "Differences in pteridine urinary levels in patients with malignant and benign ovarian tumors in comparison with healthyindividuals", Journal of Photochemistry and Photobiology B: Biology, vol. 153, pp. 191-197.
Kollárik, B., Zvarík, M., Bujdák, P., Weibl, P., Rybár, L., Šikurová, L., Hunáková, Ľ. (2018). Urinary fluorescence analysis in diagnosis of bladder cancer. Neoplasma. Vol. 65., No. 2, s. 234-241.
Džubinská, D., Zvarík, M., Kollárik, B., Šikurová, L. 2021. "Multiple Chromatographhic Analysis of Urine in the Detection of Bladder Cancer", Diagnostics 2021, 11(10), 1793.
Šutý, Š., Oravczová, V., Garaiová, Z., Šubjaková, V., Ionov, M., Shcharbin, D., Šimoníková, Z., Bartek, P., Zvarík, M., Shi, X., Mignani, S., Majoral, J., Bryszewska, M., Hianik, T., Waczulikova, I. (2021). Blood Compatibility of Amphiphilic Phosphorous Dendrons—Prospective Drug Nanocarriers. Biomedicines. Vol 9, No. 11, s. 1-13.
Lešková, A., Zvarík, M., Araya, T., Giehl, R. (2019). Nickel Toxicity Targets Cell Wall-Related Processes and PIN2-Mediated Auxin Transport to Inhibit Root Elongation and Gravitropic Responses in Arabidopsis. Plant & cell physiology., Vol 61, No. 3, s. 519-535.
Majerová, K., Zvarík, M., Ricon-Becker, I., Hanalis-Miller, T., Mikolášková, I., Bella, V., Mravec, B., Hunáková, Ľ. (2022) Increased sympathetic modulation in breast cancer survivors determined by measurement of heart rate variability. Scientific reports. 12(1), art. no. 1466 (s. [1-10]).
Prokop, P., Zvaríková, M., Zvarík, M., & Fedor, P. (2020). Cues of pregnancy decrease female physical attractiveness for males. Current Psychology.
Stafford N., Wilson C., Oceandy D., Neyses L., Cartwright E.J.(2017) The plasma membrane calcium ATPases and their role as major new players in human disease. Physiological Reviews, 97 (3), pp. 1089 - 1125; SCI, SCOPUS (IF 49,5).
Jordaens S., Zwaenepoel K., Tjalma W., Deben C., Beyers K., Vankerckhoven V., Pauwels P., Vorsters A. (2023) Urine biomarkers in cancer detection: A systematic review of preanalytical parameters and applied methods. International Journal of Cancer, 152 (10), pp. 2186 - 2205; SCI; SCOPUS (IF 15,2)
Atta N., Shahbaz M., Farhat F., Maqsood M.F., Zulfiqar U., Naz N., Ahmed M.M., Hassan N.U., Mujahid N., Mustafa A.E.-Z.M.A., Elshikh M.S., Chaudhary T. (2024) Proline-mediated redox regulation in wheat for mitigating nickel-induced stress and soil decontamination. Scientific Reports, 14 (1), art. no. 456; SCI ; SCOPUS (IF 7,5)
Zhao X., Zheng W., Qin T., Du X., Lei Y., Lv T., Zhou M., Xu Z., Wang L., Liu B., Peng X. (2022) An anti-interference fluorescent probe for point-of-care diagnosis of albuminuria. Sensors and Actuators B: Chemical, 351, art. no. 130980; SCI; SCOPUS (IF 15)
Liu B., Zhao X., Zhou M., Song C., Zeng C., Qin T., Zhang M., Xu Z. (2022) Modulating donor of dicyanoisophorone-based fluorophores to detect human serum albumin with NIR fluorescence. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 268, art. no. 120666; SCI ; SCOPUS (IF 7,1)
BIOCARD - Bioenergetic and proteomic diagnostics in cardioprotection: a tool for monitoring the regulation of mitochondrial signaling pathways (team leader FMPI). Oxygen-limited supply significantly increases the myocardial energy requirements. The onset of compensatory mechanisms against this disorder is associated with regulation at the level of cardiac mitochondria. It is mitochondrial dysfunction that is currently the goal of a therapeutic cardioprotective strategy. This project will combine the latest scientific insights with state-of-the-art methodological approaches. A key aspect of the presented research is to ensure sufficient energy production in the heart in conditions of increased energy requirements caused by reduced oxygen utilization and ischemic heart disease in combination with various types of preconditioning. The use of modern methodology will allow for investigation into the complex structure of mitochondrial protein signaling pathways, their regulations, proteome and metabolome alterations in heart and mitochondria. Description and comprehension of complex system of protein interactions can help identify signaling pathways in cardioprotection processes. Changes at the level of mitochondrial respiratory chain complexes that play an important role in the cellular energy maintenance will also be identified. One of the considered mechanisms of cardioprotection is the inhibition of mitochondrial permeability transition pores (mPTP) opening. Regulation of mPTP in terms of changes of individual proteins has already been presented. We aim to contribute to the understanding of the protein interactions presumably related to the protective modulation of mPTP. In connection with the remodeling of mitochondrial function, calcium homeostasis and signaling of free oxygen radicals will also be monitored. The presented project will deal with the stimulation of adaptation processes in order to contribute to the elimination of mitochondrial dysfunction and ensure the maintenance of dynamic balance under conditions of energy deprivation in diseased heart. [APVV-22-0264]
