M. B. Jackson: Molecular and cellular biophysics. Cambridge. Cambridge University Press, 2006
D. G. Nicholls, S. J. Ferguson: Bioenergetics 4th edition. London : Academic Press, 2013
D. Uhríková a kol.: Biofyzika - Vybrané kapitoly, Učebnica pre vysoké školy, Univerzita Komenského v Bratislave, 2015
P. F. Dillon, Biophysics: A physiological approach, Cambridge University Press, 2012;
B. Alberts et al., Základy buněčné biologie: Úvod do molekulární biologie buňky. Espero Publishing, 2001
oral state exam
Slovak, English
1. Structure and function of biopolymers, characteristic types of bonds, polymerization as a chemical process, types of biopolymers
2. Structure, physical properties and function of nucleic acids, genetic code, gene, information transfer
3. Structure, physical properties and function of proteins, peptide bond, types of protein structures
4. Structure, physical properties and function of glycans
5. Principles of cell structural organization, types of organelles and their importance, cell locomotor system, cell growth and division
6. Cell division, intercellular connections, necrosis, apoptosis, excessive cell proliferation (cancer)
7. Membrane biophysics, lipid bilayer, phase transitions, membrane models, role of lipids and proteins in the membrane
8. Passive transport of substances across membranes
9. Active transport of substances across membranes
10. Protein-lipid interactions, ion channels, exchangers, membrane receptors
11. Electrical properties of cells. Rest potential.
12. Physics of nerve impulse, structure of nerve cell, formation of action potential, Hodgkin-Huxley model
13. Synaptic transmission in the neuromuscular junction and in the central nervous system.
14. Molecular mechanisms of memory and learning
15. Muscle contraction, muscle structure, muscle proteins, biophysics of muscle contraction, mechanochemical coupling, basics of muscle regulation
16. Electrical activity of skeletal muscle cells and heart muscle.
17. Cell bioenergetics, mechanisms of membrane phosphorylation
18. Influence of physical factors on biosystems, influence of ionizing and non-ionizing radiation mechanisms
19. Photosynthesis of plants and bacteria
20. Photoreception, mechanisms of vertebrate and invertebrate vision
0/100
The student will repeat the theoretical and experimental methods of medical biophysics will gain the necessary overview.
T. Furukawa (Ed.): Biological Imaging and Sensing. Berlin, Springer, 2004
D. Shi (Ed.): Biomedical devices and their applications. Berlin, Springer, 2004
K. Najarian, R. Splinter.: Biomedical signal and image processing, second edition, CRP Press, Taylor & Francis, 2012
J. B. Pawley (Ed.): Handbook of biological confocal microscopy. New York, Springer, 2006
G. G. Hammes: Spectroscopy for the biological sciences. Wiley on line books, 2005
B. Nölting: Methods in modern biophysics, 3rd edition. Springer Verlag Berlin, 2009
oral state exam
Slovak, English
1. Thin films, micelles, liposomes and interfaces
2. Rheology of biological fluids
3. Microscopic techniques (light, polarized, confocal, electron microscopy)
4. Force microscopes
5. Optical absorption spectroscopy and its applications in cell diagnostics
6. Fluorescence spectroscopy, fluorescence microscopy
7. Mass, Raman, Infrared spectroscopy
8. Turbidimetry, nephelometry, analyzers in hematology - aggregometry
9. Flow cytometry and its use in medicine
10. Stem cells - classification, principle, use in medicine,
11. Separation methods of biological samples: electrophoresis, centrifugation, distillation, extraction
12. Dialysis; Calorimetry (differential scanning, isothermal titration)
13. Chromatographic methods (paper, thin film, ion exchange, gel, affinity, capillary, gas, HPLC)
14. Types of biological signals, their origin, sensing and significance in medicine
15. Statistical analysis of biosignals, mathematical modeling and signal fitting
16. Visualization of biosignals
17. Tomography - principle and types
18. X-ray and CT (computed tomography) - principles and medical applications
19. PET - Positron emission tomography, gammagraphy, scintigraphy
20. SPECT - Single photon emission computed tomography
21. Electrophysiological methods of cell study
22. Methods of recording and analysis of bio-electromagnetic signals
23. Phototherapy and photodiagnostics
24. Ultrasound in medicine
25. Radiotherapy
26. Methods of genetic modulation
27. Medical applications of magnetic resonance
28. Internet portal eHealth, information systems
0/100
Harsh Mohan: Patológia. KNIŽNICA LF UK
Examination: oral state exam
Slovak, English
1. Atrophy, dystrophy, necrosis
2. Hypertrophy, hyperplasia
3. Disorders of ventilation, diffusion and perfusion
4. Types of hypoxia
5. Lung diseases caused by pollutants in the inhaled air
6. Chronic respiratory diseases (bronchitis, emphysema, asthma)
7. Respiratory insufficiency
8. Anemia
9. Leukocyte disorders
10. Contraction-relaxation cycle of the heart muscle
11. Myocardial contractile function, pump function of the heart
12. Hypertrophy of the heart
13. Cardiomyopathy
14. Heart failure
15. Acquired heart defects
16. Congenital heart defects
17. Systemic arterial hypertension
18. Shock states
19. Atherosclerosis
20. Ischemic heart disease, angina pectoris, myocardial infarction
21. Pulmonary hypertension, cor pulmonale
22. Pathophysiology of cerebral circulation, intracranial hemorrhage, cerebral infarction
23. Electrophysiological basis of heart rhythm disorders
24. Disorders of sinusoatrial node function, disorders of A-V conduction, tachyarrhythmias
25. Diseases of the venous system
26. Disorders of glomerular function, glomerulonephritis, glomerulopathy
27. Renal failure
28. Diabetes mellitus
29. Intracranial hypertension
30. Epilepsy
31. Demyelinating and degenerative CNS disease
32. Liver cirrhosis, portal hypertension, ascites, liver failure
33. Jaundice
34. Generalized skeletal disorders
35. Dehydration, hyperhydration
36. Disorders of electrolyte economy (Na +, K +, Ca2 +)
37. Disorders of acid-base balance
38. Pathophysiology of the thyroid gland
39. Pathophysiology of parathyroid glands
0/100
The student will repeat the theoretical foundations of medicine and thus gain the necessary overview.
Introduction to physics in modern medicine / Suzanne Amador Kane. Abingdon : Taylor & Francis, 2003
Statistical Methods in Medical Research / P. Armitage, G. Berry, J.N.S. Matthews. Malden, Mass. : Blackwell Science, 2002
Biomedical signal image processing / Kayyvan Najarian, Robert Splinter. Boca Raton, Fla. : Taylor & Francis, 2006
Exam: Diploma thesis defense
Slovak, English
Presentation, defense and discussion of own results in the field of biomedical physics.
0/100
After completing the course, students will be able to present, defend and discuss their own results in the field of biomedical physics.