Cardiac mitochondrial bioenergetics regulated by reduced oxygen consumption: In-depth proteomic analysis of cardioprotective signaling pathways (team leaderFMPI). Reduced oxygen utilization significantly increases the myocardial energy requirements. The compensatory mechanisms against this serious metabolic disorder is associated with regulation of cardiac mitochondria. It is mitochondrial dysfunction that is currently the goal of a therapeutic cardioprotective strategy, effective against energy and dynamic imbalance. Part of the identification of preconditioning-induced adaptation processes will be the monitoring of the role of mitochondria on redox equilibrium, signaling of free oxygen radicals, changes in oxidative phosphorylation and energy pathways, mitochondrial dynamics and ion homeostasis. The definition of hypoxic damage, the effect of preconditioning and the identification of a potential cardioprotective signal carrier will be indicated by proteomic and metabolomic analyzes by LC-MS. The comprehensive analysis will provide detailed information on changes of proteins as potential markers as well as the characteristics of their signaling pathways.[VEGA 2/0016/23]
Diagnostic potential of body fluid fluorescent characteristics and extracellular microvesicles analyses in urogenital malignancies (team leader). The project focuses on the blood serum and urine metabolites detection, which may be potentially associated with the neoplasia process to provide a new direction in the present searching for tumor diseases predictive markers. Therefore, the project fundamental objectives include, in particular, mapping of fluorescence characteristics of body fluids for their potential for use in the diagnosis and screening of tumor diseases. Using modern separation and fluorescence techniques, the metabolic "fingerprint" of urine and blood serum of healthy volunteers and patients with bladder, prostate, testicular and kidney cancer will be assessed. To maximize the use of the media, the project deals with the isolation and analysis of extracellular microvesicles present in biological samples (exosome-like vesicles). In the environment of modern multidimensional statistical methods, all obtained data analyses shall be carried out, which will subsequently serve to select the most suitable parameters - potential biomarkers. [VEGA - 0136/18]
Analysis of Interaction between Amphiphilic Dendrons and Biological Systems (team member). For decades chemists have been developing approaches to functional nanoscale molecules with application in targeted therapy such as dendrimers - highly branched polymers. Various types of dendrimers have been synthesized to increase biocompatibility, reduce toxicity and improve the selectivity of absorption by targeted cells. One of these successful modifications is the combination of the advantages of a dendritic structure with lipid-like properties. In the proposed project several chemically improved amphiphilic phosphorus-containing dendrons, which are intended as a platform for the delivery of anti-apoptotic small interfering RNA (siRNA), will be examined and mechanisms of their interactions with various biological objects will be studied by means of various biophysical methods. The assessment of biocompatibility is, however, a mandatory prerequisite before further investigation of biomedical applications. The overall objective of the proposal is therefore to produce relevant fact-based knowledge about the nature of interaction of the originally synthesized amphiphilic dendritic blocks and their self-assemblies with biological systems on several levels of organization, molecular (plasma proteins), supramolecular (biomembranes and artificial models), cellular (erythrocytes and platelets), as well as tissue level (blood as a fluid connective tissue). We believe that new knowledge on the mechanisms of interaction of amphiphilic dendrons with biological systems will help in their application in targeted drug delivery in nanomedicine. Both teams dispose of an array of modern and high-power biophysical methods which enable to perform project tasks, successfully solve planned goals and select suitable nanoconstructs as potential non-viral vectors for gene therapy. Among project priorities will be extensive collaboration between Slovak and Belarusian teams with focus on joint experiments, preparation of joint publications, organisation of joint seminars and workshops. [APVV_SK-BY-RD-19-0019]
Strengthening and spreading international partnership activities of the Faculty of Biology and Environmental Protection for interdisciplinary research and innovation of the University of Lodz (team member). The aim of the project is to strengthen the international partnership of the Faculty of Biology and Environmental Protection of the University of Lodz by preparing a consortium partnership to submit a competitive application to the Horizon 2020 program dedicated to innovative interdisciplinary and cross-sectoral PhD studies in the Maria Skłodowska-Curie call for proposal. [NAWA EUROPARTNER (Poland)]
VII.a - Activity, position | VII.b - Name of the institution, board | VII.c - Duration |
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Member of the state examination | Comenius University in Bratislava, Faculty of Mathematics, Physics and Informatics | 2019 - present |